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Aliases for ZDHHC12 Gene

Aliases for ZDHHC12 Gene

  • Zinc Finger DHHC-Type Containing 12 2 3 5
  • Zinc Finger DHHC Domain-Containing Protein 12 3 4
  • Zinc Finger Protein 400 3 4
  • DHHC-12 3 4
  • ZNF400 3 4
  • Probable Palmitoyltransferase ZDHHC12 3
  • EC 4

External Ids for ZDHHC12 Gene

Previous GeneCards Identifiers for ZDHHC12 Gene

  • GC09M122597
  • GC09M123129
  • GC09M124936
  • GC09M126859
  • GC09M128562
  • GC09M130522
  • GC09M131484
  • GC09M101092

Summaries for ZDHHC12 Gene

GeneCards Summary for ZDHHC12 Gene

ZDHHC12 (Zinc Finger DHHC-Type Containing 12) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein-cysteine S-palmitoyltransferase activity and palmitoyltransferase activity. An important paralog of this gene is ZDHHC3.

Additional gene information for ZDHHC12 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZDHHC12 Gene

Genomics for ZDHHC12 Gene

GeneHancer (GH) Regulatory Elements for ZDHHC12 Gene

Promoters and enhancers for ZDHHC12 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I128722 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 -0.2 -242 3.7 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 POLR2B LOC100506100 ZDHHC12 NUP188 NAIF1 GLE1 ODF2 CIZ1 GOLGA2 PKN3 TBC1D13
GH09I128687 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 12.1 +34.5 34526 4 HDGF PKNOX1 CLOCK SMAD1 ARNT SIN3A DMAP1 ZNF2 YY1 POLR2B SET FPGS LOC102723566 LOC100506100 ZDHHC12 URM1 LOC105376287 PKN3
GH09I128786 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.5 -63.5 -63479 2.6 PKNOX1 CLOCK MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 TBC1D13 SPOUT1 MIGA2 LOC100506100 ZDHHC12 PKN3 KYAT1 LRRC8A SLC25A25-AS1 CIZ1
GH09I128877 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.2 -159.1 -159143 12.3 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 E2F8 KYAT1 LRRC8A NUP188 NAIF1 GLE1 SPOUT1 PHYHD1 TOR1B DOLK PKN3
GH09I129035 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.1 -313.2 -313153 2.9 HDGF PKNOX1 CLOCK ARID4B SIN3A FEZF1 ZNF2 ZBTB7B YY1 POLR2B MIGA2 NAIF1 GLE1 TOR1B NUP188 LOC100506100 ZDHHC12 PKN3 ENSG00000268707 DOLPP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZDHHC12 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZDHHC12 gene promoter:

Genomic Locations for ZDHHC12 Gene

Genomic Locations for ZDHHC12 Gene
3,273 bases
Minus strand

Genomic View for ZDHHC12 Gene

Genes around ZDHHC12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZDHHC12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZDHHC12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZDHHC12 Gene

Proteins for ZDHHC12 Gene

  • Protein details for ZDHHC12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable palmitoyltransferase ZDHHC12
    Protein Accession:
    Secondary Accessions:
    • A6NH95
    • B2RE03
    • Q5T265
    • Q5T267
    • Q5T268
    • Q86VT5
    • Q96T09

    Protein attributes for ZDHHC12 Gene

    267 amino acids
    Molecular mass:
    30813 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZDHHC12 Gene


neXtProt entry for ZDHHC12 Gene

Post-translational modifications for ZDHHC12 Gene

No Post-translational modifications

No data available for DME Specific Peptides for ZDHHC12 Gene

Domains & Families for ZDHHC12 Gene

Gene Families for ZDHHC12 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for ZDHHC12 Gene

Suggested Antigen Peptide Sequences for ZDHHC12 Gene

Graphical View of Domain Structure for InterPro Entry



  • The DHHC domain is required for palmitoyltransferase activity.
  • Belongs to the DHHC palmitoyltransferase family.
  • The DHHC domain is required for palmitoyltransferase activity.
  • Belongs to the DHHC palmitoyltransferase family.
genes like me logo Genes that share domains with ZDHHC12: view

Function for ZDHHC12 Gene

Molecular function for ZDHHC12 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

Enzyme Numbers (IUBMB) for ZDHHC12 Gene

Phenotypes From GWAS Catalog for ZDHHC12 Gene

Gene Ontology (GO) - Molecular Function for ZDHHC12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016409 palmitoyltransferase activity IDA 23034182
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
GO:0019706 protein-cysteine S-palmitoyltransferase activity IEA --
genes like me logo Genes that share ontologies with ZDHHC12: view
genes like me logo Genes that share phenotypes with ZDHHC12: view

