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Aliases for ZDHHC15 Gene

Aliases for ZDHHC15 Gene

  • Zinc Finger DHHC-Type Containing 15 2 3 5
  • Zinc Finger DHHC Domain-Containing Protein 15 3 4
  • DHHC-15 3 4
  • Zinc Finger, DHHC Domain Containing 15 3
  • Palmitoyltransferase ZDHHC15 3
  • EC 4
  • EC 2.3.1 56
  • DHHC15 3
  • MRX91 3

External Ids for ZDHHC15 Gene

Previous GeneCards Identifiers for ZDHHC15 Gene

  • GC0XM071766
  • GC0XM072806
  • GC0XM073458
  • GC0XM073459
  • GC0XM074375
  • GC0XM074504
  • GC0XM074588
  • GC0XM068222

Summaries for ZDHHC15 Gene

Entrez Gene Summary for ZDHHC15 Gene

  • The protein encoded by this gene belongs to the DHHC palmitoyltransferase family. Mutations in this gene are associated with mental retardatio X-linked type 91 (MRX91). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

GeneCards Summary for ZDHHC15 Gene

ZDHHC15 (Zinc Finger DHHC-Type Containing 15) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include receptor activity and palmitoyltransferase activity. An important paralog of this gene is ZDHHC2.

UniProtKB/Swiss-Prot for ZDHHC15 Gene

  • Palmitoyltransferase specific for GAP43 and DLG4/PSD95.

Additional gene information for ZDHHC15 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZDHHC15 Gene

Genomics for ZDHHC15 Gene

GeneHancer (GH) Regulatory Elements for ZDHHC15 Gene

Promoters and enhancers for ZDHHC15 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI075522 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 558.7 +0.4 426 2 SMARCA5 MXI1 HCFC1 EBF1 ELF1 POLR2A NBN ZNF143 MLLT1 NR2C2 ZDHHC15 UPRT PIR41146
GH0XI076147 Enhancer 1.2 Ensembl ENCODE dbSUPER 14.1 -626.1 -626130 5.3 PKNOX1 ATF1 ZSCAN4 ZNF335 ZNF366 ATF7 ZEB2 ZNF585B GLIS1 PRDM1 PIR52738 ZDHHC15 TTC3P1 PBDC1 ENSG00000232186 MAGEE1 GC0XP076095
GH0XI076171 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 7.5 -649.6 -649643 3.1 PKNOX1 SIN3A DMAP1 YY1 POLR2B GLIS2 FOS SP3 YY2 REST PBDC1 GC0XP076173 ZDHHC15 LOC100216356
GH0XI075155 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 5 +367.4 367417 2.4 PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 IRF4 ZNF48 YY1 POLR2B ABCB7 RN7SL648P RAB11FIP1P1 ZDHHC15 ENSG00000271533 GC0XP075081
GH0XI076427 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 5.9 -904.4 -904413 1.9 SAP130 NRF1 ZNF48 ZNF335 ZFHX2 POLR2A PRDM10 ZFX EGR2 MAGEE1 ZDHHC15 TTC3P1 PBDC1 GC0XP076431
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZDHHC15 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZDHHC15 gene promoter:

Genomic Locations for ZDHHC15 Gene

Genomic Locations for ZDHHC15 Gene
155,200 bases
Minus strand

Genomic View for ZDHHC15 Gene

Genes around ZDHHC15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZDHHC15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZDHHC15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZDHHC15 Gene

Proteins for ZDHHC15 Gene

  • Protein details for ZDHHC15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Palmitoyltransferase ZDHHC15
    Protein Accession:
    Secondary Accessions:
    • B3KVG7
    • Q3SY30
    • Q6UWH3

    Protein attributes for ZDHHC15 Gene

    337 amino acids
    Molecular mass:
    39331 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZDHHC15 Gene


neXtProt entry for ZDHHC15 Gene

Selected DME Specific Peptides for ZDHHC15 Gene


Post-translational modifications for ZDHHC15 Gene

Other Protein References for ZDHHC15 Gene

Domains & Families for ZDHHC15 Gene

Gene Families for ZDHHC15 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Plasma proteins
  • Potential drug targets
  • Predicted membrane proteins

