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Aliases for ZC3H15 Gene

Aliases for ZC3H15 Gene

  • Zinc Finger CCCH-Type Containing 15 2 3 5
  • Likely Ortholog Of Mouse Immediate Early Response Erythropoietin 4 3 4
  • DRG Family-Regulatory Protein 1 3 4
  • LEREPO4 3 4
  • Likely Ortholog Of Mouse Immediate Early Response, Erythropoietin 4 2
  • Zinc Finger CCCH Domain-Containing Protein 15 3
  • MSTP012 3
  • HT010 3
  • DFRP1 4

External Ids for ZC3H15 Gene

Previous GeneCards Identifiers for ZC3H15 Gene

  • GC02P187060
  • GC02P187350
  • GC02P179210

Summaries for ZC3H15 Gene

GeneCards Summary for ZC3H15 Gene

ZC3H15 (Zinc Finger CCCH-Type Containing 15) is a Protein Coding gene.

UniProtKB/Swiss-Prot for ZC3H15 Gene

  • Protects DRG1 from proteolytic degradation.

Additional gene information for ZC3H15 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZC3H15 Gene

Genomics for ZC3H15 Gene

GeneHancer (GH) Regulatory Elements for ZC3H15 Gene

Promoters and enhancers for ZC3H15 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I186482 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 550.8 -0.9 -874 5.8 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZC3H15 ITGAV ENSG00000259915 FSIP2-AS1 LOC101927196 LOC105373785
GH02I186129 Enhancer 1.1 Ensembl ENCODE 3.6 -355.7 -355723 1.9 ELF3 FOXA2 MZF1 FEZF1 ZSCAN9 RARA ZNF366 SCRT2 CREM THAP11 ENSG00000259915 MED28P3 ZC3H15 ENSG00000226410 GC02P186098
GH02I186555 Enhancer 0.6 FANTOM5 4.3 +69.3 69282 0.2 CTCF GATA3 CTBP1 POLR2A NRF1 SMC3 ZNF24 ITGAV ZC3H15 DPRXP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZC3H15 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZC3H15 gene promoter:

Genomic Locations for ZC3H15 Gene

Genomic Locations for ZC3H15 Gene
23,208 bases
Plus strand

Genomic View for ZC3H15 Gene

Genes around ZC3H15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZC3H15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZC3H15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZC3H15 Gene

Proteins for ZC3H15 Gene

  • Protein details for ZC3H15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger CCCH domain-containing protein 15
    Protein Accession:
    Secondary Accessions:
    • B4DMW2
    • D3DPG7
    • Q5QTQ4
    • Q8WZ06
    • Q9NUZ3
    • Q9NZ37
    • Q9P079

    Protein attributes for ZC3H15 Gene

    426 amino acids
    Molecular mass:
    48602 Da
    Quaternary structure:
    • Interacts with DRG1; the interaction forms a polysomal DRG1-DFRP1/ZC3H15 complex which provides protein stability to DRG1 possibly by blocking poly-ubiquitination.
    • Sequence=AAF28981.1; Type=Frameshift; Positions=17; Evidence={ECO:0000305}; Sequence=AAF67649.1; Type=Frameshift; Positions=392, 407, 422; Evidence={ECO:0000305}; Sequence=AAL55770.1; Type=Frameshift; Positions=92; Evidence={ECO:0000305}; Sequence=AAQ13514.1; Type=Frameshift; Positions=404, 424; Evidence={ECO:0000305};

    Alternative splice isoforms for ZC3H15 Gene


neXtProt entry for ZC3H15 Gene

Post-translational modifications for ZC3H15 Gene

  • Ubiquitination at posLast=2727, posLast=4444, and isoforms=51
  • Modification sites at PhosphoSitePlus

Other Protein References for ZC3H15 Gene

No data available for DME Specific Peptides for ZC3H15 Gene

Domains & Families for ZC3H15 Gene

Gene Families for ZC3H15 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZC3H15 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ZC3H15/TMA46 family.
  • Belongs to the ZC3H15/TMA46 family.
genes like me logo Genes that share domains with ZC3H15: view

Function for ZC3H15 Gene

Molecular function for ZC3H15 Gene

UniProtKB/Swiss-Prot Function:
Protects DRG1 from proteolytic degradation.

