Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZCCHC4 Gene

Aliases for ZCCHC4 Gene

  • Zinc Finger CCHC-Type Containing 4 2 3 5
  • Zinc Finger, GRF-Type Containing 4 2 3
  • Zinc Finger CCHC Domain-Containing Protein 4 3
  • DHHC Domain-Containing Zinc Finger Protein 3
  • Zinc Finger, CCHC Domain Containing 4 3
  • HSPC052 3
  • ZGRF4 3

External Ids for ZCCHC4 Gene

Previous GeneCards Identifiers for ZCCHC4 Gene

  • GC04U900073
  • GC04P025065
  • GC04P024990
  • GC04P024923
  • GC04P024654

Summaries for ZCCHC4 Gene

GeneCards Summary for ZCCHC4 Gene

ZCCHC4 (Zinc Finger CCHC-Type Containing 4) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and methyltransferase activity.

UniProtKB/Swiss-Prot for ZCCHC4 Gene

  • May be a methyltransferase.

Additional gene information for ZCCHC4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZCCHC4 Gene

Genomics for ZCCHC4 Gene

GeneHancer (GH) Regulatory Elements for ZCCHC4 Gene

Promoters and enhancers for ZCCHC4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I025312 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 575.8 +0.3 294 1.9 HDGF CLOCK MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B ZCCHC4 ANAPC4 DHX15 PI4K2B PIR58322
GH04I025912 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 13.4 +601.5 601505 3 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF766 SMIM20 LOC105374538 SEL1L3 ANAPC4 ZCCHC4 SEPSECS PIR49686
GH04I024469 Enhancer 1.5 FANTOM5 Ensembl ENCODE 17.5 -841.1 -841078 4.2 ATF1 SIN3A FEZF1 GLI4 ZNF2 ZNF121 ZNF766 GLIS2 ZNF143 KLF7 PPARGC1A DHX15 ZCCHC4 ANAPC4 MIR573 LINC02473 GC04P024448
GH04I025233 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 11.8 -77.8 -77775 3.6 HDGF FOXA2 PKNOX1 SMAD1 ARNT ARID4B SIN3A ZNF2 YY1 POLR2B PI4K2B LOC105374535 ANAPC4 DHX15 ZCCHC4 PIR48003 ENSG00000281028
GH04I025908 Enhancer 0.9 Ensembl ENCODE 22.9 +595.8 595824 1 SOX13 TFAP4 FOXA2 SAP130 JUN ARID4B ZNF140 ZNF644 FOSL1 FOXK2 ANAPC4 SMIM20 ZCCHC4 SEL1L3 STIM2 LOC105374538 GC04M025896
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZCCHC4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZCCHC4 gene promoter:

Genomic Locations for ZCCHC4 Gene

Genomic Locations for ZCCHC4 Gene
60,403 bases
Plus strand

Genomic View for ZCCHC4 Gene

Genes around ZCCHC4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZCCHC4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZCCHC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZCCHC4 Gene

Proteins for ZCCHC4 Gene

  • Protein details for ZCCHC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger CCHC domain-containing protein 4
    Protein Accession:
    Secondary Accessions:
    • B2RXF6
    • B4DRD8
    • B7ZW20
    • Q5IW78
    • Q96AN7

    Protein attributes for ZCCHC4 Gene

    513 amino acids
    Molecular mass:
    59010 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH16914.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB15524.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZCCHC4 Gene


neXtProt entry for ZCCHC4 Gene

Post-translational modifications for ZCCHC4 Gene

No Post-translational modifications

Other Protein References for ZCCHC4 Gene

No data available for DME Specific Peptides for ZCCHC4 Gene

Domains & Families for ZCCHC4 Gene

Suggested Antigen Peptide Sequences for ZCCHC4 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZCCHC4: view

No data available for UniProtKB/Swiss-Prot for ZCCHC4 Gene

Function for ZCCHC4 Gene

Molecular function for ZCCHC4 Gene

UniProtKB/Swiss-Prot Function:
May be a methyltransferase.

