Aliases for ZDHHC17 Gene

Aliases for ZDHHC17 Gene

  • Zinc Finger DHHC-Type Palmitoyltransferase 17 2 3 5
  • HIP14 2 3 4
  • HYPH 2 3 4
  • Zinc Finger DHHC Domain-Containing Protein 17 3 4
  • Putative NF-Kappa-B-Activating Protein 205 3 4
  • Putative MAPK-Activating Protein PM11 3 4
  • Zinc Finger DHHC-Type Containing 17 2 3
  • Huntingtin-Interacting Protein H 3 4
  • Palmitoyltransferase ZDHHC17 3 4
  • Huntingtin Yeast Partner H 3 4
  • KIAA0946 2 4
  • DHHC-17 3 4
  • HIP3 3 4
  • Huntingtin Interacting Protein 14 3
  • Huntingtin-Interacting Protein 14 4
  • Huntingtin Interacting Protein 3 3
  • Huntingtin-Interacting Protein 3 4
  • EC 2.3.1.225 4
  • EC 2.3.1 51
  • HSPC294 3
  • ZDHHC17 5
  • HIP-14 4
  • HIP-3 4

External Ids for ZDHHC17 Gene

Previous GeneCards Identifiers for ZDHHC17 Gene

  • GC12P075660
  • GC12P075681
  • GC12P077157
  • GC12P074210

Summaries for ZDHHC17 Gene

GeneCards Summary for ZDHHC17 Gene

ZDHHC17 (Zinc Finger DHHC-Type Palmitoyltransferase 17) is a Protein Coding gene. Diseases associated with ZDHHC17 include Huntington Disease and Hypoparathyroidism, X-Linked. Gene Ontology (GO) annotations related to this gene include identical protein binding and protein-cysteine S-palmitoyltransferase activity. An important paralog of this gene is ZDHHC13.

UniProtKB/Swiss-Prot Summary for ZDHHC17 Gene

  • Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HTT (PubMed:15603740, PubMed:15489887, PubMed:19139280, PubMed:28757145). Also palmitoylates neuronal protein GPM6A as well as SPRED1 and SPRED3 (PubMed:24705354). May be involved in the sorting or targeting of critical proteins involved in the initiating events of endocytosis at the plasma membrane (PubMed:12393793). May play a role in Mg(2+) transport (PubMed:18794299).

Gene Wiki entry for ZDHHC17 Gene

Additional gene information for ZDHHC17 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZDHHC17 Gene

Genomics for ZDHHC17 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZDHHC17 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J076557 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 600.1 -204.4 -204387 4.8 SP1 HNRNPL CREB1 GATAD2A PRDM10 ZNF629 REST TFE3 POLR2A BACH1 OSBPL8 LOC105369850 lnc-BBS10-5 ZDHHC17 BBS10 piR-31199-070
GH12J076762 Promoter/Enhancer 1.9 Ensembl ENCODE CraniofacialAtlas 607.1 +0.7 656 3.9 HNRNPL GATAD2A ZBTB33 TEAD4 PRDM10 IKZF1 ZNF692 POLR2A NFRKB TARDBP ZDHHC17 lnc-CSRP2-2 RF00017-1192 CSRP2
GH12J075848 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 13.3 -911.9 -911868 7.8 SCRT2 SP1 ESR1 NFE2 ZNF316 MAFF MEF2D MAFK JUND FOSL1 PHLDA1 KRR1 CAPS2 ZDHHC17 LOC105369846 lnc-GLIPR1-7 ENSG00000258091 ENSG00000258077 LOC105369844
GH12J076781 Enhancer 1 Ensembl ENCODE 16.6 +20.8 20774 6.5 PRDM10 IKZF1 PKNOX1 NR2C1 DPF2 EP300 CBX3 HMBOX1 EGR1 NFE2 ZDHHC17 RF00017-1192 piR-43107-070 CSRP2
GH12J076611 Enhancer 1.1 FANTOM5 Ensembl ENCODE 13.4 -152.2 -152188 2.8 CREB1 CEBPB CTBP1 NFE2 NR3C1 ZNF316 CHD2 OSR2 JUN FOS ZDHHC17 OSBPL8 YWHAQP7 ENSG00000287030 ENSG00000257526 LOC105369850
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZDHHC17 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZDHHC17

