ZDHHC1 Gene (Protein Coding)

Zinc Finger DHHC-Type Containing 1

GC16M067394
GIFtS:
35
See more...

Aliases for ZDHHC1 Gene

Aliases for ZDHHC1 Gene

  • Zinc Finger DHHC-Type Containing 1 2 3 5
  • ZNF377 2 3 4
  • DHHC Domain-Containing Cysteine-Rich Protein 1 3 4
  • Zinc Finger DHHC Domain-Containing Protein 1 3 4
  • Palmitoyltransferase ZDHHC1 3 4
  • Zinc Finger Protein 377 3 4
  • HSU90653 2 3
  • C16orf1 3 4
  • DHHC-1 3 4
  • Zinc Finger, DHHC Domain Containing 1 3
  • Probable Palmitoyltransferase ZDHHC1 3
  • Chromosome 16 Open Reading Frame 1 2
  • EC 2.3.1.225 4
  • ZDHHC1 5

External Ids for ZDHHC1 Gene

Previous HGNC Symbols for ZDHHC1 Gene

  • C16orf1

Previous GeneCards Identifiers for ZDHHC1 Gene

  • GC16M058122
  • GC16M067806
  • GC16M067163
  • GC16M067204
  • GC16M065985
  • GC16M067428
  • GC16M053301

Summaries for ZDHHC1 Gene

GeneCards Summary for ZDHHC1 Gene

ZDHHC1 (Zinc Finger DHHC-Type Containing 1) is a Protein Coding gene. Diseases associated with ZDHHC1 include Phencyclidine Abuse. Gene Ontology (GO) annotations related to this gene include protein-cysteine S-palmitoyltransferase activity and palmitoyltransferase activity. An important paralog of this gene is ZDHHC11B.

UniProtKB/Swiss-Prot Summary for ZDHHC1 Gene

  • Has a palmitoyltransferase activity and palmitoylates NCDN thereby regulating its association with endosome membranes.
  • Could also be involved in DNA virus-triggered and CGAS-mediated innate immune response through the regulation of MITA activation by cGAMP (PubMed:25299331). The function in innate immune response is probably independent of the palmitoyltransferase activity (PubMed:25299331).

Additional gene information for ZDHHC1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZDHHC1 Gene

Genomics for ZDHHC1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for ZDHHC1 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH16J067413 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 600.7 +1.8 1799 4.1 RNF2 RFX1 KDM1A CTCF ZNF692 LARP7 ZNF143 ZIC2 RBFOX2 RXRB ZDHHC1 lnc-ZDHHC1-1 TPPP3 PRMT7 ATP6V0D1 LRRC36 THAP11 FHOD1 PLEKHG4 SLC12A4
GH16J067417 Enhancer 0.4 FANTOM5 600.7 -1.0 -983 0.3 CREB1 ZNF335 TOE1 ZDHHC1 lnc-ZDHHC1-1 PLEKHG4 RRAD RIPOR1 CBFB FHOD1 HSD11B2
GH16J067479 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 38.5 -64.9 -64933 5.5 SP1 CREB1 GATAD2A CTCF ZNF629 TFE3 RFX1 LEF1 IKZF1 NFKBIZ ATP6V0D1 AGRP LOC101927837 lnc-AGRP-6 ZDHHC1 ENKD1 NAE1 EDC4 CENPT CTCF
GH16J067841 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas 39.6 -428.1 -428124 7.5 SP1 HNRNPL CREB1 GATAD2A CTCF TEAD4 PRDM10 ZNF629 TFE3 SIX5 NUTF2 ZDHHC1 NAE1 EDC4 CENPT ENKD1 RANBP10 CTCF ZFP90 ACD
GH16J067555 Enhancer 1 ENCODE dbSUPER 78.2 -139.5 -139475 2 ZNF629 ZNF692 PATZ1 ZNF501 ZNF341 SCRT2 ZBTB44 RBAK ZNF140 ZNF639 ZDHHC1 EDC4 CENPT ENSG00000260465 ENKD1 CTCF E2F4 NAE1 ENSG00000263276 ACD
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZDHHC1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZDHHC1

Top Transcription factor binding sites by QIAGEN in the ZDHHC1 gene promoter:
  • C/EBPalpha
  • CUTL1
  • HNF-4alpha1
  • HNF-4alpha2
  • Olf-1
  • Sp1
  • SRY

Genomic Locations for ZDHHC1 Gene

Genomic Locations for ZDHHC1 Gene
chr16:67,394,152-67,416,833
(GRCh38/hg38)
Size:
22,682 bases
Orientation:
Minus strand
chr16:67,428,322-67,450,736
(GRCh37/hg19)
Size:
22,415 bases
Orientation:
Minus strand

Genomic View for ZDHHC1 Gene

Genes around ZDHHC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZDHHC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZDHHC1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ZDHHC1 Gene

Proteins for ZDHHC1 Gene

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  1. Antibody
  2. Protein
  3. Assay

