Aliases for ZBTB9 Gene

Aliases for ZBTB9 Gene

  • Zinc Finger And BTB Domain Containing 9 2 3 5
  • Zinc Finger And BTB Domain-Containing Protein 9 3 4
  • ZNF919 3

External Ids for ZBTB9 Gene

Previous GeneCards Identifiers for ZBTB9 Gene

  • GC06P033469
  • GC06P033496
  • GC06P033530
  • GC06P033164
  • GC06P033422

Summaries for ZBTB9 Gene

GeneCards Summary for ZBTB9 Gene

ZBTB9 (Zinc Finger And BTB Domain Containing 9) is a Protein Coding gene. An important paralog of this gene is ZBTB22.

UniProtKB/Swiss-Prot Summary for ZBTB9 Gene

Additional gene information for ZBTB9 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZBTB9 Gene

Genomics for ZBTB9 Gene

GeneHancer (GH) Regulatory Elements for ZBTB9 Gene

Promoters and enhancers for ZBTB9 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J033452 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 762 +0.3 253 3.2 SP1 ZBTB40 MLX SMARCE1 RBPJ POLR2A ATF1 FOS CREB1 HCFC1 ZBTB9 SYNGAP1-AS1 DAXX BRD2 VPS52 LEMD2 WDR46 RXRB RING1 RPS18
GH06J033423 Promoter/Enhancer 2.3 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 31.5 -24.6 -24640 10.7 SP1 ZBTB40 CTCF ZBTB6 SMARCE1 RBPJ POLR2A USF2 NR2F1 NR2F6 DAXX BRD2 LEMD2 WDR46 HCG25 RING1 VPS52 RXRB RPS18 KIFC1
GH06J032965 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 11.4 -483.3 -483301 10.4 ZNF785 ZNF24 ZBTB40 CTCF SREBF1 ZBTB6 FOXA1 LCORL RBPJ SMARCE1 BRD2 HLA-DMA ENSG00000223837 NONHSAG045804.2 LEMD2 VPS52 RXRB ATF6B DAXX RING1
GH06J033270 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 11.5 -179.0 -179012 8.7 GTF3C2 FOXK2 ZNF24 SP1 ZBTB40 CTCF SIX5 ZBTB6 MLX SMARCE1 VPS52 RPS18 NONHSAG046700.2 piR-32331-006 BRD2 LEMD2 DAXX RXRB WDR46 RING1
GH06J033311 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 11.5 -135.7 -135669 13.4 E2F8 SP1 ZBTB40 SREBF1 SIX5 ZBTB6 MLX RBPJ SMARCE1 POLR2A DAXX TAPBP ZBTB22 RING1 VPS52 PHF1 HCG25 SYNGAP1 HCG24 TAP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZBTB9 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZBTB9 gene promoter:
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • Olf-1
  • p300
  • Sp1
  • Zic3

Genomic Locations for ZBTB9 Gene

Genomic Locations for ZBTB9 Gene
chr6:33,453,970-33,457,544
(GRCh38/hg38)
Size:
3,575 bases
Orientation:
Plus strand
chr6:33,422,356-33,425,325
(GRCh37/hg19)
Size:
2,970 bases
Orientation:
Plus strand

Genomic View for ZBTB9 Gene

Genes around ZBTB9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBTB9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBTB9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB9 Gene

Proteins for ZBTB9 Gene

  • Protein details for ZBTB9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96C00-ZBTB9_HUMAN
    Recommended name:
    Zinc finger and BTB domain-containing protein 9
    Protein Accession:
    Q96C00
    Secondary Accessions:
    • A2AB19

    Protein attributes for ZBTB9 Gene

    Size:
    473 amino acids
    Molecular mass:
    50602 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZBTB9 Gene

Post-translational modifications for ZBTB9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZBTB9 Gene

No data available for DME Specific Peptides for ZBTB9 Gene

Domains & Families for ZBTB9 Gene

Gene Families for ZBTB9 Gene

Protein Domains for ZBTB9 Gene

Suggested Antigen Peptide Sequences for ZBTB9 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ16072 fis, clone IMR321000253, highly similar to Zinc finger and BTB domain-containing protein 9 (A2AB19_HUMAN)
  • Zinc finger and BTB domain-containing protein 9 (ZBTB9_HUMAN)
genes like me logo Genes that share domains with ZBTB9: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ZBTB9 Gene

