Aliases for ZDHHC2 Gene

Aliases for ZDHHC2 Gene

  • Zinc Finger DHHC-Type Palmitoyltransferase 2 2 3 5
  • ZNF372 2 3 4
  • Reduced Expression Associated With Metastasis Protein 3 4
  • Zinc Finger DHHC Domain-Containing Protein 2 3 4
  • Reduced Expression In Cancer Protein 3 4
  • Zinc Finger DHHC-Type Containing 2 2 3
  • Palmitoyltransferase ZDHHC2 3 4
  • Zinc Finger Protein 372 3 4
  • Acyltransferase ZDHHC2 3 4
  • DHHC-2 3 4
  • DHHC2 2 3
  • Ream 3 4
  • Rec 3 4
  • Testis Tissue Sperm-Binding Protein Li 56e 3
  • Zinc Finger, DHHC Domain Containing 2 3
  • EC 2.3.1.225 4
  • EC 2.3.1.- 4
  • EC 2.3.1 50
  • ZDHHC2 5
  • REAM 4
  • REC 4

External Ids for ZDHHC2 Gene

Previous GeneCards Identifiers for ZDHHC2 Gene

  • GC08P016907
  • GC08P017093
  • GC08P017024
  • GC08P017023
  • GC08P017058
  • GC08P015559

Summaries for ZDHHC2 Gene

GeneCards Summary for ZDHHC2 Gene

ZDHHC2 (Zinc Finger DHHC-Type Palmitoyltransferase 2) is a Protein Coding gene. Diseases associated with ZDHHC2 include Chikungunya and Arthrogryposis, Distal, Type 2A. Among its related pathways are Surfactant metabolism and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include palmitoyltransferase activity. An important paralog of this gene is ZDHHC20.

UniProtKB/Swiss-Prot Summary for ZDHHC2 Gene

  • Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and is involved in a variety of cellular processes (PubMed:18508921, PubMed:18296695, PubMed:19144824, PubMed:21343290, PubMed:22034844, PubMed:23793055). Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (By similarity). In the nervous system, plays a role in long term synaptic potentiation by palmitoylating AKAP5 through which it regulates protein trafficking from the dendritic recycling endosomes to the plasma membrane and controls both structural and functional plasticity at excitatory synapses (By similarity). In dendrites, mediates the palmitoylation of DLG4 when synaptic activity decreases and induces synaptic clustering of DLG4 and associated AMPA-type glutamate receptors (By similarity). Also mediates the de novo and turnover palmitoylation of RGS7BP, a shuttle for Gi/o-specific GTPase-activating proteins/GAPs, promoting its localization to the plasma membrane in response to the activation of G protein-coupled receptors. Through the localization of these GTPase-activating proteins/GAPs, it also probably plays a role in G protein-coupled receptors signaling in neurons (By similarity). Also probably plays a role in cell adhesion by palmitoylating CD9 and CD151 to regulate their expression and function (PubMed:18508921). Palmitoylates the endoplasmic reticulum protein CKAP4 and regulates its localization to the plasma membrane (PubMed:18296695, PubMed:19144824). Could also palmitoylate LCK and regulate its localization to the plasma membrane (PubMed:22034844).
  • (Microbial infection) Promotes Chikungunya virus (CHIKV) replication by mediating viral nsp1 palmitoylation.

Gene Wiki entry for ZDHHC2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZDHHC2 Gene

Genomics for ZDHHC2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZDHHC2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J017155 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 291.3 +1.4 1401 4.8 ZNF600 JUND KLF9 ZNF10 POLR2A ZIC2 MXD4 NONO CEBPB KLF11 ZDHHC2 HSALNG0063648 LOC107986918 RF00017-6309 CNOT7
GH08J017183 Enhancer 0.7 Ensembl ENCODE 35.1 +28.1 28101 1.4 CEBPA ZNF223 ZIC2 MXD4 FEZF1 PRDM6 CEBPG HLF ZXDB OSR2 ZDHHC2 lnc-CNOT7-1 lnc-CNOT7-3 RF00017-6309 CNOT7
GH08J016825 Enhancer 1 ENCODE 16.4 -329.6 -329601 2.2 ZNF654 ZNF600 JUND ZNF580 ATF2 ZNF10 NFIC ZIC2 ZBTB10 CEBPB MICU3 ZDHHC2 ENSG00000249258 MTUS1 CNOT7 FJ601678-104 piR-36846-006 LOC105379297 ENSG00000253496 FGF20
GH08J017162 Promoter/Enhancer 0.8 Ensembl ENCODE 18.4 +7.1 7101 1.4 EBF1 PRDM6 HNF4A OSR2 POLR2A ZDHHC2 LOC107986918 lnc-CNOT7-1 RF00017-6309 CNOT7
GH08J017167 Enhancer 0.7 Ensembl ENCODE 18.4 +12.5 12500 6.6 ZNF600 MAFF ZNF316 MAFK PRDM6 MAFG ZNF362 ZBTB17 PRDM10 EMSY ZDHHC2 lnc-CNOT7-1 LOC107986918 RF00017-6309 CNOT7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZDHHC2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZDHHC2

