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Aliases for ZCWPW1 Gene

Aliases for ZCWPW1 Gene

  • Zinc Finger CW-Type And PWWP Domain Containing 1 2 3 5
  • Zinc Finger, CW-Type With PWWP Domain 1 2 3
  • Zinc Finger CW-Type PWWP Domain Protein 1 3
  • Zinc Finger CW-Type And PWWP Domain 1 3
  • ZCW1 3

External Ids for ZCWPW1 Gene

Previous GeneCards Identifiers for ZCWPW1 Gene

  • GC07M099609
  • GC07M099643
  • GC07M099836
  • GC07M099998
  • GC07M094634

Summaries for ZCWPW1 Gene

GeneCards Summary for ZCWPW1 Gene

ZCWPW1 (Zinc Finger CW-Type And PWWP Domain Containing 1) is a Protein Coding gene. An important paralog of this gene is ZCWPW2.

Additional gene information for ZCWPW1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZCWPW1 Gene

Genomics for ZCWPW1 Gene

GeneHancer (GH) Regulatory Elements for ZCWPW1 Gene

Promoters and enhancers for ZCWPW1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I100427 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 550.8 -3.8 -3785 10.8 CLOCK ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 PPP1R35 MEPCE PIR54054 ZCWPW1 ZSCAN25 TRIM4 SRRT GIGYF1 ZNF3 PILRA
GH07I100364 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 16.9 +58.4 58445 12.5 HDGF PKNOX1 ATF1 YBX1 ZBTB7B ZNF121 POLR2B E2F8 ZNF207 ZNF143 PILRA ZCWPW1 MEPCE MOSPD3 LAMTOR4 C7orf43 PVRIG ENSG00000241357 STAG3 GPC2
GH07I100475 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.1 -48.3 -48341 4.4 HDGF PKNOX1 FOXA2 SMAD1 ARNT ZFP64 ARID4B SIN3A FEZF1 ZNF2 TSC22D4 ZSCAN25 SRRT TRIM4 ZNF655 GIGYF1 ZNF3 ENSG00000242798 STAG3L5P PILRA
GH07I100343 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 15 +84.4 84382 3 HDGF PKNOX1 ARNT SIN3A FEZF1 ZNF2 E2F8 ZNF207 ZNF143 FOS PILRA C7orf43 MBLAC1 ZCWPW1 MEPCE FAM200A LAMTOR4 ENSG00000241357 GPC2 GAL3ST4
GH07I100450 Enhancer 1.3 Ensembl ENCODE 12.3 -21.3 -21314 1.5 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 POLR2B ZNF766 ZSCAN25 ZNF655 GIGYF1 ZNF3 TRIM4 SRRT STAG3L5P AP4M1 ENSG00000242798 TSC22D4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZCWPW1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZCWPW1 gene promoter:

Genomic Locations for ZCWPW1 Gene

Genomic Locations for ZCWPW1 Gene
chr7:100,400,826-100,429,414
(GRCh38/hg38)
Size:
28,589 bases
Orientation:
Minus strand
chr7:99,998,449-100,026,615
(GRCh37/hg19)

Genomic View for ZCWPW1 Gene

Genes around ZCWPW1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZCWPW1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZCWPW1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZCWPW1 Gene

Proteins for ZCWPW1 Gene

  • Protein details for ZCWPW1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0M4-ZCPW1_HUMAN
    Recommended name:
    Zinc finger CW-type PWWP domain protein 1
    Protein Accession:
    Q9H0M4
    Secondary Accessions:
    • A8MVF5
    • B4DUQ2
    • Q8NA98
    • Q9BUD0
    • Q9NWF7

    Protein attributes for ZCWPW1 Gene

    Size:
    648 amino acids
    Molecular mass:
    72007 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAB66669.1; Type=Frameshift; Positions=487; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ZCWPW1 Gene

    Alternative splice isoforms for ZCWPW1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZCWPW1 Gene

Post-translational modifications for ZCWPW1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZCWPW1 Gene

Domains & Families for ZCWPW1 Gene

Gene Families for ZCWPW1 Gene

Protein Domains for ZCWPW1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZCWPW1: view

No data available for UniProtKB/Swiss-Prot for ZCWPW1 Gene

Function for ZCWPW1 Gene

Phenotypes From GWAS Catalog for ZCWPW1 Gene

Gene Ontology (GO) - Molecular Function for ZCWPW1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZCWPW1: view
genes like me logo Genes that share phenotypes with ZCWPW1: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZCWPW1 Gene

