This gene encodes a CCCH-type zinc finger protein that is thought to prevent infection by retroviruses. Studies of the rat homolog indicate that the protein may primarily function to inhibit viral gene expression and induce an innate immunity to viral infection. Alternative splicing occurs at this locus and two variants, each encoding distinct isoforms, are described. [provided... See more...

Aliases for ZC3HAV1 Gene

Aliases for ZC3HAV1 Gene

  • Zinc Finger CCCH-Type Containing, Antiviral 1 2 3 5
  • ADP-Ribosyltransferase Diphtheria Toxin-Like 13 3 4
  • Zinc Finger CCCH Domain-Containing Protein 2 3 4
  • Zinc Finger CCCH-Type Antiviral Protein 1 3 4
  • Inactive Poly [ADP-Ribose] Polymerase 13 3 4
  • Zinc Finger Antiviral Protein 2 4
  • ZC3HDC2 3 4
  • ARTD13 3 4
  • PARP13 3 4
  • ZAP 3 4
  • CCCH-Type Zinc Finger Antiviral Protein 2
  • Zinc Finger CCCH-Type, Antiviral 1 3
  • FLB6421 3
  • ZC3H2 3

External Ids for ZC3HAV1 Gene

Previous GeneCards Identifiers for ZC3HAV1 Gene

  • GC07M138142
  • GC07M138185
  • GC07M138378
  • GC07M138728
  • GC07M133038

Summaries for ZC3HAV1 Gene

Entrez Gene Summary for ZC3HAV1 Gene

  • This gene encodes a CCCH-type zinc finger protein that is thought to prevent infection by retroviruses. Studies of the rat homolog indicate that the protein may primarily function to inhibit viral gene expression and induce an innate immunity to viral infection. Alternative splicing occurs at this locus and two variants, each encoding distinct isoforms, are described. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZC3HAV1 Gene

ZC3HAV1 (Zinc Finger CCCH-Type Containing, Antiviral 1) is a Protein Coding gene. Among its related pathways are Oncogenic MAPK signaling and HIV Life Cycle. Gene Ontology (GO) annotations related to this gene include NAD+ ADP-ribosyltransferase activity. An important paralog of this gene is PARP12.

UniProtKB/Swiss-Prot Summary for ZC3HAV1 Gene

  • Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of DDX58/RIG-I signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs).

Gene Wiki entry for ZC3HAV1 Gene

Additional gene information for ZC3HAV1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZC3HAV1 Gene

Genomics for ZC3HAV1 Gene

GeneHancer (GH) Regulatory Elements for ZC3HAV1 Gene

Promoters and enhancers for ZC3HAV1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J139100 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 527.9 +3.2 3181 13.1 FOXK2 ZBTB40 ZNF217 CTCF SIN3A NRF1 POLR2G BCLAF1 NONO GTF2E2 TTC26 ZC3HAV1 UBN2 LUC7L2 ZC3HAV1L PARP12 piR-56451-096
GH07J139117 Enhancer 1.5 FANTOM5 ENCODE dbSUPER 23.8 -9.4 -9448 1.9 CTCF SIN3A NRF1 TCF12 USF1 JUND FOS ZNF639 EP300 ZIC2 lnc-ZC3HAV1-2 ZC3HAV1 LUC7L2 UBN2 TTC26
GH07J139074 Enhancer 1.2 Ensembl ENCODE dbSUPER 21.7 +34.3 34319 2 CTCF NCOR1 TEAD4 REST TOE1 RAD21 CTBP1 SKI TRIM22 ZNF830 RF00017-6675 piR-42491-212 ZC3HAV1 ZC3HAV1L KIAA1549 lnc-ZC3HAV1L-2
GH07J139070 Enhancer 1 FANTOM5 Ensembl ENCODE dbSUPER 26.2 +37.3 37319 3.6 SPI1 MEIS2 ZBTB33 ZNF274 RUNX3 RF00017-6675 ZC3HAV1 ZC3HAV1L SVOPL lnc-ZC3HAV1L-2 RPL17P28 lnc-ZC3HAV1L-1
GH07J139090 Promoter/Enhancer 1.6 Ensembl ENCODE dbSUPER 11.2 +15.8 15777 6.6 NRF1 USF1 GTF2E2 PHB2 ZBTB5 ZIC2 ZBTB11 AFF1 TRIM28 TARDBP piR-38716-148 UBN2 ZC3HAV1 TTC26 piR-56451-096
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZC3HAV1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZC3HAV1

Top Transcription factor binding sites by QIAGEN in the ZC3HAV1 gene promoter:
  • c-Rel
  • En-1
  • Evi-1
  • HNF-3beta
  • HSF2
  • LUN-1
  • USF-1
  • USF-1:USF-2
  • USF1
  • USF2

Genomic Locations for ZC3HAV1 Gene

Genomic Locations for ZC3HAV1 Gene
chr7:139,043,515-139,109,720
(GRCh38/hg38)
Size:
66,206 bases
Orientation:
Minus strand
chr7:138,728,266-138,794,465
(GRCh37/hg19)
Size:
66,200 bases
Orientation:
Minus strand

Genomic View for ZC3HAV1 Gene

Genes around ZC3HAV1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZC3HAV1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZC3HAV1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZC3HAV1 Gene

Proteins for ZC3HAV1 Gene

  • Protein details for ZC3HAV1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z2W4-ZCCHV_HUMAN
    Recommended name:
    Zinc finger CCCH-type antiviral protein 1
    Protein Accession:
    Q7Z2W4
    Secondary Accessions:
    • A4D1R2
    • A4D1S4
    • Q8IW57
    • Q8TAJ3
    • Q96N79
    • Q9H8R9
    • Q9P0Y7

    Protein attributes for ZC3HAV1 Gene

    Size:
    902 amino acids
    Molecular mass:
    101431 Da
    Quaternary structure:
    • Homodimer or homooligomer. Homooligomerization is essential for its antiviral activity. Interacts with EXOSC5 (By similarity). Interacts (via N-terminal domain) with DDX17 in an RNA-independent manner (By similarity). Interacts with EXOSC3, EXOSC7, DCP2 and DCP1A. Interacts with PARN in an RNA-independent manner. Interacts with XRN1 in an RNA-dependent manner. Isoform 2 interacts (via zinc-fingers) with DDX58/RIG-I in an RNA-dependent manner. Interacts (via N-terminal domain) with DHX30 (via N-terminus) in an RNA-independent manner.

    Three dimensional structures from OCA and Proteopedia for ZC3HAV1 Gene

    Alternative splice isoforms for ZC3HAV1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZC3HAV1 Gene

Post-translational modifications for ZC3HAV1 Gene

  • Phosphorylation at Ser-275 is essential for sequential phosphorylation of Ser-271, Ser-267, Ser-263 and Ser-257 by GSK3-beta. Phosphorylation by GSK3-beta enhances its antiviral activity (By similarity).
  • Ubiquitination at Lys12, Lys695, and Lys783
  • Modification sites at PhosphoSitePlus

Other Protein References for ZC3HAV1 Gene

No data available for DME Specific Peptides for ZC3HAV1 Gene

Domains & Families for ZC3HAV1 Gene

Gene Families for ZC3HAV1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for ZC3HAV1 Gene

Blocks:
  • Zn-finger, C-x8-C-x5-C-x3-H type
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZC3HAV1 Gene

GenScript: Design optimal peptide antigens:
  • ZC3HAV1 protein (Q05DV5_HUMAN)
  • Zinc finger antiviral protein (ZCCHV_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q7Z2W4

UniProtKB/Swiss-Prot:

ZCCHV_HUMAN :
  • The N-terminal domain is sufficient to bind to viral RNAs and promote their degradation. The second and fourth zinc fingers are involved in binding to specific viral RNAs (PubMed:20451500). Contains a divergent PARP homology ADP-ribosyltransferase domain which lacks the structural requirements for NAD[+] binding (PubMed:25635049). It is therefore inactive (PubMed:25043379, PubMed:25635049).
Domain:
  • The N-terminal domain is sufficient to bind to viral RNAs and promote their degradation. The second and fourth zinc fingers are involved in binding to specific viral RNAs (PubMed:20451500). Contains a divergent PARP homology ADP-ribosyltransferase domain which lacks the structural requirements for NAD[+] binding (PubMed:25635049). It is therefore inactive (PubMed:25043379, PubMed:25635049).
genes like me logo Genes that share domains with ZC3HAV1: view

Function for ZC3HAV1 Gene

Molecular function for ZC3HAV1 Gene

UniProtKB/Swiss-Prot Function:
Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of DDX58/RIG-I signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs).
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Temperature dependence: Thermostable. {ECO:0000269 PubMed:20451500};
UniProtKB/Swiss-Prot Induction:
By type I interferon (IFN) and viruses. Isoform 2 is up-regulated by 3'-PPP-RNA.

Phenotypes From GWAS Catalog for ZC3HAV1 Gene

Gene Ontology (GO) - Molecular Function for ZC3HAV1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA,HDA 22658674
GO:0003950 NOT NAD+ ADP-ribosyltransferase activity IEA,IMP 25635049
GO:0005515 protein binding IPI 21102435
GO:0045296 cadherin binding HDA 25468996
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZC3HAV1: view
genes like me logo Genes that share phenotypes with ZC3HAV1: view

Animal Models for ZC3HAV1 Gene

MGI Knock Outs for ZC3HAV1:

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZC3HAV1 Gene

Localization for ZC3HAV1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZC3HAV1 Gene

[Isoform 1]: Cytoplasm. Nucleus. Note=Localizes in the cytoplasm at steady state, but shuttles between nucleus and cytoplasm in a XPO1-dependent manner. {ECO:0000250 UniProtKB:Q8K3Y6}.
[Isoform 2]: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZC3HAV1 gene
Compartment Confidence
cytosol 5
nucleus 4
extracellular 2
mitochondrion 2
golgi apparatus 2
plasma membrane 1
cytoskeleton 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZC3HAV1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with ZC3HAV1: view

Pathways & Interactions for ZC3HAV1 Gene

genes like me logo Genes that share pathways with ZC3HAV1: view

Pathways by source for ZC3HAV1 Gene

Gene Ontology (GO) - Biological Process for ZC3HAV1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006471 NOT protein ADP-ribosylation IEA,IDA 25043379
GO:0009615 response to virus IDA 21876179
GO:0045071 negative regulation of viral genome replication IDA 21876179
GO:0045087 innate immune response IEA --
GO:0051607 defense response to virus IEA --
genes like me logo Genes that share ontologies with ZC3HAV1: view

No data available for SIGNOR curated interactions for ZC3HAV1 Gene

Drugs & Compounds for ZC3HAV1 Gene

(1) Drugs for ZC3HAV1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with ZC3HAV1: view

Transcripts for ZC3HAV1 Gene

mRNA/cDNA for ZC3HAV1 Gene

3 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZC3HAV1 Gene

No ASD Table

Relevant External Links for ZC3HAV1 Gene

GeneLoc Exon Structure for
ZC3HAV1

Expression for ZC3HAV1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZC3HAV1 Gene

mRNA differential expression in normal tissues according to GTEx for ZC3HAV1 Gene

This gene is overexpressed in Whole Blood (x6.4).

Protein differential expression in normal tissues from HIPED for ZC3HAV1 Gene

This gene is overexpressed in Lung (40.1) and Peripheral blood mononuclear cells (11.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZC3HAV1 Gene



Protein tissue co-expression partners for ZC3HAV1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZC3HAV1

SOURCE GeneReport for Unigene cluster for ZC3HAV1 Gene:

Hs.133512

Evidence on tissue expression from TISSUES for ZC3HAV1 Gene

  • Nervous system(4.5)
  • Liver(4.4)
  • Blood(4.3)
  • Kidney(4.3)
genes like me logo Genes that share expression patterns with ZC3HAV1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZC3HAV1 Gene

Orthologs for ZC3HAV1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZC3HAV1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZC3HAV1 31 30
  • 98.78 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZC3HAV1 31 30
  • 78.21 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ZC3HAV1 31 30
  • 76.77 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zc3hav1 30
  • 71.06 (n)
mouse
(Mus musculus)
Mammalia Zc3hav1 17 31 30
  • 69.66 (n)
oppossum
(Monodelphis domestica)
Mammalia ZC3HAV1 31
  • 37 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZC3HAV1 31
  • 27 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZC3HAV1 31 30
  • 56.53 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZC3HAV1 31
  • 30 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii parp12b 31
  • 34 (a)
ManyToMany
Species where no ortholog for ZC3HAV1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZC3HAV1 Gene

ENSEMBL:
Gene Tree for ZC3HAV1 (if available)
TreeFam:
Gene Tree for ZC3HAV1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZC3HAV1: view image

Paralogs for ZC3HAV1 Gene

Paralogs for ZC3HAV1 Gene

(1) SIMAP similar genes for ZC3HAV1 Gene using alignment to 4 proteins:

  • ZCCHV_HUMAN
  • C9J6P4_HUMAN
  • H7C5K1_HUMAN
  • Q05DV5_HUMAN
genes like me logo Genes that share paralogs with ZC3HAV1: view

Variants for ZC3HAV1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZC3HAV1 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
775256 Benign: not provided 139,055,274(-) C/T SYNONYMOUS_VARIANT
785236 Benign: not provided 139,074,035(-) GA/G INTRON_VARIANT
788271 Benign: not provided 139,076,342(-) C/T SYNONYMOUS_VARIANT
rs2236426 - p.Arg485Lys
rs2297236 - p.Gln701Glu

Additional dbSNP identifiers (rs#s) for ZC3HAV1 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZC3HAV1 Gene

Variant ID Type Subtype PubMed ID
dgv3677n106 CNV deletion 24896259
dgv6640n100 CNV gain 25217958
esv1644522 CNV insertion 17803354
esv1728101 CNV deletion 17803354
esv2303577 CNV deletion 18987734
esv2494461 CNV deletion 19546169
esv2735212 CNV deletion 23290073
esv2735229 CNV deletion 23290073
esv2759567 CNV gain 17122850
esv3022 CNV loss 18987735
esv3542508 CNV deletion 23714750
esv5513 CNV loss 19470904
nsv1076956 CNV deletion 25765185
nsv1147149 CNV deletion 26484159
nsv831155 CNV loss 17160897
nsv957595 CNV deletion 24416366

Variation tolerance for ZC3HAV1 Gene

Residual Variation Intolerance Score: 84% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.81; 58.41% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZC3HAV1 Gene

Human Gene Mutation Database (HGMD)
ZC3HAV1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZC3HAV1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZC3HAV1 Gene

Disorders for ZC3HAV1 Gene

Additional Disease Information for ZC3HAV1

No disorders were found for ZC3HAV1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZC3HAV1 Gene

Publications for ZC3HAV1 Gene

  1. Structural basis for lack of ADP-ribosyltransferase activity in poly(ADP-ribose) polymerase-13/zinc finger antiviral protein. (PMID: 25635049) Karlberg T … Schüler H (The Journal of biological chemistry 2015) 2 3 4 54
  2. Positive selection and increased antiviral activity associated with the PARP-containing isoform of human zinc-finger antiviral protein. (PMID: 18225958) Kerns JA … Malik HS (PLoS genetics 2008) 3 4 23 54
  3. Identification and characterization of human TIPARP gene within the CCNL amplicon at human chromosome 3q25.31. (PMID: 12851707) Katoh M … Katoh M (International journal of oncology 2003) 2 3 23 54
  4. Inhibition of retroviral RNA production by ZAP, a CCCH-type zinc finger protein. (PMID: 12215647) Gao G … Goff SP (Science (New York, N.Y.) 2002) 2 3 23 54
  5. Family-wide analysis of poly(ADP-ribose) polymerase activity. (PMID: 25043379) Vyas S … Chang P (Nature communications 2014) 3 4 54

Products for ZC3HAV1 Gene

Sources for ZC3HAV1 Gene