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Aliases for ZDHHC14 Gene

Aliases for ZDHHC14 Gene

  • Zinc Finger DHHC-Type Containing 14 2 3 5
  • Zinc Finger DHHC Domain-Containing Protein 14 3 4
  • NEW1 Domain-Containing Protein 3 4
  • DHHC-14 3 4
  • NEW1CP 3 4
  • Zinc Finger, DHHC Domain Containing 14 3
  • Probable Palmitoyltransferase ZDHHC14 3
  • EC 2.3.1.225 4
  • EC 2.3.1 56

External Ids for ZDHHC14 Gene

Previous GeneCards Identifiers for ZDHHC14 Gene

  • GC06P157676
  • GC06P157711
  • GC06P157772
  • GC06P155266

Summaries for ZDHHC14 Gene

GeneCards Summary for ZDHHC14 Gene

ZDHHC14 (Zinc Finger DHHC-Type Containing 14) is a Protein Coding gene. Diseases associated with ZDHHC14 include Chromosome 6Q24-Q25 Deletion Syndrome. Gene Ontology (GO) annotations related to this gene include protein-cysteine S-palmitoyltransferase activity and palmitoyltransferase activity. An important paralog of this gene is ZDHHC18.

Additional gene information for ZDHHC14 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZDHHC14 Gene

Genomics for ZDHHC14 Gene

GeneHancer (GH) Regulatory Elements for ZDHHC14 Gene

Promoters and enhancers for ZDHHC14 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I157379 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +0.1 103 3.5 HDGF MLX ARNT ZFP64 ARID4B SIN3A FEZF1 ZNF2 SLC30A9 POLR2B ZDHHC14 LOC100420839 GC06P157399 GC06P157400
GH06I157460 Enhancer 1.4 FANTOM5 Ensembl ENCODE 15 +80.4 80446 2.7 HDGF PKNOX1 ATF1 FOXA2 SMAD1 ARNT YBX1 IRF4 TCF12 ZNF121 ZDHHC14 SNX9 GC06P157399 GC06P157400 MIR3692
GH06I157518 Enhancer 1.3 Ensembl ENCODE dbSUPER 11.4 +137.6 137634 1 HDAC1 ATF1 FOXA2 TAF9B ARNT NFRKB ZNF766 SCRT2 CREM ZNF362 ZDHHC14 MIR3692 GC06P157399 GC06P157400
GH06I157517 Enhancer 1 ENCODE dbSUPER 11.4 +136.7 136687 0.6 DRAP1 ELF3 SOX13 TFAP4 FOXA2 SAP130 MLX ARID4B RAD21 RARA ZDHHC14 MIR3692 GC06P157399 GC06P157400
GH06I157464 Enhancer 1 Ensembl ENCODE 11.2 +84.1 84097 1.3 HDGF SMAD1 RB1 BMI1 YBX1 BATF IRF4 ZBTB40 ATF7 ETV6 ZDHHC14 MIR3692 GC06P157399 GC06P157400
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZDHHC14 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZDHHC14 gene promoter:

Genomic Locations for ZDHHC14 Gene

Genomic Locations for ZDHHC14 Gene
chr6:157,381,133-157,678,146
(GRCh38/hg38)
Size:
297,014 bases
Orientation:
Plus strand
chr6:157,802,165-158,099,178
(GRCh37/hg19)

Genomic View for ZDHHC14 Gene

Genes around ZDHHC14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZDHHC14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZDHHC14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZDHHC14 Gene

Proteins for ZDHHC14 Gene

  • Protein details for ZDHHC14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZN3-ZDH14_HUMAN
    Recommended name:
    Probable palmitoyltransferase ZDHHC14
    Protein Accession:
    Q8IZN3
    Secondary Accessions:
    • A6NDB7
    • Q5JS07
    • Q5JS08
    • Q6PHS4
    • Q8IZN2
    • Q9H7F1

