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Aliases for ZDHHC20 Gene

Aliases for ZDHHC20 Gene

  • Zinc Finger DHHC-Type Containing 20 2 3 5
  • Zinc Finger DHHC Domain-Containing Protein 20 3 4
  • DHHC-20 3 4
  • Probable Palmitoyltransferase ZDHHC20 3
  • 4933421L13Rik 3
  • EC 4
  • EC 2.3.1 56
  • DHHC20 3

External Ids for ZDHHC20 Gene

Previous GeneCards Identifiers for ZDHHC20 Gene

  • GC00U907486
  • GC13M020845
  • GC13M020826
  • GC13M021950
  • GC13M002751

Summaries for ZDHHC20 Gene

GeneCards Summary for ZDHHC20 Gene

ZDHHC20 (Zinc Finger DHHC-Type Containing 20) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein-cysteine S-palmitoyltransferase activity and palmitoyltransferase activity. An important paralog of this gene is ZDHHC2.

Additional gene information for ZDHHC20 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZDHHC20 Gene

Genomics for ZDHHC20 Gene

GeneHancer (GH) Regulatory Elements for ZDHHC20 Gene

Promoters and enhancers for ZDHHC20 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13I021457 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 561.1 +0.4 443 2.3 PKNOX1 SIN3A DMAP1 ZNF48 GTF3C2 ATF7 RUNX3 SP3 YY2 REST ZDHHC20 GC13P021458 PIR62825
GH13I021434 Enhancer 1.1 Ensembl ENCODE 11 +23.3 23345 3.2 HDAC1 ELF3 ATF1 BATF IRF4 ZSCAN9 YY1 CHAMP1 TCF12 HSF1 PIR53166 ZDHHC20 PIR62825
GH13I021453 Enhancer 0.7 Ensembl 10.7 +5.7 5715 0.7 SOX5 SOX13 GATAD2A HLF CEBPB CEBPG HMG20A ZNF644 RARA RCOR2 ZDHHC20 PIR62825 PIR53166
GH13I021464 Enhancer 0.7 ENCODE 8.3 -7.0 -6963 2.7 SOX13 ESRRA FOXA2 SAP130 RARA TEAD3 CTBP1 RERE NR2F6 SOX5 ZDHHC20 MICU2 HIST1H2BPS3
GH13I021583 Enhancer 0.7 Ensembl ENCODE 4.9 -124.4 -124367 0.7 SP1 TEAD1 POLR2A ZNF143 ZNF644 SETDB1 TEAD3 MICU2 ZDHHC20 GC13M021552 RNU6-59P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZDHHC20 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZDHHC20 gene promoter:

Genomic Locations for ZDHHC20 Gene

Genomic Locations for ZDHHC20 Gene
86,800 bases
Minus strand

Genomic View for ZDHHC20 Gene

Genes around ZDHHC20 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZDHHC20 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZDHHC20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZDHHC20 Gene

Proteins for ZDHHC20 Gene

  • Protein details for ZDHHC20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable palmitoyltransferase ZDHHC20
    Protein Accession:
    Secondary Accessions:
    • A8MTV9
    • C9JG20
    • I6L9D4
    • Q2TB82
    • Q6NVU8

    Protein attributes for ZDHHC20 Gene

    365 amino acids
    Molecular mass:
    42278 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZDHHC20 Gene


neXtProt entry for ZDHHC20 Gene

Selected DME Specific Peptides for ZDHHC20 Gene


Post-translational modifications for ZDHHC20 Gene

  • Ubiquitination at isoforms=2, 3, 496 and posLast=123123
  • Modification sites at PhosphoSitePlus

Domains & Families for ZDHHC20 Gene

Gene Families for ZDHHC20 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for ZDHHC20 Gene

Graphical View of Domain Structure for InterPro Entry



  • The DHHC domain is required for palmitoyltransferase activity.
  • Belongs to the DHHC palmitoyltransferase family.
  • The DHHC domain is required for palmitoyltransferase activity.
  • Belongs to the DHHC palmitoyltransferase family.
genes like me logo Genes that share domains with ZDHHC20: view

Function for ZDHHC20 Gene

Molecular function for ZDHHC20 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

Enzyme Numbers (IUBMB) for ZDHHC20 Gene

Phenotypes From GWAS Catalog for ZDHHC20 Gene

Gene Ontology (GO) - Molecular Function for ZDHHC20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016409 palmitoyltransferase activity IDA 23034182
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
GO:0019706 protein-cysteine S-palmitoyltransferase activity IEA --
genes like me logo Genes that share ontologies with ZDHHC20: view
genes like me logo Genes that share phenotypes with ZDHHC20: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ZDHHC20

miRNA for ZDHHC20 Gene

miRTarBase miRNAs that target ZDHHC20

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZDHHC20 Gene

Localization for ZDHHC20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZDHHC20 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZDHHC20 gene
Compartment Confidence
plasma membrane 5
mitochondrion 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (1)
  • Plasma membrane (1)
  • Vesicles (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZDHHC20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 16647879
GO:0016020 membrane IEA,HDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZDHHC20: view

