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Aliases for ZDHHC11 Gene

Aliases for ZDHHC11 Gene

  • Zinc Finger DHHC-Type Containing 11 2 3 5
  • Zinc Finger DHHC Domain-Containing Protein 11 3 4
  • Zinc Finger Protein 399 3 4
  • DHHC-11 3 4
  • ZNF399 3 4
  • Zinc Finger, DHHC Domain Containing 11 3
  • Probable Palmitoyltransferase ZDHHC11 3
  • EC 4

External Ids for ZDHHC11 Gene

Previous GeneCards Identifiers for ZDHHC11 Gene

  • GC05M000838
  • GC05M000848
  • GC05M000764
  • GC05M000715
  • GC05M000717
  • GC05M000718
  • GC05M000719
  • GC05M000720
  • GC05M000721

Summaries for ZDHHC11 Gene

GeneCards Summary for ZDHHC11 Gene

ZDHHC11 (Zinc Finger DHHC-Type Containing 11) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein-cysteine S-palmitoyltransferase activity. An important paralog of this gene is ZDHHC11B.

Additional gene information for ZDHHC11 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZDHHC11 Gene

Genomics for ZDHHC11 Gene

GeneHancer (GH) Regulatory Elements for ZDHHC11 Gene

Promoters and enhancers for ZDHHC11 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I000752 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 13.6 +102.5 102500 7.9 HDGF FOXA2 ARID4B YBX1 ZBTB7B THRB RAD21 RARA ZNF207 ZNF143 ZDHHC11B ZDHHC11 SLC9A3-AS1 SLC9A3 EXOC3 ENSG00000271781 BRD9 TPPP PIR41835 PIR51794
GH05I000781 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 5.5 +74.7 74695 5 ATF1 ZNF121 GLIS2 KLF7 REST ZNF592 ZNF610 GLIS1 MYNN WT1 LOC101928768 ZDHHC11B BRD9 SDHAP3 LOC728613 ENSG00000271119 ZDHHC11 TPPP PIR45253
GH05I000668 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 5.2 +186.2 186197 8 HDGF HNRNPUL1 PKNOX1 SMAD1 ATF1 FOXA2 ARID4B NEUROD1 SIN3A GLI4 EXOC3 LOC100421419 ENSG00000271781 BRD9P2 ZDHHC11B BRD9 LOC100132773 TPPP CEP72 SLC9A3-AS1
GH05I000766 Enhancer 0.8 dbSUPER 10.5 +87.0 86989 11.3 HDGF SIX4 MEIS2 KLF1 PKNOX1 NFATC3 ASH1L ZIC2 E4F1 HIC1 ZDHHC11 SLC9A3-AS1 SLC9A3 ZDHHC11B GC05M000777 GC05M000779 GC05M000780 GC05M000781 PIR47044 PIR41472
GH05I000760 Enhancer 0.5 dbSUPER 15.3 +97.0 97022 2.3 STAT1 PKNOX1 POLR2A MNT FEZF1 MAFK ZDHHC11 SLC9A3-AS1 SLC9A3 PIR41835 PIR51794 ZDHHC11B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZDHHC11 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZDHHC11 gene promoter:

Genomic Locations for ZDHHC11 Gene

Genomic Locations for ZDHHC11 Gene
63,369 bases
Minus strand

Genomic View for ZDHHC11 Gene

Genes around ZDHHC11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZDHHC11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZDHHC11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZDHHC11 Gene

Proteins for ZDHHC11 Gene

  • Protein details for ZDHHC11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable palmitoyltransferase ZDHHC11
    Protein Accession:
    Secondary Accessions:
    • Q6UWR9

    Protein attributes for ZDHHC11 Gene

    412 amino acids
    Molecular mass:
    45975 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZDHHC11 Gene


neXtProt entry for ZDHHC11 Gene

Post-translational modifications for ZDHHC11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZDHHC11 Gene

Domains & Families for ZDHHC11 Gene

Gene Families for ZDHHC11 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for ZDHHC11 Gene