    Protein attributes for ZDHHC14 Gene

    Size:
    488 amino acids
    Molecular mass:
    53388 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14941.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZDHHC14 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZDHHC14 Gene

Selected DME Specific Peptides for ZDHHC14 Gene

Q8IZN3:
  • TTNEDIKGSW
  • NCVERFDHHCPW
  • TLLRTSFSDPGV
  • YRPPPRT
  • FDCPYLA
  • RFDHHCPWVG
  • RPPRASHCS
  • RRKWEVFPGRN
  • ILFFFVM

Post-translational modifications for ZDHHC14 Gene

No Post-translational modifications

Domains & Families for ZDHHC14 Gene

Gene Families for ZDHHC14 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for ZDHHC14 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IZN3

UniProtKB/Swiss-Prot:

ZDH14_HUMAN :
  • The DHHC domain is required for palmitoyltransferase activity.
  • Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
Domain:
  • The DHHC domain is required for palmitoyltransferase activity.
Family:
  • Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
genes like me logo Genes that share domains with ZDHHC14: view

Function for ZDHHC14 Gene

Molecular function for ZDHHC14 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

Enzyme Numbers (IUBMB) for ZDHHC14 Gene

Phenotypes From GWAS Catalog for ZDHHC14 Gene

Gene Ontology (GO) - Molecular Function for ZDHHC14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016409 palmitoyltransferase activity IDA 23034182
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
GO:0019706 protein-cysteine S-palmitoyltransferase activity IEA --
genes like me logo Genes that share ontologies with ZDHHC14: view

Phenotypes for ZDHHC14 Gene

GenomeRNAi human phenotypes for ZDHHC14:
genes like me logo Genes that share phenotypes with ZDHHC14: view

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZDHHC14 Gene

Localization for ZDHHC14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZDHHC14 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZDHHC14 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
peroxisome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZDHHC14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 16647879
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZDHHC14: view

Pathways & Interactions for ZDHHC14 Gene

SuperPathways for ZDHHC14 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZDHHC14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0018345 protein palmitoylation IDA 23034182
genes like me logo Genes that share ontologies with ZDHHC14: view

No data available for Pathways by source and SIGNOR curated interactions for ZDHHC14 Gene

Drugs & Compounds for ZDHHC14 Gene

(1) Drugs for ZDHHC14 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coenzyme A Investigational Nutra 0

(1) Additional Compounds for ZDHHC14 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
hexadecanoyl-CoA
genes like me logo Genes that share compounds with ZDHHC14: view

Transcripts for ZDHHC14 Gene

Unigene Clusters for ZDHHC14 Gene

Zinc finger, DHHC-type containing 14:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC14 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b
SP1: - - -
SP2: - - - -
SP3:
SP4: - -
SP5: -

Relevant External Links for ZDHHC14 Gene

GeneLoc Exon Structure for
ZDHHC14
ECgene alternative splicing isoforms for
ZDHHC14

Expression for ZDHHC14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZDHHC14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZDHHC14 Gene

This gene is overexpressed in Breast (62.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZDHHC14 Gene



Protein tissue co-expression partners for ZDHHC14 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZDHHC14 Gene:

ZDHHC14

SOURCE GeneReport for Unigene cluster for ZDHHC14 Gene:

Hs.745003

Evidence on tissue expression from TISSUES for ZDHHC14 Gene

  • Stomach(4.3)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZDHHC14: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZDHHC14 Gene

