Aliases for ZCCHC6 Gene
External Ids for ZCCHC6 Gene
Previous GeneCards Identifiers for ZCCHC6 Gene
GeneCards Summary for ZCCHC6 Gene
ZCCHC6 (Zinc Finger CCHC-Type Containing 6) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA uridylyltransferase activity. An important paralog of this gene is ZCCHC11.
UniProtKB/Swiss-Prot for ZCCHC6 Gene
Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay (PubMed:19703396, PubMed:25480299). Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets (PubMed:25480299). Also acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7). Uridylated pre-let-7 RNA is not processed by Dicer and undergo degradation. Pre-let-7 uridylation is strongly enhanced in the presence of LIN28A (PubMed:22898984). Due to functional redundancy between ZCCHC6 and ZCCHC11, the identification of the specific role of each of these proteins is difficult.