Top Transcription factor binding sites by QIAGEN in the ZDHHC17 gene promoter:
  • ATF-2
  • CUTL1
  • FOXJ2
  • FOXJ2 (long isoform)
  • HSF2
  • Nkx2-5
  • POU2F1
  • POU2F1a
  • Roaz
  • Spz1

Genomic Locations for ZDHHC17 Gene

Genomic Locations for ZDHHC17 Gene
chr12:76,763,588-76,853,701
(GRCh38/hg38)
Size:
90,114 bases
Orientation:
Plus strand
chr12:77,157,368-77,247,476
(GRCh37/hg19)
Size:
90,109 bases
Orientation:
Plus strand

Genomic View for ZDHHC17 Gene

Genes around ZDHHC17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZDHHC17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZDHHC17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZDHHC17 Gene

Proteins for ZDHHC17 Gene

  • Protein details for ZDHHC17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IUH5-ZDH17_HUMAN
    Recommended name:
    Palmitoyltransferase ZDHHC17
    Protein Accession:
    Q8IUH5
    Secondary Accessions:
    • B4DR39
    • O75407
    • Q7Z2I0
    • Q86W89
    • Q86YK0
    • Q9P088
    • Q9UPZ8

    Protein attributes for ZDHHC17 Gene

    Size:
    632 amino acids
    Molecular mass:
    72640 Da
    Quaternary structure:
    • Interacts (via ANK repeats) with numerous proteins (via the consensus sequence motif [VIAP]-[VIT]-x-x-Q-P) (PubMed:28882895). Interacts (via ANK repeats) with CLIP3 (PubMed:26198635, PubMed:28882895). Interacts (via ANK repeats) with HTT; this interaction is inversely correlated to the length of the polyglutamine tract added to the huntingtin protein in Huntington disease (PubMed:12393793, PubMed:9700202, PubMed:26198635, PubMed:28882895, PubMed:28757145). Interacts (via ANK repeats) with DNAJC5 (via C-terminus) (PubMed:28882895). Interacts (via ANK repeats) with MAP6 (PubMed:26198635). Interacts (via ANK repeats) with SNAP23 (PubMed:28882895). Interacts (via ANK repeats) with SNAP25 (PubMed:28882895, PubMed:28757145). Interacts (via ANK repeats) with EVL (PubMed:28882895). Interacts with SPRED1 and SPRED3 (PubMed:24705354). Interacts with GPM6A and OPTN (PubMed:24705354). May interact (via ANK repeats) with SPRED2 (By similarity).
    SequenceCaution:
    • Sequence=AAF28972.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAH30990.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=BAA76790.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=BAC77366.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAC77388.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ZDHHC17 Gene

    Alternative splice isoforms for ZDHHC17 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZDHHC17 Gene

Selected DME Specific Peptides for ZDHHC17 Gene

Q8IUH5:
  • LHWAAIN
  • LAETGSLD

Post-translational modifications for ZDHHC17 Gene

  • Autopalmitoylated (PubMed:15603740, PubMed:18794299). Autopalmitoylation has a regulatory role in ZDHHC17-mediated Mg(2+) transport (PubMed:18794299).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for ZDHHC17 Gene

Gene Families for ZDHHC17 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for ZDHHC17 Gene

InterPro:
Blocks:
  • Ankyrin repeat signature
  • Zn-finger, DHHC type
ProtoNet:

Suggested Antigen Peptide Sequences for ZDHHC17 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger DHHC domain-containing protein 17 (ZDH17_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8IUH5

UniProtKB/Swiss-Prot:

ZDH17_HUMAN :
  • The DHHC domain is required for palmitoyltransferase activity.
  • Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.
Domain:
  • The DHHC domain is required for palmitoyltransferase activity.
Family:
  • Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.
genes like me logo Genes that share domains with ZDHHC17: view

Function for ZDHHC17 Gene

Molecular function for ZDHHC17 Gene

UniProtKB/Swiss-Prot Function:
Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HTT (PubMed:15603740, PubMed:15489887, PubMed:19139280, PubMed:28757145). Also palmitoylates neuronal protein GPM6A as well as SPRED1 and SPRED3 (PubMed:24705354). May be involved in the sorting or targeting of critical proteins involved in the initiating events of endocytosis at the plasma membrane (PubMed:12393793). May play a role in Mg(2+) transport (PubMed:18794299).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151; EC=2.3.1.225; Evidence={ECO:0000269|PubMed:15489887, ECO:0000269|PubMed:15603740, ECO:0000269|PubMed:24705354, ECO:0000269|PubMed:28757145};.