Suggested Antigen Peptide Sequences for ZDHHC11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The DHHC domain is required for palmitoyltransferase activity.
  • Belongs to the DHHC palmitoyltransferase family.
  • The DHHC domain is required for palmitoyltransferase activity.
  • Belongs to the DHHC palmitoyltransferase family.
genes like me logo Genes that share domains with ZDHHC11: view

Function for ZDHHC11 Gene

Molecular function for ZDHHC11 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

Enzyme Numbers (IUBMB) for ZDHHC11 Gene

Phenotypes From GWAS Catalog for ZDHHC11 Gene

Gene Ontology (GO) - Molecular Function for ZDHHC11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
GO:0019706 protein-cysteine S-palmitoyltransferase activity IEA --
genes like me logo Genes that share ontologies with ZDHHC11: view
genes like me logo Genes that share phenotypes with ZDHHC11: view

Animal Models for ZDHHC11 Gene

MGI Knock Outs for ZDHHC11:

Animal Model Products

  • Taconic Biosciences Mouse Models for ZDHHC11

miRNA for ZDHHC11 Gene

miRTarBase miRNAs that target ZDHHC11

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZDHHC11 Gene

Localization for ZDHHC11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZDHHC11 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZDHHC11 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Lipid droplets (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZDHHC11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 16647879
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZDHHC11: view

Pathways & Interactions for ZDHHC11 Gene

SuperPathways for ZDHHC11 Gene

No Data Available

Interacting Proteins for ZDHHC11 Gene

Gene Ontology (GO) - Biological Process for ZDHHC11 Gene


No data available for Pathways by source and SIGNOR curated interactions for ZDHHC11 Gene

Drugs & Compounds for ZDHHC11 Gene

(1) Drugs for ZDHHC11 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coenzyme A Investigational Nutra 0

(1) Additional Compounds for ZDHHC11 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ZDHHC11: view

Transcripts for ZDHHC11 Gene

Unigene Clusters for ZDHHC11 Gene

Zinc finger, DHHC-type containing 11:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC11 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^
SP1: - - - - - - - - - - - - -
SP2: - -
SP3: - - - - - - - - - - - - - - - - - -
SP4: - - - - - - - - - - - - - - - - - - -
SP6: - - - - - - - - - - - - - - - - -
SP7: -
SP8: - -
SP10: - - -

ExUns: 17 ^ 18 ^ 19 ^ 20

Relevant External Links for ZDHHC11 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZDHHC11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZDHHC11 Gene

Protein differential expression in normal tissues from HIPED for ZDHHC11 Gene

This gene is overexpressed in Urine (39.3), Ovary (20.1), and Pancreatic juice (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZDHHC11 Gene

Protein tissue co-expression partners for ZDHHC11 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZDHHC11 Gene:


SOURCE GeneReport for Unigene cluster for ZDHHC11 Gene:


Evidence on tissue expression from TISSUES for ZDHHC11 Gene

  • Skin(4.2)
genes like me logo Genes that share expression patterns with ZDHHC11: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZDHHC11 Gene

Orthologs for ZDHHC11 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZDHHC11 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZDHHC11 33
  • 97.37 (n)
-- 34
  • 93 (a)
(Mus musculus)
Mammalia Zdhhc11 33 16 34
  • 69.55 (n)
(Rattus norvegicus)
Mammalia Zdhhc11 33
  • 67.7 (n)
(Bos Taurus)
Mammalia ZDHHC11 33
  • 67.47 (n)
(Canis familiaris)
Mammalia ZDHHC11 33
  • 64.78 (n)
-- 34
  • 46 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 53 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 48 (a)
(Danio rerio)
Actinopterygii LOC100334198 33
  • 54.73 (n)
CU694320.1 34
  • 33 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG17075 34
  • 11 (a)
(Caenorhabditis elegans)
Secernentea dhhc-11 34
  • 21 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ERF2 34
  • 16 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10560 34
  • 27 (a)
Species where no ortholog for ZDHHC11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ZDHHC11 Gene