Pathways & Interactions for ZDHHC20 Gene

SuperPathways for ZDHHC20 Gene

No Data Available

Interacting Proteins for ZDHHC20 Gene

Gene Ontology (GO) - Biological Process for ZDHHC20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0018345 protein palmitoylation IDA 23034182
genes like me logo Genes that share ontologies with ZDHHC20: view

No data available for Pathways by source and SIGNOR curated interactions for ZDHHC20 Gene

Drugs & Compounds for ZDHHC20 Gene

(1) Drugs for ZDHHC20 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coenzyme A Investigational Nutra 0

(1) Additional Compounds for ZDHHC20 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ZDHHC20: view

Transcripts for ZDHHC20 Gene

Unigene Clusters for ZDHHC20 Gene

Zinc finger, DHHC-type containing 20:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC20 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c
SP1: -
SP2: -
SP3: - - - -
SP4: - - -
SP5: - -
SP6: -

Relevant External Links for ZDHHC20 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZDHHC20 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZDHHC20 Gene

mRNA differential expression in normal tissues according to GTEx for ZDHHC20 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.5).

Protein differential expression in normal tissues from HIPED for ZDHHC20 Gene

This gene is overexpressed in Nasal epithelium (41.3) and Breast (16.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZDHHC20 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZDHHC20 Gene:


SOURCE GeneReport for Unigene cluster for ZDHHC20 Gene:


Evidence on tissue expression from TISSUES for ZDHHC20 Gene

  • Liver(4.4)
  • Nervous system(2.8)
genes like me logo Genes that share expression patterns with ZDHHC20: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZDHHC20 Gene

Orthologs for ZDHHC20 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ZDHHC20 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZDHHC20 33 34
  • 99.44 (n)
(Canis familiaris)
Mammalia ZDHHC20 33 34
  • 93.5 (n)
(Bos Taurus)
Mammalia ZDHHC20 33 34
  • 91.69 (n)
(Rattus norvegicus)
Mammalia Zdhhc20 33
  • 90.45 (n)
(Mus musculus)
Mammalia Zdhhc20 33 16 34
  • 89.99 (n)
(Ornithorhynchus anatinus)
Mammalia ZDHHC20 34
  • 70 (a)
(Monodelphis domestica)
Mammalia ZDHHC20 34
  • 62 (a)
(Gallus gallus)
Aves ZDHHC20 33 34
  • 78.74 (n)
(Anolis carolinensis)
Reptilia ZDHHC20 34
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia zdhhc20 33
  • 70.09 (n)
(Danio rerio)
Actinopterygii zgc:162723 33
  • 64.07 (n)
ZDHHC20 (1 of 2) 34
  • 63 (a)
ZDHHC20 (2 of 2) 34
  • 58 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004938 33
  • 53.99 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG1407 33 34
  • 53.79 (n)
CG17287 34
  • 36 (a)
(Caenorhabditis elegans)
Secernentea dhhc-4 34
  • 32 (a)
spe-10 34
  • 31 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PFA3 34
  • 27 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons SMO1-3 33
  • 48.64 (n)
(Oryza sativa)
Liliopsida Os10g0545200 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 45 (a)
Species where no ortholog for ZDHHC20 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZDHHC20 Gene

Gene Tree for ZDHHC20 (if available)
Gene Tree for ZDHHC20 (if available)

Paralogs for ZDHHC20 Gene

Variants for ZDHHC20 Gene

Sequence variations from dbSNP and Humsavar for ZDHHC20 Gene

SNP ID Clin Chr 13 pos Variation AA Info Type
rs1000002909 -- 21,402,149(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000005849 -- 21,373,831(-) G/C 3_prime_UTR_variant, non_coding_transcript_variant
rs1000054998 -- 21,406,436(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000059890 -- 21,374,181(-) A/T 3_prime_UTR_variant, non_coding_transcript_variant
rs1000091556 -- 21,410,771(-) A/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZDHHC20 Gene

Variant ID Type Subtype PubMed ID
esv1388531 CNV insertion 17803354
esv2668027 CNV deletion 23128226
esv28175 CNV loss 19812545
esv992961 CNV insertion 20482838
nsv1078303 OTHER inversion 25765185
nsv1138196 CNV deletion 24896259
nsv1140246 OTHER inversion 24896259
nsv1151909 OTHER inversion 26484159
nsv561258 CNV loss 21841781
nsv976085 CNV duplication 23825009

Variation tolerance for ZDHHC20 Gene

Residual Variation Intolerance Score: 58.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.43; 42.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZDHHC20 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZDHHC20 Gene

Disorders for ZDHHC20 Gene

Additional Disease Information for ZDHHC20

No disorders were found for ZDHHC20 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZDHHC20 Gene

Publications for ZDHHC20 Gene

  1. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A … Ross MT (Nature 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Inhibition of DHHC20-Mediated EGFR Palmitoylation Creates a Dependence on EGFR Signaling. (PMID: 27153536) Runkle KB … Witze ES (Molecular cell 2016) 3 58
  5. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta GD … Pelletier L (Cell 2015) 3 58

Products for ZDHHC20 Gene

Sources for ZDHHC20 Gene

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