Enzyme Numbers (IUBMB) for ZDHHC17 Gene

Phenotypes From GWAS Catalog for ZDHHC17 Gene

Gene Ontology (GO) - Molecular Function for ZDHHC17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 15603740
GO:0015095 magnesium ion transmembrane transporter activity IEA --
GO:0016409 palmitoyltransferase activity IEA,IMP 24705354
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
genes like me logo Genes that share ontologies with ZDHHC17: view
genes like me logo Genes that share phenotypes with ZDHHC17: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZDHHC17

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZDHHC17 Gene

Localization for ZDHHC17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZDHHC17 Gene

Golgi apparatus membrane. Multi-pass membrane protein. Cytoplasmic vesicle membrane. Multi-pass membrane protein. Cell junction, synapse, presynaptic cell membrane. Multi-pass membrane protein. Note=Low extracellular Mg(2+) induces increase in Golgi and in post-Golgi membrane vesicles. {ECO:0000269 PubMed:18794299}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZDHHC17 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 4
cytosol 3
endoplasmic reticulum 2
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (3)
  • Vesicles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZDHHC17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA,IDA 18794299
GO:0005794 Golgi apparatus IEA,IDA 16647879
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZDHHC17: view

Pathways & Interactions for ZDHHC17 Gene

PathCards logo

SuperPathways for ZDHHC17 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZDHHC17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0018345 protein palmitoylation IEA,IMP 24705354
GO:0042953 lipoprotein transport IDA 15603740
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling HMP 12761501
GO:1903830 magnesium ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with ZDHHC17: view

No data available for Pathways by source and SIGNOR curated interactions for ZDHHC17 Gene

Drugs & Compounds for ZDHHC17 Gene

(1) Drugs for ZDHHC17 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coenzyme A Investigational Nutra 0

(1) Additional Compounds for ZDHHC17 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
hexadecanoyl-CoA
  • coenzyme A, S-Hexadecanoate
  • Palmitoyl coenzyme A
  • S-Palmitoylcoenzyme A
  • coenzyme A, S-Hexadecanoic acid
genes like me logo Genes that share compounds with ZDHHC17: view

Transcripts for ZDHHC17 Gene

mRNA/cDNA for ZDHHC17 Gene

2 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
16 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZDHHC17

Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC17 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18a ·
SP1: - - - - -
SP2: - -
SP3:
SP4: - - - - - - - - - - -
SP5: -
SP6: -
SP7:

ExUns: 18b · 18c ^ 19 ^ 20a · 20b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for ZDHHC17 Gene

GeneLoc Exon Structure for
ZDHHC17

Expression for ZDHHC17 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZDHHC17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZDHHC17 Gene

This gene is overexpressed in Breast (52.6) and Placenta (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZDHHC17 Gene



Protein tissue co-expression partners for ZDHHC17 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZDHHC17

SOURCE GeneReport for Unigene cluster for ZDHHC17 Gene:

Hs.4014

mRNA Expression by UniProt/SwissProt for ZDHHC17 Gene:

Q8IUH5-ZDH17_HUMAN
Tissue specificity: Expressed in all brain regions. Expression is highest in the cortex, cerebellum, occipital lobe and caudate and lowest in the spinal cord. Expression is also seen in testis, pancreas, heart and kidney.

