Aliases for ZDHHC13 Gene

Aliases for ZDHHC13 Gene

  • Zinc Finger DHHC-Type Containing 13 2 3 5
  • Huntingtin-Interacting Protein 14-Related Protein 3 4
  • Zinc Finger DHHC Domain-Containing Protein 13 3 4
  • Putative NF-Kappa-B-Activating Protein 209 3 4
  • Putative MAPK-Activating Protein PM03 3 4
  • Palmitoyltransferase ZDHHC13 3 4
  • HIP14-Related Protein 3 4
  • DHHC-13 3 4
  • HIP14L 3 4
  • HIP3RP 3 4
  • Zinc Finger, DHHC Domain Containing 13 3
  • Huntingtin Interacting Protein HIP3RP 3
  • Probable Palmitoyltransferase ZDHHC13 3
  • Huntingtin-Interacting Protein HIP3RP 4
  • EC 4
  • EC 2.3.1 54

External Ids for ZDHHC13 Gene

Previous GeneCards Identifiers for ZDHHC13 Gene

  • GC11P019104
  • GC11P018822

Summaries for ZDHHC13 Gene

GeneCards Summary for ZDHHC13 Gene

ZDHHC13 (Zinc Finger DHHC-Type Containing 13) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity and palmitoyltransferase activity. An important paralog of this gene is ZDHHC17.

UniProtKB/Swiss-Prot Summary for ZDHHC13 Gene

  • Palmitoyltransferase for HTT and GAD2. May play a role in Mg(2+) transport.

Additional gene information for ZDHHC13 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZDHHC13 Gene

Genomics for ZDHHC13 Gene

GeneHancer (GH) Regulatory Elements for ZDHHC13 Gene

Promoters and enhancers for ZDHHC13 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J019116 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 760.3 +0.3 310 2.4 SP1 CTCF SREBF1 SMARCE1 POLR2A NFYC ELF1 RELA L3MBTL2 MNT ZDHHC13 piR-51137-019
GH11J019236 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.7 +123.6 123621 9.1 E2F8 ZBTB40 SP1 RBPJ POLR2A TCF7L2 HDAC2 FOS ZNF217 HCFC1 E2F8 PTPN5 GTF2H1 ZDHHC13 ENSG00000255160 lnc-CSRP3-1 ENSG00000255308-001
GH11J019172 Enhancer 1 VISTA dbSUPER 15 +56.7 56664 2.5 TEAD4 CBFA2T2 TRIM24 PKNOX1 EP300 SOX6 ZNF766 E2F5 ZSCAN29 GABPA ZDHHC13 GTF2H1 CSRP3-AS1 CSRP3 ENSG00000256282 piR-38579-009 HSALNG0083042
GH11J019077 Enhancer 0.8 Ensembl ENCODE 18.4 -37.9 -37898 4.8 CTCF HLF RAD21 SP7 REST TRIM22 ZNF143 CEBPB NFE2 RAD51 ZDHHC13 PTPN5 MRGPRX2
GH11J019087 Enhancer 0.7 Ensembl ENCODE 19.6 -28.9 -28898 3.2 ZNF740 STAT1 GTF2A2 JUN FOS ZNF354B ZDHHC13 SAAL1 GTF2H1 SPTY2D1 MRGPRX2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZDHHC13 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZDHHC13 gene promoter:
  • aMEF-2
  • HEN1
  • MEF-2
  • MEF-2A
  • NCX
  • NF-kappaB
  • NF-kappaB1
  • NF-kappaB2
  • TBP

Genomic Locations for ZDHHC13 Gene

Genomic Locations for ZDHHC13 Gene
59,324 bases
Plus strand
59,324 bases
Plus strand

Genomic View for ZDHHC13 Gene

Genes around ZDHHC13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZDHHC13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZDHHC13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZDHHC13 Gene

Proteins for ZDHHC13 Gene

  • Protein details for ZDHHC13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Palmitoyltransferase ZDHHC13
    Protein Accession:
    Secondary Accessions:
    • Q7Z2D3
    • Q86VK2
    • Q9NV30
    • Q9NV99

