Aliases for ZDHHC4 Gene

Aliases for ZDHHC4 Gene

  • Zinc Finger DHHC-Type Palmitoyltransferase 4 2 3
  • Zinc Finger DHHC-Type Containing 4 2 3 5
  • Zinc Finger DHHC Domain-Containing Protein 4 3 4
  • Probable Palmitoyltransferase ZDHHC4 3 4
  • Zinc Finger Protein 374 3 4
  • DHHC-4 3 4
  • ZNF374 3 4
  • Zinc Finger, DHHC Domain Containing 4 3
  • EC 4
  • EC 2.3.1 52

External Ids for ZDHHC4 Gene

Previous GeneCards Identifiers for ZDHHC4 Gene

  • GC07P006261
  • GC07P006361
  • GC07P006362
  • GC07P006390
  • GC07P006583

Summaries for ZDHHC4 Gene

GeneCards Summary for ZDHHC4 Gene

ZDHHC4 (Zinc Finger DHHC-Type Palmitoyltransferase 4) is a Protein Coding gene. Diseases associated with ZDHHC4 include Diclofenac Allergy and Dentin Caries. Gene Ontology (GO) annotations related to this gene include cytochrome-c oxidase activity and protein-cysteine S-palmitoyltransferase activity. An important paralog of this gene is ZDHHC23.

Gene Wiki entry for ZDHHC4 Gene

Additional gene information for ZDHHC4 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZDHHC4 Gene

Genomics for ZDHHC4 Gene

GeneHancer (GH) Regulatory Elements for ZDHHC4 Gene

Promoters and enhancers for ZDHHC4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZDHHC4 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZDHHC4

Top Transcription factor binding sites by QIAGEN in the ZDHHC4 gene promoter:
  • AREB6
  • C/EBPalpha
  • FOXJ2
  • FOXJ2 (long isoform)
  • FOXO1
  • FOXO1a
  • FOXO4
  • HFH-1
  • POU2F1
  • POU2F1a

Genomic Locations for ZDHHC4 Gene

Genomic Locations for ZDHHC4 Gene
11,963 bases
Plus strand
11,941 bases
Plus strand

Genomic View for ZDHHC4 Gene

Genes around ZDHHC4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZDHHC4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZDHHC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZDHHC4 Gene

Proteins for ZDHHC4 Gene

  • Protein details for ZDHHC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable palmitoyltransferase ZDHHC4
    Protein Accession:
    Secondary Accessions:
    • A4D2N9
    • Q53EV7
    • Q6FIB5
    • Q9H0R9

    Protein attributes for ZDHHC4 Gene

    344 amino acids
    Molecular mass:
    39787 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZDHHC4 Gene

Selected DME Specific Peptides for ZDHHC4 Gene


Post-translational modifications for ZDHHC4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for ZDHHC4 Gene

Gene Families for ZDHHC4 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for ZDHHC4 Gene

  • Zn-finger, DHHC type

Suggested Antigen Peptide Sequences for ZDHHC4 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 374 (ZDHC4_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • The C-terminal di-lysine motif confers endoplasmic reticulum localization.
  • Belongs to the DHHC palmitoyltransferase family.
  • The C-terminal di-lysine motif confers endoplasmic reticulum localization.
  • The DHHC domain is required for palmitoyltransferase activity.
  • Belongs to the DHHC palmitoyltransferase family.
genes like me logo Genes that share domains with ZDHHC4: view

Function for ZDHHC4 Gene

Molecular function for ZDHHC4 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151; EC=;.

Enzyme Numbers (IUBMB) for ZDHHC4 Gene

Phenotypes From GWAS Catalog for ZDHHC4 Gene

Gene Ontology (GO) - Molecular Function for ZDHHC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016409 palmitoyltransferase activity IEA --
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
GO:0019706 protein-cysteine S-palmitoyltransferase activity IBA 21873635
genes like me logo Genes that share ontologies with ZDHHC4: view
genes like me logo Genes that share phenotypes with ZDHHC4: view

Animal Model Products

CRISPR Products

miRNA for ZDHHC4 Gene

miRTarBase miRNAs that target ZDHHC4

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZDHHC4

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZDHHC4 Gene

Localization for ZDHHC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZDHHC4 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZDHHC4 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 5
plasma membrane 3
nucleus 2
extracellular 1
cytoskeleton 1
mitochondrion 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZDHHC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 21926431
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005794 Golgi apparatus IDA,IBA 16647879
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZDHHC4: view

Pathways & Interactions for ZDHHC4 Gene

PathCards logo

SuperPathways for ZDHHC4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZDHHC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006612 protein targeting to membrane IBA 21873635
GO:0018230 peptidyl-L-cysteine S-palmitoylation IBA 21873635
genes like me logo Genes that share ontologies with ZDHHC4: view

No data available for Pathways by source and SIGNOR curated interactions for ZDHHC4 Gene

