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Aliases for ZDHHC2 Gene
Aliases for ZDHHC2 Gene
- Zinc Finger DHHC-Type Palmitoyltransferase 2 2 3 5
- ZNF372 2 3 4
- Reduced Expression Associated With Metastasis Protein 3 4
- Zinc Finger DHHC Domain-Containing Protein 2 3 4
- Reduced Expression In Cancer Protein 3 4
- Zinc Finger DHHC-Type Containing 2 2 3
- Palmitoyltransferase ZDHHC2 3 4
- Zinc Finger Protein 372 3 4
- Acyltransferase ZDHHC2 3 4
- DHHC-2 3 4
External Ids for ZDHHC2 Gene
- HGNC: 18469
- NCBI Entrez Gene: 51201
- Ensembl: ENSG00000104219
- OMIM®: 618621
- UniProtKB/Swiss-Prot: Q9UIJ5
Previous GeneCards Identifiers for ZDHHC2 Gene
- GC08P016907
- GC08P017093
- GC08P017024
- GC08P017023
- GC08P017058
- GC08P015559
Summaries for ZDHHC2 Gene
GeneCards Summary for ZDHHC2 Gene
ZDHHC2 (Zinc Finger DHHC-Type Palmitoyltransferase 2) is a Protein Coding gene. Diseases associated with ZDHHC2 include Chikungunya and Arthrogryposis, Distal, Type 2A. Among its related pathways are Metabolism of proteins and Surfactant metabolism. Gene Ontology (GO) annotations related to this gene include palmitoyltransferase activity. An important paralog of this gene is ZDHHC20.
UniProtKB/Swiss-Prot Summary for ZDHHC2 Gene
-
Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and is involved in a variety of cellular processes (PubMed:18508921, PubMed:18296695, PubMed:19144824, PubMed:21343290, PubMed:22034844, PubMed:23793055). Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (By similarity). In the nervous system, plays a role in long term synaptic potentiation by palmitoylating AKAP5 through which it regulates protein trafficking from the dendritic recycling endosomes to the plasma membrane and controls both structural and functional plasticity at excitatory synapses (By similarity). In dendrites, mediates the palmitoylation of DLG4 when synaptic activity decreases and induces synaptic clustering of DLG4 and associated AMPA-type glutamate receptors (By similarity). Also mediates the de novo and turnover palmitoylation of RGS7BP, a shuttle for Gi/o-specific GTPase-activating proteins/GAPs, promoting its localization to the plasma membrane in response to the activation of G protein-coupled receptors. Through the localization of these GTPase-activating proteins/GAPs, it also probably plays a role in G protein-coupled receptors signaling in neurons (By similarity). Also probably plays a role in cell adhesion by palmitoylating CD9 and CD151 to regulate their expression and function (PubMed:18508921). Palmitoylates the endoplasmic reticulum protein CKAP4 and regulates its localization to the plasma membrane (PubMed:18296695, PubMed:19144824). Could also palmitoylate LCK and regulate its localization to the plasma membrane (PubMed:22034844).
-
(Microbial infection) Promotes Chikungunya virus (CHIKV) replication by mediating viral nsp1 palmitoylation.
