Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZCWPW2 Gene

Aliases for ZCWPW2 Gene

  • Zinc Finger CW-Type And PWWP Domain Containing 2 2 3 5
  • Zinc Finger, CW Type With PWWP Domain 2 2 3
  • Zinc Finger CW-Type PWWP Domain Protein 2 3
  • Zinc Finger CW-Type And PWWP Domain 2 3
  • ZCW2 3

External Ids for ZCWPW2 Gene

Previous GeneCards Identifiers for ZCWPW2 Gene

  • GC00U920636

Summaries for ZCWPW2 Gene

GeneCards Summary for ZCWPW2 Gene

ZCWPW2 (Zinc Finger CW-Type And PWWP Domain Containing 2) is a Protein Coding gene. An important paralog of this gene is ENSG00000283563.

Additional gene information for ZCWPW2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZCWPW2 Gene

Genomics for ZCWPW2 Gene

GeneHancer (GH) Regulatory Elements for ZCWPW2 Gene

Promoters and enhancers for ZCWPW2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I028346 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 -0.9 -936 3.9 HDGF PKNOX1 CLOCK SMAD1 ARNT ARID4B SIN3A DMAP1 IRF4 YY1 AZI2 ZCWPW2 ENSG00000283563 GC03P028315
GH03I028392 Promoter 0.5 EPDnew 550.3 +42.9 42914 0.1 ZCWPW2 FAM96AP1 AZI2 ENSG00000283563
GH03I027479 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 4.8 -866.7 -866683 6.4 PKNOX1 ATF1 ARID4B SIN3A DMAP1 ZBTB7B ZNF48 YY1 ETS1 GLIS2 SLC4A7 RNU1-96P NEK10 ZCWPW2 RPS20P15
GH03I027665 Enhancer 0.8 Ensembl ENCODE 10.4 -682.4 -682416 1.5 PKNOX1 MXI1 USF1 RFX1 MAX SIN3A BMI1 ETS1 RFX3 POLR2A RNU1-96P ZCWPW2 AZI2 ENSG00000271943 ENSG00000232766
GH03I028326 Enhancer 0.7 ENCODE 11.5 -22.4 -22401 1 PKNOX1 SMAD1 BMI1 GATA3 ATF7 NFE2 IKZF2 RUNX3 SRF SMARCA5 ZCWPW2 AZI2 CMC1 GC03P028315
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZCWPW2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZCWPW2 gene promoter:

Genomic Locations for ZCWPW2 Gene

Genomic Locations for ZCWPW2 Gene
chr3:28,349,146-28,538,122
(GRCh38/hg38)
Size:
188,977 bases
Orientation:
Plus strand
chr3:28,390,637-28,579,613
(GRCh37/hg19)

Genomic View for ZCWPW2 Gene

Genes around ZCWPW2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZCWPW2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZCWPW2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZCWPW2 Gene

Proteins for ZCWPW2 Gene

  • Protein details for ZCWPW2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q504Y3-ZCPW2_HUMAN
    Recommended name:
    Zinc finger CW-type PWWP domain protein 2
    Protein Accession:
    Q504Y3

    Protein attributes for ZCWPW2 Gene

    Size:
    356 amino acids
    Molecular mass:
    41376 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ZCWPW2 Gene

neXtProt entry for ZCWPW2 Gene

Post-translational modifications for ZCWPW2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for ZCWPW2 Gene

Domains & Families for ZCWPW2 Gene

Gene Families for ZCWPW2 Gene

Protein Domains for ZCWPW2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ZCWPW2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZCWPW2: view

No data available for UniProtKB/Swiss-Prot for ZCWPW2 Gene

Function for ZCWPW2 Gene

Phenotypes From GWAS Catalog for ZCWPW2 Gene

Gene Ontology (GO) - Molecular Function for ZCWPW2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZCWPW2: view

Phenotypes for ZCWPW2 Gene

genes like me logo Genes that share phenotypes with ZCWPW2: view

Animal Model Products

CRISPR Products

miRNA for ZCWPW2 Gene

miRTarBase miRNAs that target ZCWPW2

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZCWPW2 Gene

Localization for ZCWPW2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZCWPW2 gene
Compartment Confidence
nucleus 2
cytosol 2
plasma membrane 1
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ZCWPW2 Gene

