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Aliases for ZDHHC2 Gene

Aliases for ZDHHC2 Gene

  • Zinc Finger DHHC-Type Containing 2 2 3 5
  • Reduced Expression Associated With Metastasis Protein 3 4
  • Zinc Finger DHHC Domain-Containing Protein 2 3 4
  • Reduced Expression In Cancer Protein 3 4
  • Zinc Finger Protein 372 3 4
  • DHHC-2 3 4
  • ZNF372 3 4
  • Ream 3 4
  • Rec 3 4
  • Testis Tissue Sperm-Binding Protein Li 56e 3
  • Zinc Finger, DHHC Domain Containing 2 3
  • Palmitoyltransferase ZDHHC2 3
  • EC 4
  • EC 2.3.1 56
  • DHHC2 3

External Ids for ZDHHC2 Gene

Previous GeneCards Identifiers for ZDHHC2 Gene

  • GC08P016907
  • GC08P017093
  • GC08P017024
  • GC08P017023
  • GC08P017058
  • GC08P015559

Summaries for ZDHHC2 Gene

GeneCards Summary for ZDHHC2 Gene

ZDHHC2 (Zinc Finger DHHC-Type Containing 2) is a Protein Coding gene. Among its related pathways are Surfactant metabolism and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include receptor activity and palmitoyltransferase activity. An important paralog of this gene is ZDHHC20.

UniProtKB/Swiss-Prot for ZDHHC2 Gene

  • Palmitoyltransferase specific for GAP43 and DLG4/PSD95.

Gene Wiki entry for ZDHHC2 Gene

Additional gene information for ZDHHC2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZDHHC2 Gene

Genomics for ZDHHC2 Gene

GeneHancer (GH) Regulatory Elements for ZDHHC2 Gene

Promoters and enhancers for ZDHHC2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I017155 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 591.4 +1.4 1396 4.5 PKNOX1 FOXA2 ARID4B SIN3A FEZF1 ZNF2 ZNF48 YY1 GLIS2 ZNF213 ZDHHC2 MICU3 MTMR7 GC08P017223
GH08I017183 Enhancer 0.8 Ensembl ENCODE 35.1 +28.2 28232 1.1 HLF CEBPB ZNF223 CEBPG FEZF1 ZIC2 OSR2 PRDM6 CEBPA ZXDB ZDHHC2 GC08P017223
GH08I016825 Enhancer 1.2 Ensembl ENCODE 16.4 -329.6 -329621 2.2 PKNOX1 SMAD1 FEZF1 ZNF2 ZNF213 ZNF302 FOS DEK SP3 JUNB ENSG00000249258 MICU3 MTUS1 ZDHHC2 ENSG00000253671 CNOT7 ENSG00000253944 GC08M016797 RN7SL474P ENSG00000253496
GH08I017254 Enhancer 0.9 Ensembl ENCODE 15.4 +98.4 98365 0.5 MEIS2 PKNOX1 ZBTB40 ZIC2 CTBP1 SCRT2 ZNF600 SCRT1 ZEB2 DPF2 ZDHHC2 CNOT7 VPS37A LOC102724838
GH08I017162 Enhancer 0.7 Ensembl ENCODE 18.4 +7.1 7114 1.4 OSR2 PRDM6 POLR2A HNF4A EBF1 ZDHHC2 GC08P017223
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZDHHC2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZDHHC2 gene promoter:

Genomic Locations for ZDHHC2 Gene

Genomic Locations for ZDHHC2 Gene
68,780 bases
Plus strand

Genomic View for ZDHHC2 Gene

Genes around ZDHHC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZDHHC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZDHHC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZDHHC2 Gene

Proteins for ZDHHC2 Gene

  • Protein details for ZDHHC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Palmitoyltransferase ZDHHC2
    Protein Accession:
    Secondary Accessions:
    • D3DSP5

    Protein attributes for ZDHHC2 Gene

    367 amino acids
    Molecular mass:
    42022 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZDHHC2 Gene

Selected DME Specific Peptides for ZDHHC2 Gene


Post-translational modifications for ZDHHC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for ZDHHC2 Gene

Gene Families for ZDHHC2 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for ZDHHC2 Gene

Suggested Antigen Peptide Sequences for ZDHHC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The DHHC domain is required for palmitoyltransferase activity.
  • Belongs to the DHHC palmitoyltransferase family.
  • The DHHC domain is required for palmitoyltransferase activity.
  • Belongs to the DHHC palmitoyltransferase family.
genes like me logo Genes that share domains with ZDHHC2: view

Function for ZDHHC2 Gene

Molecular function for ZDHHC2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.
UniProtKB/Swiss-Prot Function:
Palmitoyltransferase specific for GAP43 and DLG4/PSD95.

Enzyme Numbers (IUBMB) for ZDHHC2 Gene

Phenotypes From GWAS Catalog for ZDHHC2 Gene

Gene Ontology (GO) - Molecular Function for ZDHHC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016409 palmitoyltransferase activity TAS,IEA --
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
GO:0019706 protein-cysteine S-palmitoyltransferase activity IEA --
genes like me logo Genes that share ontologies with ZDHHC2: view
genes like me logo Genes that share phenotypes with ZDHHC2: view

Animal Models for ZDHHC2 Gene

MGI Knock Outs for ZDHHC2:

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZDHHC2 Gene

Localization for ZDHHC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZDHHC2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZDHHC2 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 5
golgi apparatus 5
endosome 3
extracellular 2

Gene Ontology (GO) - Cellular Components for ZDHHC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 16647879
GO:0005794 Golgi apparatus IDA 16647879
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ZDHHC2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZDHHC2 Gene

