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Aliases for ZDHHC7 Gene
Aliases for ZDHHC7 Gene
External Ids for ZDHHC7 Gene
- HGNC: 18459
- Entrez Gene: 55625
- Ensembl: ENSG00000153786
- OMIM: 614604
- UniProtKB: Q9NXF8
Previous GeneCards Identifiers for ZDHHC7 Gene
- GC16M075554
- GC16M085974
- GC16M084746
- GC16M084787
- GC16M083565
- GC16M085007
- GC16M070760
Summaries for ZDHHC7 Gene
GeneCards Summary for ZDHHC7 Gene
ZDHHC7 (Zinc Finger DHHC-Type Palmitoyltransferase 7) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein-cysteine S-palmitoyltransferase activity and palmitoyltransferase activity. An important paralog of this gene is ZDHHC3.
UniProtKB/Swiss-Prot Summary for ZDHHC7 Gene
-
Golgi-localized palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and therefore functions in several unrelated biological processes (PubMed:22031296, PubMed:27380321, PubMed:28196865). Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane and their function in rapid intracellular signaling upon binding of sex hormones (PubMed:22031296). Palmitoylates GNAQ, a heterotrimeric G protein, regulating its dynamic localization at the plasma membrane and is thereby involved in GNAQ-dependent G protein-coupled receptor signaling pathways (PubMed:19001095). Functions also in ligand-induced cell death by regulating the FAS signaling pathway through the palmitoylation and stabilization of the receptor at the plasma membrane (PubMed:25301068). In epithelial cells, palmitoylates SCRIB and regulates its localization to the plasma membrane, regulating indirectly cell polarity and differentiation (PubMed:27380321). Also palmitoylates JAM3 and promotes its expression at tight junctions and regulates its function in cell migration (PubMed:28196865). Palmitoylates the glucose transporter GLUT4/SLC2A4 and controls the insulin-dependent translocation of GLUT4 to the plasma membrane (By similarity). In brain, could also palmitoylate SNAP25 and DLG4/PSD95 (By similarity). Could also palmitoylate DNAJC5 and regulate its localization to the Golgi membrane (By similarity). Could also palmitoylate NCDN (By similarity). May play a role in follicle stimulation hormone (FSH) activation of testicular Sertoli cells (By similarity).
Additional gene information for ZDHHC7 Gene
- HGNC(18459)
- Entrez Gene(55625)
- Ensembl(ENSG00000153786)
- OMIM(614604)
- UniProtKB(Q9NXF8)
- Open Targets Platform(ENSG00000153786)
- Search for ZDHHC7 at DataMed
- Search for ZDHHC7 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZDHHC7 Gene
Genomics for ZDHHC7 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for ZDHHC7 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ZDHHC7 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZDHHC7
- Top Transcription factor binding sites by QIAGEN in the ZDHHC7 gene promoter:
-
- Bach2
- ER-alpha
- HOXA5
- JunB
- JunD
- Nkx6-1
- Olf-1
- Pax-2
- Pax-2a
- TGIF
Genomic Locations for ZDHHC7 Gene
Genomic Locations for ZDHHC7 Gene
- chr16:84,974,175-85,011,535
- (GRCh38/hg38)
- Size:
- 37,361 bases
- Orientation:
- Minus strand
- chr16:85,007,787-85,045,141
- (GRCh37/hg19)
- Size:
- 37,355 bases
- Orientation:
- Minus strand
Genomic View for ZDHHC7 Gene
Genes around ZDHHC7 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16q24.1 by HGNC
- 16q24.1 by Entrez Gene
- 16q24.1 by Ensembl
ZDHHC7 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ZDHHC7 Gene
Proteins for ZDHHC7 Gene
-
Protein details for ZDHHC7 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9NXF8-ZDHC7_HUMAN
- Recommended name:
- Palmitoyltransferase ZDHHC7
- Protein Accession:
- Q9NXF8
- D3DUM1
- Q8WV42
- Q9NVD8
Protein attributes for ZDHHC7 Gene
- Size:
- 308 amino acids
- Molecular mass:
- 35140 Da
- Quaternary structure:
-
- Homooligomers. Heterooligomers with ZDHHC3.
