This gene encodes a protein that contains a tetratricopeptide repeat domain. The encoded protein also interacts with the rotavirus non-structural protein NSP3. [provided by RefSeq, Jul 2008] See more...

Aliases for ZC3H7B Gene

Aliases for ZC3H7B Gene

  • Zinc Finger CCCH-Type Containing 7B 2 3 5
  • Rotavirus 'X'-Associated Non-Structural Protein 3 4
  • Zinc Finger CCCH Domain-Containing Protein 7B 3 4
  • RoXaN 3 4
  • Ubiquitous Tetratricopeptide Containing Protein RoXaN 3
  • Rotavirus 'X' Associated Non-Structural Protein 3
  • Rotavirus X Protein Associated With NSP3 3
  • KIAA1031 4
  • ROXAN1 3

External Ids for ZC3H7B Gene

Previous GeneCards Identifiers for ZC3H7B Gene

  • GC22P040023
  • GC22P041697
  • GC22P024664

Summaries for ZC3H7B Gene

Entrez Gene Summary for ZC3H7B Gene

  • This gene encodes a protein that contains a tetratricopeptide repeat domain. The encoded protein also interacts with the rotavirus non-structural protein NSP3. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZC3H7B Gene

ZC3H7B (Zinc Finger CCCH-Type Containing 7B) is a Protein Coding gene. Diseases associated with ZC3H7B include Myxoid Leiomyosarcoma and Ossifying Fibromyxoid Tumor. An important paralog of this gene is ZC3H7A.

UniProtKB/Swiss-Prot Summary for ZC3H7B Gene

  • May be a specific regulator of miRNA biogenesis. Binds to microRNAs MIR7-1, MIR16-2 and MIR29A hairpins recognizing the 'ATA(A/T)' motif in the apical loop.

Gene Wiki entry for ZC3H7B Gene

Additional gene information for ZC3H7B Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZC3H7B Gene

Genomics for ZC3H7B Gene

GeneHancer (GH) Regulatory Elements for ZC3H7B Gene

Promoters and enhancers for ZC3H7B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZC3H7B on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZC3H7B

Top Transcription factor binding sites by QIAGEN in the ZC3H7B gene promoter:
  • AhR
  • AP-1
  • ATF-2
  • c-Jun
  • CREB
  • deltaCREB

Genomic Locations for ZC3H7B Gene

Genomic Locations for ZC3H7B Gene
chr22:41,301,503-41,360,147
(GRCh38/hg38)
Size:
58,645 bases
Orientation:
Plus strand
chr22:41,697,526-41,756,151
(GRCh37/hg19)
Size:
58,626 bases
Orientation:
Plus strand

Genomic View for ZC3H7B Gene

Genes around ZC3H7B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZC3H7B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZC3H7B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZC3H7B Gene

Proteins for ZC3H7B Gene

  • Protein details for ZC3H7B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UGR2-Z3H7B_HUMAN
    Recommended name:
    Zinc finger CCCH domain-containing protein 7B
    Protein Accession:
    Q9UGR2
    Secondary Accessions:
    • A7YY88
    • B2RCA4
    • Q5TFX9
    • Q8TBT9
    • Q9H8B6
    • Q9UGQ9
    • Q9UGR0
    • Q9UGR1
    • Q9UK03
    • Q9UPW9

    Protein attributes for ZC3H7B Gene

    Size:
    977 amino acids
    Molecular mass:
    109858 Da
    Quaternary structure:
    • (Microbial infection) Interacts (via LD motif) with rotavirus A NSP3 (via the coiled-coil region).

neXtProt entry for ZC3H7B Gene

Post-translational modifications for ZC3H7B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZC3H7B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZC3H7B Gene

Domains & Families for ZC3H7B Gene

Gene Families for ZC3H7B Gene

Protein Domains for ZC3H7B Gene

Blocks:
  • Zn-finger, C-x8-C-x5-C-x3-H type
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZC3H7B Gene

GenScript: Design optimal peptide antigens:
  • ZC3H7B protein (Q9BSS8_HUMAN)
  • Rotavirus 'X'-associated non-structural protein (Z3H7B_HUMAN)
genes like me logo Genes that share domains with ZC3H7B: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ZC3H7B Gene

Function for ZC3H7B Gene

Molecular function for ZC3H7B Gene

UniProtKB/Swiss-Prot Function:
May be a specific regulator of miRNA biogenesis. Binds to microRNAs MIR7-1, MIR16-2 and MIR29A hairpins recognizing the 'ATA(A/T)' motif in the apical loop.