Additional gene information for ZDHHC2 Gene
- HGNC (18469)
- NCBI Entrez Gene (51201)
- Ensembl (ENSG00000104219)
- OMIM® (618621)
- UniProtKB/Swiss-Prot (Q9UIJ5)
- Open Targets Platform(ENSG00000104219)
- Monarch Initiative
- Search for ZDHHC2 at DataMed
- Search for ZDHHC2 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZDHHC2 Gene
Genomics for ZDHHC2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for ZDHHC2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ZDHHC2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZDHHC2
- Top Transcription factor binding sites by QIAGEN in the ZDHHC2 gene promoter:
-
- aMEF-2
- AP-1
- ATF-2
- c-Jun
- GATA-3
- MEF-2A
- POU2F1
- POU2F1a
Genomic Locations for ZDHHC2 Gene
Latest Assembly
- chr8:17,156,000-17,230,706
- (GRCh38/hg38)
- Size:
- 74,707 bases
- Orientation:
- Plus strand
Previous Assembly
- chr8:17,013,991-17,082,308
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 68,318 bases
- Orientation:
- Plus strand
- chr8:17,013,538-17,082,308
- (GRCh37/hg19 by Ensembl)
- Size:
- 68,771 bases
- Orientation:
- Plus strand
Genomic View for ZDHHC2 Gene
Genes around ZDHHC2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 8p22 by HGNC
- 8p22 by Entrez Gene
- 8p22 by Ensembl
ZDHHC2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ZDHHC2 Gene
Proteins for ZDHHC2 Gene
-
Protein details for ZDHHC2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UIJ5-ZDHC2_HUMAN
- Recommended name:
- Palmitoyltransferase ZDHHC2
- Protein Accession:
- Q9UIJ5
- D3DSP5
Protein attributes for ZDHHC2 Gene
- Size:
- 367 amino acids
- Molecular mass:
- 42022 Da
- Quaternary structure:
-
- Monomer (PubMed:23793055). Homodimer (PubMed:23793055). The monomeric form has a higher catalytic activity (PubMed:23793055).
Protein Expression for ZDHHC2 Gene
Selected DME Specific Peptides for ZDHHC2 Gene
- Q9UIJ5:
-
- CILKMDH
- LFGYHCWLVS
- NYKFFLLFL
- MDHHCPW
- KPDRCHHCS
Post-translational modifications for ZDHHC2 Gene
- Autopalmitoylated.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for ZDHHC2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences ZDHHC2 Antibody
- G Biosciences Immunotag™ ZDHHC2 Antibody
-
Custom Antibody ServicesOriGene Antibodies for ZDHHC2
- Novus Biologicals Antibodies for ZDHHC2
- Invitrogen Antibodies for ZDHHC2 (AFLGC-ZDHHC2)
-
Custom Antibody ServicesProSci Antibodies for ZDHHC2
-
Santa Cruz Biotechnology (SCBT) Antibodies for ZDHHC2
Protein products for research
- Search Origene for MassSpec and Protein Over-expression Lysates for ZDHHC2
- Origene Custom Protein Services for ZDHHC2
Assay products for research
Domains & Families for ZDHHC2 Gene
Gene Families for ZDHHC2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for ZDHHC2 Gene
- InterPro:
- Blocks:
-
- Zn-finger, DHHC type
- ProtoNet:
Suggested Antigen Peptide Sequences for ZDHHC2 Gene
- GenScript: Design optimal peptide antigens:
-
- Zinc finger protein 372 (ZDHC2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9UIJ5UniProtKB/Swiss-Prot:
ZDHC2_HUMAN :- The DHHC domain is required for palmitoyltransferase activity.
- Belongs to the DHHC palmitoyltransferase family.
- Domain:
-
- The DHHC domain is required for palmitoyltransferase activity.
- Family:
-
- Belongs to the DHHC palmitoyltransferase family.
Function for ZDHHC2 Gene
Molecular function for ZDHHC2 Gene
- UniProtKB/Swiss-Prot Function:
- Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and is involved in a variety of cellular processes (PubMed:18508921, PubMed:18296695, PubMed:19144824, PubMed:21343290, PubMed:22034844, PubMed:23793055). Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (By similarity). In the nervous system, plays a role in long term synaptic potentiation by palmitoylating AKAP5 through which it regulates protein trafficking from the dendritic recycling endosomes to the plasma membrane and controls both structural and functional plasticity at excitatory synapses (By similarity). In dendrites, mediates the palmitoylation of DLG4 when synaptic activity decreases and induces synaptic clustering of DLG4 and associated AMPA-type glutamate receptors (By similarity). Also mediates the de novo and turnover palmitoylation of RGS7BP, a shuttle for Gi/o-specific GTPase-activating proteins/GAPs, promoting its localization to the plasma membrane in response to the activation of G protein-coupled receptors. Through the localization of these GTPase-activating proteins/GAPs, it also probably plays a role in G protein-coupled receptors signaling in neurons (By similarity). Also probably plays a role in cell adhesion by palmitoylating CD9 and CD151 to regulate their expression and function (PubMed:18508921). Palmitoylates the endoplasmic reticulum protein CKAP4 and regulates its localization to the plasma membrane (PubMed:18296695, PubMed:19144824). Could also palmitoylate LCK and regulate its localization to the plasma membrane (PubMed:22034844).
