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Aliases for ZC3H7A Gene

Aliases for ZC3H7A Gene

  • Zinc Finger CCCH-Type Containing 7A 2 3 5
  • Zinc Finger CCCH-Type Domain Containing 7 2 3
  • ZC3HDC7 3 4
  • ZC3H7 3 4
  • Zinc Finger CCCH Domain-Containing Protein 7A 3
  • Zinc Finger CCCH-Type Containing 7 2
  • Zinc-Finger Protein AY163807 3
  • HSPC055 3

External Ids for ZC3H7A Gene

Previous HGNC Symbols for ZC3H7A Gene

  • ZC3HDC7
  • ZC3H7

Previous GeneCards Identifiers for ZC3H7A Gene

  • GC16M011752
  • GC16M011845
  • GC16M011846
  • GC16M011848
  • GC16M011849

Summaries for ZC3H7A Gene

GeneCards Summary for ZC3H7A Gene

ZC3H7A (Zinc Finger CCCH-Type Containing 7A) is a Protein Coding gene. An important paralog of this gene is ZC3H7B.

UniProtKB/Swiss-Prot for ZC3H7A Gene

  • May be a specific regulator of miRNA biogenesis. Binds to microRNAs MIR7-1, MIR16-2 and MIR29A hairpins recognizing the 3-ATA(A/T)-5 motif in the apical loop.

Additional gene information for ZC3H7A Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZC3H7A Gene

Genomics for ZC3H7A Gene

GeneHancer (GH) Regulatory Elements for ZC3H7A Gene

Promoters and enhancers for ZC3H7A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I011790 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 557.1 +1.4 1365 10.1 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF213 ZNF143 SP3 NFYC SSRP1 ZC3H7A ENSG00000277369 GC16P011798 PRM2 NPIPB2 PRM1 LITAF SNN TXNDC11 LOC105371089
GH16I011780 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 555.3 +14.2 14247 5.2 HDGF PKNOX1 SMAD1 RB1 ARNT BMI1 FEZF1 YBX1 BATF KLF5 ZC3H7A RSL1D1 LOC105371089 TXNDC11 ENSG00000274505
GH16I012061 Enhancer 1.3 Ensembl ENCODE dbSUPER 69.9 -265.5 -265499 2.5 ZNF493 ZFP64 BRCA1 ZNF213 ZNF143 KLF7 FOS ZNF202 ZC3H11A REST LOC105371084 ENSG00000261560 HNRNPCP4 ZC3H7A NPIPB2 COX6CP1 ENSG00000261216 SOCS1 TXNDC11 RSL1D1
GH16I011639 Enhancer 2 VISTA FANTOM5 Ensembl ENCODE dbSUPER 34.3 +156.6 156609 3.3 PKNOX1 FOXA2 ARID4B NEUROD1 SIN3A YBX1 DMAP1 ZNF2 YY1 SLC30A9 LOC105371084 HNRNPCP4 ENSG00000261560 LITAF COX6CP1 ZC3H7A ENSG00000261216 TXNDC11 NPIPB2 SOCS1
GH16I011667 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 24.3 +126.9 126874 6.7 IRF4 ZNF48 GLIS2 ZNF143 ATF7 FOS RUNX3 SP5 NFYC MXD4 SNN ZC3H7A TXNDC11 LITAF LOC105371084 ENSG00000261560 HNRNPCP4 RSL1D1 COX6CP1 SNX29
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZC3H7A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZC3H7A gene promoter:

Genomic Locations for ZC3H7A Gene

Genomic Locations for ZC3H7A Gene
chr16:11,750,586-11,797,267
(GRCh38/hg38)
Size:
46,682 bases
Orientation:
Minus strand
chr16:11,844,442-11,891,123
(GRCh37/hg19)

Genomic View for ZC3H7A Gene

Genes around ZC3H7A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZC3H7A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZC3H7A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZC3H7A Gene

Proteins for ZC3H7A Gene

  • Protein details for ZC3H7A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IWR0-Z3H7A_HUMAN
    Recommended name:
    Zinc finger CCCH domain-containing protein 7A
    Protein Accession:
    Q8IWR0
    Secondary Accessions:
    • D3DUG5
    • Q9NPE9

    Protein attributes for ZC3H7A Gene

    Size:
    971 amino acids
    Molecular mass:
    110538 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ZC3H7A Gene

    Alternative splice isoforms for ZC3H7A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZC3H7A Gene

Post-translational modifications for ZC3H7A Gene

  • Ubiquitination at isoforms=425 and isoforms=709
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZC3H7A Gene

Domains & Families for ZC3H7A Gene

Gene Families for ZC3H7A Gene

Suggested Antigen Peptide Sequences for ZC3H7A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZC3H7A: view

No data available for UniProtKB/Swiss-Prot for ZC3H7A Gene

Function for ZC3H7A Gene

Molecular function for ZC3H7A Gene

UniProtKB/Swiss-Prot Function:
May be a specific regulator of miRNA biogenesis. Binds to microRNAs MIR7-1, MIR16-2 and MIR29A hairpins recognizing the 3-ATA(A/T)-5 motif in the apical loop.

