Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZBTB8B Gene

Aliases for ZBTB8B Gene

  • Zinc Finger And BTB Domain Containing 8B 2 3 5
  • Putative Zinc Finger And BTB Domain-Containing Protein 8B 3
  • Zinc Finger And BTB Domain-Containing Protein 8B 3
  • ZNF916B 3

External Ids for ZBTB8B Gene

Previous GeneCards Identifiers for ZBTB8B Gene

  • GC01P032694
  • GC01P032930
  • GC01P031046

Summaries for ZBTB8B Gene

GeneCards Summary for ZBTB8B Gene

ZBTB8B (Zinc Finger And BTB Domain Containing 8B) is a Protein Coding gene. An important paralog of this gene is ENSG00000254553.

UniProtKB/Swiss-Prot for ZBTB8B Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZBTB8B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB8B Gene

Genomics for ZBTB8B Gene

GeneHancer (GH) Regulatory Elements for ZBTB8B Gene

Promoters and enhancers for ZBTB8B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I032464 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 550.8 0.0 -42 0.9 PKNOX1 ARID4B SIN3A FEZF1 GLI4 ZNF2 ZNF48 ETS1 GLIS2 ZNF143 ENSG00000254553 ZBTB8B TSSK3 RBBP4 TXLNA KHDRBS1 ENSG00000224066 FAM229A ZBTB8OS S100PBP
GH01I032465 Enhancer 0.5 ENCODE 550.8 -0.6 -642 0.2 SCRT1 ZNF335 ZSCAN21 L3MBTL2 SCRT2 ZFP37 ZNF501 ENSG00000254553 ZBTB8B LRRC37A12P RN7SL122P
GH01I031572 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 21.1 -889.4 -889437 6.1 PKNOX1 FOXA2 MLX ZFP64 ARID4B DMAP1 ZNF143 FOS SP5 ZHX2 TINAGL1 ZBTB8B SNRNP40 TSSK3 TXLNA TMEM39B ADGRB2 KHDRBS1 FAM229A IQCC
GH01I032271 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 21.1 -191.5 -191507 5.1 ZNF493 ZNF133 GLI4 ETS1 ZNF121 GLIS2 SP3 YY2 NCOA1 SMARCA4 LCK RBBP4 ZBTB8A TXLNA KHDRBS1 IQCC SNRNP40 S100PBP ZBTB8B ENSG00000224066
GH01I031924 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.3 -529.2 -529224 22.1 CLOCK MLX ZFP64 YBX1 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 GC01P031934 PTP4A2 TXLNA SNRNP40 KHDRBS1 RBBP4 ENSG00000229447 TSSK3 ZBTB8A TMEM39B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZBTB8B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZBTB8B gene promoter:

Genomic Locations for ZBTB8B Gene

Genomic Locations for ZBTB8B Gene
31,630 bases
Plus strand

Genomic View for ZBTB8B Gene

Genes around ZBTB8B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBTB8B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBTB8B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB8B Gene

Proteins for ZBTB8B Gene

  • Protein details for ZBTB8B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger and BTB domain-containing protein 8B
    Protein Accession:
    Secondary Accessions:
    • Q15DG5
    • Q5VXR5
    • Q69YT7

    Protein attributes for ZBTB8B Gene

    495 amino acids
    Molecular mass:
    54175 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZBTB8B Gene


neXtProt entry for ZBTB8B Gene

Post-translational modifications for ZBTB8B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZBTB8B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZBTB8B Gene

Domains & Families for ZBTB8B Gene

Gene Families for ZBTB8B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZBTB8B Gene

Suggested Antigen Peptide Sequences for ZBTB8B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZBTB8B: view

No data available for UniProtKB/Swiss-Prot for ZBTB8B Gene

Function for ZBTB8B Gene

Molecular function for ZBTB8B Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZBTB8B Gene

Gene Ontology (GO) - Molecular Function for ZBTB8B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZBTB8B: view