Pathways & Interactions for ZCWPW2 Gene

SuperPathways for ZCWPW2 Gene

No Data Available

Interacting Proteins for ZCWPW2 Gene

Selected Interacting proteins: Q504Y3-ZCPW2_HUMAN for ZCWPW2 Gene via IID

Gene Ontology (GO) - Biological Process for ZCWPW2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZCWPW2 Gene

Drugs & Compounds for ZCWPW2 Gene

No Compound Related Data Available

Transcripts for ZCWPW2 Gene

Unigene Clusters for ZCWPW2 Gene

Zinc finger, CW type with PWWP domain 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZCWPW2 Gene

No ASD Table

Relevant External Links for ZCWPW2 Gene

GeneLoc Exon Structure for
ZCWPW2
ECgene alternative splicing isoforms for
ZCWPW2

Expression for ZCWPW2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZCWPW2 Gene

mRNA differential expression in normal tissues according to GTEx for ZCWPW2 Gene

This gene is overexpressed in Testis (x6.0).

NURSA nuclear receptor signaling pathways regulating expression of ZCWPW2 Gene:

ZCWPW2

SOURCE GeneReport for Unigene cluster for ZCWPW2 Gene:

Hs.539824
genes like me logo Genes that share expression patterns with ZCWPW2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZCWPW2 Gene

Orthologs for ZCWPW2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZCWPW2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZCWPW2 33 34
  • 98.88 (n)
dog
(Canis familiaris)
Mammalia ZCWPW2 33 34
  • 88.2 (n)
cow
(Bos Taurus)
Mammalia ZCWPW2 33 34
  • 85.12 (n)
mouse
(Mus musculus)
Mammalia Zcwpw2 33 16 34
  • 76.5 (n)
rat
(Rattus norvegicus)
Mammalia Zcwpw2 33
  • 74.75 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 71 (a)
OneToMany
-- 34
  • 46 (a)
OneToMany
-- 34
  • 7 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia ZCWPW2 34
  • 60 (a)
OneToOne
Species where no ortholog for ZCWPW2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZCWPW2 Gene

ENSEMBL:
Gene Tree for ZCWPW2 (if available)
TreeFam:
Gene Tree for ZCWPW2 (if available)

Paralogs for ZCWPW2 Gene

Paralogs for ZCWPW2 Gene

(12) SIMAP similar genes for ZCWPW2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZCWPW2: view

Variants for ZCWPW2 Gene

Sequence variations from dbSNP and Humsavar for ZCWPW2 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000007672 -- 28,376,588(+) C/G genic_upstream_transcript_variant, intron_variant
rs1000050273 -- 28,407,435(+) A/G/T intron_variant
rs1000076633 -- 28,481,047(+) A/T intron_variant
rs1000099845 -- 28,411,197(+) C/T intron_variant
rs1000100240 -- 28,498,528(+) G/A genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZCWPW2 Gene

Variant ID Type Subtype PubMed ID
esv2480638 CNV deletion 19546169
esv2664973 CNV deletion 23128226
esv2674700 CNV deletion 23128226
esv2725072 CNV deletion 23290073
esv3389027 CNV insertion 20981092
esv3595688 CNV loss 21293372
esv3595689 CNV loss 21293372
nsv979813 CNV duplication 23825009
nsv590010 CNV gain 21841781
nsv473874 CNV novel sequence insertion 20440878
nsv3746 CNV insertion 18451855
nsv1120136 OTHER inversion 24896259
nsv1015015 CNV gain 25217958
nsv1004457 CNV loss 25217958
esv996568 OTHER inversion 20482838
esv3595691 CNV gain 21293372
esv3595690 CNV loss 21293372

Variation tolerance for ZCWPW2 Gene

Residual Variation Intolerance Score: 71.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.28; 70.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZCWPW2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZCWPW2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZCWPW2 Gene

Disorders for ZCWPW2 Gene

Additional Disease Information for ZCWPW2

No disorders were found for ZCWPW2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZCWPW2 Gene

Publications for ZCWPW2 Gene

  1. The CW domain, a structural module shared amongst vertebrates, vertebrate-infecting parasites and higher plants. (PMID: 14607086) Perry J … Zhao Y (Trends in biochemical sciences 2003) 2 3 58
  2. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PMID: 23314748) Nathan JA … Goldberg AL (The EMBO journal 2013) 3 58
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  5. Molecular characterization of a human monoclonal antibody to B antigen in ABO blood type. (PMID: 12600744) Kaneko M … Osawa M (Immunology letters 2003) 3 58

Products for ZCWPW2 Gene

Sources for ZCWPW2 Gene

Content
Loading form....