Top Transcription factor binding sites by QIAGEN in the ZDHHC2 gene promoter:
  • aMEF-2
  • AP-1
  • ATF-2
  • c-Jun
  • GATA-3
  • MEF-2A
  • POU2F1
  • POU2F1a

Genomic Locations for ZDHHC2 Gene

Latest Assembly
chr8:17,156,000-17,230,706
(GRCh38/hg38)
Size:
74,707 bases
Orientation:
Plus strand

Previous Assembly
chr8:17,013,991-17,082,308
(GRCh37/hg19 by Entrez Gene)
Size:
68,318 bases
Orientation:
Plus strand

chr8:17,013,538-17,082,308
(GRCh37/hg19 by Ensembl)
Size:
68,771 bases
Orientation:
Plus strand

Genomic View for ZDHHC2 Gene

Genes around ZDHHC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZDHHC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZDHHC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZDHHC2 Gene

Proteins for ZDHHC2 Gene

  • Protein details for ZDHHC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UIJ5-ZDHC2_HUMAN
    Recommended name:
    Palmitoyltransferase ZDHHC2
    Protein Accession:
    Q9UIJ5
    Secondary Accessions:
    • D3DSP5

    Protein attributes for ZDHHC2 Gene

    Size:
    367 amino acids
    Molecular mass:
    42022 Da
    Quaternary structure:
    • Monomer (PubMed:23793055). Homodimer (PubMed:23793055). The monomeric form has a higher catalytic activity (PubMed:23793055).

neXtProt entry for ZDHHC2 Gene

Selected DME Specific Peptides for ZDHHC2 Gene

Q9UIJ5:
  • CILKMDH
  • LFGYHCWLVS
  • NYKFFLLFL
  • MDHHCPW
  • KPDRCHHCS

Post-translational modifications for ZDHHC2 Gene

Antibodies for research

Domains & Families for ZDHHC2 Gene

Gene Families for ZDHHC2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for ZDHHC2 Gene

InterPro:
Blocks:
  • Zn-finger, DHHC type

Suggested Antigen Peptide Sequences for ZDHHC2 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 372 (ZDHC2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UIJ5

UniProtKB/Swiss-Prot:

ZDHC2_HUMAN :
  • The DHHC domain is required for palmitoyltransferase activity.
  • Belongs to the DHHC palmitoyltransferase family.
Domain:
  • The DHHC domain is required for palmitoyltransferase activity.
Family:
  • Belongs to the DHHC palmitoyltransferase family.
genes like me logo Genes that share domains with ZDHHC2: view

Function for ZDHHC2 Gene

Molecular function for ZDHHC2 Gene

UniProtKB/Swiss-Prot Function:
Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and is involved in a variety of cellular processes (PubMed:18508921, PubMed:18296695, PubMed:19144824, PubMed:21343290, PubMed:22034844, PubMed:23793055). Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (By similarity). In the nervous system, plays a role in long term synaptic potentiation by palmitoylating AKAP5 through which it regulates protein trafficking from the dendritic recycling endosomes to the plasma membrane and controls both structural and functional plasticity at excitatory synapses (By similarity). In dendrites, mediates the palmitoylation of DLG4 when synaptic activity decreases and induces synaptic clustering of DLG4 and associated AMPA-type glutamate receptors (By similarity). Also mediates the de novo and turnover palmitoylation of RGS7BP, a shuttle for Gi/o-specific GTPase-activating proteins/GAPs, promoting its localization to the plasma membrane in response to the activation of G protein-coupled receptors. Through the localization of these GTPase-activating proteins/GAPs, it also probably plays a role in G protein-coupled receptors signaling in neurons (By similarity). Also probably plays a role in cell adhesion by palmitoylating CD9 and CD151 to regulate their expression and function (PubMed:18508921). Palmitoylates the endoplasmic reticulum protein CKAP4 and regulates its localization to the plasma membrane (PubMed:18296695, PubMed:19144824). Could also palmitoylate LCK and regulate its localization to the plasma membrane (PubMed:22034844).
UniProtKB/Swiss-Prot Function:
(Microbial infection) Promotes Chikungunya virus (CHIKV) replication by mediating viral nsp1 palmitoylation.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151; EC=2.3.1.225; Evidence={ECO:0000269|PubMed:23793055};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=L-cysteinyl-[protein] + tetradecanoyl-CoA = CoA + S-tetradecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:59736, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:15433, ChEBI:CHEBI:29950, ChEBI:CHEBI:57287, ChEBI:CHEBI:57385, ChEBI:CHEBI:143199; Evidence={ECO:0000250|UniProtKB:P59267};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=L-cysteinyl-[protein] + octadecanoyl-CoA = CoA + S-octadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:59740, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:15434, ChEBI:CHEBI:29950, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394, ChEBI:CHEBI:143200; Evidence={ECO:0000250|UniProtKB:P59267};.