  • Protein details for ZDHHC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WTX9-ZDHC1_HUMAN
    Recommended name:
    Palmitoyltransferase ZDHHC1
    Protein Accession:
    Q8WTX9
    Secondary Accessions:
    • O15461

    Protein attributes for ZDHHC1 Gene

    Size:
    485 amino acids
    Molecular mass:
    54818 Da
    Quaternary structure:
    • Interacts with STING1; ZDHHC1 constitutively interacts with STING1 and in presence of DNA viruses activates it by promoting its cGAMP-induced oligomerization and the recruitment of downstream signaling components.

neXtProt entry for ZDHHC1 Gene

Protein Expression for ZDHHC1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for ZDHHC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZDHHC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZDHHC1 Gene

Domains & Families for ZDHHC1 Gene

Gene Families for ZDHHC1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for ZDHHC1 Gene

InterPro:
Blocks:
  • Zn-finger, DHHC type
ProtoNet:

Suggested Antigen Peptide Sequences for ZDHHC1 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 377 (ZDHC1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8WTX9

UniProtKB/Swiss-Prot:

ZDHC1_HUMAN :
  • The DHHC domain is required for palmitoyltransferase activity.
  • Belongs to the DHHC palmitoyltransferase family.
Domain:
  • The DHHC domain is required for palmitoyltransferase activity.
Family:
  • Belongs to the DHHC palmitoyltransferase family.
genes like me logo Genes that share domains with ZDHHC1: view

Function for ZDHHC1 Gene

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  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
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  6. Cell Line

Molecular function for ZDHHC1 Gene

UniProtKB/Swiss-Prot Function:
Has a palmitoyltransferase activity and palmitoylates NCDN thereby regulating its association with endosome membranes.
UniProtKB/Swiss-Prot Function:
Could also be involved in DNA virus-triggered and CGAS-mediated innate immune response through the regulation of MITA activation by cGAMP (PubMed:25299331). The function in innate immune response is probably independent of the palmitoyltransferase activity (PubMed:25299331).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151; EC=2.3.1.225; Evidence={ECO:0000250|UniProtKB:Q8R0N9};.

Enzyme Numbers (IUBMB) for ZDHHC1 Gene

Phenotypes From GWAS Catalog for ZDHHC1 Gene

Gene Ontology (GO) - Molecular Function for ZDHHC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding NAS 10395086
GO:0005515 protein binding IPI 25299331
GO:0016409 palmitoyltransferase activity IDA 23034182
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
genes like me logo Genes that share ontologies with ZDHHC1: view
genes like me logo Genes that share phenotypes with ZDHHC1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ZDHHC1

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZDHHC1

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZDHHC1 Gene

Localization for ZDHHC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZDHHC1 Gene

Endosome membrane. Multi-pass membrane protein. Endoplasmic reticulum membrane. Multi-pass membrane protein. Golgi apparatus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZDHHC1 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 5
extracellular 4
endosome 3
plasma membrane 2
cytosol 2
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZDHHC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IBA,IDA 16647879
GO:0005789 endoplasmic reticulum membrane IDA 25299331
GO:0005794 Golgi apparatus IBA,IDA 25299331
GO:0010008 endosome membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ZDHHC1: view

Pathways & Interactions for ZDHHC1 Gene

PathCards logo

SuperPathways for ZDHHC1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZDHHC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002230 positive regulation of defense response to virus by host IEA,IMP 25299331
GO:0006612 protein targeting to membrane IBA 21873635
GO:0018230 peptidyl-L-cysteine S-palmitoylation IEA,IBA 21873635
GO:0018345 protein palmitoylation IEA,IDA 23034182
GO:0032461 positive regulation of protein oligomerization IEA --
genes like me logo Genes that share ontologies with ZDHHC1: view

No data available for Pathways by source and SIGNOR curated interactions for ZDHHC1 Gene

Drugs & Compounds for ZDHHC1 Gene

Products:

  1. Drug

(1) Drugs for ZDHHC1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coenzyme A Investigational Nutra 0

(1) Additional Compounds for ZDHHC1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
hexadecanoyl-CoA
  • coenzyme A, S-Hexadecanoate
  • Palmitoyl coenzyme A
  • S-Palmitoylcoenzyme A
  • coenzyme A, S-Hexadecanoic acid
genes like me logo Genes that share compounds with ZDHHC1: view

Transcripts for ZDHHC1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for ZDHHC1 Gene

2 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZDHHC1

Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15a · 15b
SP1: - - - -
SP2:
SP3:
SP4:
SP5: -
SP6: -

Relevant External Links for ZDHHC1 Gene

GeneLoc Exon Structure for
ZDHHC1

Expression for ZDHHC1 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZDHHC1 Gene

mRNA expression in normal human tissues for ZDHHC1 Gene
mRNA expression by GTEx for ZDHHC1 GenemRNA expression by BioGPS for ZDHHC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZDHHC1 Gene

This gene is overexpressed in Placenta (60.3) and Urine (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZDHHC1 Gene



Protein tissue co-expression partners for ZDHHC1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZDHHC1

SOURCE GeneReport for Unigene cluster for ZDHHC1 Gene:

Hs.624541

mRNA Expression by UniProt/SwissProt for ZDHHC1 Gene:

Q8WTX9-ZDHC1_HUMAN
Tissue specificity: Widely expressed with significant expression in heart, brain, placenta, lung, liver, kidney, testis, thymus and small intestine (PubMed:16647879). Expressed at lower levels in adult pancreas and lung (PubMed:10395086).