Protein Domains for ZDHHC15 Gene

Graphical View of Domain Structure for InterPro Entry



  • The DHHC domain is required for palmitoyltransferase activity.
  • Belongs to the DHHC palmitoyltransferase family.
  • The DHHC domain is required for palmitoyltransferase activity.
  • Belongs to the DHHC palmitoyltransferase family.
genes like me logo Genes that share domains with ZDHHC15: view

Function for ZDHHC15 Gene

Molecular function for ZDHHC15 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.
UniProtKB/Swiss-Prot Function:
Palmitoyltransferase specific for GAP43 and DLG4/PSD95.

Enzyme Numbers (IUBMB) for ZDHHC15 Gene

Gene Ontology (GO) - Molecular Function for ZDHHC15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016409 palmitoyltransferase activity IDA 23034182
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
GO:0019706 protein-cysteine S-palmitoyltransferase activity IEA --
genes like me logo Genes that share ontologies with ZDHHC15: view
genes like me logo Genes that share phenotypes with ZDHHC15: view

Human Phenotype Ontology for ZDHHC15 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

  • Taconic Biosciences Mouse Models for ZDHHC15

Clone Products

No data available for Phenotypes From GWAS Catalog , Animal Models , Transcription Factor Targets and HOMER Transcription for ZDHHC15 Gene

Localization for ZDHHC15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZDHHC15 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZDHHC15 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
plasma membrane 3
nucleus 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZDHHC15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IDA 16647879
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA,HDA 23376485
genes like me logo Genes that share ontologies with ZDHHC15: view

Pathways & Interactions for ZDHHC15 Gene

SuperPathways for ZDHHC15 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZDHHC15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016188 synaptic vesicle maturation IBA --
GO:0018345 protein palmitoylation IDA 23034182
GO:0045184 establishment of protein localization IEA --
genes like me logo Genes that share ontologies with ZDHHC15: view

No data available for Pathways by source and SIGNOR curated interactions for ZDHHC15 Gene

Drugs & Compounds for ZDHHC15 Gene

(1) Drugs for ZDHHC15 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coenzyme A Investigational Nutra 0

(1) Additional Compounds for ZDHHC15 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ZDHHC15: view

Transcripts for ZDHHC15 Gene

Unigene Clusters for ZDHHC15 Gene

Zinc finger, DHHC-type containing 15:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC15 Gene

No ASD Table

Relevant External Links for ZDHHC15 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZDHHC15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZDHHC15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZDHHC15 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZDHHC15 Gene

Protein tissue co-expression partners for ZDHHC15 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZDHHC15 Gene:


SOURCE GeneReport for Unigene cluster for ZDHHC15 Gene:


mRNA Expression by UniProt/SwissProt for ZDHHC15 Gene:

Tissue specificity: Expressed in placenta, liver, lung, kidney, heart and brain.

Evidence on tissue expression from TISSUES for ZDHHC15 Gene

  • Nervous system(4.3)

Phenotype-based relationships between genes and organs from Gene ORGANizer for ZDHHC15 Gene

Germ Layers:
  • ectoderm
  • mesoderm
  • digestive
  • integumentary
  • nervous
  • skeletal muscle
  • skeleton
Head and neck:
  • brain
  • eye
  • eyelid
  • face
  • forehead
  • head
  • jaw
  • mandible
  • maxilla
  • mouth
  • nose
  • scalp
  • skull
  • tooth
  • arm
  • digit
  • elbow
  • finger
  • foot
  • forearm
  • hand
  • humerus
  • lower limb
  • radius
  • ulna
  • upper limb
  • hair
  • skin
genes like me logo Genes that share expression patterns with ZDHHC15: view

No data available for mRNA differential expression in normal tissues for ZDHHC15 Gene

