Aliases for ZDHHC18 Gene

Aliases for ZDHHC18 Gene

  • Zinc Finger DHHC-Type Containing 18 2 3 5
  • Zinc Finger DHHC Domain-Containing Protein 18 3 4
  • Palmitoyltransferase ZDHHC18 3 4
  • DHHC-18 3 4
  • Zinc Finger, DHHC Domain Containing 18 3
  • EC 2.3.1.225 4
  • EC 2.3.1 54
  • DHHC18 3

External Ids for ZDHHC18 Gene

Previous GeneCards Identifiers for ZDHHC18 Gene

  • GC01P026185
  • GC01P026386
  • GC01P026757
  • GC01P027025
  • GC01P027153
  • GC01P025406

Summaries for ZDHHC18 Gene

GeneCards Summary for ZDHHC18 Gene

ZDHHC18 (Zinc Finger DHHC-Type Containing 18) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein-cysteine S-palmitoyltransferase activity and palmitoyltransferase activity. An important paralog of this gene is ZDHHC14.

UniProtKB/Swiss-Prot Summary for ZDHHC18 Gene

Additional gene information for ZDHHC18 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZDHHC18 Gene

Genomics for ZDHHC18 Gene

GeneHancer (GH) Regulatory Elements for ZDHHC18 Gene

Promoters and enhancers for ZDHHC18 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZDHHC18 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZDHHC18 gene promoter:
  • AP-4
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • LCR-F1
  • Pax-3
  • SRF
  • SRF (504 AA)
  • YY1

Genomic Locations for ZDHHC18 Gene

Genomic Locations for ZDHHC18 Gene
chr1:26,826,688-26,857,604
(GRCh38/hg38)
Size:
30,917 bases
Orientation:
Plus strand
chr1:27,153,201-27,184,093
(GRCh37/hg19)
Size:
30,893 bases
Orientation:
Plus strand

Genomic View for ZDHHC18 Gene

Genes around ZDHHC18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZDHHC18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZDHHC18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZDHHC18 Gene

Proteins for ZDHHC18 Gene

  • Protein details for ZDHHC18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NUE0-ZDH18_HUMAN
    Recommended name:
    Palmitoyltransferase ZDHHC18
    Protein Accession:
    Q9NUE0
    Secondary Accessions:
    • A6NHY9
    • B4DQ84
    • Q5JYH0
    • Q9H020

    Protein attributes for ZDHHC18 Gene

    Size:
    388 amino acids
    Molecular mass:
    42031 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZDHHC18 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZDHHC18 Gene

Selected DME Specific Peptides for ZDHHC18 Gene

Q9NUE0:
  • TTNEDIKGSW
  • NCVERFDHHCPW
  • YRPPPRT
  • FDCPYLA
  • RFDHHCPWVG
  • RRKWEVFPGRN
  • VLCGPLPPS
  • ILFFFVM

Post-translational modifications for ZDHHC18 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZDHHC18 Gene

Domains & Families for ZDHHC18 Gene

Gene Families for ZDHHC18 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for ZDHHC18 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZDHHC18 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ59953, highly similar to Palmitoyltransferase ZDHHC18 (EC 2.3.1.-) (B4DQ84_HUMAN)
  • Zinc finger DHHC domain-containing protein 18 (ZDH18_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NUE0

UniProtKB/Swiss-Prot:

ZDH18_HUMAN :
  • The DHHC domain is required for palmitoyltransferase activity.
  • Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
Domain:
  • The DHHC domain is required for palmitoyltransferase activity.
Family:
  • Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
genes like me logo Genes that share domains with ZDHHC18: view

Function for ZDHHC18 Gene

Molecular function for ZDHHC18 Gene

UniProtKB/Swiss-Prot Function:
Has palmitoyltransferase activity towards HRAS and LCK.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151; EC=2.3.1.225;.

Enzyme Numbers (IUBMB) for ZDHHC18 Gene

Phenotypes From GWAS Catalog for ZDHHC18 Gene

Gene Ontology (GO) - Molecular Function for ZDHHC18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016409 palmitoyltransferase activity IDA 23034182
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
GO:0019706 protein-cysteine S-palmitoyltransferase activity IEA,IBA 21873635
genes like me logo Genes that share ontologies with ZDHHC18: view
genes like me logo Genes that share phenotypes with ZDHHC18: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ZDHHC18

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZDHHC18

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZDHHC18 Gene

Localization for ZDHHC18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZDHHC18 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZDHHC18 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 3
endoplasmic reticulum 3
cytoskeleton 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZDHHC18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IBA 21873635
GO:0005794 Golgi apparatus IBA,IDA 16647879
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZDHHC18: view

