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Aliases for ZDHHC11B Gene

Aliases for ZDHHC11B Gene

  • Zinc Finger DHHC-Type Containing 11B 2 3 5
  • Zinc Finger DHHC Domain-Containing Protein 11B 3 4
  • DHHC-11B 3 4
  • Probable Palmitoyltransferase ZDHHC11B 3
  • EC 2.3.1.225 4

External Ids for ZDHHC11B Gene

Previous GeneCards Identifiers for ZDHHC11B Gene

  • GC05M000769

Summaries for ZDHHC11B Gene

GeneCards Summary for ZDHHC11B Gene

ZDHHC11B (Zinc Finger DHHC-Type Containing 11B) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein-cysteine S-palmitoyltransferase activity. An important paralog of this gene is ZDHHC11.

Additional gene information for ZDHHC11B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZDHHC11B Gene

Genomics for ZDHHC11B Gene

GeneHancer (GH) Regulatory Elements for ZDHHC11B Gene

Promoters and enhancers for ZDHHC11B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I000781 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 550.8 +0.5 471 5 ATF1 ZNF121 GLIS2 KLF7 REST ZNF592 ZNF610 GLIS1 MYNN WT1 LOC101928768 ZDHHC11B BRD9 SDHAP3 LOC728613 ENSG00000271119 ZDHHC11 TPPP PIR45253
GH05I000752 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 19.9 +28.3 28276 7.9 HDGF FOXA2 ARID4B YBX1 ZBTB7B THRB RAD21 RARA ZNF207 ZNF143 ZDHHC11B ZDHHC11 SLC9A3-AS1 SLC9A3 EXOC3 ENSG00000271781 BRD9 TPPP PIR41835 PIR51794
GH05I000668 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 13 +112.0 111973 8 HDGF HNRNPUL1 PKNOX1 SMAD1 ATF1 FOXA2 ARID4B NEUROD1 SIN3A GLI4 EXOC3 LOC100421419 ENSG00000271781 BRD9P2 ZDHHC11B BRD9 LOC100132773 TPPP CEP72 SLC9A3-AS1
GH05I001199 Promoter/Enhancer 2 EPDnew FANTOM5 ENCODE dbSUPER 9.7 -417.7 -417747 6.5 HDGF PKNOX1 ARNT ARID4B ZBTB7B POLR2B ZNF766 E2F8 MCM3 MCM5 SLC6A19 BRD9 LOC100132773 LOC100421419 SLC6A18 EXOC3 CTD-3080P12.3 ENSG00000271119 CCDC127 ENSG00000250173
GH05I000656 Enhancer 1.1 ENCODE dbSUPER 10.5 +127.1 127091 1.9 ATF1 RB1 ARNT BATF ZBTB40 TCF12 GATA2 EGR1 FOS CREM CEP72 ENSG00000271781 TRIP13 BRD9 BRD9P2 ZDHHC11B ENSG00000250173 SLC9A3 PIR37264 GC05P000643
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZDHHC11B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZDHHC11B gene promoter:

Genomic Locations for ZDHHC11B Gene

Genomic Locations for ZDHHC11B Gene
chr5:710,355-784,749
(GRCh38/hg38)
Size:
74,395 bases
Orientation:
Minus strand
chr5:710,475-767,067
(GRCh37/hg19)

Genomic View for ZDHHC11B Gene

Genes around ZDHHC11B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZDHHC11B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZDHHC11B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZDHHC11B Gene

Proteins for ZDHHC11B Gene

  • Protein details for ZDHHC11B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C7U3-ZH11B_HUMAN
    Recommended name:
    Probable palmitoyltransferase ZDHHC11B
    Protein Accession:
    P0C7U3
    Secondary Accessions:
    • A6NHR3

    Protein attributes for ZDHHC11B Gene

    Size:
    371 amino acids
    Molecular mass:
    41895 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZDHHC11B Gene

Post-translational modifications for ZDHHC11B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZDHHC11B Gene

Domains & Families for ZDHHC11B Gene

Gene Families for ZDHHC11B Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for ZDHHC11B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZDHHC11B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P0C7U3

UniProtKB/Swiss-Prot:

ZH11B_HUMAN :
  • The DHHC domain is required for palmitoyltransferase activity.
  • Belongs to the DHHC palmitoyltransferase family.
Domain:
  • The DHHC domain is required for palmitoyltransferase activity.
Family:
  • Belongs to the DHHC palmitoyltransferase family.
genes like me logo Genes that share domains with ZDHHC11B: view

Function for ZDHHC11B Gene

Molecular function for ZDHHC11B Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

Enzyme Numbers (IUBMB) for ZDHHC11B Gene

Gene Ontology (GO) - Molecular Function for ZDHHC11B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
GO:0019706 protein-cysteine S-palmitoyltransferase activity IEA --
genes like me logo Genes that share ontologies with ZDHHC11B: view

Phenotypes for ZDHHC11B Gene

GenomeRNAi human phenotypes for ZDHHC11B:
genes like me logo Genes that share phenotypes with ZDHHC11B: view

Animal Model Products

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZDHHC11B Gene

Localization for ZDHHC11B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZDHHC11B Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZDHHC11B gene
Compartment Confidence
plasma membrane 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Lipid droplets (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZDHHC11B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZDHHC11B: view

Pathways & Interactions for ZDHHC11B Gene

SuperPathways for ZDHHC11B Gene

No Data Available

Interacting Proteins for ZDHHC11B Gene

Gene Ontology (GO) - Biological Process for ZDHHC11B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZDHHC11B Gene

Drugs & Compounds for ZDHHC11B Gene

(1) Drugs for ZDHHC11B Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coenzyme A Investigational Nutra 0

(1) Additional Compounds for ZDHHC11B Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
hexadecanoyl-CoA
genes like me logo Genes that share compounds with ZDHHC11B: view

Transcripts for ZDHHC11B Gene

mRNA/cDNA for ZDHHC11B Gene

(18) REFSEQ mRNAs :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC11B Gene

No ASD Table

Relevant External Links for ZDHHC11B Gene

GeneLoc Exon Structure for
ZDHHC11B
ECgene alternative splicing isoforms for
ZDHHC11B

Expression for ZDHHC11B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZDHHC11B Gene

mRNA differential expression in normal tissues according to GTEx for ZDHHC11B Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x4.6) and Brain - Cerebellum (x4.3).

Protein differential expression in normal tissues from HIPED for ZDHHC11B Gene

This gene is overexpressed in Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZDHHC11B Gene



Protein tissue co-expression partners for ZDHHC11B Gene

NURSA nuclear receptor signaling pathways regulating expression of ZDHHC11B Gene:

ZDHHC11B
genes like me logo Genes that share expression patterns with ZDHHC11B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZDHHC11B Gene

Orthologs for ZDHHC11B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZDHHC11B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZDHHC11B 33
  • 96.51 (n)
-- 34
  • 95 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 53 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Zdhhc11 34
  • 52 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 47 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 44 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii CU694320.1 34
  • 32 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG17075 34
  • 11 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dhhc-11 34
  • 20 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ERF2 34
  • 15 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10560 34
  • 26 (a)
OneToMany
Species where no ortholog for ZDHHC11B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ZDHHC11B Gene

ENSEMBL:
Gene Tree for ZDHHC11B (if available)
TreeFam:
Gene Tree for ZDHHC11B (if available)

Paralogs for ZDHHC11B Gene

(4) SIMAP similar genes for ZDHHC11B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZDHHC11B: view

Variants for ZDHHC11B Gene

Sequence variations from dbSNP and Humsavar for ZDHHC11B Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000423341 -- 724,995(-) A/G genic_downstream_transcript_variant, intron_variant
rs1000734327 -- 773,928(-) C/G genic_upstream_transcript_variant, intron_variant
rs1000784782 -- 745,819(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000859682 -- 747,043(-) T/C genic_downstream_transcript_variant, intron_variant
rs1001104322 -- 772,546(-) G/A genic_upstream_transcript_variant, intron_variant

Variation tolerance for ZDHHC11B Gene

Gene Damage Index Score: 6.32; 76.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZDHHC11B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZDHHC11B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZDHHC11B Gene

Disorders for ZDHHC11B Gene

Additional Disease Information for ZDHHC11B

No disorders were found for ZDHHC11B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZDHHC11B Gene

Publications for ZDHHC11B Gene

  1. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J … Rubin EM (Nature 2004) 3 4 58

Products for ZDHHC11B Gene

Sources for ZDHHC11B Gene

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