Aliases for ZCCHC7 Gene

Aliases for ZCCHC7 Gene

  • Zinc Finger CCHC-Type Containing 7 2 3 5
  • Zinc Finger CCHC Domain-Containing Protein 7 3 4
  • TRAMP-Like Complex RNA-Binding Factor ZCCHC7 3 4
  • AIR1 2 3
  • Zinc Finger, CCHC Domain Containing 7 3
  • FLJ22611 2
  • HSPC086 3
  • ZCCHC7 5

External Ids for ZCCHC7 Gene

Previous GeneCards Identifiers for ZCCHC7 Gene

  • GC09P037111
  • GC09P037112
  • GC09P037113
  • GC09P037071

Summaries for ZCCHC7 Gene

GeneCards Summary for ZCCHC7 Gene

ZCCHC7 (Zinc Finger CCHC-Type Containing 7) is a Protein Coding gene. Among its related pathways are Deadenylation-dependent mRNA decay. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is CNBP.

Additional gene information for ZCCHC7 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZCCHC7 Gene

Genomics for ZCCHC7 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZCCHC7 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZCCHC7 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZCCHC7

Top Transcription factor binding sites by QIAGEN in the ZCCHC7 gene promoter:
  • Evi-1
  • Max1
  • POU2F1
  • POU2F1a
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c

Genomic Locations for ZCCHC7 Gene

Genomic Locations for ZCCHC7 Gene
chr9:37,120,166-37,358,149
(GRCh38/hg38)
Size:
237,984 bases
Orientation:
Plus strand
chr9:37,120,469-37,358,146
(GRCh37/hg19)
Size:
237,678 bases
Orientation:
Plus strand

Genomic View for ZCCHC7 Gene

Genes around ZCCHC7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZCCHC7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZCCHC7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZCCHC7 Gene

Proteins for ZCCHC7 Gene

  • Protein details for ZCCHC7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N3Z6-ZCHC7_HUMAN
    Recommended name:
    Zinc finger CCHC domain-containing protein 7
    Protein Accession:
    Q8N3Z6
    Secondary Accessions:
    • B2RCI4
    • D3DRQ0
    • Q5T0Q8
    • Q5T0Q9
    • Q5T0R0
    • Q8N2M1
    • Q8N4J2
    • Q8TBK8
    • Q9H648
    • Q9P0F0

    Protein attributes for ZCCHC7 Gene

    Size:
    543 amino acids
    Molecular mass:
    63052 Da
    Quaternary structure:
    • Component of a nucleolar TRAMP-like complex, an ATP-dependent exosome regulatory complex consisting of a helicase (MTREX), an oligadenylate polymerase (TENT4B or TENT4A), and a substrate specific RNA-binding factor (ZCCHC7 or ZCCHC8). Several TRAMP-like complexes exist with specific compositions and are associated with nuclear, or nucleolar RNA exosomes.
    SequenceCaution:
    • Sequence=AAH36940.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAB15418.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAC11087.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAG37581.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZCCHC7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZCCHC7 Gene

Post-translational modifications for ZCCHC7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZCCHC7 Gene

Domains & Families for ZCCHC7 Gene

Gene Families for ZCCHC7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZCCHC7 Gene

InterPro:
Blocks:
  • C2HC-type zinc-finger signature
ProtoNet:

Suggested Antigen Peptide Sequences for ZCCHC7 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ57248, highly similar to Zinc finger CCHC domain-containing protein 7 (B4E024_HUMAN)
  • ZCCHC7 protein (Q05DN1_HUMAN)
  • Zinc finger CCHC domain-containing protein 7 (ZCHC7_HUMAN)
genes like me logo Genes that share domains with ZCCHC7: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ZCCHC7 Gene

Function for ZCCHC7 Gene

Phenotypes From GWAS Catalog for ZCCHC7 Gene

Gene Ontology (GO) - Molecular Function for ZCCHC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding HDA 22658674
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZCCHC7: view
genes like me logo Genes that share phenotypes with ZCCHC7: view

Animal Model Products

CRISPR Products

miRNA for ZCCHC7 Gene

miRTarBase miRNAs that target ZCCHC7

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZCCHC7

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZCCHC7 Gene

Localization for ZCCHC7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZCCHC7 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZCCHC7 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Nucleoli (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZCCHC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005730 nucleolus IEA,IDA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with ZCCHC7: view

Pathways & Interactions for ZCCHC7 Gene

PathCards logo

SuperPathways for ZCCHC7 Gene

SuperPathway Contained pathways
1 Deadenylation-dependent mRNA decay
genes like me logo Genes that share pathways with ZCCHC7: view