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZDHHC12 Gene

Localization for ZDHHC12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZDHHC12 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZDHHC12 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 5
plasma membrane 3
extracellular 2
cytoskeleton 2
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZDHHC12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 16647879
GO:0005794 Golgi apparatus IDA 16647879
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZDHHC12: view

Pathways & Interactions for ZDHHC12 Gene

SuperPathways for ZDHHC12 Gene

No Data Available

Interacting Proteins for ZDHHC12 Gene

Gene Ontology (GO) - Biological Process for ZDHHC12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0018345 protein palmitoylation IDA 23034182
genes like me logo Genes that share ontologies with ZDHHC12: view

No data available for Pathways by source and SIGNOR curated interactions for ZDHHC12 Gene

Drugs & Compounds for ZDHHC12 Gene

(1) Drugs for ZDHHC12 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coenzyme A Investigational Nutra 0

(1) Additional Compounds for ZDHHC12 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ZDHHC12: view

Transcripts for ZDHHC12 Gene

Unigene Clusters for ZDHHC12 Gene

Zinc finger, DHHC-type containing 12:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC12 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d · 5e · 5f
SP1: - - -
SP2: - -
SP3: - - - -
SP4: - - -
SP5: -

Relevant External Links for ZDHHC12 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZDHHC12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZDHHC12 Gene

mRNA differential expression in normal tissues according to GTEx for ZDHHC12 Gene

This gene is overexpressed in Whole Blood (x6.3).

NURSA nuclear receptor signaling pathways regulating expression of ZDHHC12 Gene:


SOURCE GeneReport for Unigene cluster for ZDHHC12 Gene:

genes like me logo Genes that share expression patterns with ZDHHC12: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZDHHC12 Gene

Orthologs for ZDHHC12 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZDHHC12 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZDHHC12 33 34
  • 99.25 (n)
(Canis familiaris)
Mammalia ZDHHC12 33 34
  • 92.32 (n)
(Bos Taurus)
Mammalia ZDHHC12 33 34
  • 91.39 (n)
(Rattus norvegicus)
Mammalia Zdhhc12 33
  • 87.64 (n)
(Mus musculus)
Mammalia Zdhhc12 33 16 34
  • 86.02 (n)
(Monodelphis domestica)
Mammalia ZDHHC12 34
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia ZDHHC12 34
  • 68 (a)
(Gallus gallus)
Aves ZDHHC12 33 34
  • 62.89 (n)
(Anolis carolinensis)
Reptilia ZDHHC12 34
  • 26 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia zdhhc12 33
  • 60.48 (n)
(Danio rerio)
Actinopterygii LOC569129 33
  • 63.98 (n)
zdhhc12b 34
  • 54 (a)
zdhhc12a 34
  • 47 (a)
fruit fly
(Drosophila melanogaster)
Insecta Patsas 34
  • 12 (a)
(Caenorhabditis elegans)
Secernentea dhhc-14 34
  • 9 (a)
dhhc-13 34
  • 8 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AKR1 34
  • 8 (a)
AKR2 34
  • 7 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 28 (a)
Species where no ortholog for ZDHHC12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZDHHC12 Gene

Gene Tree for ZDHHC12 (if available)
Gene Tree for ZDHHC12 (if available)

Paralogs for ZDHHC12 Gene

Paralogs for ZDHHC12 Gene

genes like me logo Genes that share paralogs with ZDHHC12: view

Variants for ZDHHC12 Gene

Sequence variations from dbSNP and Humsavar for ZDHHC12 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1001029491 -- 128,723,737(-) C/T intron_variant
rs1002020588 -- 128,720,804(-) T/G downstream_transcript_variant
rs1002170123 -- 128,722,974(-) G/A intron_variant
rs1002304604 -- 128,722,621(-) A/T coding_sequence_variant, intron_variant, synonymous_variant
rs1003023282 -- 128,721,902(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZDHHC12 Gene

Variant ID Type Subtype PubMed ID
nsv951777 CNV deletion 24416366

Variation tolerance for ZDHHC12 Gene

Residual Variation Intolerance Score: 74.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.01; 68.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZDHHC12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZDHHC12 Gene

Disorders for ZDHHC12 Gene

Additional Disease Information for ZDHHC12

No disorders were found for ZDHHC12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZDHHC12 Gene

Publications for ZDHHC12 Gene

  1. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error. (PMID: 24144296) Cheng CY … Baird PN (American journal of human genetics 2013) 3 58

Products for ZDHHC12 Gene

Sources for ZDHHC12 Gene

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