Aliases for ZDHHC3 Gene

Aliases for ZDHHC3 Gene

  • Zinc Finger DHHC-Type Palmitoyltransferase 3 2 3 5
  • Zinc Finger DHHC Domain-Containing Protein 3 3 4
  • Golgi-Specific DHHC Zinc Finger Protein 2 3
  • Zinc Finger DHHC-Type Containing 3 2 3
  • Palmitoyltransferase ZDHHC3 3 4
  • DHHC-3 3 4
  • ZNF373 2 3
  • DHHC3 2 3
  • GODZ 2 3
  • Golgi Apparatus-Specific Protein With DHHC Zinc Finger Domain 3
  • Zinc Finger, DHHC Domain Containing 3 3
  • Zinc Finger Protein 373 3
  • DHHC1 Protein 3
  • Protein DHHC1 4
  • EC 2.3.1.225 4
  • EC 2.3.1 51
  • ZDHHC3 5

External Ids for ZDHHC3 Gene

Previous GeneCards Identifiers for ZDHHC3 Gene

  • GC03M043924
  • GC03M044146
  • GC03M044785
  • GC03M044927
  • GC03M044941

Summaries for ZDHHC3 Gene

GeneCards Summary for ZDHHC3 Gene

ZDHHC3 (Zinc Finger DHHC-Type Palmitoyltransferase 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein-cysteine S-palmitoyltransferase activity and palmitoyltransferase activity. An important paralog of this gene is ZDHHC7.

UniProtKB/Swiss-Prot Summary for ZDHHC3 Gene

  • Golgi-localized palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates (PubMed:19001095, PubMed:21926431, PubMed:22240897, PubMed:23034182, PubMed:22314500). Plays an important role in G protein-coupled receptor signaling pathways involving GNAQ and potentially other heterotrimeric G proteins by regulating their dynamic association with the plasma membrane (PubMed:19001095). Palmitoylates ITGA6 and ITGB4, thereby regulating the alpha-6/beta-4 integrin localization, expression and function in cell adhesion to laminin (PubMed:22314500). Plays a role in the TRAIL-activated apoptotic signaling pathway most probably through the palmitoylation and localization to the plasma membrane of TNFRSF10A (PubMed:22240897). In the brain, by palmitoylating the gamma subunit GABRG2 of GABA(A) receptors and regulating their postsynaptic accumulation, plays a role in synaptic GABAergic inhibitory function and GABAergic innervation. Palmitoylates the neuronal protein GAP43 which is also involved in the formation of GABAergic synapses. Palmitoylates NCDN thereby regulating its association with endosome membranes. Probably palmitoylates PRCD and is involved in its proper localization within the photoreceptor. Could mediate the palmitoylation of NCAM1 and regulate neurite outgrowth. Could palmitoylate DNAJC5 and regulate its localization to Golgi membranes. Also constitutively palmitoylates DLG4. May also palmitoylate SNAP25. Could palmitoylate the glutamate receptors GRIA1 and GRIA2 but this has not been confirmed in vivo (By similarity). Could also palmitoylate the D(2) dopamine receptor DRD2 (PubMed:26535572).
  • May also function as a calcium transporter.

Gene Wiki entry for ZDHHC3 Gene

Additional gene information for ZDHHC3 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZDHHC3 Gene

Genomics for ZDHHC3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZDHHC3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZDHHC3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZDHHC3

Top Transcription factor binding sites by QIAGEN in the ZDHHC3 gene promoter:
  • AML1a
  • AREB6
  • E47
  • GATA-1
  • NF-E2
  • NF-E2 p45
  • POU2F1
  • POU2F1a
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for ZDHHC3 Gene

Genomic Locations for ZDHHC3 Gene
chr3:44,915,257-44,976,185
(GRCh38/hg38)
Size:
60,929 bases
Orientation:
Minus strand
chr3:44,956,749-45,017,677
(GRCh37/hg19)
Size:
60,929 bases
Orientation:
Minus strand