Enzyme Numbers (IUBMB) for ZDHHC2 Gene

Phenotypes From GWAS Catalog for ZDHHC2 Gene

Gene Ontology (GO) - Molecular Function for ZDHHC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016409 palmitoyltransferase activity IEA,TAS --
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
GO:0019706 protein-cysteine S-palmitoyltransferase activity IEA,IDA 23793055
GO:0042803 protein homodimerization activity IDA 23793055
genes like me logo Genes that share ontologies with ZDHHC2: view
genes like me logo Genes that share phenotypes with ZDHHC2: view

Animal Models for ZDHHC2 Gene

MGI Knock Outs for ZDHHC2:
  • Zdhhc2 Zdhhc2<tm1b(KOMP)Wtsi>

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZDHHC2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZDHHC2 Gene

Localization for ZDHHC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZDHHC2 Gene

Cell junction, synapse, postsynaptic density. Postsynaptic recycling endosome membrane. Multi-pass membrane protein. Cell membrane. Multi-pass membrane protein. Endoplasmic reticulum membrane. Multi-pass membrane protein. Golgi apparatus membrane. Multi-pass membrane protein. Note=Translocates to postsynaptic density when synaptic activity decreases. {ECO:0000250 UniProtKB:Q9JKR5}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZDHHC2 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 5
golgi apparatus 5
endosome 4
extracellular 2
cytoskeleton 1
mitochondrion 1
nucleus 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZDHHC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005768 endosome IEA --
GO:0005783 endoplasmic reticulum IBA,IDA 16647879
GO:0005789 endoplasmic reticulum membrane IEA,IDA 22034844
GO:0005794 Golgi apparatus IBA,IDA 16647879
genes like me logo Genes that share ontologies with ZDHHC2: view

Pathways & Interactions for ZDHHC2 Gene

PathCards logo

SuperPathways for ZDHHC2 Gene

genes like me logo Genes that share pathways with ZDHHC2: view

Pathways by source for ZDHHC2 Gene

2 Reactome pathways for ZDHHC2 Gene

SIGNOR curated interactions for ZDHHC2 Gene

Activates:

Gene Ontology (GO) - Biological Process for ZDHHC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006612 protein targeting to membrane IBA 21873635
GO:0016188 synaptic vesicle maturation IBA 21873635
GO:0018215 protein phosphopantetheinylation IEA --
GO:0018230 peptidyl-L-cysteine S-palmitoylation IMP 18296695
GO:0018345 protein palmitoylation IDA 23034182
genes like me logo Genes that share ontologies with ZDHHC2: view

Drugs & Compounds for ZDHHC2 Gene

(1) Drugs for ZDHHC2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coenzyme A Investigational Nutra 0

(1) Additional Compounds for ZDHHC2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
hexadecanoyl-CoA
  • coenzyme A, S-Hexadecanoate
  • Palmitoyl coenzyme A
  • S-Palmitoylcoenzyme A
  • coenzyme A, S-Hexadecanoic acid
  • Hexadecanoyl-CoA
genes like me logo Genes that share compounds with ZDHHC2: view

Transcripts for ZDHHC2 Gene

mRNA/cDNA for ZDHHC2 Gene

3 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZDHHC2

Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b
SP1: - -
SP2: - -
SP3:
SP4:

Relevant External Links for ZDHHC2 Gene

GeneLoc Exon Structure for
ZDHHC2

Expression for ZDHHC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZDHHC2 Gene

Protein differential expression in normal tissues from HIPED for ZDHHC2 Gene

This gene is overexpressed in Pancreatic juice (40.3) and Peripheral blood mononuclear cells (22.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZDHHC2 Gene



Protein tissue co-expression partners for ZDHHC2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZDHHC2

SOURCE GeneReport for Unigene cluster for ZDHHC2 Gene:

Hs.744097

mRNA Expression by UniProt/SwissProt for ZDHHC2 Gene:

Q9UIJ5-ZDHC2_HUMAN
Tissue specificity: Ubiquitously expressed (PubMed:10918388, PubMed:22034844). Reduced expression in colorectal cancers with liver metastasis (PubMed:10918388).