Evidence on tissue expression from TISSUES for ZDHHC1 Gene

  • Pancreas(4.2)
  • Nervous system(3)
genes like me logo Genes that share expression patterns with ZDHHC1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZDHHC1 Gene

Orthologs for ZDHHC1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZDHHC1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia ZDHHC1 30 31
  • 99.66 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia ZDHHC1 30 31
  • 88.77 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Zdhhc1 30 17 31
  • 85.22 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Zdhhc1 30
  • 84.66 (n)
Platypus
(Ornithorhynchus anatinus)
 Mammalia -- 31
  • 79 (a)
 OneToMany
-- 31
  • 77 (a)
 OneToMany
Cow
(Bos Taurus)
 Mammalia ZDHHC1 31
  • 75 (a)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia ZDHHC1 31
  • 61 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves ZDHHC1 30 31
  • 63.25 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia ZDHHC1 31
  • 51 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia zdhhc1 30
  • 60.6 (n)
Zebrafish
(Danio rerio)
 Actinopterygii LOC562614 30
  • 63.02 (n)
ZDHHC1 31
  • 38 (a)
 OneToOne
Fruit Fly
(Drosophila melanogaster)
 Insecta CG17075 31
  • 15 (a)
 OneToMany
Worm
(Caenorhabditis elegans)
 Secernentea dhhc-11 31
  • 22 (a)
 OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes ERF2 31
  • 19 (a)
 OneToMany
Sea Squirt
(Ciona savignyi)
 Ascidiacea CSA.10560 31
  • 30 (a)
 OneToMany
Species where no ortholog for ZDHHC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ZDHHC1 Gene

ENSEMBL:
Gene Tree for ZDHHC1 (if available)
TreeFam:
Gene Tree for ZDHHC1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZDHHC1: view image

Paralogs for ZDHHC1 Gene

Paralogs for ZDHHC1 Gene

(7) SIMAP similar genes for ZDHHC1 Gene using alignment to 2 proteins:

  • ZDHC1_HUMAN
  • I3L202_HUMAN

Pseudogenes.org Pseudogenes for ZDHHC1 Gene

genes like me logo Genes that share paralogs with ZDHHC1: view

Variants for ZDHHC1 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZDHHC1 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
790708 Benign: not provided 67,406,302(-) C/T SYNONYMOUS_VARIANT
rs34229857 - p.Arg124Gln

Additional dbSNP identifiers (rs#s) for ZDHHC1 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZDHHC1 Gene

Variant ID Type Subtype PubMed ID
nsv471092 CNV gain 18288195
nsv522852 CNV gain 19592680
nsv524363 CNV loss 19592680
nsv827710 CNV gain 20364138
nsv833266 CNV loss 17160897
nsv952045 CNV deletion 24416366

Variation tolerance for ZDHHC1 Gene

Residual Variation Intolerance Score: 12.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.39; 42.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZDHHC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZDHHC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZDHHC1 Gene

Disorders for ZDHHC1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZDHHC1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
phencyclidine abuse
  • pcp abuse
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZDHHC1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with ZDHHC1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZDHHC1 Gene

Publications for ZDHHC1 Gene

  1. Intracellular localization and tissue-specific distribution of human and yeast DHHC cysteine-rich domain-containing proteins. (PMID: 16647879) Ohno Y … Igarashi Y (Biochimica et biophysica acta 2006) 3 4 23
  2. The DHHC domain: a new highly conserved cysteine-rich motif. (PMID: 10395086) Putilina T … Gentleman S (Molecular and cellular biochemistry 1999) 2 3 4
  3. The ER-associated protein ZDHHC1 is a positive regulator of DNA virus-triggered, MITA/STING-dependent innate immune signaling. (PMID: 25299331) Zhou Q … Wang YY (Cell host & microbe 2014) 3 4
  4. In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in its targeting to Rab5-positive endosomes. (PMID: 23687301) Oku S … Fukata M (The Journal of biological chemistry 2013) 2 3
  5. Genome-wide searching of rare genetic variants in WTCCC data. (PMID: 20549515) Feng T … Zhu X (Human genetics 2010) 3 41

ExternalLinks

View latest publications for ZDHHC1 gene in Mastermind

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