Aliases for ZC3H8 Gene
External Ids for ZC3H8 Gene
Previous HGNC Symbols for ZC3H8 Gene
Previous GeneCards Identifiers for ZC3H8 Gene
GeneCards Summary for ZC3H8 Gene
ZC3H8 (Zinc Finger CCCH-Type Containing 8) is a Protein Coding gene. Among its related pathways are Tat-mediated elongation of the HIV-1 transcript and Gene Expression. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is ZC3H6.
UniProtKB/Swiss-Prot Summary for ZC3H8 Gene
Acts as a transcriptional repressor of the GATA3 promoter. Sequence-specific DNA-binding factor that binds to the 5'-AGGTCTC-3' sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene (By similarity). Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:23932780). Induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis.