This gene encodes a zinc finger-containing transcription factor that acts as a key regulator of lineage commitment of immature T-cell precursors. It is necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. It also functions as a transcriptional repressor of type I collagen genes. Alternatively spliced transcript variants have been foun... See more...

Aliases for ZBTB7B Gene

Aliases for ZBTB7B Gene

  • Zinc Finger And BTB Domain Containing 7B 2 3 5
  • ZNF857B 2 3 4
  • ZBTB15 2 3 4
  • Zinc Finger And BTB Domain-Containing Protein 7B 3 4
  • T-Helper-Inducing POZ/Krueppel-Like Factor 3 4
  • Krueppel-Related Zinc Finger Protein CKrox 3 4
  • Zinc Finger And BTB Domain Containing 15 2 3
  • Zinc Finger Protein 67 Homolog 3 4
  • Zinc Finger Protein Th-POK 3 4
  • Zinc Finger Protein 857B 3 4
  • HcKrox 2 4
  • ZFP67 3 4
  • Zinc Finger And BTB Domain-Containing Protein 15 4
  • Zinc Finger Protein 67 Homolog (Mouse) 2
  • ZFP-67 3
  • C-KROX 3
  • HcKROX 3
  • ZBTB7B 5
  • C-Krox 2
  • Zfp-67 4
  • CKROX 3
  • THPOK 3

External Ids for ZBTB7B Gene

Previous HGNC Symbols for ZBTB7B Gene

  • ZFP67

Previous GeneCards Identifiers for ZBTB7B Gene

  • GC01P151790
  • GC01P153242
  • GC01P154975
  • GC01P126337

Summaries for ZBTB7B Gene

Entrez Gene Summary for ZBTB7B Gene

  • This gene encodes a zinc finger-containing transcription factor that acts as a key regulator of lineage commitment of immature T-cell precursors. It is necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. It also functions as a transcriptional repressor of type I collagen genes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]

GeneCards Summary for ZBTB7B Gene

ZBTB7B (Zinc Finger And BTB Domain Containing 7B) is a Protein Coding gene. Diseases associated with ZBTB7B include Malignant Essential Hypertension. Among its related pathways are Ectoderm Differentiation and NF-kappaB Signaling. An important paralog of this gene is ZBTB3.

UniProtKB/Swiss-Prot Summary for ZBTB7B Gene

  • Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Exerts distinct biological functions in the mammary epithelial cells and T cells in a tissue-specific manner. Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. Cross-antagonism between ZBTB7B and CBF complexes are determinative to CD4 versus CD8 cell fate decision. Suppresses RUNX3 expression and imposes CD4+ lineage fate by inducing the SOCS suppressors of cytokine signaling. induces, as a transcriptional activator, SOCS genes expression which represses RUNX3 expression and promotes the CD4+ lineage fate. During CD4 lineage commitment, associates with multiple sites at the CD8 locus, acting as a negative regulator of the CD8 promoter and enhancers by epigenetic silencing through the recruitment of class II histone deacetylases, such as HDAC4 and HDAC5, to these loci. Regulates the development of IL17-producing CD1d-restricted naural killer (NK) T cells. Also functions as an important metabolic regulator in the lactating mammary glands. Critical feed-forward regulator of insulin signaling in mammary gland lactation, directly regulates expression of insulin receptor substrate-1 (IRS-1) and insulin-induced Akt-mTOR-SREBP signaling (By similarity). Transcriptional repressor of the collagen COL1A1 and COL1A2 genes. May also function as a repressor of fibronectin and possibly other extracellular matrix genes (PubMed:9370309). Potent driver of brown fat development, thermogenesis and cold-induced beige fat formation. Recruits the brown fat lncRNA 1 (Blnc1):HNRNPU ribonucleoprotein complex to activate thermogenic gene expression in brown and beige adipocytes (By similarity).

Gene Wiki entry for ZBTB7B Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZBTB7B Gene

Genomics for ZBTB7B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZBTB7B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZBTB7B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZBTB7B

Top Transcription factor binding sites by QIAGEN in the ZBTB7B gene promoter:
  • AML1a
  • ATF-2
  • c-Jun
  • CREB
  • deltaCREB

Genomic Locations for ZBTB7B Gene

Genomic Locations for ZBTB7B Gene
chr1:155,002,628-155,018,523
(GRCh38/hg38)
Size:
15,896 bases
Orientation:
Plus strand
chr1:154,975,112-154,990,999
(GRCh37/hg19)
Size:
15,888 bases
Orientation:
Plus strand

Genomic View for ZBTB7B Gene

Genes around ZBTB7B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBTB7B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBTB7B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB7B Gene

