Aliases for ZDHHC5 Gene

Aliases for ZDHHC5 Gene

  • Zinc Finger DHHC-Type Palmitoyltransferase 5 2 3
  • Zinc Finger DHHC-Type Containing 5 2 3 5
  • Zinc Finger DHHC Domain-Containing Protein 5 3 4
  • Palmitoyltransferase ZDHHC5 3 4
  • Zinc Finger Protein 375 3 4
  • DHHC-5 3 4
  • ZNF375 3 4
  • Membrane-Associated DHHC5 Zinc Finger Protein 3
  • Zinc Finger, DHHC Domain Containing 5 3
  • Probable Palmitoyltransferase ZDHHC5 3
  • EC 4
  • KIAA1748 4
  • EC 2.3.1 52
  • DHHC5 3

External Ids for ZDHHC5 Gene

Previous GeneCards Identifiers for ZDHHC5 Gene

  • GC11P059829
  • GC11P058948
  • GC11P057686
  • GC11P057210
  • GC11P057192
  • GC11P057435
  • GC11P053784

Summaries for ZDHHC5 Gene

GeneCards Summary for ZDHHC5 Gene

ZDHHC5 (Zinc Finger DHHC-Type Palmitoyltransferase 5) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include palmitoyltransferase activity. An important paralog of this gene is ZDHHC8.

UniProtKB/Swiss-Prot Summary for ZDHHC5 Gene

  • Palmitoyl acyltransferase for the G-protein coupled receptor SSTR5. Also palmitoylates FLOT2 (By similarity).

Additional gene information for ZDHHC5 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZDHHC5 Gene

Genomics for ZDHHC5 Gene

GeneHancer (GH) Regulatory Elements for ZDHHC5 Gene

Promoters and enhancers for ZDHHC5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZDHHC5 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZDHHC5

Top Transcription factor binding sites by QIAGEN in the ZDHHC5 gene promoter:
  • AP-1
  • AREB6
  • C/EBPbeta
  • CREB
  • deltaCREB
  • FOXJ2 (long isoform)
  • IRF-2
  • IRF-7A
  • MIF-1

Genomic Locations for ZDHHC5 Gene

Genomic Locations for ZDHHC5 Gene
33,441 bases
Plus strand
33,441 bases
Plus strand

Genomic View for ZDHHC5 Gene

Genes around ZDHHC5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZDHHC5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZDHHC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZDHHC5 Gene

Proteins for ZDHHC5 Gene

  • Protein details for ZDHHC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Palmitoyltransferase ZDHHC5
    Protein Accession:
    Secondary Accessions:
    • Q2TGF0
    • Q6ZMF0
    • Q8TAK8
    • Q9H923
    • Q9UFI7

    Protein attributes for ZDHHC5 Gene

    715 amino acids
    Molecular mass:
    77545 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB21839.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=BAD18778.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZDHHC5 Gene


neXtProt entry for ZDHHC5 Gene

Selected DME Specific Peptides for ZDHHC5 Gene


Post-translational modifications for ZDHHC5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for ZDHHC5 Gene

Gene Families for ZDHHC5 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for ZDHHC5 Gene

  • Zn-finger, DHHC type

Suggested Antigen Peptide Sequences for ZDHHC5 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger, DHHC-type containing 5, isoform CRA_a (Q2TGF0_HUMAN)
  • Zinc finger protein 375 (ZDHC5_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • The DHHC domain is required for palmitoyltransferase activity.
  • Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
  • The DHHC domain is required for palmitoyltransferase activity.
  • Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
genes like me logo Genes that share domains with ZDHHC5: view

Function for ZDHHC5 Gene

Molecular function for ZDHHC5 Gene

UniProtKB/Swiss-Prot Function:
Palmitoyl acyltransferase for the G-protein coupled receptor SSTR5. Also palmitoylates FLOT2 (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151; EC=;.

Enzyme Numbers (IUBMB) for ZDHHC5 Gene

Phenotypes From GWAS Catalog for ZDHHC5 Gene

Gene Ontology (GO) - Molecular Function for ZDHHC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016409 palmitoyltransferase activity IDA,IEA 22325201
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
GO:0019706 protein-cysteine S-palmitoyltransferase activity IEA --
genes like me logo Genes that share ontologies with ZDHHC5: view
genes like me logo Genes that share phenotypes with ZDHHC5: view

Animal Model Products

CRISPR Products

miRNA for ZDHHC5 Gene

miRTarBase miRNAs that target ZDHHC5

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZDHHC5 Gene

Localization for ZDHHC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZDHHC5 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZDHHC5 gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 2
endoplasmic reticulum 2
cytosol 2
golgi apparatus 2
cytoskeleton 1
mitochondrion 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (2)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZDHHC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 16647879
GO:0016020 membrane IEA,HDA 19946888
GO:0016021 integral component of membrane IEA --
GO:0030425 dendrite IEA --
genes like me logo Genes that share ontologies with ZDHHC5: view

Pathways & Interactions for ZDHHC5 Gene

PathCards logo

SuperPathways for ZDHHC5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZDHHC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0018345 protein palmitoylation IBA,IDA 22325201
genes like me logo Genes that share ontologies with ZDHHC5: view

