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Aliases for ZC3H8 Gene

Aliases for ZC3H8 Gene

  • Zinc Finger CCCH-Type Containing 8 2 3 5
  • Zinc Finger CCCH-Type Domain Containing 8 2 3
  • ZC3HDC8 3 4
  • Zinc Finger CCCH Domain-Containing Protein 8 3
  • Fliz1 3

External Ids for ZC3H8 Gene

Previous HGNC Symbols for ZC3H8 Gene

  • ZC3HDC8

Previous GeneCards Identifiers for ZC3H8 Gene

  • GC02M112690
  • GC02M112973
  • GC02M105489

Summaries for ZC3H8 Gene

GeneCards Summary for ZC3H8 Gene

ZC3H8 (Zinc Finger CCCH-Type Containing 8) is a Protein Coding gene. Among its related pathways are Gene Expression and RNA polymerase II transcribes snRNA genes. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is ZC3H6.

UniProtKB/Swiss-Prot for ZC3H8 Gene

  • Acts as a transcriptional repressor of the GATA3 promoter. Sequence-specific DNA-binding factor that binds to the 5-AGGTCTC-3 sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene (By similarity). Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:23932780). Induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis.

Additional gene information for ZC3H8 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZC3H8 Gene

Genomics for ZC3H8 Gene

GeneHancer (GH) Regulatory Elements for ZC3H8 Gene

Promoters and enhancers for ZC3H8 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I112253 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.3 332 1.8 HDGF PKNOX1 FOXA2 ARNT MLX ZFP64 ARID4B SIN3A DMAP1 YY1 ZC3H8 PIR62235
GH02I112541 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.1 -287.4 -287443 2.9 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 POLR2B POLR1B LOC105373562 CHCHD5 ANAPC1 RGPD8 RPS20P11 TMEM87B ENSG00000207383 ENSG00000243389 ZC3H8
GH02I112867 Enhancer 1.4 Ensembl ENCODE dbSUPER 10.5 -614.1 -614104 3.6 PKNOX1 CLOCK SMAD1 ATF1 FEZF1 ZNF2 ZNF121 ZNF213 KLF7 FOS IL1B WASH2P IL1A RABL2A IL37 RGPD8 CKAP2L ZC3H8 PIR40727 XIAPP3
GH02I113013 Enhancer 1 ENCODE 11.1 -757.9 -757943 0.2 HDGF PKNOX1 ATF1 ARNT NCOA2 GTF3C2 TCF12 ZNF766 GATA2 FOS ZC3H8 RNU6-1180P IL1F10 IL36A IL36B
GH02I111919 Enhancer 0.9 ENCODE 10.6 +336.5 336497 0.2 SMAD1 FOXA2 TCF12 FOS ATF7 REST TSHZ1 MAFF GMEB1 SMARCA4 ZC3H8 RN7SL297P MERTK
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZC3H8 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZC3H8 gene promoter:

Genomic Locations for ZC3H8 Gene

Genomic Locations for ZC3H8 Gene
chr2:112,211,525-112,255,136
(GRCh38/hg38)
Size:
43,612 bases
Orientation:
Minus strand
chr2:112,969,102-113,012,713
(GRCh37/hg19)

Genomic View for ZC3H8 Gene

Genes around ZC3H8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZC3H8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZC3H8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZC3H8 Gene

Proteins for ZC3H8 Gene

  • Protein details for ZC3H8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N5P1-ZC3H8_HUMAN
    Recommended name:
    Zinc finger CCCH domain-containing protein 8
    Protein Accession:
    Q8N5P1
    Secondary Accessions:
    • Q9BZ75

    Protein attributes for ZC3H8 Gene

    Size:
    291 amino acids
    Molecular mass:
    33576 Da
    Quaternary structure:
    • Component of the little elongation complex (LEC), at least composed of ELL (ELL, ELL2 or ELL3), ZC3H8, ICE1 and ICE2. Interacts with ICE1 (via C-terminus domain).
    SequenceCaution:
    • Sequence=AAH32001.1; Type=Frameshift; Positions=291; Evidence={ECO:0000305};

neXtProt entry for ZC3H8 Gene

Post-translational modifications for ZC3H8 Gene

No Post-translational modifications

Other Protein References for ZC3H8 Gene

No data available for DME Specific Peptides for ZC3H8 Gene

Domains & Families for ZC3H8 Gene

Gene Families for ZC3H8 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZC3H8 Gene

Suggested Antigen Peptide Sequences for ZC3H8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N5P1

UniProtKB/Swiss-Prot:

ZC3H8_HUMAN :
  • The N-terminal region and all three C3H1-type zinc fingers are necessary to induce transcriptional repression.
Domain:
  • The N-terminal region and all three C3H1-type zinc fingers are necessary to induce transcriptional repression.
genes like me logo Genes that share domains with ZC3H8: view

Function for ZC3H8 Gene

Molecular function for ZC3H8 Gene

UniProtKB/Swiss-Prot Function:
Acts as a transcriptional repressor of the GATA3 promoter. Sequence-specific DNA-binding factor that binds to the 5-AGGTCTC-3 sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene (By similarity). Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:23932780). Induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis.

