Aliases for ZDHHC6 Gene
External Ids for ZDHHC6 Gene
Previous GeneCards Identifiers for ZDHHC6 Gene
GeneCards Summary for ZDHHC6 Gene
ZDHHC6 (Zinc Finger DHHC-Type Palmitoyltransferase 6) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein-cysteine S-palmitoyltransferase activity and palmitoyltransferase activity. An important paralog of this gene is ZDHHC3.
UniProtKB/Swiss-Prot Summary for ZDHHC6 Gene
Endoplasmic reticulum palmitoyl acyltransferase that mediates palmitoylation of proteins such as AMFR, CALX, ITPR1 and TFRC (PubMed:22314232, PubMed:22728137, PubMed:25368151, PubMed:28826475). Palmitoylates calnexin (CALX), which is required for its association with the ribosome-translocon complex and efficient folding of glycosylated proteins (PubMed:22314232). Mediates palmitoylation of AMFR, promoting AMFR distribution to the peripheral endoplasmic reticulum (PubMed:22728137). Together with SELENOK, palmitoylates ITPR1 in immune cells, leading to regulate ITPR1 stability and function (PubMed:25368151).