- SequenceCaution:
-
- Sequence=AAH17702.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAA91814.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
Protein Expression for ZDHHC7 Gene
Selected DME Specific Peptides for ZDHHC7 Gene
- Q9NXF8:
-
- MDHHCPW
- WFIRDGCG
- MLTDPGAVPKGNATKE
- FVLFTMYIAL
Post-translational modifications for ZDHHC7 Gene
- Autopalmitoylated.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for ZDHHC7 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ ZDHHC7 Antibody
-
Custom Antibody ServicesOriGene Antibodies for ZDHHC7
- Novus Biologicals Antibodies for ZDHHC7
-
Abcam antibodies for ZDHHC7
- Invitrogen Antibodies for ZDHHC7 (AFLGC-ZDHHC7)
-
Biorbyt antibodies for ZDHHC7
-
Boster Bio Antibodies for ZDHHC7
Protein Products
-
OriGene Purified Proteins for ZDHHC7
- Search Origene for MassSpec and Protein Over-expression Lysates for ZDHHC7
- Origene Custom Protein Services for ZDHHC7
-
Abcam proteins for ZDHHC7
Domains & Families for ZDHHC7 Gene
Gene Families for ZDHHC7 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted membrane proteins
Protein Domains for ZDHHC7 Gene
- InterPro:
- Blocks:
-
- Zn-finger, DHHC type
- ProtoNet:
Suggested Antigen Peptide Sequences for ZDHHC7 Gene
- GenScript: Design optimal peptide antigens:
-
- Zinc finger protein 370 (ZDHC7_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9NXF8UniProtKB/Swiss-Prot:
ZDHC7_HUMAN :- The DHHC domain is required for palmitoyltransferase activity.
- Belongs to the DHHC palmitoyltransferase family.
- Domain:
-
- The DHHC domain is required for palmitoyltransferase activity.
- Family:
-
- Belongs to the DHHC palmitoyltransferase family.
Function for ZDHHC7 Gene
Molecular function for ZDHHC7 Gene
- UniProtKB/Swiss-Prot Function:
- Golgi-localized palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and therefore functions in several unrelated biological processes (PubMed:22031296, PubMed:27380321, PubMed:28196865). Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane and their function in rapid intracellular signaling upon binding of sex hormones (PubMed:22031296). Palmitoylates GNAQ, a heterotrimeric G protein, regulating its dynamic localization at the plasma membrane and is thereby involved in GNAQ-dependent G protein-coupled receptor signaling pathways (PubMed:19001095). Functions also in ligand-induced cell death by regulating the FAS signaling pathway through the palmitoylation and stabilization of the receptor at the plasma membrane (PubMed:25301068). In epithelial cells, palmitoylates SCRIB and regulates its localization to the plasma membrane, regulating indirectly cell polarity and differentiation (PubMed:27380321). Also palmitoylates JAM3 and promotes its expression at tight junctions and regulates its function in cell migration (PubMed:28196865). Palmitoylates the glucose transporter GLUT4/SLC2A4 and controls the insulin-dependent translocation of GLUT4 to the plasma membrane (By similarity). In brain, could also palmitoylate SNAP25 and DLG4/PSD95 (By similarity). Could also palmitoylate DNAJC5 and regulate its localization to the Golgi membrane (By similarity). Could also palmitoylate NCDN (By similarity). May play a role in follicle stimulation hormone (FSH) activation of testicular Sertoli cells (By similarity).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151; EC=2.3.1.225; Evidence={ECO:0000269|PubMed:22031296, ECO:0000269|PubMed:25301068, ECO:0000269|PubMed:27380321, ECO:0000269|PubMed:28196865};.
Enzyme Numbers (IUBMB) for ZDHHC7 Gene
Phenotypes From GWAS Catalog for ZDHHC7 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016409 | palmitoyltransferase activity | IEA,IDA | 23034182 |
| GO:0016740 | transferase activity | IEA | -- |
| GO:0016746 | transferase activity, transferring acyl groups | IEA | -- |
| GO:0019706 | protein-cysteine S-palmitoyltransferase activity | IEA,IMP | 25301068 |
Phenotypes for ZDHHC7 Gene
- GenomeRNAi human phenotypes for ZDHHC7:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ZDHHC7 - Select products 50% OFF >
- * ZDHHC7 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ZDHHC7
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ZDHHC7
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZDHHC7
miRNA for ZDHHC7 Gene
- miRTarBase miRNAs that target ZDHHC7
-
- mmu-miR-181a-5p (MIRT014303)
- mmu-miR-9-5p (MIRT015379)
- hsa-miR-26b-5p (MIRT028769)
- hsa-miR-1229-3p (MIRT036367)
- hsa-miR-877-3p (MIRT037109)
- hsa-miR-615-3p (MIRT039953)
- hsa-miR-507 (MIRT144633)
- hsa-miR-557 (MIRT144636)
- hsa-miR-298 (MIRT564780)
- hsa-miR-3529-3p (MIRT564781)
- hsa-miR-3646 (MIRT564782)
- hsa-miR-19b-3p (MIRT564783)
- hsa-miR-19a-3p (MIRT564784)
- mmu-miR-342-3p (MIRT579844)
- mmu-miR-377-3p (MIRT579845)
- mmu-miR-362-3p (MIRT579846)
- mmu-miR-329-3p (MIRT579847)
- hsa-miR-192-3p (MIRT641777)
- hsa-miR-4480 (MIRT641778)
- hsa-miR-8064 (MIRT641779)
- hsa-miR-216b-3p (MIRT641780)
- hsa-miR-603 (MIRT641781)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ZDHHC7
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Clone Products
- Applied Biological Materials (abm): Clones for ZDHHC7 - Select products 50% OFF >
- * ZDHHC7 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for ZDHHC7
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ZDHHC7
Cell Line Products
-
Horizon Cell Lines for ZDHHC7
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZDHHC7 Gene
Localization for ZDHHC7 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ZDHHC7 Gene
- Golgi apparatus membrane. Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| golgi apparatus | 5 |
| plasma membrane | 4 |
| nucleus | 4 |
| endoplasmic reticulum | 4 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endosome | 1 |
| cytosol | 1 |
| lysosome | 1 |
- Golgi apparatus (3)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | IEA | -- |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005783 | endoplasmic reticulum | IBA | 21873635 |
| GO:0005794 | Golgi apparatus | IDA | 16647879 |
| GO:0016020 | membrane | IEA | -- |
Pathways & Interactions for ZDHHC7 Gene
Interacting Proteins for ZDHHC7 Gene
Selected Interacting proteins:
Q9NXF8-ZDHC7_HUMAN
ENSP00000456782
for ZDHHC7 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for ZDHHC7
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006612 | protein targeting to membrane | IBA | 21873635 |
| GO:0008277 | regulation of G protein-coupled receptor signaling pathway | IMP | 19001095 |
| GO:0009895 | negative regulation of catabolic process | IMP | 25301068 |
| GO:0018230 | peptidyl-L-cysteine S-palmitoylation | IEA,IMP | 22031296 |
| GO:0018345 | protein palmitoylation | IEA,IMP | 19001095 |
No data available for Pathways by source and SIGNOR curated interactions for ZDHHC7 Gene
Drugs & Compounds for ZDHHC7 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| hexadecanoyl-CoA |
|
|
Transcripts for ZDHHC7 Gene
mRNA/cDNA for ZDHHC7 Gene
- 2 REFSEQ mRNAs :
- 10 NCBI additional mRNA sequence :
- 8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000313732 3448 nts (view in UCSC)
- ENST00000344861 2727 nts (view in UCSC)
- ENST00000564466 1488 nts (view in UCSC)
- ENST00000564526 603 nts (view in UCSC)
- ENST00000566909 582 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ZDHHC7 - Select products 50% OFF >
- * ZDHHC7 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ZDHHC7
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ZDHHC7
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZDHHC7
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ZDHHC7
- Browse OriGene Inhibitory RNA Products For ZDHHC7
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZDHHC7
Clone Products
- Applied Biological Materials (abm): Clones for ZDHHC7 - Select products 50% OFF >
- * ZDHHC7 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for ZDHHC7
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ZDHHC7
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | · | 10c | · | 10d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||||||
| SP7: |
Relevant External Links for ZDHHC7 Gene
- GeneLoc Exon Structure for
- ZDHHC7
Expression for ZDHHC7 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Monocytes Peripheral Blood
-
Limb (Muscoskeletal System)
- Limb Bud Mesenchyme Cells Limb Bud
-
Mesoderm (Gastrulation Derivatives)
- Limb Bud Mesenchyme Cells Limb Bud
-
Stomach (Gastrointestinal Tract)
This gene is overexpressed in Placenta (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZDHHC7 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZDHHC7
SOURCE GeneReport for Unigene cluster for ZDHHC7 Gene:
Hs.461610Evidence on tissue expression from TISSUES for ZDHHC7 Gene
- Skin(4.4)
- Intestine(4.4)
- Nervous system(2.8)
- Kidney(2.3)
- Heart(2.1)
Primer Products
-
OriGene qPCR primer pairs for ZDHHC7
-
OriGene qPCR primer pairs and template standards for ZDHHC7
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZDHHC7 Gene
Orthologs for ZDHHC7 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | ZDHHC7 30 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | ZDHHC7 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | ZDHHC7 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | ZDHHC7 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Zdhhc7 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Zdhhc7 30 17 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | ZDHHC7 30 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | ZDHHC7 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | ZDHHC7 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100485887 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | zdhhc7 30 31 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG8314 31 32 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | F33D11.12 32 |
|
|