Pathways & Interactions for ZDHHC2 Gene

genes like me logo Genes that share pathways with ZDHHC2: view

Pathways by source for ZDHHC2 Gene

2 Reactome pathways for ZDHHC2 Gene

Interacting Proteins for ZDHHC2 Gene

Gene Ontology (GO) - Biological Process for ZDHHC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0018345 protein palmitoylation IEA,IDA 23034182
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with ZDHHC2: view

No data available for SIGNOR curated interactions for ZDHHC2 Gene

Drugs & Compounds for ZDHHC2 Gene

(1) Drugs for ZDHHC2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coenzyme A Investigational Nutra 0

(1) Additional Compounds for ZDHHC2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ZDHHC2: view

Transcripts for ZDHHC2 Gene

Unigene Clusters for ZDHHC2 Gene

Zinc finger, DHHC-type containing 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b
SP1: - -
SP2: - -

Relevant External Links for ZDHHC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZDHHC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZDHHC2 Gene

Protein differential expression in normal tissues from HIPED for ZDHHC2 Gene

This gene is overexpressed in Pancreatic juice (40.3) and Peripheral blood mononuclear cells (22.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZDHHC2 Gene

Protein tissue co-expression partners for ZDHHC2 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZDHHC2 Gene:


SOURCE GeneReport for Unigene cluster for ZDHHC2 Gene:


mRNA Expression by UniProt/SwissProt for ZDHHC2 Gene:

Tissue specificity: Ubiquitously expressed. Reduced expression in colorectal cancers with liver metastasis.

Evidence on tissue expression from TISSUES for ZDHHC2 Gene

  • Nervous system(4.4)
  • Intestine(4.2)
genes like me logo Genes that share expression patterns with ZDHHC2: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZDHHC2 Gene

Orthologs for ZDHHC2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ZDHHC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZDHHC2 33 34
  • 99.64 (n)
(Canis familiaris)
Mammalia -- 34
  • 97 (a)
-- 34
  • 94 (a)
-- 34
  • 94 (a)
LOC100687370 33
  • 93.83 (n)
(Mus musculus)
Mammalia Zdhhc2 33 16 34
  • 91.35 (n)
(Rattus norvegicus)
Mammalia Zdhhc2 33
  • 91.35 (n)
(Bos Taurus)
Mammalia ZDHHC2 34
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia ZDHHC2 34
  • 86 (a)
(Monodelphis domestica)
Mammalia ZDHHC2 34
  • 83 (a)
(Gallus gallus)
Aves ZDHHC2 33 34
  • 81.19 (n)
(Anolis carolinensis)
Reptilia ZDHHC2 34
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia zdhhc2 33
  • 78.51 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.19130 33
(Danio rerio)
Actinopterygii zdhhc2 33 34
  • 69.81 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG1407 35 34
  • 50 (a)
CG17287 35 34
  • 38 (a)
(Caenorhabditis elegans)
Secernentea ZK757.4 33
  • 50.45 (n)
ZK757.1 35
  • 38 (a)
dhhc-4 34
  • 32 (a)
spe-10 34
  • 28 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PFA3 34
  • 26 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G00840 33
  • 48.93 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.10082 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 47 (a)
Species where no ortholog for ZDHHC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZDHHC2 Gene

Gene Tree for ZDHHC2 (if available)
Gene Tree for ZDHHC2 (if available)

Paralogs for ZDHHC2 Gene

Paralogs for ZDHHC2 Gene

(9) SIMAP similar genes for ZDHHC2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZDHHC2: view

Variants for ZDHHC2 Gene

Sequence variations from dbSNP and Humsavar for ZDHHC2 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs568589179 A colorectal cancer sample 17,217,176(+) G/C coding_sequence_variant, genic_downstream_transcript_variant, missense_variant
VAR_015229 A hepatocellular carcinoma sample p.Ser306Phe
rs1000031578 -- 17,175,948(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000045642 -- 17,173,992(+) G/C genic_upstream_transcript_variant, intron_variant
rs1000049362 -- 17,215,118(+) G/A genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZDHHC2 Gene

Variant ID Type Subtype PubMed ID
esv1030364 CNV deletion 17803354
esv2736683 CNV deletion 23290073
esv2736685 CNV deletion 23290073
esv2736686 CNV deletion 23290073
esv2761416 CNV gain 21179565
nsv1126847 CNV deletion 24896259
nsv1128406 CNV deletion 24896259
nsv831244 CNV gain 17160897

Variation tolerance for ZDHHC2 Gene

Residual Variation Intolerance Score: 59.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.10; 22.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZDHHC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZDHHC2 Gene

Disorders for ZDHHC2 Gene

Additional Disease Information for ZDHHC2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ZDHHC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZDHHC2 Gene

Publications for ZDHHC2 Gene

  1. Isolation of a novel gene on 8p21.3-22 whose expression is reduced significantly in human colorectal cancers with liver metastasis. (PMID: 10918388) Oyama T … Nakamura Y (Genes, chromosomes & cancer 2000) 2 3 4 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. A critical role for ZDHHC2 in metastasis and recurrence in human hepatocellular carcinoma. (PMID: 24995331) Peng C … Zheng S (BioMed research international 2014) 3 58
  5. Reduced expression of ZDHHC2 is associated with lymph node metastasis and poor prognosis in gastric adenocarcinoma. (PMID: 23457560) Yan SM … Du ZM (PloS one 2013) 3 58

Products for ZDHHC2 Gene

Sources for ZDHHC2 Gene

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