Phenotypes From GWAS Catalog for ZCCHC4 Gene

Gene Ontology (GO) - Molecular Function for ZCCHC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0008168 methyltransferase activity IEA --
GO:0008270 zinc ion binding IEA --
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
genes like me logo Genes that share ontologies with ZCCHC4: view
genes like me logo Genes that share phenotypes with ZCCHC4: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZCCHC4 Gene

Localization for ZCCHC4 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZCCHC4 gene
Compartment Confidence
nucleus 2
cytosol 2
golgi apparatus 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nuclear speckles (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ZCCHC4 Gene

Pathways & Interactions for ZCCHC4 Gene

SuperPathways for ZCCHC4 Gene

No Data Available

Interacting Proteins for ZCCHC4 Gene

Gene Ontology (GO) - Biological Process for ZCCHC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with ZCCHC4: view

No data available for Pathways by source and SIGNOR curated interactions for ZCCHC4 Gene

Drugs & Compounds for ZCCHC4 Gene

No Compound Related Data Available

Transcripts for ZCCHC4 Gene

Unigene Clusters for ZCCHC4 Gene

Zinc finger, CCHC domain containing 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZCCHC4 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b
SP2: - - - -
SP4: - -
SP5: -

Relevant External Links for ZCCHC4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZCCHC4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZCCHC4 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZCCHC4 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZCCHC4 Gene:


SOURCE GeneReport for Unigene cluster for ZCCHC4 Gene:


Evidence on tissue expression from TISSUES for ZCCHC4 Gene

  • Kidney(4.3)
  • Lung(4.3)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZCCHC4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZCCHC4 Gene

Orthologs for ZCCHC4 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZCCHC4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZCCHC4 33 34
  • 99.15 (n)
(Canis familiaris)
Mammalia ZCCHC4 33 34
  • 91.16 (n)
(Bos Taurus)
Mammalia ZCCHC4 33 34
  • 90.32 (n)
(Rattus norvegicus)
Mammalia Zcchc4 33
  • 86.3 (n)
(Mus musculus)
Mammalia Zcchc4 33 16 34
  • 82.52 (n)
(Ornithorhynchus anatinus)
Mammalia ZCCHC4 34
  • 78 (a)
(Monodelphis domestica)
Mammalia ZCCHC4 34
  • 76 (a)
(Gallus gallus)
Aves ZCCHC4 33 34
  • 67.28 (n)
(Anolis carolinensis)
Reptilia ZCCHC4 34
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia zcchc4 33
  • 64.45 (n)
(Danio rerio)
Actinopterygii zgc:172248 33
  • 60.94 (n)
  • 55 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12863 33 34
  • 49.08 (n)
(Caenorhabditis elegans)
Secernentea F33A8.4 33 34
  • 45.91 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 40 (a)
Species where no ortholog for ZCCHC4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZCCHC4 Gene

Gene Tree for ZCCHC4 (if available)
Gene Tree for ZCCHC4 (if available)

Paralogs for ZCCHC4 Gene

No data available for Paralogs for ZCCHC4 Gene

Variants for ZCCHC4 Gene

Sequence variations from dbSNP and Humsavar for ZCCHC4 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000006328 -- 25,321,670(+) G/A intron_variant
rs1000013833 -- 25,372,826(+) T/C 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant
rs1000086427 -- 25,343,297(+) T/C intron_variant
rs1000086963 -- 25,372,596(+) C/T 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant
rs1000131705 -- 25,328,403(+) C/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZCCHC4 Gene

Variant ID Type Subtype PubMed ID
nsv997544 CNV gain 25217958
nsv1136826 CNV deletion 24896259

Variation tolerance for ZCCHC4 Gene

Residual Variation Intolerance Score: 95.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.24; 70.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZCCHC4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZCCHC4 Gene

Disorders for ZCCHC4 Gene

Additional Disease Information for ZCCHC4

No disorders were found for ZCCHC4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZCCHC4 Gene

Publications for ZCCHC4 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Novel Sm-like proteins with long C-terminal tails and associated methyltransferases. (PMID: 15225602) Albrecht M … Lengauer T (FEBS letters 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 2 3 58
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 58

Products for ZCCHC4 Gene

Sources for ZCCHC4 Gene

Loading form....