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Aliases for ZCCHC14 Gene

Aliases for ZCCHC14 Gene

  • Zinc Finger CCHC-Type Containing 14 2 3 5
  • BDG-29 3 4
  • Zinc Finger CCHC Domain-Containing Protein 14 3
  • Zinc Finger, CCHC Domain Containing 14 3
  • KIAA0579 4
  • BDG29 3

External Ids for ZCCHC14 Gene

Previous GeneCards Identifiers for ZCCHC14 Gene

  • GC16M085997
  • GC16M073182

Summaries for ZCCHC14 Gene

GeneCards Summary for ZCCHC14 Gene

ZCCHC14 (Zinc Finger CCHC-Type Containing 14) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and phosphatidylinositol binding. An important paralog of this gene is ZCCHC2.

Additional gene information for ZCCHC14 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZCCHC14 Gene

Genomics for ZCCHC14 Gene

GeneHancer (GH) Regulatory Elements for ZCCHC14 Gene

Promoters and enhancers for ZCCHC14 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I087483 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 566.5 +3.5 3516 10.3 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B NEUROD1 SIN3A FEZF1 ZCCHC14 MTHFSD LOC101928659 KLHDC4 BANP LOC101928737 ENSG00000276337
GH16I086950 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 40.5 +539.9 539938 3.1 HDGF ATF1 YBX1 ZBTB7B TCF12 ZNF207 ZNF143 ATF7 FOS YY2 MTHFSD ZCCHC14 LOC101928659 KLHDC4 LINC02181 FOXC2 FOXL1 GC16M086906 LOC105371393
GH16I087380 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 24.9 +109.3 109283 5.3 CLOCK MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 FBXO31 MAP1LC3B TRM-CAT6-1 GC16M087385 ZCCHC14 PIR52096
GH16I088329 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 29.1 -840.6 -840587 6 HDGF PKNOX1 ARNT SIN3A YBX1 ZBTB7B POLR2B ZNF766 ZNF207 FOS ENSG00000259877 ACSF3 ZC3H18 BANP ENSG00000268218 ENSG00000260121 ZCCHC14 CTU2 GALNS PIEZO1
GH16I087947 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 13.3 -460.6 -460630 10.5 CLOCK MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 BANP ZC3H18 ZCCHC14 GALNS ENSG00000269901 FBXO31 LOC400553 SLC7A5 PIR49178
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZCCHC14 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZCCHC14 gene promoter:

Genomic Locations for ZCCHC14 Gene

Genomic Locations for ZCCHC14 Gene
chr16:87,406,246-87,492,269
(GRCh38/hg38)
Size:
86,024 bases
Orientation:
Minus strand
chr16:87,439,852-87,525,651
(GRCh37/hg19)

Genomic View for ZCCHC14 Gene

Genes around ZCCHC14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZCCHC14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZCCHC14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZCCHC14 Gene

Proteins for ZCCHC14 Gene

  • Protein details for ZCCHC14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WYQ9-ZCH14_HUMAN
    Recommended name:
    Zinc finger CCHC domain-containing protein 14
    Protein Accession:
    Q8WYQ9
    Secondary Accessions:
    • D3DUN1
    • O60324
    • Q3MJD8
    • Q9UFP0

    Protein attributes for ZCCHC14 Gene

    Size:
    949 amino acids
    Molecular mass:
    100042 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZCCHC14 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZCCHC14 Gene

Post-translational modifications for ZCCHC14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZCCHC14 Gene

No data available for DME Specific Peptides for ZCCHC14 Gene

Domains & Families for ZCCHC14 Gene

Gene Families for ZCCHC14 Gene

Suggested Antigen Peptide Sequences for ZCCHC14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZCCHC14: view

No data available for UniProtKB/Swiss-Prot for ZCCHC14 Gene

Function for ZCCHC14 Gene

Phenotypes From GWAS Catalog for ZCCHC14 Gene

Gene Ontology (GO) - Molecular Function for ZCCHC14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0008270 zinc ion binding IEA --
GO:0035091 phosphatidylinositol binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZCCHC14: view
genes like me logo Genes that share phenotypes with ZCCHC14: view

Animal Models for ZCCHC14 Gene

MGI Knock Outs for ZCCHC14:

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZCCHC14 Gene

Localization for ZCCHC14 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZCCHC14 gene
Compartment Confidence
nucleus 3
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (1)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ZCCHC14 Gene

Pathways & Interactions for ZCCHC14 Gene

SuperPathways for ZCCHC14 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZCCHC14 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZCCHC14 Gene