Orthologs for ZDHHC14 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ZDHHC14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZDHHC14 33 34
  • 99.43 (n)
cow
(Bos Taurus)
Mammalia ZDHHC14 33 34
  • 92.88 (n)
dog
(Canis familiaris)
Mammalia ZDHHC14 33 34
  • 92.27 (n)
mouse
(Mus musculus)
Mammalia Zdhhc14 33 16 34
  • 90.1 (n)
oppossum
(Monodelphis domestica)
Mammalia ZDHHC14 34
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zdhhc14 33
  • 89.75 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ZDHHC14 34
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZDHHC14 33 34
  • 81.15 (n)
lizard
(Anolis carolinensis)
Reptilia ZDHHC14 34
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zdhhc14 33
  • 76.04 (n)
zebrafish
(Danio rerio)
Actinopterygii zdhhc14 33 34
  • 69.19 (n)
fruit fly
(Drosophila melanogaster)
Insecta app 33 34
  • 64.48 (n)
worm
(Caenorhabditis elegans)
Secernentea dhhc-2 33 34
  • 51.91 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G26935 33
  • 51.4 (n)
rice
(Oryza sativa)
Liliopsida Os01g0925300 33
  • 52.86 (n)
wheat
(Triticum aestivum)
Liliopsida Ta.6808 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3762 34
  • 54 (a)
OneToMany
Species where no ortholog for ZDHHC14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for ZDHHC14 Gene

ENSEMBL:
Gene Tree for ZDHHC14 (if available)
TreeFam:
Gene Tree for ZDHHC14 (if available)

Paralogs for ZDHHC14 Gene

(5) SIMAP similar genes for ZDHHC14 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZDHHC14: view

Variants for ZDHHC14 Gene

Sequence variations from dbSNP and Humsavar for ZDHHC14 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000011710 -- 157,631,371(+) G/A intron_variant
rs1000014528 -- 157,675,103(+) C/T downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1000027361 -- 157,391,947(+) G/A/C genic_upstream_transcript_variant, intron_variant
rs1000029699 -- 157,554,744(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000066463 -- 157,604,255(+) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZDHHC14 Gene

Variant ID Type Subtype PubMed ID
nsv509156 CNV insertion 20534489
nsv1132024 CNV deletion 24896259
nsv1073599 CNV deletion 25765185
esv996138 CNV deletion 20482838
esv6974 CNV loss 19470904
esv3571489 CNV loss 25503493
esv3571488 CNV loss 25503493
esv3571486 CNV loss 25503493
esv3540725 CNV deletion 23714750
esv3496 CNV loss 18987735
esv3431419 CNV insertion 20981092
esv33442 CNV loss 17666407
esv33371 CNV loss 17666407
esv3309699 CNV mobile element insertion 20981092
esv3306470 CNV mobile element insertion 20981092
esv33003 CNV loss 17666407
esv3282829 CNV deletion 24192839
esv28761 CNV gain 19812545
esv2763603 CNV gain 21179565
esv2732982 CNV deletion 23290073
esv2732981 CNV deletion 23290073
esv2732980 CNV deletion 23290073
esv2660140 CNV deletion 23128226
esv2610603 CNV deletion 19546169
esv2124670 CNV deletion 18987734
esv2076685 CNV deletion 18987734
esv1113682 CNV deletion 17803354
dgv407e215 CNV deletion 23714750
dgv3686e59 CNV insertion 20981092
dgv3420n106 CNV deletion 24896259
dgv10984n54 CNV loss 21841781

Variation tolerance for ZDHHC14 Gene

Residual Variation Intolerance Score: 38% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.69; 32.28% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZDHHC14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZDHHC14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZDHHC14 Gene

Disorders for ZDHHC14 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZDHHC14 Gene - From: DISEASES

Disorder Aliases PubMed IDs
chromosome 6q24-q25 deletion syndrome
  • chromosome 6q25-q25 deletion syndrome
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZDHHC14

genes like me logo Genes that share disorders with ZDHHC14: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZDHHC14 Gene

Publications for ZDHHC14 Gene

  1. Pharmacogenomic study of side-effects for antidepressant treatment options in STAR*D. (PMID: 22041458) Clark SL … van den Oord EJ (Psychological medicine 2012) 3 44 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 58
  5. Identification of ZDHHC14 as a novel human tumour suppressor gene. (PMID: 24407904) Yeste-Velasco M … Lu YJ (The Journal of pathology 2014) 3 58

Products for ZDHHC14 Gene

Sources for ZDHHC14 Gene

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