Aliases for ZDHHC18 Gene
Aliases for ZDHHC18 Gene
External Ids for ZDHHC18 Gene
- HGNC: 20712
- Entrez Gene: 84243
- Ensembl: ENSG00000204160
- UniProtKB: Q9NUE0
Previous GeneCards Identifiers for ZDHHC18 Gene
- GC01P026185
- GC01P026386
- GC01P026757
- GC01P027025
- GC01P027153
- GC01P025406
Summaries for ZDHHC18 Gene
GeneCards Summary for ZDHHC18 Gene
ZDHHC18 (Zinc Finger DHHC-Type Containing 18) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein-cysteine S-palmitoyltransferase activity and palmitoyltransferase activity. An important paralog of this gene is ZDHHC14.
UniProtKB/Swiss-Prot for ZDHHC18 Gene
-
Has palmitoyltransferase activity towards HRAS and LCK.
Additional gene information for ZDHHC18 Gene
- Monarch Initiative
- Search for ZDHHC18 at DataMed
- Search for ZDHHC18 at HumanCyc
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZDHHC18 Gene
Genomics for ZDHHC18 Gene
GeneHancer (GH) Regulatory Elements for ZDHHC18 Gene
Promoters and enhancers for ZDHHC18 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around ZDHHC18 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for ZDHHC18 Gene
Genomic Locations for ZDHHC18 Gene
- chr1:26,826,710-26,857,602
- (GRCh38/hg38)
- Size:
- 30,893 bases
- Orientation:
- Plus strand
- chr1:27,153,201-27,184,093
- (GRCh37/hg19)
Genomic View for ZDHHC18 Gene
Genes around ZDHHC18 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p36.11 by Ensembl
- 1p36.11 by Entrez Gene
- 1p36.11 by HGNC
ZDHHC18 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ZDHHC18 Gene
Proteins for ZDHHC18 Gene
-
Protein details for ZDHHC18 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9NUE0-ZDH18_HUMAN
- Recommended name:
- Palmitoyltransferase ZDHHC18
- Protein Accession:
- Q9NUE0
- A6NHY9
- B4DQ84
- Q5JYH0
- Q9H020
Protein attributes for ZDHHC18 Gene
- Size:
- 388 amino acids
- Molecular mass:
- 42031 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=CAI21624.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for ZDHHC18 Gene
Selected DME Specific Peptides for ZDHHC18 Gene
- Q9NUE0:
-
- TTNEDIKGSW
- NCVERFDHHCPW
- YRPPPRT
- FDCPYLA
- RFDHHCPWVG
- RRKWEVFPGRN
- VLCGPLPPS
- ILFFFVM
Post-translational modifications for ZDHHC18 Gene
No Post-translational modifications
Other Protein References for ZDHHC18 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for ZDHHC18
-
Abcam antibodies for ZDHHC18
- Invitrogen Antibodies for ZDHHC18
- GeneTex ZDHHC18 antibody for ZDHHC18
Protein Products
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Assay Products
Domains & Families for ZDHHC18 Gene
Gene Families for ZDHHC18 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted membrane proteins
Protein Domains for ZDHHC18 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ZDHHC18 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9NUE0UniProtKB/Swiss-Prot:
ZDH18_HUMAN :- The DHHC domain is required for palmitoyltransferase activity.
- Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
- Domain:
-
- The DHHC domain is required for palmitoyltransferase activity.
- Family:
-
- Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
Function for ZDHHC18 Gene
Molecular function for ZDHHC18 Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.
- UniProtKB/Swiss-Prot Function:
- Has palmitoyltransferase activity towards HRAS and LCK.
