Aliases for ZBTB8B Gene

Aliases for ZBTB8B Gene

  • Zinc Finger And BTB Domain Containing 8B 2 3 5
  • Zinc Finger And BTB Domain-Containing Protein 8B 3 4
  • ZNF916B 2 3
  • Putative Zinc Finger And BTB Domain-Containing Protein 8B 3
  • DKFZp547H154 2
  • RP1-27O5.1 2
  • ZBTB8B 5

External Ids for ZBTB8B Gene

Previous GeneCards Identifiers for ZBTB8B Gene

  • GC01P032694
  • GC01P032930
  • GC01P031046

Summaries for ZBTB8B Gene

GeneCards Summary for ZBTB8B Gene

ZBTB8B (Zinc Finger And BTB Domain Containing 8B) is a Protein Coding gene. Diseases associated with ZBTB8B include Syndromic Microphthalmia. An important paralog of this gene is ENSG00000254553.

UniProtKB/Swiss-Prot Summary for ZBTB8B Gene

Additional gene information for ZBTB8B Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZBTB8B Gene

Genomics for ZBTB8B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZBTB8B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZBTB8B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZBTB8B

Top Transcription factor binding sites by QIAGEN in the ZBTB8B gene promoter:
  • AML1a
  • Arnt
  • ATF6
  • HOXA5
  • MRF-2
  • p300
  • STAT1
  • STAT1alpha
  • STAT1beta
  • YY1

Genomic Locations for ZBTB8B Gene

Genomic Locations for ZBTB8B Gene
chr1:32,465,072-32,496,686
(GRCh38/hg38)
Size:
31,615 bases
Orientation:
Plus strand
chr1:32,930,658-32,962,287
(GRCh37/hg19)
Size:
31,630 bases
Orientation:
Plus strand

Genomic View for ZBTB8B Gene

Genes around ZBTB8B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBTB8B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBTB8B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB8B Gene

Proteins for ZBTB8B Gene

  • Protein details for ZBTB8B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NAP8-ZBT8B_HUMAN
    Recommended name:
    Zinc finger and BTB domain-containing protein 8B
    Protein Accession:
    Q8NAP8
    Secondary Accessions:
    • Q15DG5
    • Q5VXR5
    • Q69YT7

    Protein attributes for ZBTB8B Gene

    Size:
    495 amino acids
    Molecular mass:
    54175 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Alternative splice isoforms for ZBTB8B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZBTB8B Gene

Post-translational modifications for ZBTB8B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZBTB8B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZBTB8B Gene

Domains & Families for ZBTB8B Gene

Gene Families for ZBTB8B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZBTB8B Gene

InterPro:
Blocks:
  • BTB/POZ domain
ProtoNet:

Suggested Antigen Peptide Sequences for ZBTB8B Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger and BTB domain-containing protein 8B (ZBT8B_HUMAN)
genes like me logo Genes that share domains with ZBTB8B: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ZBTB8B Gene

Function for ZBTB8B Gene

Molecular function for ZBTB8B Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZBTB8B Gene

Gene Ontology (GO) - Molecular Function for ZBTB8B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA,IBA 21873635
GO:0005515 protein binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZBTB8B: view

Phenotypes for ZBTB8B Gene

genes like me logo Genes that share phenotypes with ZBTB8B: view

Animal Model Products

CRISPR Products

miRNA for ZBTB8B Gene

miRTarBase miRNAs that target ZBTB8B

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZBTB8B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZBTB8B Gene

Localization for ZBTB8B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB8B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZBTB8B gene
Compartment Confidence
nucleus 4
cytosol 1
mitochondrion 0
endoplasmic reticulum 0
golgi apparatus 0

Gene Ontology (GO) - Cellular Components for ZBTB8B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IEA,IBA 21873635
genes like me logo Genes that share ontologies with ZBTB8B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZBTB8B Gene

Pathways & Interactions for ZBTB8B Gene

PathCards logo

SuperPathways for ZBTB8B Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZBTB8B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription by RNA polymerase II IEA,IBA 21873635
genes like me logo Genes that share ontologies with ZBTB8B: view

No data available for Pathways by source and SIGNOR curated interactions for ZBTB8B Gene

Drugs & Compounds for ZBTB8B Gene

No Compound Related Data Available

Transcripts for ZBTB8B Gene

mRNA/cDNA for ZBTB8B Gene

1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZBTB8B

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB8B Gene

No ASD Table

Relevant External Links for ZBTB8B Gene

GeneLoc Exon Structure for
ZBTB8B

Expression for ZBTB8B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZBTB8B Gene

mRNA expression in normal human tissues for ZBTB8B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZBTB8B Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZBTB8B Gene



Protein tissue co-expression partners for ZBTB8B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZBTB8B

SOURCE GeneReport for Unigene cluster for ZBTB8B Gene:

Hs.647658

Evidence on tissue expression from TISSUES for ZBTB8B Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with ZBTB8B: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZBTB8B Gene

Orthologs for ZBTB8B Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB8B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia -- 31
  • 100 (a)
OneToMany
ZBTB8B 30
  • 99.53 (n)
Dog
(Canis familiaris)
Mammalia -- 31
  • 89 (a)
OneToMany
ZBTB8B 30
  • 88.17 (n)
Rat
(Rattus norvegicus)
Mammalia Zbtb8b 30
  • 82.3 (n)
Cow
(Bos Taurus)
Mammalia -- 31
  • 82 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Zbtb8b 30 17 31
  • 81.54 (n)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 77 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 75 (a)
OneToMany
Chicken
(Gallus gallus)
Aves ZBTB8B 30 31
  • 75.19 (n)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia zbtb8b 30
  • 64.97 (n)
Zebrafish
(Danio rerio)
Actinopterygii zbtb8b 31
  • 48 (a)
OneToMany
Species where no ortholog for ZBTB8B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ZBTB8B Gene

ENSEMBL:
Gene Tree for ZBTB8B (if available)
TreeFam:
Gene Tree for ZBTB8B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZBTB8B: view image

Paralogs for ZBTB8B Gene

Paralogs for ZBTB8B Gene

(18) SIMAP similar genes for ZBTB8B Gene using alignment to 1 proteins:

  • ZBT8B_HUMAN
genes like me logo Genes that share paralogs with ZBTB8B: view

Variants for ZBTB8B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZBTB8B Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
VAR_035602 A colorectal cancer sample p.Glu181Lys

Additional dbSNP identifiers (rs#s) for ZBTB8B Gene

Variation tolerance for ZBTB8B Gene

Gene Damage Index Score: 1.32; 26.14% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZBTB8B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZBTB8B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZBTB8B Gene

Disorders for ZBTB8B Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZBTB8B Gene - From: DISEASES

Disorder Aliases PubMed IDs
syndromic microphthalmia
  • microphthalmia, syndromic
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with ZBTB8B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZBTB8B Gene

Publications for ZBTB8B Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. A census of human soluble protein complexes. (PMID: 22939629) Havugimana PC … Emili A (Cell 2012) 3
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for ZBTB8B Gene

Sources for ZBTB8B Gene