Drugs & Compounds for ZDHHC4 Gene

(1) Drugs for ZDHHC4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coenzyme A Investigational Nutra 0

(1) Additional Compounds for ZDHHC4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • coenzyme A, S-Hexadecanoate
  • Palmitoyl coenzyme A
  • S-Palmitoylcoenzyme A
  • coenzyme A, S-Hexadecanoic acid
genes like me logo Genes that share compounds with ZDHHC4: view

Transcripts for ZDHHC4 Gene

mRNA/cDNA for ZDHHC4 Gene

11 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZDHHC4

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC4 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - - - - -
SP4: - - - -
SP5: - - - - -
SP6: - - - - -
SP7: - - - - - - -
SP8: - - - - - -
SP9: - -
SP10: - - - - -

Relevant External Links for ZDHHC4 Gene

GeneLoc Exon Structure for

Expression for ZDHHC4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZDHHC4 Gene

Protein differential expression in normal tissues from HIPED for ZDHHC4 Gene

This gene is overexpressed in Ovary (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZDHHC4 Gene

Protein tissue co-expression partners for ZDHHC4 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZDHHC4

SOURCE GeneReport for Unigene cluster for ZDHHC4 Gene:


Evidence on tissue expression from TISSUES for ZDHHC4 Gene

  • Nervous system(4.6)
  • Lymph node(4.4)
  • Spleen(4.4)
  • Blood(4.3)
genes like me logo Genes that share expression patterns with ZDHHC4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZDHHC4 Gene

Orthologs for ZDHHC4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZDHHC4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZDHHC4 31 30
  • 99.03 (n)
(Bos Taurus)
Mammalia ZDHHC4 31 30
  • 84.16 (n)
(Canis familiaris)
Mammalia ZDHHC4 31 30
  • 83.19 (n)
(Mus musculus)
Mammalia Zdhhc4 17 31 30
  • 79.01 (n)
(Rattus norvegicus)
Mammalia Zdhhc4 30
  • 78.43 (n)
(Monodelphis domestica)
Mammalia ZDHHC4 31
  • 60 (a)
(Ornithorhynchus anatinus)
Mammalia ZDHHC4 31
  • 57 (a)
(Gallus gallus)
Aves ZDHHC4 31 30
  • 61.11 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia zdhhc4 30
  • 58.2 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.18776 30
(Danio rerio)
Actinopterygii zdhhc4 31 30
  • 53.02 (n)
wufa97b04 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5703 30
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ERF2 31
  • 19 (a)
Species where no ortholog for ZDHHC4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZDHHC4 Gene

Gene Tree for ZDHHC4 (if available)
Gene Tree for ZDHHC4 (if available)
Evolutionary constrained regions (ECRs) for ZDHHC4: view image

Paralogs for ZDHHC4 Gene Pseudogenes for ZDHHC4 Gene

genes like me logo Genes that share paralogs with ZDHHC4: view

Variants for ZDHHC4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZDHHC4 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
VAR_036260 A breast cancer sample p.Pro104Ser
rs11559146 - p.Val53Met

Additional dbSNP identifiers (rs#s) for ZDHHC4 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZDHHC4 Gene

Variant ID Type Subtype PubMed ID
dgv1090n67 CNV gain 20364138
dgv11172n54 CNV loss 21841781
esv1914954 OTHER inversion 16254605
esv2123966 CNV deletion 18987734
nsv1020236 CNV gain 25217958
nsv436904 CNV insertion 17901297
nsv508444 CNV deletion 20534489
nsv515978 CNV loss 19592680
nsv606003 CNV loss 21841781
nsv7392 OTHER inversion 18451855
nsv830895 CNV loss 17160897

Variation tolerance for ZDHHC4 Gene

Residual Variation Intolerance Score: 66.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.81; 58.39% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZDHHC4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZDHHC4 Gene

Disorders for ZDHHC4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ZDHHC4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
diclofenac allergy
  • voltaren allergy
dentin caries
  • compound dental caries
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZDHHC4

genes like me logo Genes that share disorders with ZDHHC4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZDHHC4 Gene

Publications for ZDHHC4 Gene

  1. DHHC4 and DHHC5 Facilitate Fatty Acid Uptake by Palmitoylating and Targeting CD36 to the Plasma Membrane. (PMID: 30605677) Wang J … Zhao TJ (Cell reports 2019) 2 3 54
  2. Effect of C-Terminal S-Palmitoylation on D2 Dopamine Receptor Trafficking and Stability. (PMID: 26535572) Ebersole B … Levenson R (PloS one 2015) 2 3 54
  3. Endoplasmic reticulum localization of DHHC palmitoyltransferases mediated by lysine-based sorting signals. (PMID: 21926431) Gorleku OA … Chamberlain LH (The Journal of biological chemistry 2011) 3 4 54
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54

Products for ZDHHC4 Gene

Sources for ZDHHC4 Gene