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Aliases for ZDHHC4 Gene

Aliases for ZDHHC4 Gene

  • Zinc Finger DHHC-Type Containing 4 2 3 5
  • Zinc Finger DHHC Domain-Containing Protein 4 3 4
  • Zinc Finger Protein 374 3 4
  • DHHC-4 3 4
  • ZNF374 3 4
  • Zinc Finger, DHHC Domain Containing 4 3
  • Probable Palmitoyltransferase ZDHHC4 3
  • EC 4
  • EC 2.3.1 56

External Ids for ZDHHC4 Gene

Previous GeneCards Identifiers for ZDHHC4 Gene

  • GC07P006261
  • GC07P006361
  • GC07P006362
  • GC07P006390

Summaries for ZDHHC4 Gene

GeneCards Summary for ZDHHC4 Gene

ZDHHC4 (Zinc Finger DHHC-Type Containing 4) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include cytochrome-c oxidase activity and protein-cysteine S-palmitoyltransferase activity. An important paralog of this gene is ZDHHC18.

Gene Wiki entry for ZDHHC4 Gene

Additional gene information for ZDHHC4 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZDHHC4 Gene

Genomics for ZDHHC4 Gene

GeneHancer (GH) Regulatory Elements for ZDHHC4 Gene

Promoters and enhancers for ZDHHC4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I006576 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 573 +0.1 120 2.8 HDGF PKNOX1 SMAD1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZBTB7B ZDHHC4 PMS2 CCZ1B PIR51415 ENSG00000232581 GC07M006567
GH07I006589 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 23.7 +12.9 12863 2 PKNOX1 ATF1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZNF48 ZNF121 ELK1 C7orf26 ENSG00000232581 GC07M006589 GC07M006590 GC07M006591 GC07M006592 GC07M006593 GC07M006594 GC07M006595 GC07M006596
GH07I006614 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 16.8 +38.1 38105 1.9 ELF3 ARID4B KLF17 SIN3A ZNF2 THRB ZNF48 RARA ZNF335 GLIS2 ZNF853 ZDHHC4 CCZ1 GC07M006567
GH07I006636 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 12.2 +60.4 60369 2.8 HDGF SMAD1 ATF1 ARID4B SIN3A ZBTB7B ZNF48 GLIS2 ELK1 ZNF207 ZNF316 C7orf26 ENSG00000232581 ZDHHC4 ENSG00000198580 PMS2CL PMS2 ZNF12 DAGLB GC07P006652
GH07I006729 Promoter/Enhancer 1.5 Ensembl ENCODE 11.4 +152.8 152807 2.3 MLX ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9 POLR2B ZNF143 JUNB PIR60249 PMS2 C7orf26 ENSG00000232581 ZDHHC4 ENSG00000198580 ZNF12 PMS2CL PIR36947 GC07P006753
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZDHHC4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZDHHC4 gene promoter:

Genomic Locations for ZDHHC4 Gene

Genomic Locations for ZDHHC4 Gene
11,963 bases
Plus strand

Genomic View for ZDHHC4 Gene

Genes around ZDHHC4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZDHHC4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZDHHC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZDHHC4 Gene

Proteins for ZDHHC4 Gene

  • Protein details for ZDHHC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable palmitoyltransferase ZDHHC4
    Protein Accession:
    Secondary Accessions:
    • A4D2N9
    • Q53EV7
    • Q6FIB5
    • Q9H0R9

    Protein attributes for ZDHHC4 Gene

    344 amino acids
    Molecular mass:
    39787 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZDHHC4 Gene

Selected DME Specific Peptides for ZDHHC4 Gene


Post-translational modifications for ZDHHC4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for ZDHHC4 Gene

Gene Families for ZDHHC4 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for ZDHHC4 Gene

Suggested Antigen Peptide Sequences for ZDHHC4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The C-terminal di-lysine motif confers endoplasmic reticulum localization.
  • Belongs to the DHHC palmitoyltransferase family.
  • The C-terminal di-lysine motif confers endoplasmic reticulum localization.
  • The DHHC domain is required for palmitoyltransferase activity.
  • Belongs to the DHHC palmitoyltransferase family.
genes like me logo Genes that share domains with ZDHHC4: view

Function for ZDHHC4 Gene

Molecular function for ZDHHC4 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

Enzyme Numbers (IUBMB) for ZDHHC4 Gene

Phenotypes From GWAS Catalog for ZDHHC4 Gene

Gene Ontology (GO) - Molecular Function for ZDHHC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
GO:0019706 protein-cysteine S-palmitoyltransferase activity IEA --
genes like me logo Genes that share ontologies with ZDHHC4: view
genes like me logo Genes that share phenotypes with ZDHHC4: view

