Aliases for ZC3H12C Gene

Aliases for ZC3H12C Gene

  • Zinc Finger CCCH-Type Containing 12C 2 3 5
  • MCPIP3 2 3 4
  • Zinc Finger CCCH Domain-Containing Protein 12C 3 4
  • Probable Ribonuclease ZC3H12C 3 4
  • MCP-Induced Protein 3 3 4
  • KIAA1726 2 4
  • MCP Induced Protein 3 2
  • EC 3.1.-.- 4
  • ZC3H12C 5

External Ids for ZC3H12C Gene

Previous GeneCards Identifiers for ZC3H12C Gene

  • GC11P109512
  • GC11P109964
  • GC11P105888

Summaries for ZC3H12C Gene

GeneCards Summary for ZC3H12C Gene

ZC3H12C (Zinc Finger CCCH-Type Containing 12C) is a Protein Coding gene. Diseases associated with ZC3H12C include Entropion. Gene Ontology (GO) annotations related to this gene include endonuclease activity. An important paralog of this gene is ZC3H12B.

UniProtKB/Swiss-Prot Summary for ZC3H12C Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZC3H12C Gene

Genomics for ZC3H12C Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZC3H12C Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J110091 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 274.9 +1.5 1461 4.6 BCLAF1 ZNF600 MYC ZNF592 POLR2A CEBPA ZNF10 NFIC ZBTB10 YY1 ZC3H12C FDX1 RDX HSALNG0087041
GH11J110093 Enhancer 0.3 FANTOM5 267.3 -1.7 -1701 0.4 MLLT1 ZC3H12C LOC107984384 RDX C11orf87
GH11J110129 Promoter/Enhancer 1.8 VISTA FANTOM5 Ensembl ENCODE CraniofacialAtlas 26.7 +39.3 39262 3.6 ZNF600 ZNF580 ATF2 SP2 RXRA ZNF843 ATF1 ZNF189 HNF4A SCRT1 ZC3H12C RDX HSALNG0087041
GH11J109999 Enhancer 1.2 FANTOM5 Ensembl ENCODE 28.5 -92.2 -92225 4.4 BCLAF1 SP1 BCL11A ZNF592 TRIM22 SMC3 IRF4 EBF1 CBFB NFE2 ZC3H12C FDX1 ENSG00000270423 lnc-ARHGAP20-6 lnc-ZC3H12C-5 LOC107984384 RDX C11orf87
GH11J109984 Promoter/Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 18.6 -107.3 -107307 1.1 BCLAF1 SP1 BCL11A ZNF592 SIN3A TRIM22 SMC3 IRF4 CBFB MAX ENSG00000270423 lnc-ARHGAP20-6 ZC3H12C RPSAP50 LOC107984384 RDX C11orf87
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZC3H12C on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZC3H12C

Top Transcription factor binding sites by QIAGEN in the ZC3H12C gene promoter:
  • AML1a
  • GATA-1
  • HFH-1
  • NF-kappaB
  • NF-kappaB1
  • NF-kappaB2
  • p53
  • ZIC2
  • Zic3

Genomic Locations for ZC3H12C Gene

Latest Assembly
79,417 bases
Plus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
78,449 bases
Plus strand

(GRCh37/hg19 by Ensembl)
78,480 bases
Plus strand

Genomic View for ZC3H12C Gene

Genes around ZC3H12C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZC3H12C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZC3H12C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZC3H12C Gene

Proteins for ZC3H12C Gene

  • Protein details for ZC3H12C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable ribonuclease ZC3H12C
    Protein Accession:
    Secondary Accessions:
    • B4DI65
    • B4DR47

    Protein attributes for ZC3H12C Gene

    883 amino acids
    Molecular mass:
    99340 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZC3H12C Gene


neXtProt entry for ZC3H12C Gene

Post-translational modifications for ZC3H12C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZC3H12C Gene

Antibodies for research

  • Abcam antibodies for ZC3H12C
  • Boster Bio Antibodies for ZC3H12C

No data available for DME Specific Peptides for ZC3H12C Gene

Domains & Families for ZC3H12C Gene

Gene Families for ZC3H12C Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZC3H12C Gene

Suggested Antigen Peptide Sequences for ZC3H12C Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ55575, moderately similar to Homo sapiens zinc finger CCCH-type containing 12A (ZC3H12A), mRNA (B4DR47_HUMAN)
  • Zinc finger CCCH domain-containing protein 12C (ZC12C_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ZC3H12 family.
  • Belongs to the ZC3H12 family.
genes like me logo Genes that share domains with ZC3H12C: view

Function for ZC3H12C Gene

Molecular function for ZC3H12C Gene

UniProtKB/Swiss-Prot Function:
May function as RNase and regulate the levels of target RNA species.
UniProtKB/Swiss-Prot Induction:
By cytokines (TNF-alpha and interleukin-1) in acute monocytic leukemia cell line THP-1 cells.

