Aliases for ZDHHC1 Gene

Aliases for ZDHHC1 Gene

  • Zinc Finger DHHC-Type Containing 1 2 3 5
  • DHHC Domain-Containing Cysteine-Rich Protein 1 3 4
  • Zinc Finger DHHC Domain-Containing Protein 1 3 4
  • Probable Palmitoyltransferase ZDHHC1 3 4
  • Zinc Finger Protein 377 3 4
  • C16orf1 3 4
  • DHHC-1 3 4
  • ZNF377 3 4
  • Zinc Finger, DHHC Domain Containing 1 3
  • Chromosome 16 Open Reading Frame 1 2
  • EC 2.3.1.225 4
  • HSU90653 3

External Ids for ZDHHC1 Gene

Previous HGNC Symbols for ZDHHC1 Gene

  • C16orf1

Previous GeneCards Identifiers for ZDHHC1 Gene

  • GC16M058122
  • GC16M067806
  • GC16M067163
  • GC16M067204
  • GC16M065985
  • GC16M067428
  • GC16M053301

Summaries for ZDHHC1 Gene

GeneCards Summary for ZDHHC1 Gene

ZDHHC1 (Zinc Finger DHHC-Type Containing 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein-cysteine S-palmitoyltransferase activity and palmitoyltransferase activity. An important paralog of this gene is ZDHHC11.

Additional gene information for ZDHHC1 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZDHHC1 Gene

Genomics for ZDHHC1 Gene

GeneHancer (GH) Regulatory Elements for ZDHHC1 Gene

Promoters and enhancers for ZDHHC1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J067413 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 761.3 +1.8 1799 4.1 CTCF ZBTB6 HCFC1 ZNF362 HLF RAD21 ZNF121 HDGF POLR2A BCL6B ZDHHC1 lnc-ZDHHC1-1 TPPP3 THAP11 PRMT7 ATP6V0D1 LRRC36 E2F4 CTCF EDC4
GH16J067417 Enhancer 0.4 FANTOM5 750.6 -1.0 -983 0.3 CREB1 ZNF335 ZDHHC1 lnc-ZDHHC1-1 PLEKHG4 RRAD RIPOR1 CBFB FHOD1 HSD11B2
GH16J067479 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 28 -64.9 -64933 5.5 SIN3A SP1 ZBTB40 CTCF SREBF1 ZBTB6 FOXA1 MLX RBPJ SMARCE1 ATP6V0D1 ENSG00000270049 LOC101927837 lnc-AGRP-6 CENPT EDC4 E2F4 CTCF ZDHHC1 ENSG00000260465
GH16J067841 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas 28.4 -428.1 -428124 7.5 SP1 ZBTB40 CTCF SIX5 FOXA1 RBPJ SMARCE1 POLR2A HDAC2 NR2F6 NUTF2 EDC4 CENPT NAE1 E2F4 NFATC3 CTCF ZFP90 PRMT7 ACD
GH16J068077 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 19.8 -668.8 -668848 16 SIN3A SP1 ZBTB40 SIX5 LCORL FOXA1 MLX RBPJ SMARCE1 POLR2A NFATC3 lnc-DDX28-2 EDC4 E2F4 PRMT7 ACD CENPT TRADD CTCF PSKH1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZDHHC1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZDHHC1 gene promoter:
  • C/EBPalpha
  • CUTL1
  • HNF-4alpha1
  • HNF-4alpha2
  • Olf-1
  • Sp1
  • SRY

Genomic Locations for ZDHHC1 Gene

Genomic Locations for ZDHHC1 Gene
chr16:67,394,152-67,416,833
(GRCh38/hg38)
Size:
22,682 bases
Orientation:
Minus strand
chr16:67,428,322-67,450,736
(GRCh37/hg19)
Size:
22,415 bases
Orientation:
Minus strand

Genomic View for ZDHHC1 Gene

Genes around ZDHHC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZDHHC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZDHHC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZDHHC1 Gene

Proteins for ZDHHC1 Gene

  • Protein details for ZDHHC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WTX9-ZDHC1_HUMAN
    Recommended name:
    Probable palmitoyltransferase ZDHHC1
    Protein Accession:
    Q8WTX9
    Secondary Accessions:
    • O15461

    Protein attributes for ZDHHC1 Gene

    Size:
    485 amino acids
    Molecular mass:
    54818 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZDHHC1 Gene

Post-translational modifications for ZDHHC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZDHHC1 Gene

Domains & Families for ZDHHC1 Gene

Gene Families for ZDHHC1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for ZDHHC1 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZDHHC1 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 377 (ZDHC1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8WTX9

UniProtKB/Swiss-Prot:

ZDHC1_HUMAN :
  • The DHHC domain is required for palmitoyltransferase activity.
  • Belongs to the DHHC palmitoyltransferase family.
Domain:
  • The DHHC domain is required for palmitoyltransferase activity.
Family:
  • Belongs to the DHHC palmitoyltransferase family.
genes like me logo Genes that share domains with ZDHHC1: view

Function for ZDHHC1 Gene

Molecular function for ZDHHC1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151; EC=2.3.1.225;.