Pathways & Interactions for ZDHHC18 Gene

PathCards logo

SuperPathways for ZDHHC18 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZDHHC18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006612 protein targeting to membrane IBA 21873635
GO:0018230 peptidyl-L-cysteine S-palmitoylation IBA 21873635
GO:0018345 protein palmitoylation IDA 23034182
GO:0034613 cellular protein localization IEA --
genes like me logo Genes that share ontologies with ZDHHC18: view

No data available for Pathways by source and SIGNOR curated interactions for ZDHHC18 Gene

Drugs & Compounds for ZDHHC18 Gene

(1) Drugs for ZDHHC18 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coenzyme A Investigational Nutra 0

(1) Additional Compounds for ZDHHC18 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
hexadecanoyl-CoA
  • coenzyme A, S-Hexadecanoate
  • Palmitoyl coenzyme A
  • S-Palmitoylcoenzyme A
  • coenzyme A, S-Hexadecanoic acid
genes like me logo Genes that share compounds with ZDHHC18: view

Transcripts for ZDHHC18 Gene

mRNA/cDNA for ZDHHC18 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZDHHC18

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC18 Gene

No ASD Table

Relevant External Links for ZDHHC18 Gene

GeneLoc Exon Structure for
ZDHHC18
ECgene alternative splicing isoforms for
ZDHHC18

Expression for ZDHHC18 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZDHHC18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZDHHC18 Gene

This gene is overexpressed in Whole Blood (x18.9).

Protein differential expression in normal tissues from HIPED for ZDHHC18 Gene

This gene is overexpressed in Placenta (55.1) and Fetal Liver (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZDHHC18 Gene



Protein tissue co-expression partners for ZDHHC18 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZDHHC18 Gene:

ZDHHC18

SOURCE GeneReport for Unigene cluster for ZDHHC18 Gene:

Hs.523710

Evidence on tissue expression from TISSUES for ZDHHC18 Gene

  • Lymph node(4.2)
  • Lung(2.3)
genes like me logo Genes that share expression patterns with ZDHHC18: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZDHHC18 Gene

Orthologs for ZDHHC18 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ZDHHC18 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZDHHC18 32
  • 99.34 (n)
dog
(Canis familiaris)
Mammalia ZDHHC18 33
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zdhhc18 17 33 32
  • 90.09 (n)
cow
(Bos Taurus)
Mammalia ZDHHC18 33 32
  • 89.77 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zdhhc18 32
  • 89.15 (n)
oppossum
(Monodelphis domestica)
Mammalia ZDHHC18 33
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZDHHC18 33
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZDHHC18 33
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZDHHC18 33
  • 71 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii zdhhc18b 33
  • 71 (a)
OneToOne
zdhhc18a 32
  • 66.57 (n)
Dr.9165 32
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005111 32
  • 60.27 (n)
fruit fly
(Drosophila melanogaster)
Insecta app 33
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dhhc-2 33
  • 36 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G50020 32
  • 47.12 (n)
rice
(Oryza sativa)
Liliopsida Os01g0868200 32
  • 47.77 (n)
Os.17295 32
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3762 33
  • 52 (a)
OneToMany
Species where no ortholog for ZDHHC18 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ZDHHC18 Gene

ENSEMBL:
Gene Tree for ZDHHC18 (if available)
TreeFam:
Gene Tree for ZDHHC18 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZDHHC18: view image

Paralogs for ZDHHC18 Gene

(9) SIMAP similar genes for ZDHHC18 Gene using alignment to 4 proteins:

  • ZDH18_HUMAN
  • B4DQ84_HUMAN
  • E9PJS3_HUMAN
  • H0YEN1_HUMAN
genes like me logo Genes that share paralogs with ZDHHC18: view

Variants for ZDHHC18 Gene

Sequence variations from dbSNP and Humsavar for ZDHHC18 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000017581 -- 26,830,142(+) T/C intron_variant
rs1000054474 -- 26,834,942(+) C/T intron_variant
rs1000095457 -- 26,825,549(+) T/C upstream_transcript_variant
rs1000104672 -- 26,834,502(+) G/T intron_variant
rs1000225394 -- 26,836,118(+) A/C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZDHHC18 Gene

Variant ID Type Subtype PubMed ID
nsv1000012 CNV gain 25217958
nsv834524 CNV gain+loss 17160897

Variation tolerance for ZDHHC18 Gene

Residual Variation Intolerance Score: 35.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.30; 41.05% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZDHHC18 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZDHHC18

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZDHHC18 Gene

Disorders for ZDHHC18 Gene

Additional Disease Information for ZDHHC18

No disorders were found for ZDHHC18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZDHHC18 Gene

Publications for ZDHHC18 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 56
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 56

Products for ZDHHC18 Gene

Sources for ZDHHC18 Gene