Gene Ontology (GO) - Molecular Function for ZC3H8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding IEA --
GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IMP 12153508
GO:0003723 RNA binding IEA,HDA 22658674
GO:0005515 protein binding IPI 23932780
genes like me logo Genes that share ontologies with ZC3H8: view
genes like me logo Genes that share phenotypes with ZC3H8: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZC3H8 Gene

Localization for ZC3H8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZC3H8 Gene

Nucleus. Note=Colocalizes with coilin in subnuclear cajal and histone locus bodies. Translocates in the LEC complex to cajal and histone locus bodies at snRNA genes in a ICE1-dependent manner. Associates to transcriptionally active chromatin at snRNA genes.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZC3H8 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
mitochondrion 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZC3H8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005654 nucleoplasm TAS --
GO:0008023 transcription elongation factor complex IDA 23932780
GO:0015030 Cajal body IDA 23932780
GO:0016604 nuclear body IDA --
genes like me logo Genes that share ontologies with ZC3H8: view

Pathways & Interactions for ZC3H8 Gene

genes like me logo Genes that share pathways with ZC3H8: view

Pathways by source for ZC3H8 Gene

2 Reactome pathways for ZC3H8 Gene

Gene Ontology (GO) - Biological Process for ZC3H8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006915 apoptotic process IEA --
GO:0033085 negative regulation of T cell differentiation in thymus IMP 12153508
genes like me logo Genes that share ontologies with ZC3H8: view

No data available for SIGNOR curated interactions for ZC3H8 Gene

Drugs & Compounds for ZC3H8 Gene

No Compound Related Data Available

Transcripts for ZC3H8 Gene

Unigene Clusters for ZC3H8 Gene

Zinc finger CCCH-type containing 8:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZC3H8 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1:
SP2: - -
SP3: - - - -
SP4: - - -
SP5: - -

Relevant External Links for ZC3H8 Gene

GeneLoc Exon Structure for
ZC3H8
ECgene alternative splicing isoforms for
ZC3H8

Expression for ZC3H8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZC3H8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZC3H8 Gene

This gene is overexpressed in Liver (65.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZC3H8 Gene



Protein tissue co-expression partners for ZC3H8 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZC3H8 Gene:

ZC3H8

SOURCE GeneReport for Unigene cluster for ZC3H8 Gene:

Hs.418416

Evidence on tissue expression from TISSUES for ZC3H8 Gene

  • Skin(4.1)
genes like me logo Genes that share expression patterns with ZC3H8: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZC3H8 Gene

Orthologs for ZC3H8 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZC3H8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZC3H8 33 34
  • 99.43 (n)
dog
(Canis familiaris)
Mammalia ZC3H8 33 34
  • 89.85 (n)
cow
(Bos Taurus)
Mammalia ZC3H8 33 34
  • 86.92 (n)
mouse
(Mus musculus)
Mammalia Zc3h8 33 16 34
  • 84.31 (n)
rat
(Rattus norvegicus)
Mammalia Zc3h8 33
  • 82.36 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ZC3H8 34
  • 25 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZC3H6 34
  • 11 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 12 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ZC3H8 34
  • 10 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta su(s) 34
  • 4 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T26A8.4 34
  • 7 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4406 34
  • 2 (a)
OneToMany
Species where no ortholog for ZC3H8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ZC3H8 Gene

ENSEMBL:
Gene Tree for ZC3H8 (if available)
TreeFam:
Gene Tree for ZC3H8 (if available)

Paralogs for ZC3H8 Gene

Paralogs for ZC3H8 Gene

(2) SIMAP similar genes for ZC3H8 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZC3H8: view

Variants for ZC3H8 Gene

Sequence variations from dbSNP and Humsavar for ZC3H8 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000213601 -- 112,230,368(-) T/C intron_variant
rs1000225168 -- 112,243,963(-) T/C intron_variant
rs1000278159 -- 112,251,435(-) A/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000304748 -- 112,237,037(-) G/A intron_variant
rs1000325434 -- 112,246,717(-) G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZC3H8 Gene

Variant ID Type Subtype PubMed ID
nsv582703 CNV loss 21841781
nsv521956 CNV loss 19592680
nsv1149522 OTHER inversion 26484159
nsv1123369 CNV deletion 24896259
esv3383143 CNV insertion 20981092
esv3374040 CNV insertion 20981092
esv3305434 CNV mobile element insertion 20981092
dgv4047n100 CNV loss 25217958

Variation tolerance for ZC3H8 Gene

Residual Variation Intolerance Score: 63.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.65; 13.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZC3H8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZC3H8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZC3H8 Gene

Disorders for ZC3H8 Gene

Additional Disease Information for ZC3H8

No disorders were found for ZC3H8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZC3H8 Gene

Publications for ZC3H8 Gene

  1. The little elongation complex functions at initiation and elongation phases of snRNA gene transcription. (PMID: 23932780) Hu D … Shilatifard A (Molecular cell 2013) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  4. Regulation of thymocyte homeostasis by Fliz1. (PMID: 12153508) Hwang ES … Ho IC (Immunology 2002) 3 4 58
  5. Transcriptional regulation of GATA-3 by an intronic regulatory region and fetal liver zinc finger protein 1. (PMID: 12077251) Hwang ES … Ho IC (Journal of immunology (Baltimore, Md. : 1950) 2002) 3 4 58

Products for ZC3H8 Gene

Sources for ZC3H8 Gene

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