Aliases for ZC3HC1 Gene
External Ids for ZC3HC1 Gene
Previous GeneCards Identifiers for ZC3HC1 Gene
This gene encodes an F-box-containing protein that is a component of an SCF-type E3 ubiquitin ligase complex that regulates the onset of cell division. The G2/M transition in the cell cycle requires the interaction of the proteins cyclin B1 and cyclin-dependent kinase 1. The activated ubiquitin ligase complex targets the protein cyclin B1 for degradation, preventing this transition to mitosis. [provided by RefSeq, Aug 2013]
GeneCards Summary for ZC3HC1 Gene
ZC3HC1 (Zinc Finger C3HC-Type Containing 1) is a Protein Coding gene. Diseases associated with ZC3HC1 include Noonan Syndrome 2. Among its related pathways are Apoptosis and Autophagy and DNA Damage. Gene Ontology (GO) annotations related to this gene include protein kinase binding.
UniProtKB/Swiss-Prot Summary for ZC3HC1 Gene
Essential component of a SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. May have an antiapoptotic role in NPM-ALK-mediated signaling events.