Aliases for ZC3H7A Gene

Aliases for ZC3H7A Gene

  • Zinc Finger CCCH-Type Containing 7A 2 3 5
  • Zinc Finger CCCH Domain-Containing Protein 7A 3 4
  • Zinc Finger CCCH-Type Domain Containing 7 2 3
  • HSPC055 2 3
  • ZC3HDC7 3 4
  • ZC3H7 3 4
  • Zinc Finger CCCH-Type Containing 7 2
  • Zinc-Finger Protein AY163807 3
  • FLJ20318 2
  • ZC3H7A 5

External Ids for ZC3H7A Gene

Previous HGNC Symbols for ZC3H7A Gene

  • ZC3HDC7
  • ZC3H7

Previous GeneCards Identifiers for ZC3H7A Gene

  • GC16M011752
  • GC16M011845
  • GC16M011846
  • GC16M011848
  • GC16M011849

Summaries for ZC3H7A Gene

GeneCards Summary for ZC3H7A Gene

ZC3H7A (Zinc Finger CCCH-Type Containing 7A) is a Protein Coding gene. Diseases associated with ZC3H7A include Endometrial Stromal Tumor and Endometrial Stromal Sarcoma. An important paralog of this gene is ZC3H7B.

UniProtKB/Swiss-Prot Summary for ZC3H7A Gene

  • May be a specific regulator of miRNA biogenesis. Binds to microRNAs MIR7-1, MIR16-2 and MIR29A hairpins recognizing the 3'-ATA(A/T)-5' motif in the apical loop.

Additional gene information for ZC3H7A Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZC3H7A Gene

Genomics for ZC3H7A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZC3H7A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZC3H7A on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZC3H7A

Top Transcription factor binding sites by QIAGEN in the ZC3H7A gene promoter:
  • AML1a
  • AREB6
  • Cart-1
  • HNF-3beta
  • HOXA3
  • Oct-B1
  • oct-B2
  • Roaz
  • STAT5A

Genomic Locations for ZC3H7A Gene

Genomic Locations for ZC3H7A Gene
chr16:11,750,586-11,797,258
(GRCh38/hg38)
Size:
46,673 bases
Orientation:
Minus strand
chr16:11,844,442-11,891,123
(GRCh37/hg19)
Size:
46,682 bases
Orientation:
Minus strand

Genomic View for ZC3H7A Gene

Genes around ZC3H7A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZC3H7A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZC3H7A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZC3H7A Gene

Proteins for ZC3H7A Gene

  • Protein details for ZC3H7A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IWR0-Z3H7A_HUMAN
    Recommended name:
    Zinc finger CCCH domain-containing protein 7A
    Protein Accession:
    Q8IWR0
    Secondary Accessions:
    • D3DUG5
    • Q9NPE9

    Protein attributes for ZC3H7A Gene

    Size:
    971 amino acids
    Molecular mass:
    110538 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ZC3H7A Gene

    Alternative splice isoforms for ZC3H7A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZC3H7A Gene

Post-translational modifications for ZC3H7A Gene

  • Ubiquitination at Lys425 and Lys709
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZC3H7A Gene

Domains & Families for ZC3H7A Gene

Gene Families for ZC3H7A Gene

Protein Domains for ZC3H7A Gene

InterPro:
Blocks:
  • Zn-finger, C-x8-C-x5-C-x3-H type
ProtoNet:

Suggested Antigen Peptide Sequences for ZC3H7A Gene

GenScript: Design optimal peptide antigens:
  • ZC3H7A protein (Q8IWJ6_HUMAN)
  • Zinc finger CCCH domain-containing protein 7A (Z3H7A_HUMAN)
genes like me logo Genes that share domains with ZC3H7A: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ZC3H7A Gene

Function for ZC3H7A Gene

Molecular function for ZC3H7A Gene

UniProtKB/Swiss-Prot Function:
May be a specific regulator of miRNA biogenesis. Binds to microRNAs MIR7-1, MIR16-2 and MIR29A hairpins recognizing the 3'-ATA(A/T)-5' motif in the apical loop.

Phenotypes From GWAS Catalog for ZC3H7A Gene

Gene Ontology (GO) - Molecular Function for ZC3H7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA,HDA 22658674
GO:0005515 protein binding IEA --
GO:0035198 miRNA binding IEA,IDA 28431233
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZC3H7A: view
genes like me logo Genes that share phenotypes with ZC3H7A: view

Animal Model Products

CRISPR Products

miRNA for ZC3H7A Gene

miRTarBase miRNAs that target ZC3H7A

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZC3H7A

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZC3H7A Gene

Localization for ZC3H7A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZC3H7A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZC3H7A gene
Compartment Confidence
nucleus 4
cytosol 2
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZC3H7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZC3H7A: view

Pathways & Interactions for ZC3H7A Gene

PathCards logo

SuperPathways for ZC3H7A Gene

No Data Available

Interacting Proteins for ZC3H7A Gene

Gene Ontology (GO) - Biological Process for ZC3H7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010608 posttranscriptional regulation of gene expression IMP 28431233
GO:0035196 production of miRNAs involved in gene silencing by miRNA IMP 28431233
genes like me logo Genes that share ontologies with ZC3H7A: view

No data available for Pathways by source and SIGNOR curated interactions for ZC3H7A Gene

