Aliases for ZBTB9 Gene

Aliases for ZBTB9 Gene

  • Zinc Finger And BTB Domain Containing 9 2 3 5
  • Zinc Finger And BTB Domain-Containing Protein 9 3 4
  • ZNF919 2 3
  • MGC23166 2
  • ZBTB9 5

External Ids for ZBTB9 Gene

Previous GeneCards Identifiers for ZBTB9 Gene

  • GC06P033469
  • GC06P033496
  • GC06P033530
  • GC06P033164
  • GC06P033422

Summaries for ZBTB9 Gene

GeneCards Summary for ZBTB9 Gene

ZBTB9 (Zinc Finger And BTB Domain Containing 9) is a Protein Coding gene. An important paralog of this gene is ZBTB22.

UniProtKB/Swiss-Prot Summary for ZBTB9 Gene

Additional gene information for ZBTB9 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZBTB9 Gene

Genomics for ZBTB9 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZBTB9 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J033452 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 +0.3 253 3.2 SP1 HNRNPL CREB1 GATAD2A PRDM10 REST ZNF629 TFE3 RFX1 NFKBIZ SYNGAP1-AS1 ZBTB9 DAXX VPS52 WDR46 RPL35P2 CUTA BRD2 RPS10 BAK1
GH06J033423 Promoter/Enhancer 2.3 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 31.5 -24.6 -24640 10.7 ARHGAP35 SP1 HNRNPL GATAD2A CTCF TEAD4 PRDM10 ZNF629 TFE3 ZNF512 LEMD2 DAXX BRD2 HCG25 RING1 RXRB VPS52 WDR46 RGL2 ZBTB9
GH06J033373 Enhancer 0.9 ENCODE 10.4 -78.5 -78496 3.1 PRDM10 LEF1 IKZF1 JUND FOXA1 MTA2 PKNOX1 MTA1 REST ZNF740 DAXX PHF1 ZBTB22 TAPBP RGL2 PFDN6 WDR46 ZBTB9 RF00017-5435 LYPLA2P1
GH06J033380 Enhancer 0.8 Ensembl 10.4 -73.3 -73269 0.2 PRDM10 LEF1 JUND MTA2 PKNOX1 MTA1 DPF2 HDAC1 ZNF600 SOX6 RF00017-5435 PHF1 ZBTB22 TAPBP RGL2 PFDN6 WDR46 ZBTB9 RPL35AP4 KIFC1
GH06J034070 Enhancer 0.8 dbSUPER 9.8 +617.8 617788 1.6 ZNF300 ZNF776 ZSCAN4 ZNF239 ZNF148 KLF9 ZNF207 CBX3 ZNF248 TSC22D4 HSALNG0049596 RING1 TAF11 HCG25 LEMD2 VPS52 RXRB DAXX PHF1 ITPR3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZBTB9 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZBTB9

Top Transcription factor binding sites by QIAGEN in the ZBTB9 gene promoter:
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • Olf-1
  • p300
  • Sp1
  • Zic3

Genomic Locations for ZBTB9 Gene

Genomic Locations for ZBTB9 Gene
chr6:33,453,970-33,457,544
(GRCh38/hg38)
Size:
3,575 bases
Orientation:
Plus strand
chr6:33,422,356-33,425,325
(GRCh37/hg19)
Size:
2,970 bases
Orientation:
Plus strand

Genomic View for ZBTB9 Gene

Genes around ZBTB9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBTB9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBTB9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB9 Gene

Proteins for ZBTB9 Gene

  • Protein details for ZBTB9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96C00-ZBTB9_HUMAN
    Recommended name:
    Zinc finger and BTB domain-containing protein 9
    Protein Accession:
    Q96C00
    Secondary Accessions:
    • A2AB19

    Protein attributes for ZBTB9 Gene

    Size:
    473 amino acids
    Molecular mass:
    50602 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZBTB9 Gene

Post-translational modifications for ZBTB9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZBTB9 Gene

No data available for DME Specific Peptides for ZBTB9 Gene

Domains & Families for ZBTB9 Gene

Gene Families for ZBTB9 Gene

Protein Domains for ZBTB9 Gene

InterPro:
Blocks:
  • BTB/POZ domain
ProtoNet:

Suggested Antigen Peptide Sequences for ZBTB9 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ16072 fis, clone IMR321000253, highly similar to Zinc finger and BTB domain-containing protein 9 (A2AB19_HUMAN)
  • Zinc finger and BTB domain-containing protein 9 (ZBTB9_HUMAN)
genes like me logo Genes that share domains with ZBTB9: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ZBTB9 Gene

Function for ZBTB9 Gene

Molecular function for ZBTB9 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZBTB9 Gene

Gene Ontology (GO) - Molecular Function for ZBTB9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA,IBA 21873635
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZBTB9: view

Phenotypes for ZBTB9 Gene

genes like me logo Genes that share phenotypes with ZBTB9: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZBTB9

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZBTB9 Gene

Localization for ZBTB9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB9 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZBTB9 gene
Compartment Confidence
nucleus 4
cytosol 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZBTB9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IBA 21873635
genes like me logo Genes that share ontologies with ZBTB9: view

Pathways & Interactions for ZBTB9 Gene

PathCards logo

SuperPathways for ZBTB9 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZBTB9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
genes like me logo Genes that share ontologies with ZBTB9: view

No data available for Pathways by source and SIGNOR curated interactions for ZBTB9 Gene

Drugs & Compounds for ZBTB9 Gene

No Compound Related Data Available

Transcripts for ZBTB9 Gene

mRNA/cDNA for ZBTB9 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZBTB9

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB9 Gene

No ASD Table

Relevant External Links for ZBTB9 Gene

GeneLoc Exon Structure for
ZBTB9

Expression for ZBTB9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZBTB9 Gene

Protein differential expression in normal tissues from HIPED for ZBTB9 Gene

This gene is overexpressed in Monocytes (65.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZBTB9 Gene



Protein tissue co-expression partners for ZBTB9 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZBTB9

SOURCE GeneReport for Unigene cluster for ZBTB9 Gene:

Hs.591805

Evidence on tissue expression from TISSUES for ZBTB9 Gene

  • Eye(4)
genes like me logo Genes that share expression patterns with ZBTB9: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZBTB9 Gene

Orthologs for ZBTB9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB9 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZBTB9 31
  • 100 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia ZBTB9 30 31
  • 86.3 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZBTB9 30
  • 85.82 (n)
Mouse
(Mus musculus)
Mammalia Zbtb9 30 17 31
  • 82.68 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Zbtb9 30
  • 81.22 (n)
Oppossum
(Monodelphis domestica)
Mammalia ZBTB9 31
  • 73 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ZBTB9 31
  • 51 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia zbtb9 30
  • 58.08 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12662 30
Species where no ortholog for ZBTB9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZBTB9 Gene

ENSEMBL:
Gene Tree for ZBTB9 (if available)
TreeFam:
Gene Tree for ZBTB9 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZBTB9: view image

Paralogs for ZBTB9 Gene

Paralogs for ZBTB9 Gene

genes like me logo Genes that share paralogs with ZBTB9: view

Variants for ZBTB9 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZBTB9 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs9469425 - p.Ala274Gly

Additional dbSNP identifiers (rs#s) for ZBTB9 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZBTB9 Gene

Variant ID Type Subtype PubMed ID
esv3608630 CNV gain 21293372
nsv1073969 CNV deletion 25765185
nsv1112900 CNV deletion 24896259
nsv1119076 CNV deletion 24896259
nsv602832 CNV loss 21841781
nsv830637 CNV loss 17160897

Variation tolerance for ZBTB9 Gene

Residual Variation Intolerance Score: 50.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.42; 63.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZBTB9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZBTB9

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBTB9 Gene

Disorders for ZBTB9 Gene

Additional Disease Information for ZBTB9

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for ZBTB9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZBTB9 Gene

Publications for ZBTB9 Gene

  1. Genome-wide association study of smoking behaviours in patients with COPD. (PMID: 21685187) Siedlinski M … ECLIPSE Investigators (Thorax 2011) 3 41
  2. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos LF … Criswell LA (PLoS genetics 2009) 3 41
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3

Products for ZBTB9 Gene

  • Signalway Proteins for ZBTB9

Sources for ZBTB9 Gene