Pathways by source for ZCCHC7 Gene

1 KEGG pathway for ZCCHC7 Gene

Gene Ontology (GO) - Biological Process for ZCCHC7 Gene

None

No data available for SIGNOR curated interactions for ZCCHC7 Gene

Drugs & Compounds for ZCCHC7 Gene

No Compound Related Data Available

Transcripts for ZCCHC7 Gene

mRNA/cDNA for ZCCHC7 Gene

4 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZCCHC7

Alternative Splicing Database (ASD) splice patterns (SP) for ZCCHC7 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c ^ 16 ^
SP1: - - - - - - - - - - - - -
SP2: - - - - - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - -
SP5: - - - - - -
SP6:
SP7: - - - - - - - - - - -
SP8: - - - -
SP9: -
SP10: - - - - -
SP11: - -
SP12: - - -
SP13:
SP14:

ExUns: 17
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for ZCCHC7 Gene

GeneLoc Exon Structure for
ZCCHC7

Expression for ZCCHC7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZCCHC7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZCCHC7 Gene

This gene is overexpressed in Pancreatic juice (39.0), Fetal testis (16.2), and Testis (11.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZCCHC7 Gene



Protein tissue co-expression partners for ZCCHC7 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZCCHC7

SOURCE GeneReport for Unigene cluster for ZCCHC7 Gene:

Hs.654700

Evidence on tissue expression from TISSUES for ZCCHC7 Gene

  • Nervous system(4.5)
  • Blood(4.4)
  • Intestine(4.4)
  • Spleen(2.2)
  • Skin(2.1)
  • Muscle(2.1)
  • Lung(2.1)
  • Heart(2)
genes like me logo Genes that share expression patterns with ZCCHC7: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZCCHC7 Gene

Orthologs for ZCCHC7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZCCHC7 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZCCHC7 31
  • 99 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia ZCCHC7 30 31
  • 84.04 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZCCHC7 30 31
  • 83.52 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Zcchc7 30 17 31
  • 78.59 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Zcchc7 30
  • 77.32 (n)
Oppossum
(Monodelphis domestica)
Mammalia ZCCHC7 31
  • 55 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia ZCCHC7 31
  • 52 (a)
OneToOne
Chicken
(Gallus gallus)
Aves LOC101751525 30
  • 59.82 (n)
-- 31
  • 43 (a)
OneToMany
-- 31
  • 40 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia ZCCHC7 31
  • 41 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia zcchc7 30
  • 55.51 (n)
Str.20212 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.19467 30
Zebrafish
(Danio rerio)
Actinopterygii zcchc7 30 31
  • 49.9 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG9715 31
  • 6 (a)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AIR1 31
  • 21 (a)
OneToMany
AIR2 31 33
  • 20 (a)
OneToMany
Species where no ortholog for ZCCHC7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ZCCHC7 Gene

ENSEMBL:
Gene Tree for ZCCHC7 (if available)
TreeFam:
Gene Tree for ZCCHC7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZCCHC7: view image

Paralogs for ZCCHC7 Gene

Paralogs for ZCCHC7 Gene

Pseudogenes.org Pseudogenes for ZCCHC7 Gene

genes like me logo Genes that share paralogs with ZCCHC7: view

Variants for ZCCHC7 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZCCHC7 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
rs1051465 - p.Arg539Lys
rs35119826 - p.Gly118Asp

Additional dbSNP identifiers (rs#s) for ZCCHC7 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZCCHC7 Gene

Variant ID Type Subtype PubMed ID
dgv3989n106 CNV deletion 24896259
esv3334090 CNV insertion 20981092
esv994123 CNV deletion 20482838
nsv1016398 CNV loss 25217958
nsv1075615 CNV deletion 25765185
nsv1125318 OTHER inversion 24896259
nsv466390 CNV loss 19166990
nsv520965 CNV loss 19592680
nsv529027 CNV loss 19592680
nsv614215 CNV loss 21841781
nsv6534 CNV insertion 18451855
nsv6535 CNV insertion 18451855
nsv831551 CNV gain+loss 17160897
nsv951703 CNV duplication 24416366
nsv982215 CNV duplication 23825009

Variation tolerance for ZCCHC7 Gene

Residual Variation Intolerance Score: 95.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.92; 35.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZCCHC7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZCCHC7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZCCHC7 Gene

Disorders for ZCCHC7 Gene

Additional Disease Information for ZCCHC7

No disorders were found for ZCCHC7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZCCHC7 Gene

Publications for ZCCHC7 Gene

  1. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids. (PMID: 30804502) Nakamura K … Groth A (Nature cell biology 2019) 3

Products for ZCCHC7 Gene

Sources for ZCCHC7 Gene