Gene Ontology (GO) - Molecular Function for ZC3H15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0005515 protein binding IPI 19819225
GO:0045296 cadherin binding IDA 25468996
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZC3H15: view
genes like me logo Genes that share phenotypes with ZC3H15: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZC3H15 Gene

Localization for ZC3H15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZC3H15 Gene

Cytoplasm. Nucleus. Note=The DRG1-DFRP2/ZC3H15 complex associates with polysomes.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZC3H15 gene
Compartment Confidence
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZC3H15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with ZC3H15: view

Pathways & Interactions for ZC3H15 Gene

SuperPathways for ZC3H15 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZC3H15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019221 cytokine-mediated signaling pathway IEA --
genes like me logo Genes that share ontologies with ZC3H15: view

No data available for Pathways by source and SIGNOR curated interactions for ZC3H15 Gene

Drugs & Compounds for ZC3H15 Gene

No Compound Related Data Available

Transcripts for ZC3H15 Gene

Unigene Clusters for ZC3H15 Gene

Zinc finger CCCH-type containing 15:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZC3H15 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP3: -

Relevant External Links for ZC3H15 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZC3H15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZC3H15 Gene

Protein differential expression in normal tissues from HIPED for ZC3H15 Gene

This gene is overexpressed in Lung (19.7), Cervix (12.4), and Peripheral blood mononuclear cells (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZC3H15 Gene

Protein tissue co-expression partners for ZC3H15 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZC3H15 Gene:


SOURCE GeneReport for Unigene cluster for ZC3H15 Gene:


Evidence on tissue expression from TISSUES for ZC3H15 Gene

  • Nervous system(4.9)
  • Liver(4.4)
  • Muscle(4.3)
  • Blood(4.2)
  • Lung(2.4)
genes like me logo Genes that share expression patterns with ZC3H15: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZC3H15 Gene

Orthologs for ZC3H15 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ZC3H15 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZC3H15 33 34
  • 99.84 (n)
(Mus musculus)
Mammalia Zc3h15 34
  • 96 (a)
(Bos Taurus)
Mammalia ZC3H15 33 34
  • 95.93 (n)
(Canis familiaris)
Mammalia ZC3H15 33 34
  • 94.51 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 90 (a)
-- 34
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia ZC3H15 34
  • 88 (a)
(Gallus gallus)
Aves ZC3H15 34
  • 86 (a)
(Anolis carolinensis)
Reptilia ZC3H15 34
  • 89 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia zc3h15 33
  • 74.96 (n)
(Danio rerio)
Actinopterygii zc3h15 33 34
  • 69.45 (n)
wufi40a12 33
fruit fly
(Drosophila melanogaster)
Insecta CG8635 33 34
  • 57.66 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008634 33
  • 57.32 (n)
(Caenorhabditis elegans)
Secernentea F27D4.4 34
  • 49 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TMA46 34
  • 44 (a)
(Hordeum vulgare)
Liliopsida Hv.5360 33
(Oryza sativa)
Liliopsida Os.32086 33
(Triticum aestivum)
Liliopsida Ta.5934 33
Species where no ortholog for ZC3H15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for ZC3H15 Gene

Gene Tree for ZC3H15 (if available)
Gene Tree for ZC3H15 (if available)

Paralogs for ZC3H15 Gene

No data available for Paralogs for ZC3H15 Gene

Variants for ZC3H15 Gene

Sequence variations from dbSNP and Humsavar for ZC3H15 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000154487 -- 186,491,584(+) A/G intron_variant
rs1000161406 -- 186,504,007(+) C/A intron_variant
rs1000166880 -- 186,504,321(+) /G intron_variant
rs1000236239 -- 186,499,101(+) C/T intron_variant
rs1000476197 -- 186,493,138(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZC3H15 Gene

Variant ID Type Subtype PubMed ID
esv2759107 CNV gain 17122850
esv3593670 CNV loss 21293372
nsv459988 CNV loss 19166990
nsv584031 CNV loss 21841781

Variation tolerance for ZC3H15 Gene

Residual Variation Intolerance Score: 58.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.77; 16.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZC3H15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZC3H15 Gene

Disorders for ZC3H15 Gene

Additional Disease Information for ZC3H15

No disorders were found for ZC3H15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZC3H15 Gene

Publications for ZC3H15 Gene

  1. Independent stabilizations of polysomal Drg1/Dfrp1 complex and non-polysomal Drg2/Dfrp2 complex in mammalian cells. (PMID: 19819225) Ishikawa K … Inoue J (Biochemical and biophysical research communications 2009) 3 4 58
  2. Identification of DRG family regulatory proteins (DFRPs): specific regulation of DRG1 and DRG2. (PMID: 15676025) Ishikawa K … Inoue J (Genes to cells : devoted to molecular & cellular mechanisms 2005) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Subtraction cloning and initial characterization of novel epo-immediate response genes. (PMID: 10880228) Gregory RC … Wojchowski DM (Cytokine 2000) 2 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for ZC3H15 Gene

Sources for ZC3H15 Gene

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