No data available for Pathways by source and SIGNOR curated interactions for ZDHHC5 Gene

Drugs & Compounds for ZDHHC5 Gene

(1) Drugs for ZDHHC5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coenzyme A Investigational Nutra 0

(1) Additional Compounds for ZDHHC5 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • coenzyme A, S-Hexadecanoate
  • Palmitoyl coenzyme A
  • S-Palmitoylcoenzyme A
  • coenzyme A, S-Hexadecanoic acid
genes like me logo Genes that share compounds with ZDHHC5: view

Transcripts for ZDHHC5 Gene

mRNA/cDNA for ZDHHC5 Gene

8 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC5 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b
SP1: - - -
SP2: - - - - -
SP4: - -
SP5: - - - - - -
SP6: -

Relevant External Links for ZDHHC5 Gene

GeneLoc Exon Structure for

Expression for ZDHHC5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZDHHC5 Gene

Protein differential expression in normal tissues from HIPED for ZDHHC5 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (14.0), Plasma (11.8), Placenta (9.5), and Colon muscle (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZDHHC5 Gene

Protein tissue co-expression partners for ZDHHC5 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZDHHC5

SOURCE GeneReport for Unigene cluster for ZDHHC5 Gene:


Evidence on tissue expression from TISSUES for ZDHHC5 Gene

  • Liver(4.3)
  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with ZDHHC5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZDHHC5 Gene

Orthologs for ZDHHC5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZDHHC5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZDHHC5 31 30
  • 99.49 (n)
(Canis familiaris)
Mammalia ZDHHC5 30
  • 94.08 (n)
(Mus musculus)
Mammalia Zdhhc5 17 31 30
  • 92.54 (n)
(Rattus norvegicus)
Mammalia Zdhhc5 30
  • 92.49 (n)
(Monodelphis domestica)
Mammalia ZDHHC5 31
  • 88 (a)
(Bos Taurus)
Mammalia ZDHHC5 31 30
  • 86.32 (n)
(Ornithorhynchus anatinus)
Mammalia ZDHHC5 31
  • 81 (a)
(Gallus gallus)
Aves ZDHHC5 31 30
  • 76.69 (n)
(Anolis carolinensis)
Reptilia ZDHHC5 31
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia zdhhc5 30
  • 64.82 (n)
Str.15608 30
(Danio rerio)
Actinopterygii zdhhc5a 31 30
  • 60.77 (n)
ZDHHC5 (2 of 2) 31
  • 58 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG34449 31
  • 24 (a)
(Caenorhabditis elegans)
Secernentea Y39E4B.7 32
  • 48 (a)
dhhc-8 31
  • 36 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SWF1 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 49 (a)
Cin.8844 30
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8844 30
Species where no ortholog for ZDHHC5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZDHHC5 Gene

Gene Tree for ZDHHC5 (if available)
Gene Tree for ZDHHC5 (if available)
Evolutionary constrained regions (ECRs) for ZDHHC5: view image

Paralogs for ZDHHC5 Gene

Paralogs for ZDHHC5 Gene

(8) SIMAP similar genes for ZDHHC5 Gene using alignment to 4 proteins:

  • E9PJ97_HUMAN
genes like me logo Genes that share paralogs with ZDHHC5: view

Variants for ZDHHC5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZDHHC5 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
752215 Likely Benign: not provided 57,673,174(+) G/A SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for ZDHHC5 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZDHHC5 Gene

Variant ID Type Subtype PubMed ID
esv3579728 CNV loss 25503493
nsv508633 CNV deletion 20534489
nsv832163 CNV gain 17160897
nsv832164 CNV loss 17160897

Variation tolerance for ZDHHC5 Gene

Residual Variation Intolerance Score: 21.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.26; 40.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZDHHC5 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZDHHC5 Gene

Disorders for ZDHHC5 Gene

Additional Disease Information for ZDHHC5

No disorders were found for ZDHHC5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZDHHC5 Gene

Publications for ZDHHC5 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 54
  2. DHHC4 and DHHC5 Facilitate Fatty Acid Uptake by Palmitoylating and Targeting CD36 to the Plasma Membrane. (PMID: 30605677) Wang J … Zhao TJ (Cell reports 2019) 2 3 54
  3. DHHC5-mediated palmitoylation of S1P receptor subtype 1 determines G-protein coupling. (PMID: 29185452) Badawy SMM … Nakamura SI (Scientific reports 2017) 2 3 54
  4. DHHC5 protein palmitoylates flotillin-2 and is rapidly degraded on induction of neuronal differentiation in cultured cells. (PMID: 22081607) Li Y … Hofmann SL (The Journal of biological chemistry 2012) 2 3 54
  5. Somatostatin receptor 5 is palmitoylated by the interacting ZDHHC5 palmitoyltransferase. (PMID: 21820437) Kokkola T … Kreienkamp HJ (FEBS letters 2011) 3 4 54

Products for ZDHHC5 Gene

Sources for ZDHHC5 Gene