Proteins for ZBTB7B Gene

  • Protein details for ZBTB7B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15156-ZBT7B_HUMAN
    Recommended name:
    Zinc finger and BTB domain-containing protein 7B
    Protein Accession:
    O15156
    Secondary Accessions:
    • B4E3K5
    • D3DV83
    • J3KQQ3
    • Q68DR2
    • Q96EP2

    Protein attributes for ZBTB7B Gene

    Size:
    539 amino acids
    Molecular mass:
    58027 Da
    Quaternary structure:
    • Homodimerizes. Interacts with NCL, NEDD4 and YBX1. Interacts with HNRNPU (via RNA-binding RGG-box region); the interaction facilitates the recruitment of long non-coding RNA Blnc1 by ZBTB7B. Interacts with HDAC4 and HDAC5; the interaction allows the recruitment of HDAC4 and HDAC5 on CD8 loci for deacetylation and possible inhibition of CD8 genes expression.

    Alternative splice isoforms for ZBTB7B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZBTB7B Gene

Post-translational modifications for ZBTB7B Gene

  • Acetylated directly and specifically by EP300 (PubMed:20810990). EP300-mediated acetylation of Lys-206, Lys-212 and Lys-335 stabilizes the protein by antagonizing ubiquitin conjugation (By similarity).
  • Ubiquitinated, leading to proteasomal degradation (PubMed:20810990). Competes with acetylation on Lys-206, Lys-212 and Lys-335 (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZBTB7B Gene

Domains & Families for ZBTB7B Gene

Gene Families for ZBTB7B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZBTB7B Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature
ProtoNet:

Suggested Antigen Peptide Sequences for ZBTB7B Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein Th-POK (ZBT7B_HUMAN)
genes like me logo Genes that share domains with ZBTB7B: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ZBTB7B Gene

Function for ZBTB7B Gene

Molecular function for ZBTB7B Gene

UniProtKB/Swiss-Prot Function:
Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Exerts distinct biological functions in the mammary epithelial cells and T cells in a tissue-specific manner. Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. Cross-antagonism between ZBTB7B and CBF complexes are determinative to CD4 versus CD8 cell fate decision. Suppresses RUNX3 expression and imposes CD4+ lineage fate by inducing the SOCS suppressors of cytokine signaling. induces, as a transcriptional activator, SOCS genes expression which represses RUNX3 expression and promotes the CD4+ lineage fate. During CD4 lineage commitment, associates with multiple sites at the CD8 locus, acting as a negative regulator of the CD8 promoter and enhancers by epigenetic silencing through the recruitment of class II histone deacetylases, such as HDAC4 and HDAC5, to these loci. Regulates the development of IL17-producing CD1d-restricted naural killer (NK) T cells. Also functions as an important metabolic regulator in the lactating mammary glands. Critical feed-forward regulator of insulin signaling in mammary gland lactation, directly regulates expression of insulin receptor substrate-1 (IRS-1) and insulin-induced Akt-mTOR-SREBP signaling (By similarity). Transcriptional repressor of the collagen COL1A1 and COL1A2 genes. May also function as a repressor of fibronectin and possibly other extracellular matrix genes (PubMed:9370309). Potent driver of brown fat development, thermogenesis and cold-induced beige fat formation. Recruits the brown fat lncRNA 1 (Blnc1):HNRNPU ribonucleoprotein complex to activate thermogenic gene expression in brown and beige adipocytes (By similarity).

Phenotypes From GWAS Catalog for ZBTB7B Gene

Gene Ontology (GO) - Molecular Function for ZBTB7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA,IBA 21873635
GO:0000987 proximal promoter sequence-specific DNA binding IEA,ISS --
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with ZBTB7B: view
genes like me logo Genes that share phenotypes with ZBTB7B: view

Animal Models for ZBTB7B Gene

MGI Knock Outs for ZBTB7B:

Animal Model Products

CRISPR Products

miRNA for ZBTB7B Gene

miRTarBase miRNAs that target ZBTB7B

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZBTB7B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZBTB7B Gene

Localization for ZBTB7B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB7B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZBTB7B gene
Compartment Confidence
nucleus 5
plasma membrane 2
extracellular 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZBTB7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with ZBTB7B: view

Pathways & Interactions for ZBTB7B Gene

PathCards logo

SuperPathways for ZBTB7B Gene

genes like me logo Genes that share pathways with ZBTB7B: view

Pathways by source for ZBTB7B Gene

1 BioSystems pathway for ZBTB7B Gene
1 Cell Signaling Technology pathway for ZBTB7B Gene

Gene Ontology (GO) - Biological Process for ZBTB7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA,ISS --
GO:0001865 NK T cell differentiation IEA,ISS --
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
GO:0006366 transcription by RNA polymerase II TAS 7937772
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with ZBTB7B: view

