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Aliases for ZC3H10 Gene

Aliases for ZC3H10 Gene

  • Zinc Finger CCCH-Type Containing 10 2 3 5
  • Zinc Finger CCCH-Type Domain Containing 10 2 3
  • ZC3HDC10 3 4
  • Zinc Finger CCCH Domain-Containing Protein 10 3

External Ids for ZC3H10 Gene

Previous HGNC Symbols for ZC3H10 Gene

  • ZC3HDC10

Previous GeneCards Identifiers for ZC3H10 Gene

  • GC12P054799
  • GC12P056512
  • GC12P053553
  • GC12P056533
  • GC12P056547

Summaries for ZC3H10 Gene

GeneCards Summary for ZC3H10 Gene

ZC3H10 (Zinc Finger CCCH-Type Containing 10) is a Protein Coding gene.

UniProtKB/Swiss-Prot for ZC3H10 Gene

  • Specific regulator of miRNA biogenesis. Binds, via the C3H1-type zinc finger domains, to the binding motif 5-GCAGCGC-3 on microRNA pri-MIR143 and negatively regulates the processing to mature microRNA.

Additional gene information for ZC3H10 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZC3H10 Gene

Genomics for ZC3H10 Gene

GeneHancer (GH) Regulatory Elements for ZC3H10 Gene

Promoters and enhancers for ZC3H10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I056114 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 599.8 +0.2 165 6.8 CLOCK MLX ZFP64 DMAP1 YBX1 IRF4 YY1 ZNF213 E2F8 ZNF143 ZC3H10 RPL41 ESYT1 ENSG00000258345 GC12M056121 PIR42205 BAZ2A NEMP1 RN7SL809P DNAJC14
GH12I057109 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 69.6 +993.1 993095 3.8 CLOCK FEZF1 DMAP1 IRF4 YY1 ZNF213 ZNF416 ZNF143 ZNF548 MCM3 STAT6 NEMP1 EEF1AKMT3 ENSG00000257740 BAZ2A PAN2 SMARCC2 ANKRD52 CDK4 CTDSP2
GH12I056220 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 56.5 +104.7 104723 5.7 CLOCK MLX ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF213 E2F8 NABP2 RNF41 NEMP1 BAZ2A PAN2 DNAJC14 ANKRD52 PHC1P1 ZBTB39 RN7SL809P
GH12I056298 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 54.6 +182.7 182651 4.6 FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC ZNF610 GLIS1 ENSG00000257303 CS BAZ2A ZC3H10 NEMP1 RN7SL809P CDK2 DNAJC14 RPL41 MMP19
GH12I055827 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 53.2 -288.5 -288539 4.7 MLX FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF143 ZNF548 SP3 NFYC DNAJC14 TMEM198B GC12P055831 PIR58217 BAZ2A ENSG00000258317 ZC3H10 ENSG00000257740 PHC1P1 RN7SL809P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZC3H10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZC3H10 gene promoter:

Genomic Locations for ZC3H10 Gene

Genomic Locations for ZC3H10 Gene
chr12:56,118,159-56,127,514
(GRCh38/hg38)
Size:
9,356 bases
Orientation:
Plus strand
chr12:56,511,943-56,516,278
(GRCh37/hg19)

Genomic View for ZC3H10 Gene

Genes around ZC3H10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZC3H10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZC3H10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZC3H10 Gene

Proteins for ZC3H10 Gene

  • Protein details for ZC3H10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96K80-ZC3HA_HUMAN
    Recommended name:
    Zinc finger CCCH domain-containing protein 10
    Protein Accession:
    Q96K80

    Protein attributes for ZC3H10 Gene

    Size:
    434 amino acids
    Molecular mass:
    46052 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZC3H10 Gene

Post-translational modifications for ZC3H10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZC3H10 Gene

No data available for DME Specific Peptides for ZC3H10 Gene

Domains & Families for ZC3H10 Gene

Gene Families for ZC3H10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZC3H10 Gene

Suggested Antigen Peptide Sequences for ZC3H10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZC3H10: view

No data available for UniProtKB/Swiss-Prot for ZC3H10 Gene

Function for ZC3H10 Gene

Molecular function for ZC3H10 Gene

UniProtKB/Swiss-Prot Function:
Specific regulator of miRNA biogenesis. Binds, via the C3H1-type zinc finger domains, to the binding motif 5-GCAGCGC-3 on microRNA pri-MIR143 and negatively regulates the processing to mature microRNA.