|
| dhhc-3 31 |
|
OneToMany | |||
| C17D12.1a 32 |
|
|
|||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for ZDHHC7 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for ZDHHC7 Gene
- ENSEMBL:
- Gene Tree for ZDHHC7 (if available)
- TreeFam:
- Gene Tree for ZDHHC7 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ZDHHC7: view image
Paralogs for ZDHHC7 Gene
Paralogs for ZDHHC7 Gene
(5) SIMAP similar genes for ZDHHC7 Gene using alignment to 3 proteins:
- ZDHC7_HUMAN
- H3BMI0_HUMAN
- H3BNQ9_HUMAN
Pseudogenes.org Pseudogenes for ZDHHC7 Gene
Variants for ZDHHC7 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZDHHC7 Gene
| SNP ID | Clinical significance and condition | Chr 16 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| VAR_036261 | A colorectal cancer sample | p.Asp44Asn | |||
| rs13334011 | - | p.Val201Ile |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2660467 | CNV | deletion | 23128226 |
| esv29431 | CNV | loss | 19812545 |
| esv3639449 | CNV | loss | 21293372 |
| nsv1066260 | CNV | gain | 25217958 |
| nsv1111144 | CNV | tandem duplication | 24896259 |
| nsv1132874 | CNV | insertion | 24896259 |
| nsv1134573 | CNV | deletion | 24896259 |
| nsv483044 | CNV | gain | 15286789 |
Residual Variation Intolerance Score:
40.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.14;
51.44% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ZDHHC7 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ZDHHC7
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZDHHC7 Gene
Disorders for ZDHHC7 Gene
Additional Disease Information for ZDHHC7
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No disorders were found for ZDHHC7 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZDHHC7 Gene
Publications for ZDHHC7 Gene
- S-Palmitoylation of Junctional Adhesion Molecule C Regulates Its Tight Junction Localization and Cell Migration. (PMID: 28196865) Aramsangtienchai P … Lin H (The Journal of biological chemistry 2017) 2 3 4
- ZDHHC7-mediated S-palmitoylation of Scribble regulates cell polarity. (PMID: 27380321) Chen B … Wu X (Nature chemical biology 2016) 2 3 4
- Palmitoylation of caveolin-1 is regulated by the same DHHC acyltransferases that modify steroid hormone receptors. (PMID: 30158247) Tonn Eisinger KR … Mermelstein PG (The Journal of biological chemistry 2018) 2 3
- Fas palmitoylation by the palmitoyl acyltransferase DHHC7 regulates Fas stability. (PMID: 25301068) Rossin A … Hueber AO (Cell death and differentiation 2015) 3 4
- DHHC-7 and -21 are palmitoylacyltransferases for sex steroid receptors. (PMID: 22031296) Pedram A … Levin ER (Molecular biology of the cell 2012) 3 4
ExternalLinks
Products for ZDHHC7 Gene
- Custom Antibody ServicesOriGene Antibodies for ZDHHC7
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- Custom Assay Services
- OriGene Purified Proteins for ZDHHC7
- Search Origene for MassSpec and Protein Over-expression Lysates for ZDHHC7
- Origene Custom Protein Services for ZDHHC7
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ZDHHC7
- Browse OriGene Inhibitory RNA Products For ZDHHC7
- OriGene qPCR primer pairs for ZDHHC7
- OriGene qPCR primer pairs and template standards for ZDHHC7
- OriGene CRISPR knockouts for ZDHHC7
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For ZDHHC7
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- Novus Biologicals Antibodies for ZDHHC7
- Novus Biologicals proteins and lysates for ZDHHC7
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- Abcam antibodies for ZDHHC7
- Abcam proteins for ZDHHC7
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- Invitrogen Antibodies for ZDHHC7 (AFLGC-ZDHHC7)
- VectorBuilder Custom and pre-made DNA vectors for ZDHHC7 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for ZDHHC7 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for ZDHHC7 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for ZDHHC7 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for ZDHHC7
- antibodies-online: Show 12 available ZDHHC7 Antibodies ranked by validation data
- Compare Top ZDHHC7 Antibodies
- antibodies-online: Search results for available ZDHHC7 related products ranked by validation data
- antibodies-online: Search results for available ZDHHC7 related products ranked by validation data
- Browse Santa Cruz Biotechnology (SCBT) Antibodies
- Search Santa Cruz Biotechnology (SCBT) for ZDHHC7 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for ZDHHC7
- Horizon Cell Lines for ZDHHC7
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ZDHHC7
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ZDHHC7
- Search GeneCopoeia for miRNA 3'UTR Target clone products for ZDHHC7
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZDHHC7
- Boster Bio Antibodies for ZDHHC7
- Browse Boster Bio ELISA Kits
- Biorbyt antibodies for ZDHHC7
Sources for ZDHHC7 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB