Aliases for ZC3HAV1L Gene

Aliases for ZC3HAV1L Gene

  • Zinc Finger CCCH-Type Containing, Antiviral 1 Like 2 3 5
  • Zinc Finger CCCH-Type Antiviral Protein 1-Like 3 4
  • C7orf39 3 4
  • Zinc Finger CCCH-Type, Antiviral 1-Like 3
  • Chromosome 7 Open Reading Frame 39 2

External Ids for ZC3HAV1L Gene

Previous HGNC Symbols for ZC3HAV1L Gene

  • C7orf39

Previous GeneCards Identifiers for ZC3HAV1L Gene

  • GC07M138357
  • GC07M138706
  • GC07M133020

Summaries for ZC3HAV1L Gene

GeneCards Summary for ZC3HAV1L Gene

ZC3HAV1L (Zinc Finger CCCH-Type Containing, Antiviral 1 Like) is a Protein Coding gene. An important paralog of this gene is ZC3HAV1.

Additional gene information for ZC3HAV1L Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZC3HAV1L Gene

Genomics for ZC3HAV1L Gene

GeneHancer (GH) Regulatory Elements for ZC3HAV1L Gene

Promoters and enhancers for ZC3HAV1L Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J139034 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 508.3 +0.9 870 2.4 ZBTB40 SIN3A POLR2G PHF8 ZFX REST POLR2A ZBTB25 EZH2 MXI1 ZC3HAV1L HSALNG0061700 RF00017-6674
GH07J139037 Enhancer 0.2 Ensembl 508.5 -1.5 -1511 0.4 ZC3HAV1L MIR10399-001
GH07J139100 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 19 -70.1 -70050 13.1 FOXK2 ZBTB40 ZNF217 CTCF SIN3A NRF1 POLR2G BCLAF1 NONO GTF2E2 TTC26 ZC3HAV1 UBN2 LUC7L2 ZC3HAV1L PARP12 piR-56451-096
GH07J139773 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 18.7 -739.8 -739842 5.7 HNRNPK CTCF SIN3A NRF1 TCF12 POLR2G NCOR1 PHF8 JUND FOS HIPK2 TBXAS1 lnc-TBXAS1-3 SLC37A3 ZC3HAV1L LUC7L2 PARP12 piR-43164-066
GH07J139357 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.5 -324.0 -324024 5.4 HNRNPK ZBTB40 ZNF217 EP300 CTCF SIN3A NRF1 TCF12 USF1 POLR2G LUC7L2 ENSG00000273391 UBN2 RNU6-206P TTC26 ZC3HAV1L TBXAS1 FMC1-LUC7L2 NONHSAG048936.2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZC3HAV1L on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZC3HAV1L

Top Transcription factor binding sites by QIAGEN in the ZC3HAV1L gene promoter:
  • Nkx2-5
  • Oct-B1
  • oct-B2
  • oct-B3
  • POU2F1
  • POU2F1a
  • POU2F2
  • POU2F2 (Oct-2.1)
  • POU2F2B
  • POU2F2C

Genomic Locations for ZC3HAV1L Gene

Genomic Locations for ZC3HAV1L Gene
14,992 bases
Minus strand
10,324 bases
Minus strand

Genomic View for ZC3HAV1L Gene

Genes around ZC3HAV1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZC3HAV1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZC3HAV1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZC3HAV1L Gene

Proteins for ZC3HAV1L Gene

  • Protein details for ZC3HAV1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger CCCH-type antiviral protein 1-like
    Protein Accession:
    Secondary Accessions:
    • Q8WUD9

    Protein attributes for ZC3HAV1L Gene

    300 amino acids
    Molecular mass:
    32962 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZC3HAV1L Gene


neXtProt entry for ZC3HAV1L Gene

Post-translational modifications for ZC3HAV1L Gene

  • Ubiquitination at Lys12, Lys141, and Lys174
  • Modification sites at PhosphoSitePlus

Other Protein References for ZC3HAV1L Gene

No data available for DME Specific Peptides for ZC3HAV1L Gene

Domains & Families for ZC3HAV1L Gene

Gene Families for ZC3HAV1L Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZC3HAV1L Gene

Suggested Antigen Peptide Sequences for ZC3HAV1L Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger CCCH-type antiviral protein 1-like (ZCCHL_HUMAN)
genes like me logo Genes that share domains with ZC3HAV1L: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ZC3HAV1L Gene