Enzyme Numbers (IUBMB) for ZDHHC18 Gene
Phenotypes From GWAS Catalog for ZDHHC18 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016409 | palmitoyltransferase activity | IDA | 23034182 |
| GO:0016740 | transferase activity | IEA | -- |
| GO:0016746 | transferase activity, transferring acyl groups | IEA | -- |
| GO:0019706 | protein-cysteine S-palmitoyltransferase activity | IEA | -- |
Phenotypes for ZDHHC18 Gene
Animal Model Products
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-
-
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-
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- Search ViGene Biosciences for ZDHHC18
CRISPR Products
-
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-
Vectors and viruses for KO, Activation, Repression, and more
-
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miRNA for ZDHHC18 Gene
- miRTarBase miRNAs that target ZDHHC18
-
- hsa-mir-26a-5p (MIRT066809)
- hsa-mir-26b-5p (MIRT066810)
- hsa-mir-338-3p (MIRT066814)
- hsa-mir-498 (MIRT066815)
- hsa-mir-1202 (MIRT066816)
- hsa-mir-1297 (MIRT066817)
- hsa-mir-4310 (MIRT066818)
- hsa-mir-4465 (MIRT066819)
- hsa-mir-3972 (MIRT066821)
- hsa-mir-5697 (MIRT066822)
- hsa-mir-7157-5p (MIRT066823)
- hsa-mir-19a-3p (MIRT113580)
- hsa-mir-19b-3p (MIRT113581)
- hsa-mir-1468-3p (MIRT113582)
- hsa-mir-548f-5p (MIRT113583)
- hsa-mir-548g-5p (MIRT113584)
- hsa-mir-548x-5p (MIRT113586)
- hsa-mir-548aj-5p (MIRT113587)
- hsa-mir-548aw (MIRT113588)
- hsa-mir-3665 (MIRT339146)
- hsa-mir-4736 (MIRT339151)
- hsa-mir-4423-3p (MIRT510456)
- hsa-mir-550a-5p (MIRT510457)
- hsa-mir-550a-3-5p (MIRT510458)
- hsa-mir-1271-3p (MIRT510459)
- hsa-mir-6880-5p (MIRT510460)
- hsa-mir-6851-5p (MIRT510461)
- hsa-mir-3689d (MIRT510462)
- hsa-mir-661 (MIRT510463)
- hsa-mir-3116 (MIRT510464)
- hsa-mir-1254 (MIRT510465)
- hsa-mir-449c-5p (MIRT510466)
- hsa-mir-34b-5p (MIRT510467)
- hsa-mir-2682-5p (MIRT510468)
- hsa-mir-940 (MIRT510469)
- hsa-mir-6893-5p (MIRT510470)
- hsa-mir-6808-5p (MIRT510471)
- hsa-mir-6511a-5p (MIRT510472)
- hsa-mir-1910-3p (MIRT510473)
- hsa-mir-5006-5p (MIRT561272)
- hsa-mir-3194-5p (MIRT561273)
- hsa-mir-4482-5p (MIRT561274)
- hsa-mir-3130-5p (MIRT561275)
- hsa-mir-1912 (MIRT561276)
- hsa-mir-1295b-5p (MIRT561277)
- hsa-mir-6771-3p (MIRT561278)
miRNA Products
- Search ViGene Biosciences for ZDHHC18
Inhibitory RNA Products
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Clone Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available ZDHHC18 gene related products
- orf clones - Search results for available ZDHHC18 gene related products
- Applied Biological Materials Clones for ZDHHC18
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for ZDHHC18
-
ViGene Biosciences adenoviral particle packaged cDNA for ZDHHC18 gene
-
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No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZDHHC18 Gene
Localization for ZDHHC18 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ZDHHC18 Gene
- Membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| golgi apparatus | 5 |
| plasma membrane | 3 |
| cytoskeleton | 3 |
| peroxisome | 1 |
- Microtubules (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005794 | Golgi apparatus | IDA | 16647879 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for ZDHHC18 Gene
No Data Available
Interacting Proteins for ZDHHC18 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0018345 | protein palmitoylation | IDA | 23034182 |
| GO:0034613 | cellular protein localization | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for ZDHHC18 Gene
Drugs & Compounds for ZDHHC18 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Coenzyme A | Investigational | Nutra | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| hexadecanoyl-CoA |
|
|
|
Transcripts for ZDHHC18 Gene
mRNA/cDNA for ZDHHC18 Gene
- (1) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (197) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ZDHHC18 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ZDHHC18
- genomics-online: gRNA clones - Search results for available ZDHHC18 gene related products
- Applied Biological Materials CRISPR for ZDHHC18
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZDHHC18
- GenScript: Design CRISPR guide RNA sequences for ZDHHC18
miRNA Products
- Search ViGene Biosciences for ZDHHC18
Inhibitory RNA Products
- Origene RNAi, shrna, and sirna products in human, mouse, rat for ZDHHC18
- Browse OriGene Inhibitory RNA Products For ZDHHC18
- genomics-online: shRNA clones - Search results for available ZDHHC18 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for ZDHHC18 gene
Clone Products
- Sino Biological Human cDNA Clone for ZDHHC18
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ZDHHC18
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ZDHHC18
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available ZDHHC18 gene related products
- orf clones - Search results for available ZDHHC18 gene related products
- Applied Biological Materials Clones for ZDHHC18
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for ZDHHC18 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
mRNA differential expression in normal tissues according to GTEx for ZDHHC18 Gene
This gene is overexpressed in Whole Blood (x18.9).