    Protein attributes for ZDHHC13 Gene

    622 amino acids
    Molecular mass:
    70861 Da
    Quaternary structure:
    • Interacts (via ANK repeats) with CLIP3 (PubMed:26198635). Interacts (via ANK repeats) with DNAJC5 (via C-terminus) (By similarity). Interacts (via ANK repeats) with HTT (PubMed:26198635). Interacts (via ANK repeats) with MAP6 (PubMed:26198635). Interacts (via ANK repeats) with SNAP23. Interacts (via ANK repeats) with SNAP25. May interact (via ANK repeats) with SPRED2 (By similarity).
    • Sequence=BAA91856.1; Type=Erroneous termination; Positions=482; Note=Translated as Cys.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZDHHC13 Gene


neXtProt entry for ZDHHC13 Gene

Selected DME Specific Peptides for ZDHHC13 Gene


Post-translational modifications for ZDHHC13 Gene

  • Ubiquitination at Lys80
  • Modification sites at PhosphoSitePlus

Other Protein References for ZDHHC13 Gene

Domains & Families for ZDHHC13 Gene

Gene Families for ZDHHC13 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins
  • Transporters

Suggested Antigen Peptide Sequences for ZDHHC13 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger, DHHC-type containing 13, isoform CRA_b (C9JYJ4_HUMAN)
  • Zinc finger DHHC domain-containing protein 13 (ZDH13_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • The DHHC domain is required for palmitoyltransferase activity.
  • Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.
  • The DHHC domain is required for palmitoyltransferase activity.
  • Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.
genes like me logo Genes that share domains with ZDHHC13: view

Function for ZDHHC13 Gene

Molecular function for ZDHHC13 Gene

UniProtKB/Swiss-Prot Function:
Palmitoyltransferase for HTT and GAD2. May play a role in Mg(2+) transport.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151; EC=; Evidence=. ;.

Enzyme Numbers (IUBMB) for ZDHHC13 Gene

Phenotypes From GWAS Catalog for ZDHHC13 Gene

Gene Ontology (GO) - Molecular Function for ZDHHC13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
GO:0015095 magnesium ion transmembrane transporter activity ISS --
GO:0016409 palmitoyltransferase activity ISS --
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
genes like me logo Genes that share ontologies with ZDHHC13: view
genes like me logo Genes that share phenotypes with ZDHHC13: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZDHHC13 Gene

Localization for ZDHHC13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZDHHC13 Gene

Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Low extracellular Mg(2+) induces increase in Golgi and in post-Golgi vesicles. {ECO:0000250 UniProtKB:Q9CWU2}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZDHHC13 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 4
plasma membrane 3
mitochondrion 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZDHHC13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane ISS --
GO:0005783 endoplasmic reticulum IDA 16647879
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane HDA,IEA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZDHHC13: view

Pathways & Interactions for ZDHHC13 Gene

PathCards logo

SuperPathways for ZDHHC13 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZDHHC13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling HMP 12761501
GO:1903830 magnesium ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with ZDHHC13: view

No data available for Pathways by source and SIGNOR curated interactions for ZDHHC13 Gene

Drugs & Compounds for ZDHHC13 Gene

(1) Drugs for ZDHHC13 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coenzyme A Investigational Nutra 0

(1) Additional Compounds for ZDHHC13 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • coenzyme A, S-Hexadecanoate
  • Palmitoyl coenzyme A
  • S-Palmitoylcoenzyme A
  • coenzyme A, S-Hexadecanoic acid
genes like me logo Genes that share compounds with ZDHHC13: view

Transcripts for ZDHHC13 Gene

mRNA/cDNA for ZDHHC13 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC13 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17
SP1: -
SP2: - -
SP3: -

Relevant External Links for ZDHHC13 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZDHHC13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZDHHC13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZDHHC13 Gene

This gene is overexpressed in Esophagus - Mucosa (x5.1).