- UniProtKB/Swiss-Prot Function:
- (Microbial infection) Promotes Chikungunya virus (CHIKV) replication by mediating viral nsp1 palmitoylation.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151; EC=2.3.1.225; Evidence={ECO:0000269|PubMed:23793055};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=L-cysteinyl-[protein] + tetradecanoyl-CoA = CoA + S-tetradecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:59736, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:15433, ChEBI:CHEBI:29950, ChEBI:CHEBI:57287, ChEBI:CHEBI:57385, ChEBI:CHEBI:143199; Evidence={ECO:0000250|UniProtKB:P59267};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=L-cysteinyl-[protein] + octadecanoyl-CoA = CoA + S-octadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:59740, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:15434, ChEBI:CHEBI:29950, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394, ChEBI:CHEBI:143200; Evidence={ECO:0000250|UniProtKB:P59267};.
Enzyme Numbers (IUBMB) for ZDHHC2 Gene
Phenotypes From GWAS Catalog for ZDHHC2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016409 | palmitoyltransferase activity | IEA,TAS | -- |
| GO:0016740 | transferase activity | IEA | -- |
| GO:0016746 | transferase activity, transferring acyl groups | IEA | -- |
| GO:0019706 | protein-cysteine S-palmitoyltransferase activity | IEA,IDA | 23793055 |
| GO:0042803 | protein homodimerization activity | IDA | 23793055 |
Phenotypes for ZDHHC2 Gene
- MGI mutant phenotypes for ZDHHC2:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for ZDHHC2:
Animal Models for ZDHHC2 Gene
- MGI Knock Outs for ZDHHC2:
-
- Zdhhc2 Zdhhc2<tm1b(KOMP)Wtsi>
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for ZDHHC2 - Starting at $85 >
- * ZDHHC2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for ZDHHC2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ZDHHC2
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZDHHC2
miRNA for ZDHHC2 Gene
- miRTarBase miRNAs that target ZDHHC2
-
- mmu-miR-425-5p (MIRT008770)
- hsa-miR-132-3p (MIRT021821)
- hsa-miR-215-5p (MIRT024885)
- hsa-miR-192-5p (MIRT026589)
- hsa-miR-541-5p (MIRT439239)
- hsa-miR-578 (MIRT450447)
- hsa-miR-4762-3p (MIRT450448)
- hsa-miR-127-5p (MIRT450449)
- hsa-miR-7843-3p (MIRT450450)
- hsa-miR-526b-5p (MIRT450451)
- hsa-miR-4303 (MIRT450452)
- hsa-miR-5186 (MIRT450453)
- hsa-miR-4635 (MIRT450454)
- hsa-miR-6761-5p (MIRT450455)
- hsa-miR-4329 (MIRT450456)
- hsa-miR-4251 (MIRT450457)
- hsa-miR-1279 (MIRT450458)
- hsa-miR-487a-3p (MIRT450459)
- hsa-miR-154-3p (MIRT450460)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ZDHHC2
- Browse OriGene Inhibitory RNA Products For ZDHHC2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZDHHC2
Clone products for research
- Applied Biological Materials (abm): Clones for ZDHHC2 - Starting at $45 >
- * ZDHHC2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for ZDHHC2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ZDHHC2
Cell Lines for research
-
Horizon Cell Lines for ZDHHC2
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZDHHC2 Gene
Localization for ZDHHC2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ZDHHC2 Gene
- Cell junction, synapse, postsynaptic density. Postsynaptic recycling endosome membrane. Multi-pass membrane protein. Cell membrane. Multi-pass membrane protein. Endoplasmic reticulum membrane. Multi-pass membrane protein. Golgi apparatus membrane. Multi-pass membrane protein. Note=Translocates to postsynaptic density when synaptic activity decreases. {ECO:0000250 UniProtKB:Q9JKR5}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| endoplasmic reticulum | 5 |