Genomic View for ZDHHC3 Gene

Genes around ZDHHC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZDHHC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZDHHC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZDHHC3 Gene

Proteins for ZDHHC3 Gene

  • Protein details for ZDHHC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYG2-ZDHC3_HUMAN
    Recommended name:
    Palmitoyltransferase ZDHHC3
    Protein Accession:
    Q9NYG2
    Secondary Accessions:
    • Q53A17
    • Q96BL0

    Protein attributes for ZDHHC3 Gene

    Size:
    299 amino acids
    Molecular mass:
    34170 Da
    Quaternary structure:
    • Monomer. Homooligomers. The monomeric form has a higher catalytic activity. Forms heterooligomers with ZDHHC7 (By similarity). Interacts with TNFRSF10A (PubMed:22240897).

    Alternative splice isoforms for ZDHHC3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZDHHC3 Gene

Selected DME Specific Peptides for ZDHHC3 Gene

Q9NYG2:
  • KPDRAHH
  • MDHHCPW
  • WFIRDGCG
  • MLTDPGAVPKGNATKE
  • FVLFTMYIAL

Post-translational modifications for ZDHHC3 Gene

Antibody Products

Domains & Families for ZDHHC3 Gene

Gene Families for ZDHHC3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for ZDHHC3 Gene

InterPro:
Blocks:
  • Zn-finger, DHHC type
ProtoNet:

Suggested Antigen Peptide Sequences for ZDHHC3 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 373 (ZDHC3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NYG2

UniProtKB/Swiss-Prot:

ZDHC3_HUMAN :
  • The DHHC domain is required for palmitoyltransferase activity.
  • Belongs to the DHHC palmitoyltransferase family.
Domain:
  • The DHHC domain is required for palmitoyltransferase activity.
Family:
  • Belongs to the DHHC palmitoyltransferase family.
genes like me logo Genes that share domains with ZDHHC3: view

Function for ZDHHC3 Gene

Molecular function for ZDHHC3 Gene

UniProtKB/Swiss-Prot Function:
Golgi-localized palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates (PubMed:19001095, PubMed:21926431, PubMed:22240897, PubMed:23034182, PubMed:22314500). Plays an important role in G protein-coupled receptor signaling pathways involving GNAQ and potentially other heterotrimeric G proteins by regulating their dynamic association with the plasma membrane (PubMed:19001095). Palmitoylates ITGA6 and ITGB4, thereby regulating the alpha-6/beta-4 integrin localization, expression and function in cell adhesion to laminin (PubMed:22314500). Plays a role in the TRAIL-activated apoptotic signaling pathway most probably through the palmitoylation and localization to the plasma membrane of TNFRSF10A (PubMed:22240897). In the brain, by palmitoylating the gamma subunit GABRG2 of GABA(A) receptors and regulating their postsynaptic accumulation, plays a role in synaptic GABAergic inhibitory function and GABAergic innervation. Palmitoylates the neuronal protein GAP43 which is also involved in the formation of GABAergic synapses. Palmitoylates NCDN thereby regulating its association with endosome membranes. Probably palmitoylates PRCD and is involved in its proper localization within the photoreceptor. Could mediate the palmitoylation of NCAM1 and regulate neurite outgrowth. Could palmitoylate DNAJC5 and regulate its localization to Golgi membranes. Also constitutively palmitoylates DLG4. May also palmitoylate SNAP25. Could palmitoylate the glutamate receptors GRIA1 and GRIA2 but this has not been confirmed in vivo (By similarity). Could also palmitoylate the D(2) dopamine receptor DRD2 (PubMed:26535572).
UniProtKB/Swiss-Prot Function:
May also function as a calcium transporter.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151; EC=2.3.1.225; Evidence={ECO:0000269|PubMed:21926431, ECO:0000269|PubMed:23034182};.