Gene Tree for ZDHHC11 (if available)
Gene Tree for ZDHHC11 (if available)

Paralogs for ZDHHC11 Gene

(2) SIMAP similar genes for ZDHHC11 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZDHHC11: view

Variants for ZDHHC11 Gene

Sequence variations from dbSNP and Humsavar for ZDHHC11 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000061653 -- 850,033(-) A/G genic_upstream_transcript_variant, intron_variant
rs1000078755 -- 861,801(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000100803 -- 836,337(-) A/C intron_variant
rs1000260627 -- 821,409(-) G/A intron_variant
rs1000491909 -- 810,318(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZDHHC11 Gene

Variant ID Type Subtype PubMed ID
dgv1001e199 CNV deletion 23128226
dgv1002e199 CNV deletion 23128226
dgv1063e214 CNV gain 21293372
dgv1064e214 CNV gain 21293372
dgv115e19 CNV loss 19470904
dgv116e19 CNV loss 19470904
dgv131e203 CNV gain+loss 21179565
dgv1560e212 CNV loss 25503493
dgv1561e212 CNV gain 25503493
dgv18n31 CNV gain 19718026
dgv195e55 CNV gain 17911159
dgv197e55 CNV gain 17911159
dgv198e55 CNV gain 17911159
dgv199e55 CNV gain 17911159
dgv206n111 CNV duplication 26073780
dgv207n111 CNV duplication 26073780
dgv3191e59 CNV duplication 20981092
dgv3192e59 CNV duplication 20981092
dgv3193e59 CNV duplication 20981092
dgv3194e59 CNV duplication 20981092
dgv345e215 CNV deletion 23714750
dgv5522n100 CNV gain 25217958
dgv5524n100 CNV gain 25217958
dgv5525n100 CNV gain 25217958
dgv5527n100 CNV gain+loss 25217958
dgv5531n100 CNV gain+loss 25217958
dgv5532n100 CNV loss 25217958
dgv5533n100 CNV gain+loss 25217958
dgv5534n100 CNV gain 25217958
dgv5535n100 CNV gain+loss 25217958
dgv5536n100 CNV gain 25217958
dgv5537n100 CNV loss 25217958
dgv5538n100 CNV gain 25217958
dgv5539n100 CNV gain 25217958
dgv5540n100 CNV loss 25217958
dgv5541n100 CNV gain+loss 25217958
dgv5542n100 CNV gain+loss 25217958
dgv5543n100 CNV loss 25217958
dgv5544n100 CNV loss 25217958
dgv5545n100 CNV loss 25217958
dgv5546n100 CNV gain 25217958
dgv5547n100 CNV gain+loss 25217958
dgv5548n100 CNV loss 25217958
dgv5549n100 CNV loss 25217958
dgv5550n100 CNV gain+loss 25217958
dgv5551n100 CNV gain 25217958
dgv7n29 CNV gain 16826518
dgv909e201 CNV deletion 23290073
dgv910e201 CNV deletion 23290073
dgv923n67 CNV gain 20364138
dgv924n67 CNV gain 20364138
dgv925n67 CNV gain 20364138
dgv926n67 CNV gain 20364138
dgv9498n54 CNV gain 21841781
dgv9499n54 CNV gain 21841781
dgv9512n54 CNV loss 21841781
dgv9513n54 CNV loss 21841781
dgv9514n54 CNV gain 21841781
dgv9515n54 CNV loss 21841781
dgv9516n54 CNV loss 21841781
esv24225 CNV gain+loss 19812545
esv2660977 CNV deletion 23128226
esv2729359 CNV deletion 23290073
esv2729364 CNV deletion 23290073
esv2752078 CNV loss 17911159
esv2759316 CNV gain+loss 17122850
esv3325793 CNV duplication 20981092
esv33266 CNV gain+loss 17666407
esv3332897 CNV duplication 20981092
esv3336574 CNV duplication 20981092
esv3357898 CNV duplication 20981092
esv3375918 CNV duplication 20981092
esv3383610 CNV duplication 20981092
esv33837 CNV gain 17666407
esv3399340 CNV duplication 20981092
esv3414923 CNV duplication 20981092