Animal Model Products

CRISPR Products

miRNA for ZDHHC4 Gene

miRTarBase miRNAs that target ZDHHC4

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZDHHC4 Gene

Localization for ZDHHC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZDHHC4 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZDHHC4 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 5
plasma membrane 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZDHHC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 21926431
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005794 Golgi apparatus IDA 16647879
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZDHHC4: view

Pathways & Interactions for ZDHHC4 Gene

SuperPathways for ZDHHC4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZDHHC4 Gene


No data available for Pathways by source and SIGNOR curated interactions for ZDHHC4 Gene

Drugs & Compounds for ZDHHC4 Gene

(1) Drugs for ZDHHC4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coenzyme A Investigational Nutra 0

(1) Additional Compounds for ZDHHC4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ZDHHC4: view

Transcripts for ZDHHC4 Gene

Unigene Clusters for ZDHHC4 Gene

Zinc finger, DHHC-type containing 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC4 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - - - - -
SP4: - - - -
SP5: - - - - -
SP6: - - - - -
SP7: - - - - - - -
SP8: - - - - - -
SP9: - -
SP10: - - - - -

Relevant External Links for ZDHHC4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZDHHC4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZDHHC4 Gene

Protein differential expression in normal tissues from HIPED for ZDHHC4 Gene

This gene is overexpressed in Ovary (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZDHHC4 Gene

Protein tissue co-expression partners for ZDHHC4 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZDHHC4 Gene:


SOURCE GeneReport for Unigene cluster for ZDHHC4 Gene:


Evidence on tissue expression from TISSUES for ZDHHC4 Gene

  • Nervous system(4.6)
  • Lymph node(4.4)
  • Spleen(4.4)
  • Blood(4.3)
genes like me logo Genes that share expression patterns with ZDHHC4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZDHHC4 Gene

Orthologs for ZDHHC4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZDHHC4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZDHHC4 33 34
  • 99.03 (n)
(Bos Taurus)
Mammalia ZDHHC4 33 34
  • 84.16 (n)
(Canis familiaris)
Mammalia ZDHHC4 33 34
  • 83.19 (n)
(Mus musculus)
Mammalia Zdhhc4 33 16 34
  • 79.01 (n)
(Rattus norvegicus)
Mammalia Zdhhc4 33
  • 78.43 (n)
(Monodelphis domestica)
Mammalia ZDHHC4 34
  • 60 (a)
(Ornithorhynchus anatinus)
Mammalia ZDHHC4 34
  • 57 (a)
(Gallus gallus)
Aves ZDHHC4 33 34
  • 61.11 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia zdhhc4 33
  • 58.2 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.18776 33
(Danio rerio)
Actinopterygii zdhhc4 33 34
  • 53.02 (n)
wufa97b04 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5703 33
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ERF2 34
  • 19 (a)
Species where no ortholog for ZDHHC4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZDHHC4 Gene

Gene Tree for ZDHHC4 (if available)
Gene Tree for ZDHHC4 (if available)

Paralogs for ZDHHC4 Gene Pseudogenes for ZDHHC4 Gene

genes like me logo Genes that share paralogs with ZDHHC4: view

Variants for ZDHHC4 Gene

Sequence variations from dbSNP and Humsavar for ZDHHC4 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
VAR_036260 A breast cancer sample p.Pro104Ser
rs1000276579 -- 6,577,588(+) A/G 5_prime_UTR_variant, intron_variant, splice_acceptor_variant
rs1000351181 -- 6,587,268(+) TTTTTTT/TTTTTT intron_variant
rs1000461208 -- 6,582,306(+) A/C intron_variant
rs1000619936 -- 6,583,011(+) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZDHHC4 Gene

Variant ID Type Subtype PubMed ID
dgv1090n67 CNV gain 20364138
dgv11172n54 CNV loss 21841781
esv1914954 OTHER inversion 16254605
esv2123966 CNV deletion 18987734
nsv1020236 CNV gain 25217958
nsv436904 CNV insertion 17901297
nsv508444 CNV deletion 20534489
nsv515978 CNV loss 19592680
nsv606003 CNV loss 21841781
nsv7392 OTHER inversion 18451855
nsv830895 CNV loss 17160897

Variation tolerance for ZDHHC4 Gene

Residual Variation Intolerance Score: 66.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.81; 58.39% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZDHHC4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZDHHC4 Gene

Disorders for ZDHHC4 Gene

Additional Disease Information for ZDHHC4

No disorders were found for ZDHHC4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZDHHC4 Gene

Publications for ZDHHC4 Gene

  1. Endoplasmic reticulum localization of DHHC palmitoyltransferases mediated by lysine-based sorting signals. (PMID: 21926431) Gorleku OA … Chamberlain LH (The Journal of biological chemistry 2011) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4 58
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58

Products for ZDHHC4 Gene

Sources for ZDHHC4 Gene

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