No data available for SIGNOR curated interactions for ZBTB7B Gene

Drugs & Compounds for ZBTB7B Gene

No Compound Related Data Available

Transcripts for ZBTB7B Gene

mRNA/cDNA for ZBTB7B Gene

7 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZBTB7B

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB7B Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g ^ 8a · 8b
SP1: - - - - -
SP2: - - - -
SP3: - - - -
SP4: - - - - -
SP5: -
SP6: - - - - -
SP7:
SP8:
SP9: - - - -

Relevant External Links for ZBTB7B Gene

GeneLoc Exon Structure for
ZBTB7B

Expression for ZBTB7B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZBTB7B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZBTB7B Gene

This gene is overexpressed in Whole Blood (x6.4).

Protein differential expression in normal tissues from HIPED for ZBTB7B Gene

This gene is overexpressed in Lung (41.4) and Placenta (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZBTB7B Gene



Protein tissue co-expression partners for ZBTB7B Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZBTB7B

SOURCE GeneReport for Unigene cluster for ZBTB7B Gene:

Hs.729279

Evidence on tissue expression from TISSUES for ZBTB7B Gene

  • Skin(4.5)
  • Liver(4.4)
  • Spleen(2.6)
  • Blood(2.6)
  • Lymph node(2.5)
  • Bone marrow(2.5)
  • Intestine(2.4)
genes like me logo Genes that share expression patterns with ZBTB7B: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZBTB7B Gene

Orthologs for ZBTB7B Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB7B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZBTB7B 30 31
  • 99.71 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZBTB7B 30 31
  • 89.16 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZBTB7B 30 31
  • 88.93 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Zbtb7b 30 17 31
  • 87.82 (n)
OneToMany
Gm18856 31
  • 85 (a)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Zbtb7b 30
  • 86.97 (n)
Oppossum
(Monodelphis domestica)
Mammalia ZBTB7B 31
  • 84 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia cpg-A 30
Zebrafish
(Danio rerio)
Actinopterygii ZBTB7B 31
  • 47 (a)
OneToOne
zgc63489 30
Species where no ortholog for ZBTB7B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ZBTB7B Gene

ENSEMBL:
Gene Tree for ZBTB7B (if available)
TreeFam:
Gene Tree for ZBTB7B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZBTB7B: view image

Paralogs for ZBTB7B Gene

(2) SIMAP similar genes for ZBTB7B Gene using alignment to 1 proteins:

  • ZBT7B_HUMAN
genes like me logo Genes that share paralogs with ZBTB7B: view

Variants for ZBTB7B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZBTB7B Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
710306 Benign: not provided 155,015,230(+) G/A NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
713771 Benign: not provided 155,015,779(+) C/A NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for ZBTB7B Gene

Structural Variations from Database of Genomic Variants (DGV) for ZBTB7B Gene

Variant ID Type Subtype PubMed ID
nsv1078828 CNV deletion 25765185
nsv1112556 CNV deletion 24896259
nsv1142783 CNV deletion 24896259
nsv509502 CNV insertion 20534489
nsv824775 CNV loss 20364138
nsv952212 CNV deletion 24416366

Variation tolerance for ZBTB7B Gene

Residual Variation Intolerance Score: 55.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.72; 32.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZBTB7B Gene

Human Gene Mutation Database (HGMD)
ZBTB7B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZBTB7B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBTB7B Gene

Disorders for ZBTB7B Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZBTB7B Gene - From: DISEASES

Disorder Aliases PubMed IDs
malignant essential hypertension
  • accelerated essential hypertension
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZBTB7B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with ZBTB7B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZBTB7B Gene

Publications for ZBTB7B Gene

  1. Cloning and characterization of hcKrox, a transcriptional regulator of extracellular matrix gene expression. (PMID: 9370309) Widom RL … Korn JH (Gene 1997) 2 3 4
  2. p300-mediated acetylation stabilizes the Th-inducing POK factor. (PMID: 20810990) Zhang M … Liu X (Journal of immunology (Baltimore, Md. : 1950) 2010) 3 4
  3. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PMID: 19453261) Yerges LM … MrOS Research Group (Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2009) 3 41
  4. CD4-CD8 lineage differentiation: Thpok-ing into the nucleus. (PMID: 19696430) Wang L … Bosselut R (Journal of immunology (Baltimore, Md. : 1950) 2009) 3 23
  5. Chondroitin sulphate decreases collagen synthesis in normal and scleroderma fibroblasts through a Smad-independent TGF-beta pathway--implication of C-Krox and Sp1. (PMID: 18298657) Renard E … Galéra P (Journal of cellular and molecular medicine 2008) 3 23

Products for ZBTB7B Gene

Sources for ZBTB7B Gene