esv3450797 CNV duplication 20981092
esv34916 CNV gain 17911159
esv3565318 CNV deletion 23714750
esv3565322 CNV deletion 23714750
esv3575808 CNV gain 25503493
esv3603777 CNV loss 21293372
esv3603782 CNV loss 21293372
esv3894103 CNV loss 25118596
esv3894104 CNV loss 25118596
esv3894105 CNV gain+loss 25118596
esv3894107 CNV gain 25118596
nsv1019500 CNV loss 25217958
nsv1020000 CNV gain 25217958
nsv1020146 CNV gain+loss 25217958
nsv1031111 CNV gain+loss 25217958
nsv1032584 CNV gain 25217958
nsv10654 CNV gain+loss 18304495
nsv1073415 CNV deletion 25765185
nsv1078547 CNV duplication 25765185
nsv1110439 CNV duplication 24896259
nsv1118726 CNV duplication 24896259
nsv1126057 CNV deletion 24896259
nsv1128904 CNV duplication 24896259
nsv1130830 CNV deletion 24896259
nsv1132599 CNV duplication 24896259
nsv1133013 OTHER inversion 24896259
nsv1135950 CNV deletion 24896259
nsv1141469 CNV duplication 24896259
nsv1142629 CNV deletion 24896259
nsv1147234 OTHER inversion 26484159
nsv1147571 CNV duplication 26484159
nsv1147755 CNV duplication 26484159
nsv1161198 CNV duplication 26073780
nsv1161200 OTHER complex 26073780
nsv1161207 CNV deletion 26073780
nsv327579 CNV deletion 16902084
nsv329774 CNV insertion 16902084
nsv330058 CNV deletion 16902084
nsv428459 CNV gain+loss 18775914
nsv436473 CNV deletion 17901297
nsv436886 CNV insertion 17901297
nsv441936 CNV gain 18776908
nsv4675 CNV deletion 18451855
nsv469861 CNV gain 16826518
nsv471431 CNV gain 19718026
nsv471627 CNV gain+loss 15918152
nsv509043 CNV insertion 20534489
nsv510933 OTHER complex 20534489
nsv514286 CNV loss 21397061
nsv519464 CNV loss 19592680
nsv525620 CNV gain 19592680
nsv596629 CNV gain 21841781
nsv596711 CNV gain 21841781
nsv596714 CNV gain 21841781
nsv596741 CNV gain+loss 21841781
nsv596742 CNV gain 21841781
nsv596777 CNV gain 21841781
nsv596780 CNV loss 21841781
nsv818308 CNV gain 17921354
nsv821639 CNV gain 15273396
nsv822942 CNV loss 20364138
nsv822947 CNV gain 20364138
nsv822948 CNV gain 20364138
nsv822951 CNV gain 20364138
nsv830186 CNV gain 17160897
nsv950626 CNV duplication 24416366
nsv968133 CNV duplication 23825009
nsv968134 CNV duplication 23825009
nsv968866 CNV duplication 23825009
nsv968867 CNV duplication 23825009
nsv981008 CNV duplication 23825009

Variation tolerance for ZDHHC11 Gene

Residual Variation Intolerance Score: 97.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.11; 51.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZDHHC11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZDHHC11 Gene

Disorders for ZDHHC11 Gene

Additional Disease Information for ZDHHC11

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ZDHHC11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZDHHC11 Gene

Publications for ZDHHC11 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. Gain of 5p15.33 is associated with progression of bladder cancer. (PMID: 18025801) Yamamoto Y … Sasaki K (Oncology 2007) 3 22 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58

Products for ZDHHC11 Gene

Sources for ZDHHC11 Gene

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