Evidence on tissue expression from TISSUES for ZDHHC2 Gene

  • Nervous system(4.6)
  • Intestine(4.3)
  • Kidney(2.3)
genes like me logo Genes that share expression patterns with ZDHHC2: view

Primer products for research

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZDHHC2 Gene

Orthologs for ZDHHC2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ZDHHC2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZDHHC2 29 30
  • 99.64 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia -- 30
  • 97 (a)
OneToMany
-- 30
  • 94 (a)
OneToMany
-- 30
  • 94 (a)
OneToMany
LOC100687370 29
  • 93.83 (n)
Mouse
(Mus musculus)
Mammalia Zdhhc2 29 16 30
  • 91.35 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Zdhhc2 29
  • 91.35 (n)
Cow
(Bos Taurus)
Mammalia ZDHHC2 30
  • 87 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia ZDHHC2 30
  • 86 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ZDHHC2 30
  • 83 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ZDHHC2 29 30
  • 81.19 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ZDHHC2 30
  • 73 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia zdhhc2 29
  • 78.51 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.19130 29
Zebrafish
(Danio rerio)
Actinopterygii zdhhc2 29 30
  • 69.81 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG17287 30 31
  • 36 (a)
ManyToMany
CG1407 30 31
  • 36 (a)
ManyToMany
Worm
(Caenorhabditis elegans)
Secernentea ZK757.4 29
  • 50.45 (n)
ZK757.1 31
  • 38 (a)
dhhc-4 30
  • 32 (a)
ManyToMany
spe-10 30
  • 28 (a)
ManyToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PFA3 30
  • 26 (a)
OneToMany
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT4G00840 29
  • 48.93 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.10082 29
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 47 (a)
OneToMany
Species where no ortholog for ZDHHC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ZDHHC2 Gene

ENSEMBL:
Gene Tree for ZDHHC2 (if available)
TreeFam:
Gene Tree for ZDHHC2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZDHHC2: view image
Alliance of Genome Resources:
Additional Orthologs for ZDHHC2

Paralogs for ZDHHC2 Gene

(9) SIMAP similar genes for ZDHHC2 Gene using alignment to 2 proteins:

  • ZDHC2_HUMAN
  • E5RFZ7_HUMAN
genes like me logo Genes that share paralogs with ZDHHC2: view

Variants for ZDHHC2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZDHHC2 Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
rs568589179 A colorectal cancer sample p.Met356Ile
VAR_015229 A hepatocellular carcinoma sample p.Ser306Phe

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ZDHHC2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ZDHHC2 Gene

Variant ID Type Subtype PubMed ID
esv1030364 CNV deletion 17803354
esv2736683 CNV deletion 23290073
esv2736685 CNV deletion 23290073
esv2736686 CNV deletion 23290073
esv2761416 CNV gain 21179565
nsv1126847 CNV deletion 24896259
nsv1128406 CNV deletion 24896259
nsv831244 CNV gain 17160897

Variation tolerance for ZDHHC2 Gene

Residual Variation Intolerance Score: 59.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.10; 22.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZDHHC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZDHHC2
Leiden Open Variation Database (LOVD)
ZDHHC2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZDHHC2 Gene

Disorders for ZDHHC2 Gene

MalaCards: The human disease database

(6) MalaCards diseases for ZDHHC2 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
chikungunya
  • chikungunya fever
arthrogryposis, distal, type 2a
  • da2a
arthrogryposis, distal, type 1a
  • da1a
arthrogryposis, distal, type 1b
  • da1b
locked-in syndrome
  • locked in syndrome
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZDHHC2

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with ZDHHC2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZDHHC2 Gene

Publications for ZDHHC2 Gene

  1. Isolation of a novel gene on 8p21.3-22 whose expression is reduced significantly in human colorectal cancers with liver metastasis. (PMID: 10918388) Oyama T … Nakamura Y (Genes, chromosomes & cancer 2000) 2 3 4
  2. Oligomerization of DHHC protein S-acyltransferases. (PMID: 23793055) Lai J … Linder ME (The Journal of biological chemistry 2013) 3 4
  3. DHHC2 is a protein S-acyltransferase for Lck. (PMID: 22034844) Zeidman R … Magee AI (Molecular membrane biology 2011) 3 4
  4. The palmitoyl transferase DHHC2 targets a dynamic membrane cycling pathway: regulation by a C-terminal domain. (PMID: 21471008) Greaves J … Chamberlain LH (Molecular biology of the cell 2011) 3 4
  5. Gi/o signaling and the palmitoyltransferase DHHC2 regulate palmitate cycling and shuttling of RGS7 family-binding protein. (PMID: 21343290) Jia L … Blumer KJ (The Journal of biological chemistry 2011) 3 4

Products for ZDHHC2 Gene

Sources for ZDHHC2 Gene