Aliases for ZDHHC12 Gene

Aliases for ZDHHC12 Gene

  • Zinc Finger DHHC-Type Palmitoyltransferase 12 2 3 5
  • ZNF400 2 3 4
  • DHHC Domain-Containing Cysteine-Rich Protein 12 3 4
  • Zinc Finger DHHC Domain-Containing Protein 12 3 4
  • Zinc Finger DHHC-Type Containing 12 2 3
  • Palmitoyltransferase ZDHHC12 3 4
  • Zinc Finger Protein 400 3 4
  • DHHC-12 3 4
  • Probable Palmitoyltransferase ZDHHC12 3
  • EC 2.3.1.225 4
  • FLJ14524 2
  • ZDHHC12 5

External Ids for ZDHHC12 Gene

Previous GeneCards Identifiers for ZDHHC12 Gene

  • GC09M122597
  • GC09M123129
  • GC09M124936
  • GC09M126859
  • GC09M128562
  • GC09M130522
  • GC09M131484
  • GC09M101092

Summaries for ZDHHC12 Gene

GeneCards Summary for ZDHHC12 Gene

ZDHHC12 (Zinc Finger DHHC-Type Palmitoyltransferase 12) is a Protein Coding gene. Diseases associated with ZDHHC12 include Drug Psychosis and Drug-Induced Mental Disorder. Gene Ontology (GO) annotations related to this gene include protein-cysteine S-palmitoyltransferase activity and palmitoyltransferase activity. An important paralog of this gene is ZDHHC7.

UniProtKB/Swiss-Prot Summary for ZDHHC12 Gene

  • Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates. Has a palmitoyltransferase activity toward gephyrin/GPHN, regulating its clustering at synapses and its function in gamma-aminobutyric acid receptor clustering. Thereby, indirectly regulates GABAergic synaptic transmission.

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZDHHC12 Gene

Genomics for ZDHHC12 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZDHHC12 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZDHHC12 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZDHHC12

Top Transcription factor binding sites by QIAGEN in the ZDHHC12 gene promoter:
  • AhR
  • HOXA9
  • HOXA9B
  • Ik-3
  • Meis-1
  • Meis-1a
  • Olf-1
  • p53
  • Pax-3
  • Sp1

Genomic Locations for ZDHHC12 Gene

Latest Assembly
chr9:128,720,869-128,724,138
(GRCh38/hg38)
Size:
3,270 bases
Orientation:
Minus strand

Previous Assembly
chr9:131,483,152-131,486,406
(GRCh37/hg19 by Entrez Gene)
Size:
3,255 bases
Orientation:
Minus strand

chr9:131,483,148-131,486,406
(GRCh37/hg19 by Ensembl)
Size:
3,259 bases
Orientation:
Minus strand

Genomic View for ZDHHC12 Gene

Genes around ZDHHC12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZDHHC12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZDHHC12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZDHHC12 Gene

Proteins for ZDHHC12 Gene

  • Protein details for ZDHHC12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96GR4-ZDH12_HUMAN
    Recommended name:
    Palmitoyltransferase ZDHHC12
    Protein Accession:
    Q96GR4
    Secondary Accessions:
    • A6NH95
    • B2RE03
    • Q5T265
    • Q5T267
    • Q5T268
    • Q86VT5
    • Q96T09

    Protein attributes for ZDHHC12 Gene

    Size:
    267 amino acids
    Molecular mass:
    30813 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZDHHC12 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZDHHC12 Gene

Post-translational modifications for ZDHHC12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZDHHC12 Gene

Domains & Families for ZDHHC12 Gene

Gene Families for ZDHHC12 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for ZDHHC12 Gene

InterPro:
Blocks:
  • Zn-finger, DHHC type

Suggested Antigen Peptide Sequences for ZDHHC12 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger, DHHC-type containing 12 (Q5T266_HUMAN)
  • Zinc finger, DHHC-type containing 12 (Q5T269_HUMAN)
  • Zinc finger protein 400 (ZDH12_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96GR4

UniProtKB/Swiss-Prot:

ZDH12_HUMAN :
  • The DHHC domain is required for palmitoyltransferase activity.
  • Belongs to the DHHC palmitoyltransferase family.
Domain:
  • The DHHC domain is required for palmitoyltransferase activity.
Family:
  • Belongs to the DHHC palmitoyltransferase family.
genes like me logo Genes that share domains with ZDHHC12: view

Function for ZDHHC12 Gene

Molecular function for ZDHHC12 Gene

UniProtKB/Swiss-Prot Function:
Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates. Has a palmitoyltransferase activity toward gephyrin/GPHN, regulating its clustering at synapses and its function in gamma-aminobutyric acid receptor clustering. Thereby, indirectly regulates GABAergic synaptic transmission.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151; EC=2.3.1.225; Evidence={ECO:0000250|UniProtKB:Q8VC90};.