This gene is overexpressed in Placenta (55.1) and Fetal Liver (7.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZDHHC18 Gene
NURSA nuclear receptor signaling pathways regulating expression of ZDHHC18 Gene:
ZDHHC18SOURCE GeneReport for Unigene cluster for ZDHHC18 Gene:
Hs.523710Evidence on tissue expression from TISSUES for ZDHHC18 Gene
- Lymph node(4.2)
- Lung(2.3)
Primer Products
-
OriGene qPCR primer pairs for ZDHHC18
- genomics-online: primer clones - Search results for available ZDHHC18 gene related products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZDHHC18 Gene
Orthologs for ZDHHC18 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ZDHHC18 33 |
|
||
| dog (Canis familiaris) |
Mammalia | ZDHHC18 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Zdhhc18 33 16 34 |
|
||
| cow (Bos Taurus) |
Mammalia | ZDHHC18 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Zdhhc18 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ZDHHC18 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | ZDHHC18 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ZDHHC18 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | ZDHHC18 34 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | zdhhc18b 34 |
|
OneToOne | |
| zdhhc18a 33 |
|
||||
| Dr.9165 33 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP005111 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | app 34 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | dhhc-2 34 |
|
OneToMany | |
| thale cress (Arabidopsis thaliana) |
eudicotyledons | AT5G50020 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os01g0868200 33 |
|
||
| Os.17295 33 |
|
||||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.3762 34 |
|
OneToMany |
- Species where no ortholog for ZDHHC18 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Paralogs for ZDHHC18 Gene
Paralogs for ZDHHC18 Gene
(9) SIMAP similar genes for ZDHHC18 Gene using alignment to 4 proteins:
Variants for ZDHHC18 Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000017581 | -- | 26,830,142(+) | T/C | intron_variant | |
| rs1000054474 | -- | 26,834,942(+) | C/T | intron_variant | |
| rs1000095457 | -- | 26,825,549(+) | T/C | upstream_transcript_variant | |
| rs1000104672 | -- | 26,834,502(+) | G/T | intron_variant | |
| rs1000225394 | -- | 26,836,118(+) | A/C | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1000012 | CNV | gain | 25217958 |
| nsv834524 | CNV | gain+loss | 17160897 |
Residual Variation Intolerance Score:
35.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.30;
41.05% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ZDHHC18 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ZDHHC18
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZDHHC18 Gene
Disorders for ZDHHC18 Gene
Additional Disease Information for ZDHHC18
No disorders were found for ZDHHC18 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZDHHC18 Gene
Publications for ZDHHC18 Gene
- The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
Products for ZDHHC18 Gene
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- Invitrogen Antibodies for ZDHHC18
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- VectorBuilder custom plasmid, inducible vectors for ZDHHC18
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ZDHHC18
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 32 available ZDHHC18 Antibodies ranked by validation data
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- GeneTex ZDHHC18 antibody for ZDHHC18
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- ViGene Biosciences adenoviral particle packaged cDNA for ZDHHC18 gene
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Sources for ZDHHC18 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
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