Phenotypes for ZBTB8B Gene

GenomeRNAi human phenotypes for ZBTB8B:
genes like me logo Genes that share phenotypes with ZBTB8B: view

Animal Model Products

miRNA for ZBTB8B Gene

miRTarBase miRNAs that target ZBTB8B

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZBTB8B Gene

Localization for ZBTB8B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB8B Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZBTB8B gene
Compartment Confidence
nucleus 5
mitochondrion 1
endoplasmic reticulum 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ZBTB8B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZBTB8B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZBTB8B Gene

Pathways & Interactions for ZBTB8B Gene

SuperPathways for ZBTB8B Gene

No Data Available

Interacting Proteins for ZBTB8B Gene

Selected Interacting proteins: Q8NAP8-ZBT8B_HUMAN for ZBTB8B Gene via IID

Gene Ontology (GO) - Biological Process for ZBTB8B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZBTB8B: view

No data available for Pathways by source and SIGNOR curated interactions for ZBTB8B Gene

Drugs & Compounds for ZBTB8B Gene

No Compound Related Data Available

Transcripts for ZBTB8B Gene

mRNA/cDNA for ZBTB8B Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZBTB8B Gene

Zinc finger and BTB domain containing 8B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB8B Gene

No ASD Table

Relevant External Links for ZBTB8B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZBTB8B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZBTB8B Gene

mRNA expression in normal human tissues for ZBTB8B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZBTB8B Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZBTB8B Gene

Protein tissue co-expression partners for ZBTB8B Gene

NURSA nuclear receptor signaling pathways regulating expression of ZBTB8B Gene:


SOURCE GeneReport for Unigene cluster for ZBTB8B Gene:


Evidence on tissue expression from TISSUES for ZBTB8B Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with ZBTB8B: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZBTB8B Gene

Orthologs for ZBTB8B Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB8B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 34
  • 100 (a)
  • 99.53 (n)
(Canis familiaris)
Mammalia -- 34
  • 89 (a)
  • 88.17 (n)
(Rattus norvegicus)
Mammalia Zbtb8b 33
  • 82.3 (n)
(Bos Taurus)
Mammalia -- 34
  • 82 (a)
(Mus musculus)
Mammalia Zbtb8b 33 16 34
  • 81.54 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 75 (a)
(Gallus gallus)
Aves ZBTB8B 33 34
  • 75.19 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia zbtb8b 33
  • 64.97 (n)
(Danio rerio)
Actinopterygii zbtb8b 34
  • 48 (a)
Species where no ortholog for ZBTB8B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB8B Gene

Gene Tree for ZBTB8B (if available)
Gene Tree for ZBTB8B (if available)

Paralogs for ZBTB8B Gene

(18) SIMAP similar genes for ZBTB8B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZBTB8B: view

Variants for ZBTB8B Gene

Sequence variations from dbSNP and Humsavar for ZBTB8B Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
VAR_035602 A colorectal cancer sample p.Glu181Lys
rs1000051325 -- 32,467,745(+) A/G intron_variant
rs1000151458 -- 32,467,328(+) C/T intron_variant
rs1000329824 -- 32,482,377(+) A/G intron_variant
rs1000660689 -- 32,486,484(+) G/A 3_prime_UTR_variant

Variation tolerance for ZBTB8B Gene

Gene Damage Index Score: 1.32; 26.14% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZBTB8B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZBTB8B Gene

Disorders for ZBTB8B Gene

Additional Disease Information for ZBTB8B

No disorders were found for ZBTB8B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZBTB8B Gene

Publications for ZBTB8B Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. A census of human soluble protein complexes. (PMID: 22939629) Havugimana PC … Emili A (Cell 2012) 3 58
  4. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 58
  5. The consensus coding sequences of human breast and colorectal cancers. (PMID: 16959974) Sjöblom T … Velculescu VE (Science (New York, N.Y.) 2006) 4 58

Products for ZBTB8B Gene

Sources for ZBTB8B Gene

Loading form....