Phenotypes From GWAS Catalog for ZC3H7B Gene

Gene Ontology (GO) - Molecular Function for ZC3H7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0005515 protein binding IEA,IPI 15047801
GO:0035198 miRNA binding IDA 28431233
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZC3H7B: view
genes like me logo Genes that share phenotypes with ZC3H7B: view

Animal Model Products

CRISPR Products

miRNA for ZC3H7B Gene

miRTarBase miRNAs that target ZC3H7B

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZC3H7B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZC3H7B Gene

Localization for ZC3H7B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZC3H7B Gene

Nucleus. Note=Nuclear localization seems to be depleted upon rotavirus A infection.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZC3H7B gene
Compartment Confidence
nucleus 4
cytosol 3
cytoskeleton 1
mitochondrion 0
golgi apparatus 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZC3H7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZC3H7B: view

Pathways & Interactions for ZC3H7B Gene

PathCards logo

SuperPathways for ZC3H7B Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZC3H7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010608 posttranscriptional regulation of gene expression IMP 28431233
GO:0016032 viral process IEA --
GO:0035196 production of miRNAs involved in gene silencing by miRNA IMP 28431233
genes like me logo Genes that share ontologies with ZC3H7B: view

No data available for Pathways by source and SIGNOR curated interactions for ZC3H7B Gene

Drugs & Compounds for ZC3H7B Gene

No Compound Related Data Available

Transcripts for ZC3H7B Gene

mRNA/cDNA for ZC3H7B Gene

1 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZC3H7B

Alternative Splicing Database (ASD) splice patterns (SP) for ZC3H7B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^
SP1: - - - -
SP2:
SP3: -
SP4: -
SP5:

ExUns: 21 ^ 22 ^ 23 ^ 24 ^ 25
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for ZC3H7B Gene

GeneLoc Exon Structure for
ZC3H7B

Expression for ZC3H7B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZC3H7B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZC3H7B Gene

This gene is overexpressed in Lung (13.0) and Fetal Brain (11.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZC3H7B Gene



Protein tissue co-expression partners for ZC3H7B Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZC3H7B

SOURCE GeneReport for Unigene cluster for ZC3H7B Gene:

Hs.592188

Evidence on tissue expression from TISSUES for ZC3H7B Gene

  • Nervous system(4.7)
  • Liver(4.2)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with ZC3H7B: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZC3H7B Gene

Orthologs for ZC3H7B Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZC3H7B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZC3H7B 31 30
  • 98.33 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZC3H7B 30
  • 93.04 (n)
cow
(Bos Taurus)
Mammalia ZC3H7B 31 30
  • 91.92 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zc3h7b 30
  • 90.88 (n)
mouse
(Mus musculus)
Mammalia Zc3h7b 17 31 30
  • 90.43 (n)
oppossum
(Monodelphis domestica)
Mammalia ZC3H7B 31
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZC3H7B 31
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZC3H7B 31 30
  • 78.78 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZC3H7B 31
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zc3h7b 30
  • 62.04 (n)
Str.9266 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.12144 30
zebrafish
(Danio rerio)
Actinopterygii ZC3H7B (3 of 3) 31
  • 47 (a)
OneToMany
zc3h7b 31
  • 43 (a)
OneToMany
ZC3H7B (2 of 3) 31
  • 40 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 37 (a)
OneToMany
Species where no ortholog for ZC3H7B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZC3H7B Gene

ENSEMBL:
Gene Tree for ZC3H7B (if available)
TreeFam:
Gene Tree for ZC3H7B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZC3H7B: view image

Paralogs for ZC3H7B Gene

Paralogs for ZC3H7B Gene

(1) SIMAP similar genes for ZC3H7B Gene using alignment to 2 proteins:

  • Z3H7B_HUMAN
  • Q9BSS8_HUMAN
genes like me logo Genes that share paralogs with ZC3H7B: view

Variants for ZC3H7B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZC3H7B Gene

SNP ID Clinical significance and condition Chr 22 pos Variation AA Info Type
rs9607793 - p.Asp363Asn

Additional dbSNP identifiers (rs#s) for ZC3H7B Gene

Structural Variations from Database of Genomic Variants (DGV) for ZC3H7B Gene

Variant ID Type Subtype PubMed ID
dgv772n67 CNV gain 20364138
nsv3638 CNV insertion 18451855
nsv459888 CNV gain 19166990
nsv479224 CNV novel sequence insertion 20440878
nsv507937 OTHER sequence alteration 20534489
nsv516925 CNV loss 19592680
nsv524585 CNV loss 19592680
nsv589050 CNV gain 21841781
nsv817997 CNV gain 17921354
nsv829242 CNV gain 20364138
nsv834207 CNV loss 17160897

Variation tolerance for ZC3H7B Gene

Residual Variation Intolerance Score: 4.19% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.27; 62.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZC3H7B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZC3H7B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZC3H7B Gene

Disorders for ZC3H7B Gene

MalaCards: The human disease database

(10) MalaCards diseases for ZC3H7B Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
myxoid leiomyosarcoma
  • leiomyosarcoma, myxoid
ossifying fibromyxoid tumor
  • ossifying fibromyxoma
endometrial stromal sarcoma
  • endometrial stromal sarcoma, high grade
endometrial stromal tumor
  • endometrial stromal neoplasm
leiomyosarcoma
  • leiomyosarcomas
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZC3H7B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ZC3H7B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZC3H7B Gene

Publications for ZC3H7B Gene

  1. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 2 3 4 54
  2. A Compendium of RNA-Binding Proteins that Regulate MicroRNA Biogenesis. (PMID: 28431233) Treiber T … Meister G (Molecular cell 2017) 3 4 54
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  4. Nuclear localization of cytoplasmic poly(A)-binding protein upon rotavirus infection involves the interaction of NSP3 with eIF4G and RoXaN. (PMID: 18799579) Harb M … Poncet D (Journal of virology 2008) 3 4 54
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54

Products for ZC3H7B Gene

Sources for ZC3H7B Gene