Localization for ZCWPW1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZCWPW1 gene
Compartment Confidence
nucleus 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ZCWPW1 Gene

Pathways & Interactions for ZCWPW1 Gene

SuperPathways for ZCWPW1 Gene

No Data Available

Interacting Proteins for ZCWPW1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000381109%0d%0a9606.ENSP00000346389%0d%0a
Selected Interacting proteins: ENSP00000381109 Q9H0M4-ZCPW1_HUMAN for ZCWPW1 Gene via STRING IID

Gene Ontology (GO) - Biological Process for ZCWPW1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZCWPW1 Gene

Drugs & Compounds for ZCWPW1 Gene

No Compound Related Data Available

Transcripts for ZCWPW1 Gene

Unigene Clusters for ZCWPW1 Gene

Zinc finger, CW type with PWWP domain 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZCWPW1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1:
SP2: - -
SP3: - -
SP4: -
SP5: -

Relevant External Links for ZCWPW1 Gene

GeneLoc Exon Structure for
ZCWPW1
ECgene alternative splicing isoforms for
ZCWPW1

Expression for ZCWPW1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZCWPW1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZCWPW1 Gene

This gene is overexpressed in Testis (x11.5).

Protein differential expression in normal tissues from HIPED for ZCWPW1 Gene

This gene is overexpressed in Ovary (24.7), Testis (18.7), and Fetal ovary (17.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZCWPW1 Gene



Protein tissue co-expression partners for ZCWPW1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZCWPW1 Gene:

ZCWPW1

SOURCE GeneReport for Unigene cluster for ZCWPW1 Gene:

Hs.105191
genes like me logo Genes that share expression patterns with ZCWPW1: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZCWPW1 Gene

Orthologs for ZCWPW1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZCWPW1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZCWPW1 33 34
  • 99.59 (n)
dog
(Canis familiaris)
Mammalia ZCWPW1 33 34
  • 81.72 (n)
cow
(Bos Taurus)
Mammalia ZCWPW1 33 34
  • 81.46 (n)
mouse
(Mus musculus)
Mammalia Zcwpw1 33 16 34
  • 74.57 (n)
rat
(Rattus norvegicus)
Mammalia LOC100910636 33
  • 74.24 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ZCWPW1 34
  • 38 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZCWPW1 34
  • 53 (a)
OneToOne
Species where no ortholog for ZCWPW1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZCWPW1 Gene

ENSEMBL:
Gene Tree for ZCWPW1 (if available)
TreeFam:
Gene Tree for ZCWPW1 (if available)

Paralogs for ZCWPW1 Gene

Paralogs for ZCWPW1 Gene

genes like me logo Genes that share paralogs with ZCWPW1: view

Variants for ZCWPW1 Gene

Sequence variations from dbSNP and Humsavar for ZCWPW1 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000070255 -- 100,402,528(-) T/G coding_sequence_variant, intron_variant, missense_variant, non_coding_transcript_variant
rs1000135882 -- 100,413,824(-) G/C intron_variant
rs1000215 -- 100,406,920(-) T/C intron_variant
rs1000217 -- 100,407,147(-) C/A intron_variant
rs1000271968 -- 100,414,290(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZCWPW1 Gene

Variant ID Type Subtype PubMed ID
dgv1226e199 CNV deletion 23128226
esv2734888 CNV deletion 23290073
nsv1144194 CNV deletion 24896259
nsv527107 CNV loss 19592680
nsv819923 CNV loss 19587683
nsv831071 CNV loss 17160897

Variation tolerance for ZCWPW1 Gene

Residual Variation Intolerance Score: 88.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.19; 61.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZCWPW1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZCWPW1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZCWPW1 Gene

Disorders for ZCWPW1 Gene

Additional Disease Information for ZCWPW1

No disorders were found for ZCWPW1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZCWPW1 Gene

Publications for ZCWPW1 Gene

  1. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 4 58
  2. Structural insight into the zinc finger CW domain as a histone modification reader. (PMID: 20826339) He F … Muto Y (Structure (London, England : 1993) 2010) 2 3 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The CW domain, a structural module shared amongst vertebrates, vertebrate-infecting parasites and higher plants. (PMID: 14607086) Perry J … Zhao Y (Trends in biochemical sciences 2003) 2 3 58

Products for ZCWPW1 Gene

Sources for ZCWPW1 Gene

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