Drugs & Compounds for ZCCHC14 Gene

No Compound Related Data Available

Transcripts for ZCCHC14 Gene

Unigene Clusters for ZCCHC14 Gene

Zinc finger, CCHC domain containing 14:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZCCHC14 Gene

No ASD Table

Relevant External Links for ZCCHC14 Gene

GeneLoc Exon Structure for
ZCCHC14
ECgene alternative splicing isoforms for
ZCCHC14

Expression for ZCCHC14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZCCHC14 Gene

Protein differential expression in normal tissues from HIPED for ZCCHC14 Gene

This gene is overexpressed in Fetal testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZCCHC14 Gene



Protein tissue co-expression partners for ZCCHC14 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZCCHC14 Gene:

ZCCHC14

SOURCE GeneReport for Unigene cluster for ZCCHC14 Gene:

Hs.156231

Evidence on tissue expression from TISSUES for ZCCHC14 Gene

  • Nervous system(4.6)
  • Intestine(2.9)
genes like me logo Genes that share expression patterns with ZCCHC14: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZCCHC14 Gene

Orthologs for ZCCHC14 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZCCHC14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZCCHC14 33 34
  • 99.48 (n)
cow
(Bos Taurus)
Mammalia ZCCHC14 33 34
  • 85.41 (n)
dog
(Canis familiaris)
Mammalia ZCCHC14 33 34
  • 84.93 (n)
mouse
(Mus musculus)
Mammalia Zcchc14 33 16 34
  • 83.91 (n)
rat
(Rattus norvegicus)
Mammalia Zcchc14 33
  • 83.51 (n)
oppossum
(Monodelphis domestica)
Mammalia ZCCHC14 34
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZCCHC14 34
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100857578 33
  • 75.51 (n)
-- 34
  • 70 (a)
OneToMany
-- 34
  • 70 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia ZCCHC14 34
  • 69 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii zcchc14 33 34
  • 54.35 (n)
Species where no ortholog for ZCCHC14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZCCHC14 Gene

ENSEMBL:
Gene Tree for ZCCHC14 (if available)
TreeFam:
Gene Tree for ZCCHC14 (if available)

Paralogs for ZCCHC14 Gene

Paralogs for ZCCHC14 Gene

genes like me logo Genes that share paralogs with ZCCHC14: view

Variants for ZCCHC14 Gene

Sequence variations from dbSNP and Humsavar for ZCCHC14 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
VAR_036492 A breast cancer sample p.Leu290Val
rs1000043714 -- 87,443,383(-) A/G intron_variant
rs1000072339 -- 87,425,950(-) A/C intron_variant
rs1000093528 -- 87,475,094(-) G/C genic_upstream_transcript_variant, intron_variant
rs1000108352 -- 87,487,687(-) T/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZCCHC14 Gene

Variant ID Type Subtype PubMed ID
dgv499n67 CNV gain 20364138
dgv500n67 CNV gain 20364138
dgv501n67 CNV gain 20364138
esv1007865 CNV loss 20482838
esv24735 CNV gain 19812545
esv33545 CNV gain 17666407
esv3553846 CNV deletion 23714750
esv3639515 CNV loss 21293372
nsv428330 CNV gain 18775914
nsv525605 CNV gain 19592680
nsv827804 CNV gain 20364138
nsv827811 CNV gain 20364138
nsv833320 CNV gain 17160897
nsv833321 CNV gain+loss 17160897
nsv952064 CNV deletion 24416366

Variation tolerance for ZCCHC14 Gene

Residual Variation Intolerance Score: 7.85% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.90; 96.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZCCHC14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZCCHC14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZCCHC14 Gene

Disorders for ZCCHC14 Gene

Additional Disease Information for ZCCHC14

No disorders were found for ZCCHC14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZCCHC14 Gene

Publications for ZCCHC14 Gene

  1. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4 58
  2. A mega-analysis of genome-wide association studies for major depressive disorder. (PMID: 22472876) Major Depressive Disorder Working Group of the Psychiatric GWAS Consortium … Sullivan PF (Molecular psychiatry 2013) 3 44 58
  3. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D … Nagase T (DNA research : an international journal for rapid publication of reports on genes and genomes 2002) 3 4 58
  4. Genetic variation at 16q24.2 is associated with small vessel stroke. (PMID: 27997041) Traylor M … International Stroke Genetics Consortium (Annals of neurology 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for ZCCHC14 Gene

Sources for ZCCHC14 Gene

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