Evidence on tissue expression from TISSUES for ZDHHC17 Gene

  • Nervous system(4.9)
  • Blood(4.3)
  • Bone marrow(4.3)
  • Lung(4.2)
  • Kidney(2.2)
  • Adrenal gland(2.1)
  • Skin(2)
genes like me logo Genes that share expression patterns with ZDHHC17: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZDHHC17 Gene

Orthologs for ZDHHC17 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ZDHHC17 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZDHHC17 30 31
  • 99.84 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ZDHHC17 31
  • 98 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 96 (a)
OneToMany
-- 31
  • 88 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia ZDHHC17 30 31
  • 95.89 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZDHHC17 30 31
  • 95.6 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Zdhhc17 30
  • 92.93 (n)
Mouse
(Mus musculus)
Mammalia Zdhhc17 30 17 31
  • 92.25 (n)
OneToOne
Chicken
(Gallus gallus)
Aves ZDHHC17 30 31
  • 86.44 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ZDHHC17 31
  • 95 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia zdhhc17 30
  • 81.4 (n)
Zebrafish
(Danio rerio)
Actinopterygii zdhhc17 30 31
  • 75.75 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta Hip14 30 31
  • 53.73 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011732 30
  • 53.17 (n)
Worm
(Caenorhabditis elegans)
Secernentea tag-233 30
  • 45.65 (n)
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_AER388C 30
  • 45.23 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AKR1 30 31
  • 45.16 (n)
ManyToMany
AKR2 31
  • 20 (a)
ManyToMany
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E16721g 30
  • 44.39 (n)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons TIP1 30
  • 46.18 (n)
Rice
(Oryza sativa)
Liliopsida Os02g0184000 30
  • 46.89 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.11093 31
  • 47 (a)
OneToMany
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes akr1 30
  • 44.6 (n)
Bread mold
(Neurospora crassa)
Ascomycetes NCU08218 30
  • 42.63 (n)
Species where no ortholog for ZDHHC17 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ZDHHC17 Gene

ENSEMBL:
Gene Tree for ZDHHC17 (if available)
TreeFam:
Gene Tree for ZDHHC17 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZDHHC17: view image

Paralogs for ZDHHC17 Gene

Paralogs for ZDHHC17 Gene

(5) SIMAP similar genes for ZDHHC17 Gene using alignment to 10 proteins:

  • ZDH17_HUMAN
  • F8VPW2_HUMAN
  • F8VUG7_HUMAN
  • F8VX48_HUMAN
  • H0YHF0_HUMAN
  • H0YHW0_HUMAN
  • H0YI74_HUMAN
  • H0YIK0_HUMAN
  • H0YIN1_HUMAN
  • H0YIP7_HUMAN
genes like me logo Genes that share paralogs with ZDHHC17: view

Variants for ZDHHC17 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZDHHC17 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
rs33996476 - p.Asn383Ser

Additional dbSNP identifiers (rs#s) for ZDHHC17 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZDHHC17 Gene

Variant ID Type Subtype PubMed ID
esv3306704 CNV mobile element insertion 20981092
esv3341853 CNV insertion 20981092
nsv1047333 CNV loss 25217958

Variation tolerance for ZDHHC17 Gene

Residual Variation Intolerance Score: 32.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.46; 64.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZDHHC17 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZDHHC17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZDHHC17 Gene

Disorders for ZDHHC17 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ZDHHC17 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
huntington disease
  • hd
hypoparathyroidism, x-linked
  • hypx
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZDHHC17

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with ZDHHC17: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZDHHC17 Gene

Publications for ZDHHC17 Gene

  1. Huntingtin-interacting proteins, HIP14 and HIP14L, mediate dual functions, palmitoyl acyltransferase and Mg2+ transport. (PMID: 18794299) Goytain A … Quamme GA (The Journal of biological chemistry 2008) 2 3 4 23
  2. Huntingtin-interacting protein HIP14 is a palmitoyl transferase involved in palmitoylation and trafficking of multiple neuronal proteins. (PMID: 15603740) Huang K … El-Husseini A (Neuron 2004) 2 3 4 23
  3. Huntingtin interacting protein 14 is an oncogenic human protein: palmitoyl acyltransferase. (PMID: 15489887) Ducker CE … Smith CD (Oncogene 2004) 2 3 4 23
  4. Structural Basis for Substrate Recognition by the Ankyrin Repeat Domain of Human DHHC17 Palmitoyltransferase. (PMID: 28757145) Verardi R … Banerjee A (Structure (London, England : 1993) 2017) 2 3 4
  5. ClipR-59 interacts with Akt and regulates Akt cellular compartmentalization. (PMID: 19139280) Ding J … Du K (Molecular and cellular biology 2009) 2 3 4

Products for ZDHHC17 Gene

Sources for ZDHHC17 Gene