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Aliases for ZBTB8A Gene

Aliases for ZBTB8A Gene

  • Zinc Finger And BTB Domain Containing 8A 2 3 5
  • BTB/POZ And Zinc-Finger Domains Factor On Chromosome 1 3 4
  • BTB/POZ And Zinc-Finger Domain-Containing Factor 3 4
  • Zinc Finger And BTB Domain Containing 8 2 3
  • BOZF1 3 4
  • Zinc Finger And BTB Domain-Containing Protein 8A 3
  • ZNF916A 3
  • BOZ-F1 4
  • ZBTB8 3

External Ids for ZBTB8A Gene

Previous HGNC Symbols for ZBTB8A Gene

  • ZBTB8

Previous GeneCards Identifiers for ZBTB8A Gene

  • GC01P032779
  • GC01P032931
  • GC01P031119
  • GC01P033004

Summaries for ZBTB8A Gene

GeneCards Summary for ZBTB8A Gene

ZBTB8A (Zinc Finger And BTB Domain Containing 8A) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZBTB8B.

UniProtKB/Swiss-Prot for ZBTB8A Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZBTB8A Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB8A Gene

Genomics for ZBTB8A Gene

GeneHancer (GH) Regulatory Elements for ZBTB8A Gene

Promoters and enhancers for ZBTB8A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I032538 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 550.8 +0.7 680 2.1 HDGF SIN3A FEZF1 ZBTB7B GLIS2 SP3 MAFF GLIS1 SP7 KLF1 ZBTB8A TXLNA KHDRBS1 TSSK3 EIF3I AK2 RBBP4 LOC105378626 TMEM234 GC01P032555
GH01I031924 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 61.1 -603.3 -603312 22.1 CLOCK MLX ZFP64 YBX1 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 GC01P031934 PTP4A2 TXLNA SNRNP40 KHDRBS1 RBBP4 ENSG00000229447 TSSK3 ZBTB8A TMEM39B
GH01I032813 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 43.5 +278.1 278097 7.3 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 S100PBP YARS TXLNA TSSK3 RBBP4 ZBTB8A KHDRBS1 TMEM39B EIF3I FAM229A
GH01I033361 Enhancer 2 VISTA FANTOM5 Ensembl ENCODE dbSUPER 55.2 +825.6 825557 7 PKNOX1 ZFP64 ARID4B SIN3A FEZF1 ZNF2 ZNF766 ZNF302 ZNF416 ZNF143 ZBTB8A RBBP4 ZSCAN20 S100PBP BSDC1 PHC2 ZBTB8B CSMD2 ZBTB8OS A3GALT2
GH01I032271 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 47.3 -265.6 -265595 5.1 ZNF493 ZNF133 GLI4 ETS1 ZNF121 GLIS2 SP3 YY2 NCOA1 SMARCA4 LCK RBBP4 ZBTB8A TXLNA KHDRBS1 IQCC SNRNP40 S100PBP ZBTB8B ENSG00000224066
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZBTB8A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZBTB8A gene promoter:

Genomic Locations for ZBTB8A Gene

Genomic Locations for ZBTB8A Gene
chr1:32,539,145-32,605,950
(GRCh38/hg38)
Size:
66,806 bases
Orientation:
Plus strand
chr1:33,004,772-33,071,542
(GRCh37/hg19)

Genomic View for ZBTB8A Gene

Genes around ZBTB8A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBTB8A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBTB8A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB8A Gene

Proteins for ZBTB8A Gene

  • Protein details for ZBTB8A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96BR9-ZBT8A_HUMAN
    Recommended name:
    Zinc finger and BTB domain-containing protein 8A
    Protein Accession:
    Q96BR9
    Secondary Accessions:
    • Q8IUL5
    • Q8IWR9
    • Q8N2Y5
    • Q96BX0

    Protein attributes for ZBTB8A Gene

    Size:
    441 amino acids
    Molecular mass:
    50141 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZBTB8A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZBTB8A Gene

Post-translational modifications for ZBTB8A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZBTB8A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZBTB8A Gene

Domains & Families for ZBTB8A Gene

Gene Families for ZBTB8A Gene

Protein Domains for ZBTB8A Gene

Suggested Antigen Peptide Sequences for ZBTB8A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZBTB8A: view

No data available for UniProtKB/Swiss-Prot for ZBTB8A Gene

Function for ZBTB8A Gene

Molecular function for ZBTB8A Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZBTB8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 16189514
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZBTB8A: view
genes like me logo Genes that share phenotypes with ZBTB8A: view