Enzyme Numbers (IUBMB) for ZC3H12C Gene

Phenotypes From GWAS Catalog for ZC3H12C Gene

Gene Ontology (GO) - Molecular Function for ZC3H12C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003729 mRNA binding IBA 21873635
GO:0004518 nuclease activity IEA --
GO:0004519 endonuclease activity IEA --
GO:0004521 endoribonuclease activity IBA 21873635
genes like me logo Genes that share ontologies with ZC3H12C: view
genes like me logo Genes that share phenotypes with ZC3H12C: view

Animal Models for ZC3H12C Gene

MGI Knock Outs for ZC3H12C:
  • Zc3h12c Zc3h12c<tm2d(EUCOMM)Hmgu>

miRNA for ZC3H12C Gene

miRTarBase miRNAs that target ZC3H12C

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZC3H12C

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZC3H12C Gene

Localization for ZC3H12C Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZC3H12C gene
Compartment Confidence
nucleus 4
cytosol 2
golgi apparatus 2
plasma membrane 1
extracellular 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nuclear membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZC3H12C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IBA 21873635
GO:0036464 cytoplasmic ribonucleoprotein granule IBA 21873635
genes like me logo Genes that share ontologies with ZC3H12C: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ZC3H12C Gene

Pathways & Interactions for ZC3H12C Gene

PathCards logo

SuperPathways for ZC3H12C Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZC3H12C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0090305 nucleic acid phosphodiester bond hydrolysis IEA --
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic IBA 21873635
genes like me logo Genes that share ontologies with ZC3H12C: view

No data available for Pathways by source and SIGNOR curated interactions for ZC3H12C Gene

Drugs & Compounds for ZC3H12C Gene

No Compound Related Data Available

Transcripts for ZC3H12C Gene

mRNA/cDNA for ZC3H12C Gene

6 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZC3H12C

Alternative Splicing Database (ASD) splice patterns (SP) for ZC3H12C Gene

No ASD Table

Relevant External Links for ZC3H12C Gene

GeneLoc Exon Structure for

Expression for ZC3H12C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZC3H12C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZC3H12C Gene

This gene is overexpressed in Heart (68.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZC3H12C Gene

Protein tissue co-expression partners for ZC3H12C Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZC3H12C

SOURCE GeneReport for Unigene cluster for ZC3H12C Gene:


Evidence on tissue expression from TISSUES for ZC3H12C Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with ZC3H12C: view

Primer products for research

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZC3H12C Gene

Orthologs for ZC3H12C Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZC3H12C Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZC3H12C 29 30
  • 99.32 (n)
(Monodelphis domestica)
Mammalia ZC3H12C 30
  • 90 (a)
(Rattus norvegicus)
Mammalia Zc3h12c 29
  • 89.66 (n)
(Mus musculus)
Mammalia Zc3h12c 29 16 30
  • 89.04 (n)
(Bos Taurus)
Mammalia ZC3H12C 29 30
  • 88.77 (n)
(Ornithorhynchus anatinus)
Mammalia ZC3H12C 30
  • 85 (a)
(Canis familiaris)
Mammalia ZC3H12C 29 30
  • 84.7 (n)
(Gallus gallus)
Aves ZC3H12C 29 30
  • 81.02 (n)
(Anolis carolinensis)
Reptilia ZC3H12C 30
  • 82 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia zc3h12c 29
  • 71.42 (n)
Species where no ortholog for ZC3H12C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZC3H12C Gene

Gene Tree for ZC3H12C (if available)
Gene Tree for ZC3H12C (if available)
Evolutionary constrained regions (ECRs) for ZC3H12C: view image
Alliance of Genome Resources:
Additional Orthologs for ZC3H12C

Paralogs for ZC3H12C Gene

Paralogs for ZC3H12C Gene

(3) SIMAP similar genes for ZC3H12C Gene using alignment to 3 proteins:

  • B4DR47_HUMAN
  • E9PP00_HUMAN
genes like me logo Genes that share paralogs with ZC3H12C: view

Variants for ZC3H12C Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ZC3H12C Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ZC3H12C Gene

Variant ID Type Subtype PubMed ID
esv1940879 CNV deletion 18987734
esv2277863 CNV deletion 18987734
esv2548900 CNV deletion 19546169
esv2677867 CNV deletion 23128226
esv2745058 CNV deletion 23290073
esv2745059 CNV deletion 23290073
esv2745060 CNV deletion 23290073
esv2745061 CNV deletion 23290073
esv2745062 CNV deletion 23290073
esv3548333 CNV deletion 23714750
esv5986 CNV loss 19470904
esv997753 CNV deletion 20482838
esv999177 CNV deletion 20482838
nsv1070487 CNV deletion 25765185
nsv1070488 CNV deletion 25765185
nsv1119911 CNV deletion 24896259
nsv1122665 CNV deletion 24896259
nsv1148035 CNV deletion 26484159
nsv1159937 CNV deletion 26073780
nsv39222 CNV deletion 16902084
nsv483 CNV insertion 18451855
nsv832265 CNV gain 17160897
nsv951068 CNV duplication 24416366
nsv958607 CNV deletion 24416366

Variation tolerance for ZC3H12C Gene

Residual Variation Intolerance Score: 13.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.42; 54.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZC3H12C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZC3H12C Gene

Disorders for ZC3H12C Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZC3H12C Gene - From: COP

Disorder Aliases PubMed IDs
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZC3H12C

Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with ZC3H12C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZC3H12C Gene

Publications for ZC3H12C Gene

  1. A novel CCCH-zinc finger protein family regulates proinflammatory activation of macrophages. (PMID: 18178554) Liang J … Fu M (The Journal of biological chemistry 2008) 2 3 4
  2. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 40
  4. Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. (PMID: 17903301) Vasan RS … Benjamin EJ (BMC medical genetics 2007) 3 40
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4

Products for ZC3H12C Gene

Sources for ZC3H12C Gene