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Aliases for ZC3H12B Gene

Aliases for ZC3H12B Gene

  • Zinc Finger CCCH-Type Containing 12B 2 3 5
  • Zinc Finger CCCH Domain-Containing Protein 12B 3 4
  • MCP-Induced Protein 2 3 4
  • CXorf32 3 4
  • MCPIP2 3 4
  • Chromosome X Open Reading Frame 32 2
  • Probable Ribonuclease ZC3H12B 3
  • MCP Induced Protein 2 2
  • EC 3.1.-.- 4

External Ids for ZC3H12B Gene

Previous HGNC Symbols for ZC3H12B Gene

  • CXorf32

Previous GeneCards Identifiers for ZC3H12B Gene

  • GC0XP064492
  • GC0XP064625
  • GC0XP058536
  • GC0XP064708
  • GC0XP065366

Summaries for ZC3H12B Gene

Entrez Gene Summary for ZC3H12B Gene

  • The protein encoded by this gene belongs to a family of CCCH-type zinc finger proteins that are involved in the proinflammatory activation of macrophages. The exact function of this family member is unknown, but it is thought to function as a ribonuclease. [provided by RefSeq, May 2010]

GeneCards Summary for ZC3H12B Gene

ZC3H12B (Zinc Finger CCCH-Type Containing 12B) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include endonuclease activity. An important paralog of this gene is ZC3H12C.

UniProtKB/Swiss-Prot for ZC3H12B Gene

  • May function as RNase and regulate the levels of target RNA species.

Additional gene information for ZC3H12B Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZC3H12B Gene

Genomics for ZC3H12B Gene

GeneHancer (GH) Regulatory Elements for ZC3H12B Gene

Promoters and enhancers for ZC3H12B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI065034 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE 550.8 +0.3 348 2.1 PKNOX1 SIN3A BMI1 ZNF2 ZNF48 RAD21 ZNF335 GLIS2 EGR1 ZNF143 ZC4H2 ZC3H12B AMER1 LOC100533843
GH0XI065244 Enhancer 0.3 FANTOM5 1.4 +210.1 210094 0.3 ZC3H12B ZC4H2 CCT4P2 LOC100533843
GH0XI065195 Enhancer 0.8 ENCODE 0.1 +162.0 161968 3 SOX13 CTCF TFAP4 FOXA2 ZNF792 SAP130 ARID4B BACH1 MAX ZNF644 LOC100533843 CCT4P2 ZC3H12B
GH0XI065406 Promoter/Enhancer 0.8 FANTOM5 Ensembl 0.1 +372.6 372601 1.6 EZH2 TLE1P1 CCT4P2 LAS1L MSN PIR37197 ZC3H12B
GH0XI065299 Enhancer 0.5 ENCODE 0.1 +265.7 265702 1.3 CTCF NFIL3 HLF RAD21 CCT4P2 MORF4L1P5 ZC3H12B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZC3H12B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZC3H12B gene promoter:

Genomic Locations for ZC3H12B Gene

Genomic Locations for ZC3H12B Gene
473,089 bases
Plus strand

Genomic View for ZC3H12B Gene

Genes around ZC3H12B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZC3H12B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZC3H12B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZC3H12B Gene

Proteins for ZC3H12B Gene

  • Protein details for ZC3H12B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable ribonuclease ZC3H12B
    Protein Accession:
    Secondary Accessions:
    • B2RTQ3
    • E9PAJ6
    • Q5H9C0

    Protein attributes for ZC3H12B Gene

    836 amino acids
    Molecular mass:
    94205 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available
    • Sequence=AAI40768.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI71781.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI42594.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI42834.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI46044.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZC3H12B Gene


neXtProt entry for ZC3H12B Gene

Post-translational modifications for ZC3H12B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZC3H12B Gene

Domains & Families for ZC3H12B Gene

Gene Families for ZC3H12B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZC3H12B Gene


Suggested Antigen Peptide Sequences for ZC3H12B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ZC3H12 family.
  • Belongs to the ZC3H12 family.
genes like me logo Genes that share domains with ZC3H12B: view

Function for ZC3H12B Gene

Molecular function for ZC3H12B Gene

UniProtKB/Swiss-Prot Function:
May function as RNase and regulate the levels of target RNA species.