Enzyme Numbers (IUBMB) for ZDHHC3 Gene

Phenotypes From GWAS Catalog for ZDHHC3 Gene

Gene Ontology (GO) - Molecular Function for ZDHHC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016409 palmitoyltransferase activity IEA,IDA 21926431
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
GO:0019706 protein-cysteine S-palmitoyltransferase activity IEA,ISS --
GO:0042803 protein homodimerization activity IEA,ISS --
genes like me logo Genes that share ontologies with ZDHHC3: view
genes like me logo Genes that share phenotypes with ZDHHC3: view

Animal Models for ZDHHC3 Gene

MGI Knock Outs for ZDHHC3:
  • Zdhhc3 Zdhhc3<tm1.1(KOMP)Vlcg>

Animal Model Products

  • Taconic Biosciences Mouse Models for ZDHHC3

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZDHHC3

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZDHHC3 Gene

Localization for ZDHHC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZDHHC3 Gene

Golgi apparatus membrane. Multi-pass membrane protein. Note=Localizes to the Golgi cis cisterna. {ECO:0000250 UniProtKB:Q8R173}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZDHHC3 gene
Compartment Confidence
golgi apparatus 5
endoplasmic reticulum 4
plasma membrane 3
endosome 2
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZDHHC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005783 endoplasmic reticulum IBA 21873635
GO:0005794 Golgi apparatus IEA,IDA 16647879
GO:0016020 membrane IEA,HDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZDHHC3: view

Pathways & Interactions for ZDHHC3 Gene

PathCards logo

SuperPathways for ZDHHC3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZDHHC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006605 protein targeting IEA --
GO:0006612 protein targeting to membrane IBA 21873635
GO:0008277 regulation of G protein-coupled receptor signaling pathway IEA,IMP 19001095
GO:0018230 peptidyl-L-cysteine S-palmitoylation IEA,ISS --
GO:0018345 protein palmitoylation IEA,IMP 19001095
genes like me logo Genes that share ontologies with ZDHHC3: view

No data available for Pathways by source and SIGNOR curated interactions for ZDHHC3 Gene

Drugs & Compounds for ZDHHC3 Gene

(1) Drugs for ZDHHC3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coenzyme A Investigational Nutra 0

(1) Additional Compounds for ZDHHC3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
hexadecanoyl-CoA
  • coenzyme A, S-Hexadecanoate
  • Palmitoyl coenzyme A
  • S-Palmitoylcoenzyme A
  • coenzyme A, S-Hexadecanoic acid
genes like me logo Genes that share compounds with ZDHHC3: view

Transcripts for ZDHHC3 Gene

mRNA/cDNA for ZDHHC3 Gene

10 REFSEQ mRNAs :
19 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZDHHC3

Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d
SP1: - -
SP2: - -
SP3: - - -
SP4: -
SP5: - -
SP6:
SP7:

Relevant External Links for ZDHHC3 Gene

GeneLoc Exon Structure for
ZDHHC3

Expression for ZDHHC3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZDHHC3 Gene

Protein differential expression in normal tissues from HIPED for ZDHHC3 Gene

This gene is overexpressed in Nasal epithelium (66.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZDHHC3 Gene



Protein tissue co-expression partners for ZDHHC3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZDHHC3

SOURCE GeneReport for Unigene cluster for ZDHHC3 Gene:

Hs.61430

mRNA Expression by UniProt/SwissProt for ZDHHC3 Gene:

Q9NYG2-ZDHC3_HUMAN
Tissue specificity: Widely expressed with significant expression in heart, lung, liver, skeletal muscle, kidney, testis, thymus, small intestine and leukocyte.

Evidence on tissue expression from TISSUES for ZDHHC3 Gene

  • Intestine(4.5)
  • Nervous system(3.9)
  • Kidney(2.5)
  • Skin(2.4)
  • Adrenal gland(2.2)
genes like me logo Genes that share expression patterns with ZDHHC3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZDHHC3 Gene