Enzyme Numbers (IUBMB) for ZDHHC1 Gene

Phenotypes From GWAS Catalog for ZDHHC1 Gene

Gene Ontology (GO) - Molecular Function for ZDHHC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding NAS 10395086
GO:0016409 palmitoyltransferase activity IEA,IDA 23034182
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
GO:0019706 protein-cysteine S-palmitoyltransferase activity IBA 21873635
genes like me logo Genes that share ontologies with ZDHHC1: view
genes like me logo Genes that share phenotypes with ZDHHC1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ZDHHC1

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZDHHC1

Clone Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZDHHC1 Gene

Localization for ZDHHC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZDHHC1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZDHHC1 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 3
plasma membrane 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZDHHC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IBA,IDA 16647879
GO:0005794 Golgi apparatus IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with ZDHHC1: view

Pathways & Interactions for ZDHHC1 Gene

PathCards logo

SuperPathways for ZDHHC1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZDHHC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006612 protein targeting to membrane IBA 21873635
GO:0018230 peptidyl-L-cysteine S-palmitoylation IBA 21873635
GO:0018345 protein palmitoylation IEA,IDA 23034182
genes like me logo Genes that share ontologies with ZDHHC1: view

No data available for Pathways by source and SIGNOR curated interactions for ZDHHC1 Gene

Drugs & Compounds for ZDHHC1 Gene

(1) Drugs for ZDHHC1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coenzyme A Investigational Nutra 0

(1) Additional Compounds for ZDHHC1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
hexadecanoyl-CoA
  • coenzyme A, S-Hexadecanoate
  • Palmitoyl coenzyme A
  • S-Palmitoylcoenzyme A
  • coenzyme A, S-Hexadecanoic acid
genes like me logo Genes that share compounds with ZDHHC1: view

Transcripts for ZDHHC1 Gene

mRNA/cDNA for ZDHHC1 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZDHHC1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15a · 15b
SP1: - - - -
SP2:
SP3:
SP4:
SP5: -
SP6: -

Relevant External Links for ZDHHC1 Gene

GeneLoc Exon Structure for
ZDHHC1
ECgene alternative splicing isoforms for
ZDHHC1

Expression for ZDHHC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZDHHC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZDHHC1 Gene

This gene is overexpressed in Placenta (60.3) and Urine (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZDHHC1 Gene



Protein tissue co-expression partners for ZDHHC1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZDHHC1 Gene:

ZDHHC1

SOURCE GeneReport for Unigene cluster for ZDHHC1 Gene:

Hs.624541

mRNA Expression by UniProt/SwissProt for ZDHHC1 Gene:

Q8WTX9-ZDHC1_HUMAN
Tissue specificity: Expressed at high levels in fetal lung, kidney and heart. Expressed at lower levels in adult pancreas and lung.

Evidence on tissue expression from TISSUES for ZDHHC1 Gene

  • Pancreas(4.2)
  • Nervous system(2.8)
genes like me logo Genes that share expression patterns with ZDHHC1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZDHHC1 Gene

Orthologs for ZDHHC1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZDHHC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZDHHC1 33 32
  • 99.66 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZDHHC1 33 32
  • 88.77 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Zdhhc1 17 33 32
  • 85.22 (n)
rat
(Rattus norvegicus)
Mammalia Zdhhc1 32
  • 84.66 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 33
  • 79 (a)
OneToMany
-- 33
  • 77 (a)
OneToMany
cow
(Bos Taurus)
Mammalia ZDHHC1 33
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZDHHC1 33
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZDHHC1 33 32
  • 63.25 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZDHHC1 33
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zdhhc1 32
  • 60.6 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC562614 32
  • 63.02 (n)
ZDHHC1 33
  • 38 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG17075 33
  • 15 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dhhc-11 33
  • 22 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ERF2 33
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10560 33
  • 30 (a)
OneToMany
Species where no ortholog for ZDHHC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZDHHC1 Gene

ENSEMBL:
Gene Tree for ZDHHC1 (if available)
TreeFam:
Gene Tree for ZDHHC1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZDHHC1: view image

Paralogs for ZDHHC1 Gene

(7) SIMAP similar genes for ZDHHC1 Gene using alignment to 2 proteins:

  • ZDHC1_HUMAN
  • I3L202_HUMAN

Pseudogenes.org Pseudogenes for ZDHHC1 Gene

genes like me logo Genes that share paralogs with ZDHHC1: view

Variants for ZDHHC1 Gene

Sequence variations from dbSNP and Humsavar for ZDHHC1 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000177730 -- 67,394,562(-) A/G 3_prime_UTR_variant
rs1000179875 -- 67,398,064(-) A/C intron_variant
rs1000228402 -- 67,400,966(-) T/C coding_sequence_variant, missense_variant
rs1000781587 -- 67,399,448(-) C/T coding_sequence_variant, missense_variant
rs1000787556 -- 67,407,348(-) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZDHHC1 Gene

Variant ID Type Subtype PubMed ID
nsv471092 CNV gain 18288195
nsv522852 CNV gain 19592680
nsv524363 CNV loss 19592680
nsv827710 CNV gain 20364138
nsv833266 CNV loss 17160897
nsv952045 CNV deletion 24416366

Variation tolerance for ZDHHC1 Gene

Residual Variation Intolerance Score: 12.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.39; 42.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZDHHC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZDHHC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZDHHC1 Gene

Disorders for ZDHHC1 Gene

Additional Disease Information for ZDHHC1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ZDHHC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZDHHC1 Gene

Publications for ZDHHC1 Gene

  1. The DHHC domain: a new highly conserved cysteine-rich motif. (PMID: 10395086) Putilina T … Gentleman S (Molecular and cellular biochemistry 1999) 2 3 4 56
  2. Genome-wide searching of rare genetic variants in WTCCC data. (PMID: 20549515) Feng T … Zhu X (Human genetics 2010) 3 43 56
  3. Intracellular localization and tissue-specific distribution of human and yeast DHHC cysteine-rich domain-containing proteins. (PMID: 16647879) Ohno Y … Igarashi Y (Biochimica et biophysica acta 2006) 3 23 56
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56

Products for ZDHHC1 Gene

Sources for ZDHHC1 Gene