Aliases for ZDHHC21 Gene
External Ids for ZDHHC21 Gene
Previous GeneCards Identifiers for ZDHHC21 Gene
GeneCards Summary for ZDHHC21 Gene
ZDHHC21 (Zinc Finger DHHC-Type Palmitoyltransferase 21) is a Protein Coding gene. Diseases associated with ZDHHC21 include Chromosome 9P Deletion Syndrome. Among its related pathways are Metabolism and Metabolism of nitric oxide. Gene Ontology (GO) annotations related to this gene include protein-cysteine S-palmitoyltransferase activity and palmitoyltransferase activity. An important paralog of this gene is ZDHHC3.
UniProtKB/Swiss-Prot Summary for ZDHHC21 Gene
Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane. This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and the generation of cAMP, but does not affect that mediated by their nuclear receptor (By similarity).