Drugs & Compounds for ZC3H7A Gene

No Compound Related Data Available

Transcripts for ZC3H7A Gene

mRNA/cDNA for ZC3H7A Gene

1 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
17 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZC3H7A

Alternative Splicing Database (ASD) splice patterns (SP) for ZC3H7A Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^
SP1: - - - - - - - - -
SP2: -
SP3: - - - - - - -
SP4: - - - - - -
SP5:
SP6: - -
SP7: - - - - -
SP8: - - - - -
SP9: - - - -
SP10: - - -
SP11: -
SP12:
SP13:
SP14:

ExUns: 16 ^ 17a · 17b ^ 18 ^ 19a · 19b ^ 20 ^ 21a · 21b ^ 22a · 22b ^ 23a · 23b ^ 24 ^ 25a · 25b ^ 26a · 26b ^ 27a · 27b
SP1: -
SP2: -
SP3:
SP4:
SP5: - -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: -
SP13:
SP14:

Relevant External Links for ZC3H7A Gene

GeneLoc Exon Structure for
ZC3H7A

Expression for ZC3H7A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZC3H7A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZC3H7A Gene

This gene is overexpressed in Peripheral blood mononuclear cells (30.8), Platelet (9.6), and Placenta (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZC3H7A Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZC3H7A

SOURCE GeneReport for Unigene cluster for ZC3H7A Gene:

Hs.371856

Evidence on tissue expression from TISSUES for ZC3H7A Gene

  • Muscle(4.3)
  • Skin(4.3)
  • Liver(4.2)
  • Blood(4.2)
  • Nervous system(2.6)
genes like me logo Genes that share expression patterns with ZC3H7A: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZC3H7A Gene

Orthologs for ZC3H7A Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZC3H7A Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZC3H7A 30 31
  • 99.76 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZC3H7A 30 31
  • 92.28 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZC3H7A 30 31
  • 90.77 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Zc3h7a 30 17 31
  • 87.16 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Zc3h7a 30
  • 86.03 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 83 (a)
OneToMany
-- 31
  • 76 (a)
OneToMany
-- 31
  • 68 (a)
OneToMany
-- 31
  • 65 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia ZC3H7A 31
  • 81 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ZC3H7A 30 31
  • 76.16 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ZC3H7A 31
  • 69 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia zc3h7a 30
  • 62.81 (n)
Str.11347 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.13783 30
Zebrafish
(Danio rerio)
Actinopterygii zc3h7a 30 31
  • 60.28 (n)
OneToOne
wufa12e01 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11063 30
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 37 (a)
OneToMany
Species where no ortholog for ZC3H7A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ZC3H7A Gene

ENSEMBL:
Gene Tree for ZC3H7A (if available)
TreeFam:
Gene Tree for ZC3H7A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZC3H7A: view image

Paralogs for ZC3H7A Gene

Paralogs for ZC3H7A Gene

(1) SIMAP similar genes for ZC3H7A Gene using alignment to 10 proteins:

  • Z3H7A_HUMAN
  • I3L1Y3_HUMAN
  • I3L282_HUMAN
  • I3L2K5_HUMAN
  • I3L2N8_HUMAN
  • I3L323_HUMAN
  • I3L382_HUMAN
  • I3L3F9_HUMAN
  • I3L3S2_HUMAN
  • Q8IWJ6_HUMAN
genes like me logo Genes that share paralogs with ZC3H7A: view

Variants for ZC3H7A Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZC3H7A Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
rs1429077 - p.Asn3Ser
rs16958654 - p.His57Arg

Additional dbSNP identifiers (rs#s) for ZC3H7A Gene

Structural Variations from Database of Genomic Variants (DGV) for ZC3H7A Gene

Variant ID Type Subtype PubMed ID
esv21664 CNV loss 19812545
esv2674286 CNV deletion 23128226
esv3637939 CNV loss 21293372
nsv1043909 CNV gain 25217958
nsv1123009 CNV deletion 24896259
nsv1126416 CNV deletion 24896259
nsv1138415 CNV deletion 24896259

Variation tolerance for ZC3H7A Gene

Residual Variation Intolerance Score: 8.46% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.33; 70.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZC3H7A Gene

Human Gene Mutation Database (HGMD)
ZC3H7A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZC3H7A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZC3H7A Gene

Disorders for ZC3H7A Gene

MalaCards: The human disease database

(2) MalaCards diseases for ZC3H7A Gene - From: DISEASES

Disorder Aliases PubMed IDs
endometrial stromal tumor
  • endometrial stromal neoplasm
endometrial stromal sarcoma
  • endometrial stromal sarcoma, high grade
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZC3H7A

genes like me logo Genes that share disorders with ZC3H7A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZC3H7A Gene

Publications for ZC3H7A Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 2 3 4
  2. A Compendium of RNA-Binding Proteins that Regulate MicroRNA Biogenesis. (PMID: 28431233) Treiber T … Meister G (Molecular cell 2017) 3 4
  3. Common variants at ten loci influence QT interval duration in the QTGEN Study. (PMID: 19305408) Newton-Cheh C … Stricker BH (Nature genetics 2009) 3 41
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for ZC3H7A Gene

  • Signalway Proteins for ZC3H7A

Sources for ZC3H7A Gene