| golgi apparatus | 5 |
| endosome | 4 |
| extracellular | 2 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| nucleus | 1 |
| cytosol | 1 |
| lysosome | 1 |
- Plasma membrane (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | IEA | -- |
| GO:0005768 | endosome | IEA | -- |
| GO:0005783 | endoplasmic reticulum | IBA,IDA | 16647879 |
| GO:0005789 | endoplasmic reticulum membrane | IEA,IDA | 22034844 |
| GO:0005794 | Golgi apparatus | IBA,IDA | 16647879 |
Pathways & Interactions for ZDHHC2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Metabolism of proteins | ||
| 2 | Surfactant metabolism | ||
Pathways by source for ZDHHC2 Gene
2 Reactome pathways for ZDHHC2 Gene
Interacting Proteins for ZDHHC2 Gene
GPS-Prot Interaction Network for ZDHHC2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006612 | protein targeting to membrane | IBA | 21873635 |
| GO:0016188 | synaptic vesicle maturation | IBA | 21873635 |
| GO:0018215 | protein phosphopantetheinylation | IEA | -- |
| GO:0018230 | peptidyl-L-cysteine S-palmitoylation | IMP | 18296695 |
| GO:0018345 | protein palmitoylation | IDA | 23034182 |
Drugs & Compounds for ZDHHC2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Coenzyme A | Investigational | Nutra | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| hexadecanoyl-CoA |
|
|
Transcripts for ZDHHC2 Gene
mRNA/cDNA for ZDHHC2 Gene
- 3 REFSEQ mRNAs :
- 6 NCBI additional mRNA sequence :
- 4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000262096 5924 nts (view in UCSC)
- ENST00000517334 334 nts (view in UCSC)
- ENST00000522184 487 nts (view in UCSC)
- ENST00000523132 167 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for ZDHHC2 - Starting at $85 >
- * ZDHHC2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for ZDHHC2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ZDHHC2
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZDHHC2
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ZDHHC2
- Browse OriGene Inhibitory RNA Products For ZDHHC2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZDHHC2
Clone products for research
- Applied Biological Materials (abm): Clones for ZDHHC2 - Starting at $45 >
- * ZDHHC2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for ZDHHC2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ZDHHC2
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||
| SP4: |
Relevant External Links for ZDHHC2 Gene
- GeneLoc Exon Structure for
- ZDHHC2
Expression for ZDHHC2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Brain (Nervous System)
- Adult Dopaminergic Neurons Substantia Nigra pars Compacta
- Hypothalamus
- Thalamus
- Striatum
- Medulla Oblongata
- Neural Tube (Nervous System)
-
Testis (Reproductive System)
- Pre-Sertoli Cells Testis Cord
- Testicular Interstitial Cells Testis Interstitium
-
Neurons
- Adult Dopaminergic Neurons Substantia Nigra pars Compacta
This gene is overexpressed in Pancreatic juice (40.3) and Peripheral blood mononuclear cells (22.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZDHHC2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZDHHC2
SOURCE GeneReport for Unigene cluster for ZDHHC2 Gene:
Hs.744097mRNA Expression by UniProt/SwissProt for ZDHHC2 Gene:
Q9UIJ5-ZDHC2_HUMAN
Tissue specificity:
Ubiquitously expressed (PubMed:10918388, PubMed:22034844). Reduced expression in colorectal cancers with liver metastasis (PubMed:10918388).