Phenotypes From GWAS Catalog for ZC3H7A Gene

Gene Ontology (GO) - Molecular Function for ZC3H7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0035198 miRNA binding IDA 28431233
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZC3H7A: view

Phenotypes for ZC3H7A Gene

GenomeRNAi human phenotypes for ZC3H7A:
genes like me logo Genes that share phenotypes with ZC3H7A: view

Animal Model Products

miRNA for ZC3H7A Gene

miRTarBase miRNAs that target ZC3H7A

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZC3H7A Gene

Localization for ZC3H7A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZC3H7A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZC3H7A gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZC3H7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZC3H7A: view

Pathways & Interactions for ZC3H7A Gene

SuperPathways for ZC3H7A Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZC3H7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010608 posttranscriptional regulation of gene expression IMP 28431233
GO:0035196 production of miRNAs involved in gene silencing by miRNA IMP 28431233
genes like me logo Genes that share ontologies with ZC3H7A: view

No data available for Pathways by source and SIGNOR curated interactions for ZC3H7A Gene

Drugs & Compounds for ZC3H7A Gene

No Compound Related Data Available

Transcripts for ZC3H7A Gene

Unigene Clusters for ZC3H7A Gene

Zinc finger CCCH-type containing 7A:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZC3H7A Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^
SP1: - - - - - - - - -
SP2: -
SP3: - - - - - - -
SP4: - - - - - -
SP5:
SP6: - -
SP7: - - - - -
SP8: - - - - -
SP9: - - - -
SP10: - - -
SP11: -
SP12:
SP13:
SP14:

ExUns: 16 ^ 17a · 17b ^ 18 ^ 19a · 19b ^ 20 ^ 21a · 21b ^ 22a · 22b ^ 23a · 23b ^ 24 ^ 25a · 25b ^ 26a · 26b ^ 27a · 27b
SP1: -
SP2: -
SP3:
SP4:
SP5: - -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: -
SP13:
SP14:

Relevant External Links for ZC3H7A Gene

GeneLoc Exon Structure for
ZC3H7A
ECgene alternative splicing isoforms for
ZC3H7A

Expression for ZC3H7A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZC3H7A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZC3H7A Gene

This gene is overexpressed in Peripheral blood mononuclear cells (30.8), Platelet (9.6), and Placenta (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZC3H7A Gene



NURSA nuclear receptor signaling pathways regulating expression of ZC3H7A Gene:

ZC3H7A

SOURCE GeneReport for Unigene cluster for ZC3H7A Gene:

Hs.371856

Evidence on tissue expression from TISSUES for ZC3H7A Gene

  • Liver(4.2)
  • Muscle(4.2)
  • Skin(4.2)
  • Blood(4.1)
  • Nervous system(2.6)
genes like me logo Genes that share expression patterns with ZC3H7A: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZC3H7A Gene

Orthologs for ZC3H7A Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZC3H7A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZC3H7A 33 34
  • 99.76 (n)
dog
(Canis familiaris)
Mammalia ZC3H7A 33 34
  • 92.28 (n)
cow
(Bos Taurus)
Mammalia ZC3H7A 33 34
  • 90.77 (n)
mouse
(Mus musculus)
Mammalia Zc3h7a 33 16 34
  • 87.16 (n)
rat
(Rattus norvegicus)
Mammalia Zc3h7a 33
  • 86.03 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 83 (a)
OneToMany
-- 34
  • 76 (a)
OneToMany
-- 34
  • 68 (a)
OneToMany
-- 34
  • 65 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia ZC3H7A 34
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZC3H7A 33 34
  • 76.16 (n)
lizard
(Anolis carolinensis)
Reptilia ZC3H7A 34
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zc3h7a 33
  • 62.81 (n)
Str.11347 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.13783 33
zebrafish
(Danio rerio)
Actinopterygii zc3h7a 33 34
  • 60.28 (n)
wufa12e01 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11063 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 37 (a)
OneToMany
Species where no ortholog for ZC3H7A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZC3H7A Gene

ENSEMBL:
Gene Tree for ZC3H7A (if available)
TreeFam:
Gene Tree for ZC3H7A (if available)

Paralogs for ZC3H7A Gene

Paralogs for ZC3H7A Gene

(1) SIMAP similar genes for ZC3H7A Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with ZC3H7A: view

Variants for ZC3H7A Gene

Sequence variations from dbSNP and Humsavar for ZC3H7A Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000014974 -- 11,780,542(-) T/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000031665 -- 11,785,715(-) C/G/T genic_upstream_transcript_variant, intron_variant
rs1000076753 -- 11,779,503(-) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000166144 -- 11,791,050(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000233847 -- 11,767,726(-) G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZC3H7A Gene

Variant ID Type Subtype PubMed ID
esv21664 CNV loss 19812545
esv2674286 CNV deletion 23128226
esv3637939 CNV loss 21293372
nsv1043909 CNV gain 25217958
nsv1123009 CNV deletion 24896259
nsv1126416 CNV deletion 24896259
nsv1138415 CNV deletion 24896259

Variation tolerance for ZC3H7A Gene

Residual Variation Intolerance Score: 8.46% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.33; 70.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZC3H7A Gene

Human Gene Mutation Database (HGMD)
ZC3H7A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZC3H7A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZC3H7A Gene

Disorders for ZC3H7A Gene

Additional Disease Information for ZC3H7A

No disorders were found for ZC3H7A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZC3H7A Gene

Publications for ZC3H7A Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 2 3 4 58
  2. A Compendium of RNA-Binding Proteins that Regulate MicroRNA Biogenesis. (PMID: 28431233) Treiber T … Meister G (Molecular cell 2017) 3 4 58
  3. Common variants at ten loci influence QT interval duration in the QTGEN Study. (PMID: 19305408) Newton-Cheh C … Stricker BH (Nature genetics 2009) 3 44 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for ZC3H7A Gene

Sources for ZC3H7A Gene

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