Function for ZC3HAV1L Gene

Phenotypes From GWAS Catalog for ZC3HAV1L Gene

genes like me logo Genes that share phenotypes with ZC3HAV1L: view

Animal Models for ZC3HAV1L Gene

MGI Knock Outs for ZC3HAV1L:

Animal Model Products

  • Taconic Biosciences Mouse Models for ZC3HAV1L

CRISPR Products

miRNA for ZC3HAV1L Gene

miRTarBase miRNAs that target ZC3HAV1L

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZC3HAV1L

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZC3HAV1L Gene

Localization for ZC3HAV1L Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZC3HAV1L gene
Compartment Confidence
cytosol 5
extracellular 2
nucleus 2
mitochondrion 0
endoplasmic reticulum 0
lysosome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZC3HAV1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with ZC3HAV1L: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ZC3HAV1L Gene

Pathways & Interactions for ZC3HAV1L Gene

PathCards logo

SuperPathways for ZC3HAV1L Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZC3HAV1L Gene


No data available for Pathways by source and SIGNOR curated interactions for ZC3HAV1L Gene

Drugs & Compounds for ZC3HAV1L Gene

No Compound Related Data Available

Transcripts for ZC3HAV1L Gene

mRNA/cDNA for ZC3HAV1L Gene

3 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZC3HAV1L

Alternative Splicing Database (ASD) splice patterns (SP) for ZC3HAV1L Gene

No ASD Table

Relevant External Links for ZC3HAV1L Gene

GeneLoc Exon Structure for

Expression for ZC3HAV1L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZC3HAV1L Gene

Protein differential expression in normal tissues from HIPED for ZC3HAV1L Gene

This gene is overexpressed in Uterus (12.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZC3HAV1L Gene

Protein tissue co-expression partners for ZC3HAV1L Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZC3HAV1L

SOURCE GeneReport for Unigene cluster for ZC3HAV1L Gene:


Evidence on tissue expression from TISSUES for ZC3HAV1L Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZC3HAV1L: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZC3HAV1L Gene

Orthologs for ZC3HAV1L Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZC3HAV1L Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZC3HAV1L 31 30
  • 99.44 (n)
(Canis familiaris)
Mammalia ZC3HAV1L 31 30
  • 86.62 (n)
(Bos Taurus)
Mammalia ZC3HAV1L 31 30
  • 85.55 (n)
(Mus musculus)
Mammalia Zc3hav1l 17 31 30
  • 82.64 (n)
(Rattus norvegicus)
Mammalia Zc3hav1l 30
  • 82.19 (n)
(Monodelphis domestica)
Mammalia ZC3HAV1L 31
  • 48 (a)
Species where no ortholog for ZC3HAV1L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZC3HAV1L Gene

Gene Tree for ZC3HAV1L (if available)
Gene Tree for ZC3HAV1L (if available)
Evolutionary constrained regions (ECRs) for ZC3HAV1L: view image

Paralogs for ZC3HAV1L Gene

Paralogs for ZC3HAV1L Gene

(2) SIMAP similar genes for ZC3HAV1L Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZC3HAV1L: view

Variants for ZC3HAV1L Gene

Additional dbSNP identifiers (rs#s) for ZC3HAV1L Gene

Structural Variations from Database of Genomic Variants (DGV) for ZC3HAV1L Gene

Variant ID Type Subtype PubMed ID
dgv6640n100 CNV gain 25217958
esv2735212 CNV deletion 23290073
nsv831155 CNV loss 17160897

Variation tolerance for ZC3HAV1L Gene

Residual Variation Intolerance Score: 70.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.85; 58.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZC3HAV1L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZC3HAV1L Gene

Disorders for ZC3HAV1L Gene

Additional Disease Information for ZC3HAV1L

No disorders were found for ZC3HAV1L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZC3HAV1L Gene

Publications for ZC3HAV1L Gene

  1. The Catalytically Inactive Mutation of the Ubiquitin-Conjugating Enzyme CDC34 Affects its Stability and Cell Proliferation. (PMID: 29564676) Liu X … Xu G (The protein journal 2018) 3 54
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
  3. Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones. (PMID: 28515276) Malinová A … Verheggen C (The Journal of cell biology 2017) 3 54
  4. Substrate-Trapped Interactors of PHD3 and FIH Cluster in Distinct Signaling Pathways. (PMID: 26972000) Rodriguez J … von Kriegsheim A (Cell reports 2016) 3 54
  5. Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family. (PMID: 27432908) Li X … Wang W (Molecular & cellular proteomics : MCP 2016) 3 54

Products for ZC3HAV1L Gene

Sources for ZC3HAV1L Gene