Enzyme Numbers (IUBMB) for ZDHHC12 Gene

Phenotypes From GWAS Catalog for ZDHHC12 Gene

Gene Ontology (GO) - Molecular Function for ZDHHC12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016409 palmitoyltransferase activity IEA,IDA 23034182
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
GO:0019706 protein-cysteine S-palmitoyltransferase activity IEA,ISS --
genes like me logo Genes that share ontologies with ZDHHC12: view
genes like me logo Genes that share phenotypes with ZDHHC12: view

Animal Models for research

  • Taconic Biosciences Mouse Models for ZDHHC12

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZDHHC12

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZDHHC12 Gene

Localization for ZDHHC12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZDHHC12 Gene

Golgi apparatus membrane. Multi-pass membrane protein. Endoplasmic reticulum membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZDHHC12 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 5
plasma membrane 3
nucleus 2
extracellular 1
cytoskeleton 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Intermediate filaments (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZDHHC12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005783 endoplasmic reticulum IBA,IDA 16647879
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005794 Golgi apparatus IBA,IDA 16647879
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ZDHHC12: view

Pathways & Interactions for ZDHHC12 Gene

PathCards logo

SuperPathways for ZDHHC12 Gene

No Data Available

Interacting Proteins for ZDHHC12 Gene

Gene Ontology (GO) - Biological Process for ZDHHC12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006612 protein targeting to membrane IBA 21873635
GO:0018215 protein phosphopantetheinylation IEA --
GO:0018230 peptidyl-L-cysteine S-palmitoylation ISS --
GO:0018345 protein palmitoylation IDA 23034182
GO:0032230 positive regulation of synaptic transmission, GABAergic ISS --
genes like me logo Genes that share ontologies with ZDHHC12: view

No data available for Pathways by source and SIGNOR curated interactions for ZDHHC12 Gene

Drugs & Compounds for ZDHHC12 Gene

(1) Drugs for ZDHHC12 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coenzyme A Investigational Nutra 0

(1) Additional Compounds for ZDHHC12 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
hexadecanoyl-CoA
  • coenzyme A, S-Hexadecanoate
  • Palmitoyl coenzyme A
  • S-Palmitoylcoenzyme A
  • coenzyme A, S-Hexadecanoic acid
  • Hexadecanoyl-CoA
genes like me logo Genes that share compounds with ZDHHC12: view

Transcripts for ZDHHC12 Gene

mRNA/cDNA for ZDHHC12 Gene

5 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZDHHC12

Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC12 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d · 5e · 5f
SP1: - - -
SP2: - -
SP3: - - - -
SP4: - - -
SP5: -
SP6:

Relevant External Links for ZDHHC12 Gene

GeneLoc Exon Structure for
ZDHHC12

Expression for ZDHHC12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZDHHC12 Gene

mRNA differential expression in normal tissues according to GTEx for ZDHHC12 Gene

This gene is overexpressed in Whole Blood (x6.3).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZDHHC12

SOURCE GeneReport for Unigene cluster for ZDHHC12 Gene:

Hs.133122

mRNA Expression by UniProt/SwissProt for ZDHHC12 Gene:

Q96GR4-ZDH12_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with ZDHHC12: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZDHHC12 Gene

Orthologs for ZDHHC12 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZDHHC12 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZDHHC12 29 30
  • 99.25 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZDHHC12 29 30
  • 92.32 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZDHHC12 29 30
  • 91.39 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Zdhhc12 29
  • 87.64 (n)
Mouse
(Mus musculus)
Mammalia Zdhhc12 29 16 30
  • 86.02 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ZDHHC12 30
  • 71 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia ZDHHC12 30
  • 68 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ZDHHC12 29 30
  • 62.89 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ZDHHC12 30
  • 26 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia zdhhc12 29
  • 60.48 (n)
Zebrafish
(Danio rerio)
Actinopterygii LOC569129 29
  • 63.98 (n)
zdhhc12b 30
  • 54 (a)
OneToMany
zdhhc12a 30
  • 47 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta Patsas 30
  • 12 (a)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea dhhc-14 30
  • 9 (a)
OneToMany
dhhc-13 30
  • 8 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AKR1 30
  • 8 (a)
ManyToMany
AKR2 30
  • 7 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 28 (a)
OneToOne
Species where no ortholog for ZDHHC12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ZDHHC12 Gene

ENSEMBL:
Gene Tree for ZDHHC12 (if available)
TreeFam:
Gene Tree for ZDHHC12 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZDHHC12: view image
Alliance of Genome Resources:
Additional Orthologs for ZDHHC12

Paralogs for ZDHHC12 Gene

genes like me logo Genes that share paralogs with ZDHHC12: view

Variants for ZDHHC12 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZDHHC12 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
rs2298039 -- p.Pro69Ser
rs2900268 -- p.Gln172Leu

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ZDHHC12 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ZDHHC12 Gene

Variant ID Type Subtype PubMed ID
nsv951777 CNV deletion 24416366

Variation tolerance for ZDHHC12 Gene

Residual Variation Intolerance Score: 74.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.01; 68.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZDHHC12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZDHHC12
Leiden Open Variation Database (LOVD)
ZDHHC12

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZDHHC12 Gene

Disorders for ZDHHC12 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ZDHHC12 Gene - From: COP

Disorder Aliases PubMed IDs
drug psychosis
  • drug-induced psychosis
drug-induced mental disorder
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZDHHC12

genes like me logo Genes that share disorders with ZDHHC12: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZDHHC12 Gene

Publications for ZDHHC12 Gene

  1. Palmitoylation of gephyrin controls receptor clustering and plasticity of GABAergic synapses. (PMID: 25025157) Dejanovic B … Schwarz G (PLoS biology 2014) 2 3
  2. Intracellular localization and tissue-specific distribution of human and yeast DHHC cysteine-rich domain-containing proteins. (PMID: 16647879) Ohno Y … Igarashi Y (Biochimica et biophysica acta 2006) 3 4
  3. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4

Products for ZDHHC12 Gene

  • Biorbyt antibodies for ZDHHC12

Sources for ZDHHC12 Gene