Orthologs for ZDHHC3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZDHHC3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZDHHC3 30 31
  • 99.78 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZDHHC3 30 31
  • 94.98 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Zdhhc3 30 17 31
  • 94.43 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Zdhhc3 30
  • 94.31 (n)
Cow
(Bos Taurus)
Mammalia ZDHHC3 30 31
  • 93.65 (n)
OneToMany
-- 31
  • 80 (a)
OneToMany
-- 31
  • 37 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia ZDHHC3 31
  • 85 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia ZDHHC3 31
  • 76 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ZDHHC3 30 31
  • 81.61 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ZDHHC3 31
  • 81 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia zdhhc3 30
  • 79.08 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12303 30
Zebrafish
(Danio rerio)
Actinopterygii zdhhc3b 30 31
  • 75.03 (n)
OneToMany
zdhhc3a 31
  • 69 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003613 30
  • 63.75 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG8314 30 31 32
  • 62.95 (n)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea F33D11.12 30 32
  • 57.4 (n)
dhhc-3 31
  • 54 (a)
OneToMany
C17D12.1a 32
  • 34 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 61 (a)
OneToMany
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.11968 30
Species where no ortholog for ZDHHC3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ZDHHC3 Gene

ENSEMBL:
Gene Tree for ZDHHC3 (if available)
TreeFam:
Gene Tree for ZDHHC3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZDHHC3: view image

Paralogs for ZDHHC3 Gene

(6) SIMAP similar genes for ZDHHC3 Gene using alignment to 7 proteins:

  • ZDHC3_HUMAN
  • C9JIA9_HUMAN
  • C9JNU5_HUMAN
  • F8W6M3_HUMAN
  • H0Y6A5_HUMAN
  • H7C1U6_HUMAN
  • H7C365_HUMAN

Pseudogenes.org Pseudogenes for ZDHHC3 Gene

genes like me logo Genes that share paralogs with ZDHHC3: view

Variants for ZDHHC3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZDHHC3 Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
739869 Likely Benign: not provided 44,958,627(-) C/T SYNONYMOUS_VARIANT,INTRON_VARIANT
rs367543249 Not Provided: not provided 44,929,430(-) C/G MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
rs367543250 Not Provided: not provided 44,959,290(-) G/A NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT,FIVE_PRIME_UTR_VARIANT
rs367543251 Not Provided: not provided 44,959,351(-) T/C MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,FIVE_PRIME_UTR_VARIANT

Additional dbSNP identifiers (rs#s) for ZDHHC3 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZDHHC3 Gene

Variant ID Type Subtype PubMed ID
esv3568717 CNV loss 25503493
esv3568718 CNV loss 25503493
esv3596040 CNV gain 21293372
esv3596041 CNV loss 21293372
nsv834675 CNV gain 17160897
nsv834676 CNV gain+loss 17160897

Variation tolerance for ZDHHC3 Gene

Residual Variation Intolerance Score: 52.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.47; 10.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZDHHC3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZDHHC3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZDHHC3 Gene

Disorders for ZDHHC3 Gene

No disorders were found for ZDHHC3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZDHHC3 Gene

Publications for ZDHHC3 Gene

  1. Identification of G protein alpha subunit-palmitoylating enzyme. (PMID: 19001095) Tsutsumi R … Fukata M (Molecular and cellular biology 2009) 2 3 4
  2. Palmitoylation by DHHC3 is critical for the function, expression, and stability of integrin α6β4. (PMID: 22314500) Sharma C … Hemler ME (Cellular and molecular life sciences : CMLS 2012) 3 4
  3. Regulation in the targeting of TRAIL receptor 1 to cell surface via GODZ for TRAIL sensitivity in tumor cells. (PMID: 22240897) Oh Y … Jung YK (Cell death and differentiation 2012) 3 4
  4. Analysis of substrate specificity of human DHHC protein acyltransferases using a yeast expression system. (PMID: 23034182) Ohno Y … Kihara A (Molecular biology of the cell 2012) 3 4
  5. Endoplasmic reticulum localization of DHHC palmitoyltransferases mediated by lysine-based sorting signals. (PMID: 21926431) Gorleku OA … Chamberlain LH (The Journal of biological chemistry 2011) 3 4

Products for ZDHHC3 Gene

  • Signalway Proteins for ZDHHC3

Sources for ZDHHC3 Gene