Function for ZBTB9 Gene

Molecular function for ZBTB9 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZBTB9 Gene

Gene Ontology (GO) - Molecular Function for ZBTB9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZBTB9: view
genes like me logo Genes that share phenotypes with ZBTB9: view

Animal Model Products

CRISPR Products

Clone Products

  • Addgene plasmids for ZBTB9

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZBTB9 Gene

Localization for ZBTB9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB9 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZBTB9 gene
Compartment Confidence
nucleus 4
cytosol 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZBTB9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZBTB9: view

Pathways & Interactions for ZBTB9 Gene

PathCards logo

SuperPathways for ZBTB9 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZBTB9 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZBTB9 Gene

Drugs & Compounds for ZBTB9 Gene

No Compound Related Data Available

Transcripts for ZBTB9 Gene

mRNA/cDNA for ZBTB9 Gene

CRISPR Products

Clone Products

  • Addgene plasmids for ZBTB9

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB9 Gene

No ASD Table

Relevant External Links for ZBTB9 Gene

GeneLoc Exon Structure for
ZBTB9
ECgene alternative splicing isoforms for
ZBTB9

Expression for ZBTB9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZBTB9 Gene

Protein differential expression in normal tissues from HIPED for ZBTB9 Gene

This gene is overexpressed in Monocytes (65.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZBTB9 Gene



Protein tissue co-expression partners for ZBTB9 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZBTB9 Gene:

ZBTB9

SOURCE GeneReport for Unigene cluster for ZBTB9 Gene:

Hs.591805

Evidence on tissue expression from TISSUES for ZBTB9 Gene

  • Eye(4)
genes like me logo Genes that share expression patterns with ZBTB9: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZBTB9 Gene

Orthologs for ZBTB9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZBTB9 33
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZBTB9 33 32
  • 86.3 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZBTB9 32
  • 85.82 (n)
mouse
(Mus musculus)
Mammalia Zbtb9 17 33 32
  • 82.68 (n)
rat
(Rattus norvegicus)
Mammalia Zbtb9 32
  • 81.22 (n)
oppossum
(Monodelphis domestica)
Mammalia ZBTB9 33
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZBTB9 33
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zbtb9 32
  • 58.08 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12662 32
Species where no ortholog for ZBTB9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZBTB9 Gene

ENSEMBL:
Gene Tree for ZBTB9 (if available)
TreeFam:
Gene Tree for ZBTB9 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZBTB9: view image

Paralogs for ZBTB9 Gene

Paralogs for ZBTB9 Gene

genes like me logo Genes that share paralogs with ZBTB9: view

Variants for ZBTB9 Gene

Sequence variations from dbSNP and Humsavar for ZBTB9 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000444373 -- 33,457,487(+) GGGGG/GGGG/GGGGGG 3_prime_UTR_variant
rs1000643222 -- 33,454,863(+) G/T intron_variant
rs1000878537 -- 33,457,753(+) TGTTTTGTTTTGTTTTGTTTT/TGTTTTGTTTT/TGTTTTGTTTTGTTTT/TGTTTTGTTTTGTTTTGTTTTGTTTT/TGTTTTGTTTTGTTTTGTTTTGTTTTGTTTT downstream_transcript_variant
rs1001573882 -- 33,457,058(+) C/G 3_prime_UTR_variant
rs1001884214 -- 33,454,213(+) C/G genic_upstream_transcript_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZBTB9 Gene

Variant ID Type Subtype PubMed ID
esv3608630 CNV gain 21293372
nsv1073969 CNV deletion 25765185
nsv1112900 CNV deletion 24896259
nsv1119076 CNV deletion 24896259
nsv602832 CNV loss 21841781
nsv830637 CNV loss 17160897

Variation tolerance for ZBTB9 Gene

Residual Variation Intolerance Score: 50.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.42; 63.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZBTB9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZBTB9

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBTB9 Gene

Disorders for ZBTB9 Gene

Additional Disease Information for ZBTB9

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ZBTB9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZBTB9 Gene

Publications for ZBTB9 Gene

  1. Genome-wide association study of smoking behaviours in patients with COPD. (PMID: 21685187) Siedlinski M … ECLIPSE Investigators (Thorax 2011) 3 43 56
  2. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos LF … Criswell LA (PLoS genetics 2009) 3 43 56
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 56

Products for ZBTB9 Gene

Sources for ZBTB9 Gene