Enzyme Numbers (IUBMB) for ZC3H12B Gene

Phenotypes From GWAS Catalog for ZC3H12B Gene

Gene Ontology (GO) - Molecular Function for ZC3H12B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004519 endonuclease activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZC3H12B: view
genes like me logo Genes that share phenotypes with ZC3H12B: view

Animal Model Products

CRISPR Products

miRNA for ZC3H12B Gene

miRTarBase miRNAs that target ZC3H12B

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZC3H12B Gene

Localization for ZC3H12B Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZC3H12B gene
Compartment Confidence
nucleus 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
  • Golgi apparatus (2)
  • Vesicles (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ZC3H12B Gene

Pathways & Interactions for ZC3H12B Gene

SuperPathways for ZC3H12B Gene

No Data Available

Interacting Proteins for ZC3H12B Gene

Gene Ontology (GO) - Biological Process for ZC3H12B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0090305 nucleic acid phosphodiester bond hydrolysis IEA --
genes like me logo Genes that share ontologies with ZC3H12B: view

No data available for Pathways by source and SIGNOR curated interactions for ZC3H12B Gene

Drugs & Compounds for ZC3H12B Gene

No Compound Related Data Available

Transcripts for ZC3H12B Gene

mRNA/cDNA for ZC3H12B Gene

Unigene Clusters for ZC3H12B Gene

Zinc finger CCCH-type containing 12B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZC3H12B Gene

No ASD Table

Relevant External Links for ZC3H12B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZC3H12B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZC3H12B Gene

Protein differential expression in normal tissues from HIPED for ZC3H12B Gene

This gene is overexpressed in Urine (46.1), Plasma (9.7), and Bone marrow mesenchymal stem cell (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZC3H12B Gene

NURSA nuclear receptor signaling pathways regulating expression of ZC3H12B Gene:


SOURCE GeneReport for Unigene cluster for ZC3H12B Gene:


Evidence on tissue expression from TISSUES for ZC3H12B Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with ZC3H12B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZC3H12B Gene

Orthologs for ZC3H12B Gene

This gene was present in the common ancestor of animals.

Orthologs for ZC3H12B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZC3H12B 33 34
  • 99.76 (n)
(Bos Taurus)
Mammalia ZC3H12B 33 34
  • 92.5 (n)
(Canis familiaris)
Mammalia ZC3H12B 33 34
  • 91.79 (n)
(Rattus norvegicus)
Mammalia Zc3h12b 33
  • 89.65 (n)
(Mus musculus)
Mammalia Zc3h12b 33 16 34
  • 89.57 (n)
(Monodelphis domestica)
Mammalia ZC3H12B 34
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia ZC3H12B 34
  • 65 (a)
(Gallus gallus)
Aves ZC3H12B 33 34
  • 75.99 (n)
(Anolis carolinensis)
Reptilia ZC3H12B 34
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia zc3h12b 33
  • 71.79 (n)
(Danio rerio)
Actinopterygii zc3h12b 34
  • 65 (a)
LOC100002370 33
  • 64.89 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG42360 34
  • 18 (a)
Species where no ortholog for ZC3H12B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZC3H12B Gene

Gene Tree for ZC3H12B (if available)
Gene Tree for ZC3H12B (if available)

Paralogs for ZC3H12B Gene

Paralogs for ZC3H12B Gene

(4) SIMAP similar genes for ZC3H12B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZC3H12B: view

Variants for ZC3H12B Gene

Sequence variations from dbSNP and Humsavar for ZC3H12B Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000001727 -- 65,410,472(+) A/C genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant
rs1000014720 -- 65,456,048(+) G/A genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant
rs1000015774 -- 65,222,706(+) C/T genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant
rs1000024386 -- 65,452,860(+) A/C genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant
rs1000026515 -- 65,075,103(+) C/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZC3H12B Gene

Variant ID Type Subtype PubMed ID
esv1584074 OTHER inversion 17803354

Variation tolerance for ZC3H12B Gene

Residual Variation Intolerance Score: 18.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.15; 84.70% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZC3H12B Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZC3H12B Gene

Disorders for ZC3H12B Gene

Additional Disease Information for ZC3H12B

No disorders were found for ZC3H12B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZC3H12B Gene

Publications for ZC3H12B Gene

  1. A novel CCCH-zinc finger protein family regulates proinflammatory activation of macrophages. (PMID: 18178554) Liang J … Fu M (The Journal of biological chemistry 2008) 2 3 4 58
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
  3. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L … Andersson-Svahn H (Molecular & cellular proteomics : MCP 2008) 3 58
  4. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 58
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58

Products for ZC3H12B Gene

Sources for ZC3H12B Gene

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