Protein differential expression in normal tissues from HIPED for ZDHHC13 Gene

This gene is overexpressed in Nasal epithelium (62.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZDHHC13 Gene

Protein tissue co-expression partners for ZDHHC13 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZDHHC13 Gene:


SOURCE GeneReport for Unigene cluster for ZDHHC13 Gene:


Evidence on tissue expression from TISSUES for ZDHHC13 Gene

  • Eye(4.1)
  • Lung(4.1)
genes like me logo Genes that share expression patterns with ZDHHC13: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZDHHC13 Gene

Orthologs for ZDHHC13 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZDHHC13 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZDHHC13 33 32
  • 99.62 (n)
(Canis familiaris)
Mammalia ZDHHC13 33 32
  • 92.02 (n)
(Bos Taurus)
Mammalia ZDHHC13 33 32
  • 91.16 (n)
(Mus musculus)
Mammalia Zdhhc13 17 33 32
  • 89.92 (n)
(Rattus norvegicus)
Mammalia Zdhhc13 32
  • 88.8 (n)
(Monodelphis domestica)
Mammalia ZDHHC13 33
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia ZDHHC13 33
  • 77 (a)
(Gallus gallus)
Aves ZDHHC13 33 32
  • 68.74 (n)
(Anolis carolinensis)
Reptilia ZDHHC13 33
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493145 32
  • 62.48 (n)
(Danio rerio)
Actinopterygii zdhhc13 33 32
  • 56.61 (n)
wufi22e09 32
fruit fly
(Drosophila melanogaster)
Insecta Hip14 33
  • 35 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AKR1 33
  • 20 (a)
AKR2 33
  • 19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11093 33
  • 39 (a)
Species where no ortholog for ZDHHC13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZDHHC13 Gene

Gene Tree for ZDHHC13 (if available)
Gene Tree for ZDHHC13 (if available)
Evolutionary constrained regions (ECRs) for ZDHHC13: view image

Paralogs for ZDHHC13 Gene

Paralogs for ZDHHC13 Gene

(1) SIMAP similar genes for ZDHHC13 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZDHHC13: view

Variants for ZDHHC13 Gene

Sequence variations from dbSNP and Humsavar for ZDHHC13 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000128709 -- 19,142,796(+) G/A/C coding_sequence_variant, genic_upstream_transcript_variant, intron_variant, missense_variant, non_coding_transcript_variant
rs1000131588 -- 19,138,152(+) T/A genic_upstream_transcript_variant, intron_variant
rs1000241728 -- 19,133,159(+) T/G genic_upstream_transcript_variant, intron_variant
rs1000273436 -- 19,162,376(+) C/T intron_variant
rs1000295298 -- 19,143,877(+) C/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZDHHC13 Gene

Variant ID Type Subtype PubMed ID
esv2662583 CNV deletion 23128226
esv3428572 CNV insertion 20981092
esv3625530 CNV loss 21293372
esv3625531 CNV loss 21293372
nsv476084 CNV novel sequence insertion 20440878
nsv477679 CNV novel sequence insertion 20440878

Variation tolerance for ZDHHC13 Gene

Residual Variation Intolerance Score: 27.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.13; 51.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZDHHC13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZDHHC13 Gene

Disorders for ZDHHC13 Gene

Additional Disease Information for ZDHHC13

No disorders were found for ZDHHC13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZDHHC13 Gene

Publications for ZDHHC13 Gene

  1. Huntingtin-interacting proteins, HIP14 and HIP14L, mediate dual functions, palmitoyl acyltransferase and Mg2+ transport. (PMID: 18794299) Goytain A … Quamme GA (The Journal of biological chemistry 2008) 2 3 23 56
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  4. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. (PMID: 12761501) Matsuda A … Sugano S (Oncogene 2003) 3 4 56
  5. HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis. (PMID: 12393793) Singaraja RR … Hayden MR (Human molecular genetics 2002) 3 4 56

Products for ZDHHC13 Gene

  • Biorbyt antibodies for ZDHHC13

Sources for ZDHHC13 Gene