Animal Model Products

CRISPR Products

miRNA for ZBTB8A Gene

miRTarBase miRNAs that target ZBTB8A

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZBTB8A Gene

Localization for ZBTB8A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB8A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZBTB8A gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Focal adhesion sites (2)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZBTB8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZBTB8A: view

Pathways & Interactions for ZBTB8A Gene

SuperPathways for ZBTB8A Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZBTB8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with ZBTB8A: view

No data available for Pathways by source and SIGNOR curated interactions for ZBTB8A Gene

Drugs & Compounds for ZBTB8A Gene

No Compound Related Data Available

Transcripts for ZBTB8A Gene

mRNA/cDNA for ZBTB8A Gene

(3) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZBTB8A Gene

Zinc finger and BTB domain containing 8A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB8A Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8
SP1: -
SP2: -
SP3: - -
SP4:

Relevant External Links for ZBTB8A Gene

GeneLoc Exon Structure for
ZBTB8A
ECgene alternative splicing isoforms for
ZBTB8A

Expression for ZBTB8A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZBTB8A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZBTB8A Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZBTB8A Gene



Protein tissue co-expression partners for ZBTB8A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZBTB8A Gene:

ZBTB8A

SOURCE GeneReport for Unigene cluster for ZBTB8A Gene:

Hs.546479

Evidence on tissue expression from TISSUES for ZBTB8A Gene

  • Skin(4.2)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZBTB8A: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZBTB8A Gene

Orthologs for ZBTB8A Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB8A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZBTB8A 33 34
  • 99.55 (n)
dog
(Canis familiaris)
Mammalia ZBTB8A 33 34
  • 91.21 (n)
cow
(Bos Taurus)
Mammalia ZBTB8A 33 34
  • 91.08 (n)
rat
(Rattus norvegicus)
Mammalia Zbtb8a 33
  • 81.24 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ZBTB8A 34
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zbtb8a 33 16 34
  • 80.41 (n)
oppossum
(Monodelphis domestica)
Mammalia ZBTB8A 34
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZBTB8A 33 34
  • 74.79 (n)
lizard
(Anolis carolinensis)
Reptilia ZBTB8A 34
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zbtb8a.1 33
  • 60.43 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:136874 33
  • 52.44 (n)
ZBTB8A 34
  • 44 (a)
OneToOne
Species where no ortholog for ZBTB8A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB8A Gene

ENSEMBL:
Gene Tree for ZBTB8A (if available)
TreeFam:
Gene Tree for ZBTB8A (if available)

Paralogs for ZBTB8A Gene

(6) SIMAP similar genes for ZBTB8A Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZBTB8A: view

Variants for ZBTB8A Gene

Sequence variations from dbSNP and Humsavar for ZBTB8A Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000012179 -- 32,567,960(+) T/A intron_variant
rs1000051793 -- 32,553,674(+) G/T intron_variant
rs1000084799 -- 32,545,010(+) A/G intron_variant
rs1000148468 -- 32,580,891(+) G/T intron_variant
rs1000149330 -- 32,540,164(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZBTB8A Gene

Variant ID Type Subtype PubMed ID
dgv72n106 CNV deletion 24896259
esv1277305 CNV insertion 17803354
esv2576617 CNV insertion 19546169
esv2666068 CNV deletion 23128226
esv2671633 CNV deletion 23128226
esv2746508 CNV deletion 23290073
esv3585672 CNV loss 21293372
esv3893501 CNV loss 25118596
nsv1005213 CNV gain 25217958
nsv1075804 CNV deletion 25765185
nsv461039 CNV loss 19166990
nsv475689 CNV novel sequence insertion 20440878
nsv512732 CNV insertion 21212237
nsv545960 CNV loss 21841781
nsv545961 CNV loss 21841781

Variation tolerance for ZBTB8A Gene

Residual Variation Intolerance Score: 56.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.03; 21.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZBTB8A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZBTB8A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBTB8A Gene

Disorders for ZBTB8A Gene

Additional Disease Information for ZBTB8A

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ZBTB8A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZBTB8A Gene

Publications for ZBTB8A Gene

  1. Regulation of the cyclin-dependent kinase inhibitor 1A gene (CDKN1A) by the repressor BOZF1 through inhibition of p53 acetylation and transcription factor Sp1 binding. (PMID: 23329847) Kim MK … Hur MW (The Journal of biological chemistry 2013) 2 3 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for ZBTB8A Gene

Sources for ZBTB8A Gene

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