Orthologs for ZDHHC15 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ZDHHC15 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZDHHC15 33 34
  • 97.69 (n)
(Canis familiaris)
Mammalia ZDHHC15 33 34
  • 94.3 (n)
(Bos Taurus)
Mammalia ZDHHC15 33 34
  • 94.07 (n)
(Mus musculus)
Mammalia Zdhhc15 33 16 34
  • 93.77 (n)
(Rattus norvegicus)
Mammalia Zdhhc15 33
  • 93.77 (n)
(Monodelphis domestica)
Mammalia ZDHHC15 34
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia ZDHHC15 34
  • 64 (a)
(Gallus gallus)
Aves ZDHHC15 33 34
  • 74.92 (n)
(Anolis carolinensis)
Reptilia ZDHHC15 34
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia zdhhc15 33
  • 69.25 (n)
(Danio rerio)
Actinopterygii zdhhc15b 33 34
  • 66.26 (n)
wufc02b12 33
fruit fly
(Drosophila melanogaster)
Insecta CG1407 34
  • 33 (a)
CG17287 34
  • 33 (a)
(Caenorhabditis elegans)
Secernentea dhhc-4 34
  • 30 (a)
spe-10 34
  • 29 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PFA3 34 36
  • 24 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G60800 33
  • 49.65 (n)
(Oryza sativa)
Liliopsida Os03g0804300 33
  • 48.9 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes pfa3 33
  • 46.39 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 43 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01267 33
  • 42.59 (n)
Species where no ortholog for ZDHHC15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZDHHC15 Gene

Gene Tree for ZDHHC15 (if available)
Gene Tree for ZDHHC15 (if available)

Paralogs for ZDHHC15 Gene

Paralogs for ZDHHC15 Gene

(2) SIMAP similar genes for ZDHHC15 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZDHHC15: view

Variants for ZDHHC15 Gene

Sequence variations from dbSNP and Humsavar for ZDHHC15 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs199537523 benign, uncertain-significance, not specified 75,478,993(-) AAAAAAAAAA/AAAAAAAAA/AAAAAAAAAAA/AAAAAAAAAAAA intron_variant
rs144514141 likely-benign, not provided 75,431,511(-) A/T 5_prime_UTR_variant, coding_sequence_variant, genic_downstream_transcript_variant, missense_variant, non_coding_transcript_variant
rs199542638 likely-benign, not specified 75,429,984(-) C/T genic_downstream_transcript_variant, intron_variant
rs144128364 uncertain-significance, not specified 75,379,158(-) T/C coding_sequence_variant, genic_downstream_transcript_variant, non_coding_transcript_variant, synonymous_variant
rs192529997 uncertain-significance, not specified 75,417,103(-) G/A coding_sequence_variant, genic_downstream_transcript_variant, non_coding_transcript_variant, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for ZDHHC15 Gene

Variant ID Type Subtype PubMed ID
esv1585432 CNV deletion 17803354
esv25282 CNV gain 19812545
esv2740234 CNV deletion 23290073
esv2740235 CNV deletion 23290073
esv2740236 CNV deletion 23290073
esv2740237 CNV deletion 23290073
esv3239932 CNV deletion 24192839
esv988916 CNV deletion 20482838
nsv1115270 CNV deletion 24896259
nsv425323 CNV deletion 16902084

Variation tolerance for ZDHHC15 Gene

Residual Variation Intolerance Score: 42.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.81; 16.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZDHHC15 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZDHHC15 Gene

Disorders for ZDHHC15 Gene


  • Mental retardation, X-linked 91 (MRX91) [MIM:300577]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations. {ECO:0000269 PubMed:15915161}. Note=The disease may be caused by mutations affecting the gene represented in this entry.

Additional Disease Information for ZDHHC15

No disorders were found for ZDHHC15 Gene.

No data available for MalaCards and Genatlas for ZDHHC15 Gene

Publications for ZDHHC15 Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
  2. Loss of ZDHHC15 expression in a woman with a balanced translocation t(X;15)(q13.3;cen) and severe mental retardation. (PMID: 15915161) Mansouri MR … Dahl N (European journal of human genetics : EJHG 2005) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58

Products for ZDHHC15 Gene

Sources for ZDHHC15 Gene

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