Phenotypes From GWAS Catalog for ZC3H10 Gene

Gene Ontology (GO) - Molecular Function for ZC3H10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0005515 protein binding IPI 16189514
GO:0035198 miRNA binding IDA 28431233
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZC3H10: view
genes like me logo Genes that share phenotypes with ZC3H10: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZC3H10 Gene

Localization for ZC3H10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZC3H10 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZC3H10 gene
Compartment Confidence
nucleus 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZC3H10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZC3H10: view

Pathways & Interactions for ZC3H10 Gene

SuperPathways for ZC3H10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZC3H10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010608 posttranscriptional regulation of gene expression IDA 28431233
GO:1903799 negative regulation of production of miRNAs involved in gene silencing by miRNA IDA 28431233
genes like me logo Genes that share ontologies with ZC3H10: view

No data available for Pathways by source and SIGNOR curated interactions for ZC3H10 Gene

Drugs & Compounds for ZC3H10 Gene

No Compound Related Data Available

Transcripts for ZC3H10 Gene

Unigene Clusters for ZC3H10 Gene

Zinc finger CCCH-type containing 10:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZC3H10 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b
SP1: - - -
SP2: -
SP3: - -
SP4: -

Relevant External Links for ZC3H10 Gene

GeneLoc Exon Structure for
ZC3H10
ECgene alternative splicing isoforms for
ZC3H10

Expression for ZC3H10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZC3H10 Gene

Protein differential expression in normal tissues from HIPED for ZC3H10 Gene

This gene is overexpressed in Ovary (48.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZC3H10 Gene



Protein tissue co-expression partners for ZC3H10 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZC3H10 Gene:

ZC3H10

SOURCE GeneReport for Unigene cluster for ZC3H10 Gene:

Hs.632706

Evidence on tissue expression from TISSUES for ZC3H10 Gene

  • Muscle(4.2)
genes like me logo Genes that share expression patterns with ZC3H10: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZC3H10 Gene

Orthologs for ZC3H10 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZC3H10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZC3H10 33 34
  • 99.62 (n)
dog
(Canis familiaris)
Mammalia ZC3H10 33 34
  • 93.24 (n)
cow
(Bos Taurus)
Mammalia ZC3H10 33 34
  • 92.78 (n)
rat
(Rattus norvegicus)
Mammalia Zc3h10 33
  • 89.09 (n)
mouse
(Mus musculus)
Mammalia Zc3h10 33 16 34
  • 88.17 (n)
chicken
(Gallus gallus)
Aves ZC3H10 33 34
  • 74.32 (n)
lizard
(Anolis carolinensis)
Reptilia ZC3H10 34
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zc3h10 33
  • 68.5 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15636 33
zebrafish
(Danio rerio)
Actinopterygii zc3h10 33 34
  • 57.58 (n)
Dr.19352 33
worm
(Caenorhabditis elegans)
Secernentea Y53G8AR.9 34
  • 32 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 32 (a)
OneToMany
CSA.2589 34
  • 16 (a)
OneToMany
Species where no ortholog for ZC3H10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZC3H10 Gene

ENSEMBL:
Gene Tree for ZC3H10 (if available)
TreeFam:
Gene Tree for ZC3H10 (if available)

Paralogs for ZC3H10 Gene

(2) SIMAP similar genes for ZC3H10 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZC3H10: view

No data available for Paralogs for ZC3H10 Gene

Variants for ZC3H10 Gene

Sequence variations from dbSNP and Humsavar for ZC3H10 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000598312 -- 56,121,174(+) G/A coding_sequence_variant, synonymous_variant
rs1001181999 -- 56,118,101(+) T/C upstream_transcript_variant
rs1001552584 -- 56,120,297(+) C/T intron_variant
rs1001692193 -- 56,117,959(+) T/C upstream_transcript_variant
rs1002295197 -- 56,119,025(+) C/T 5_prime_UTR_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZC3H10 Gene

Variant ID Type Subtype PubMed ID
nsv1051961 CNV gain 25217958
nsv832427 CNV loss 17160897
nsv973076 CNV duplication 23825009

Variation tolerance for ZC3H10 Gene

Residual Variation Intolerance Score: 24.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.22; 24.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZC3H10 Gene

Human Gene Mutation Database (HGMD)
ZC3H10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZC3H10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZC3H10 Gene

Disorders for ZC3H10 Gene

Additional Disease Information for ZC3H10

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ZC3H10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZC3H10 Gene

Publications for ZC3H10 Gene

  1. A Compendium of RNA-Binding Proteins that Regulate MicroRNA Biogenesis. (PMID: 28431233) Treiber T … Meister G (Molecular cell 2017) 3 4 58
  2. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G … Wijmenga C (Gut 2009) 3 44 58
  3. Gene trapping identifies a putative tumor suppressor and a new inducer of cell migration. (PMID: 18814840) Guardiola-Serrano F … Altschmied J (Biochemical and biophysical research communications 2008) 2 3 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for ZC3H10 Gene

Sources for ZC3H10 Gene

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