Evidence on tissue expression from TISSUES for ZDHHC2 Gene
- Nervous system(4.6)
- Intestine(4.3)
- Kidney(2.3)
Primer products for research
-
OriGene qPCR primer pairs for ZDHHC2
-
OriGene qPCR primer pairs and template standards for ZDHHC2
Gene Expression Assays for research
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZDHHC2 Gene
Orthologs for ZDHHC2 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | ZDHHC2 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| LOC100687370 30 |
|
||||
| Mouse (Mus musculus) |
Mammalia | Zdhhc2 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Zdhhc2 30 |
|
||
| Cow (Bos Taurus) |
Mammalia | ZDHHC2 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | ZDHHC2 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | ZDHHC2 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | ZDHHC2 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | ZDHHC2 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | zdhhc2 30 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.19130 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | zdhhc2 30 31 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG17287 31 32 |
|
ManyToMany | |
| CG1407 31 32 |
|
ManyToMany | |||
| Worm (Caenorhabditis elegans) |
Secernentea | ZK757.4 30 |
|
||
| ZK757.1 32 |
|
|
|||
| dhhc-4 31 |
|
ManyToMany | |||
| spe-10 31 |
|
ManyToMany | |||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | PFA3 31 |
|
OneToMany | |
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT4G00840 30 |
|
||
| Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.10082 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for ZDHHC2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for ZDHHC2 Gene
- ENSEMBL:
- Gene Tree for ZDHHC2 (if available)
- TreeFam:
- Gene Tree for ZDHHC2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ZDHHC2: view image
Paralogs for ZDHHC2 Gene
Paralogs for ZDHHC2 Gene
(9) SIMAP similar genes for ZDHHC2 Gene using alignment to 2 proteins:
- ZDHC2_HUMAN
- E5RFZ7_HUMAN
Variants for ZDHHC2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZDHHC2 Gene
| SNP ID | Clinical significance and condition | Chr 08 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs568589179 | A colorectal cancer sample |
p.Met356Ile |
|||
| VAR_015229 | A hepatocellular carcinoma sample |
p.Ser306Phe |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1030364 | CNV | deletion | 17803354 |
| esv2736683 | CNV | deletion | 23290073 |
| esv2736685 | CNV | deletion | 23290073 |
| esv2736686 | CNV | deletion | 23290073 |
| esv2761416 | CNV | gain | 21179565 |
| nsv1126847 | CNV | deletion | 24896259 |
| nsv1128406 | CNV | deletion | 24896259 |
| nsv831244 | CNV | gain | 17160897 |
Residual Variation Intolerance Score:
59.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.10;
22.38% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ZDHHC2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ZDHHC2
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZDHHC2 Gene
Disorders for ZDHHC2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| chikungunya |
|
|
| arthrogryposis, distal, type 2a |
|
|
| arthrogryposis, distal, type 1a |
|
|
| arthrogryposis, distal, type 1b |
|
|
| locked-in syndrome |
|
|
Search ZDHHC2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ZDHHC2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for ZDHHC2 Gene
Publications for ZDHHC2 Gene
- Isolation of a novel gene on 8p21.3-22 whose expression is reduced significantly in human colorectal cancers with liver metastasis. (PMID: 10918388) Oyama T … Nakamura Y (Genes, chromosomes & cancer 2000) 2 3 4
- Oligomerization of DHHC protein S-acyltransferases. (PMID: 23793055) Lai J … Linder ME (The Journal of biological chemistry 2013) 3 4
- Gi/o signaling and the palmitoyltransferase DHHC2 regulate palmitate cycling and shuttling of RGS7 family-binding protein. (PMID: 21343290) Jia L … Blumer KJ (The Journal of biological chemistry 2011) 3 4
- DHHC2 is a protein S-acyltransferase for Lck. (PMID: 22034844) Zeidman R … Magee AI (Molecular membrane biology 2011) 3 4
- The palmitoyl transferase DHHC2 targets a dynamic membrane cycling pathway: regulation by a C-terminal domain. (PMID: 21471008) Greaves J … Chamberlain LH (Molecular biology of the cell 2011) 3 4
ExternalLinks
Products for ZDHHC2 Gene
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Sources for ZDHHC2 Gene
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