Aliases for ZDHHC21 Gene
External Ids for ZDHHC21 Gene
Previous GeneCards Identifiers for ZDHHC21 Gene
GeneCards Summary for ZDHHC21 Gene
ZDHHC21 (Zinc Finger DHHC-Type Containing 21) is a Protein Coding gene. Among its related pathways are Metabolism and eNOS activation and regulation. Gene Ontology (GO) annotations related to this gene include protein-cysteine S-palmitoyltransferase activity and palmitoyltransferase activity. An important paralog of this gene is ZDHHC3.
UniProtKB/Swiss-Prot for ZDHHC21 Gene
Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane. This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and the generation of cAMP, but does not affect that mediated by their nuclear receptor (By similarity).