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Aliases for ZBTB7A Gene

Aliases for ZBTB7A Gene

  • Zinc Finger And BTB Domain Containing 7A 2 3 5
  • Zinc Finger And BTB Domain Containing 7A, HIV-1 Inducer Of Short Transcripts Binding Protein 2 3
  • Factor That Binds To Inducer Of Short Transcripts Protein 1 3 4
  • POZ And Krueppel Erythroid Myeloid Ontogenic Factor 3 4
  • Zinc Finger And BTB Domain-Containing Protein 7A 3 4
  • POK Erythroid Myeloid Ontogenic Factor 3 4
  • Leukemia/Lymphoma-Related Factor 3 4
  • Factor Binding IST Protein 1 3 4
  • TTF-I-Interacting Peptide 21 3 4
  • HIV-1 1st-Binding Protein 1 3 4
  • Zinc Finger Protein 857A 3 4
  • Lymphoma Related Factor 2 3
  • Pokemon 1 3 4
  • Pokemon 3 4
  • ZNF857A 3 4
  • ZBTB7 3 4
  • FBI-1 3 4
  • TIP21 3 4
  • FBI1 3 4
  • LRF 3 4
  • HIV-1 Inducer Of Short Transcripts Binding Protein 3
  • Zinc Finger And BTB Domain Containing 7 2

External Ids for ZBTB7A Gene

Previous HGNC Symbols for ZBTB7A Gene

  • ZBTB7

Previous GeneCards Identifiers for ZBTB7A Gene

  • GC19M004000
  • GC19M004001
  • GC19M003809

Summaries for ZBTB7A Gene

GeneCards Summary for ZBTB7A Gene

ZBTB7A (Zinc Finger And BTB Domain Containing 7A) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include histone acetyltransferase binding. An important paralog of this gene is ZBTB5.

UniProtKB/Swiss-Prot for ZBTB7A Gene

  • Transcription factor that represses the transcription of a wide range of genes involved in cell proliferation and differentiation (PubMed:14701838, PubMed:17595526, PubMed:20812024, PubMed:25514493, PubMed:26455326, PubMed:26816381). Directly and specifically binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3' and represses transcription both by regulating the organization of chromatin and through the direct recruitment of transcription factors to gene regulatory regions (PubMed:12004059, PubMed:17595526, PubMed:20812024, PubMed:25514493, PubMed:26816381). Negatively regulates SMAD4 transcriptional activity in the TGF-beta signaling pathway through these two mechanisms (PubMed:25514493). That is, recruits the chromatin regulator HDAC1 to the SMAD4-DNA complex and in parallel prevents the recruitment of the transcriptional activators CREBBP and EP300 (PubMed:25514493). Collaborates with transcription factors like RELA to modify the accessibility of gene transcription regulatory regions to secondary transcription factors (By similarity). Also directly interacts with transcription factors like SP1 to prevent their binding to DNA (PubMed:12004059). Functions as an androgen receptor/AR transcriptional corepressor by recruiting NCOR1 and NCOR2 to the androgen response elements/ARE on target genes (PubMed:20812024). Thereby, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Involved in the switch between fetal and adult globin expression during erythroid cells maturation (PubMed:26816381). Through its interaction with the NuRD complex regulates chromatin at the fetal globin genes to repress their transcription (PubMed:26816381). Specifically represses the transcription of the tumor suppressor ARF isoform from the CDKN2A gene (By similarity). Efficiently abrogates E2F1-dependent CDKN2A transactivation (By similarity). Regulates chondrogenesis through the transcriptional repression of specific genes via a mechanism that also requires histone deacetylation (By similarity). Regulates cell proliferation through the transcriptional regulation of genes involved in glycolysis (PubMed:26455326). Involved in adipogenesis through the regulation of genes involved in adipocyte differentiation (PubMed:14701838). Plays a key role in the differentiation of lymphoid progenitors into B and T lineages (By similarity). Promotes differentiation towards the B lineage by inhibiting the T-cell instructive Notch signaling pathway through the specific transcriptional repression of Notch downstream target genes (By similarity). Also regulates osteoclast differentiation (By similarity). May also play a role, independently of its transcriptional activity, in double-strand break repair via classical non-homologous end joining/cNHEJ (By similarity). Recruited to double-strand break sites on damage DNA, interacts with the DNA-dependent protein kinase complex and directly regulates its stability and activity in DNA repair (By similarity). May also modulate the splicing activity of KHDRBS1 toward BCL2L1 in a mechanism which is histone deacetylase-dependent and thereby negatively regulates the pro-apoptotic effect of KHDRBS1 (PubMed:24514149).

Gene Wiki entry for ZBTB7A Gene

Additional gene information for ZBTB7A Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB7A Gene

Genomics for ZBTB7A Gene

GeneHancer (GH) Regulatory Elements for ZBTB7A Gene

Promoters and enhancers for ZBTB7A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZBTB7A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZBTB7A gene promoter:
  • c-Rel
  • CREB
  • deltaCREB
  • NF-kappaB1
  • Sp1

Genomic Locations for ZBTB7A Gene

Genomic Locations for ZBTB7A Gene
chr19:4,043,303-4,066,899
(GRCh38/hg38)
Size:
23,597 bases
Orientation:
Minus strand
chr19:4,044,362-4,066,943
(GRCh37/hg19)
Size:
22,582 bases
Orientation:
Minus strand

Genomic View for ZBTB7A Gene

Genes around ZBTB7A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBTB7A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBTB7A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB7A Gene

Proteins for ZBTB7A Gene

  • Protein details for ZBTB7A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95365-ZBT7A_HUMAN
    Recommended name:
    Zinc finger and BTB domain-containing protein 7A
    Protein Accession:
    O95365
    Secondary Accessions:
    • D6W619
    • O00456
    • Q14D41
    • Q5XG86

    Protein attributes for ZBTB7A Gene

    Size:
    584 amino acids
    Molecular mass:
    61439 Da
    Quaternary structure:
    • Homodimer (PubMed:9973611). Interacts with BCL6 (By similarity). Interacts with RELA; involved in the control by RELA of the accessibility of target gene promoters (PubMed:29813070). Interacts with AR (via NR LBD domain); the interaction is direct and androgen-dependent (PubMed:20812024). Interacts with NCOR1 (PubMed:20812024). Interacts with NCOR2 (PubMed:20812024). Interacts with SMAD4; the interaction is direct and stimulated by TGFB1 (PubMed:25514493). Interacts with HDAC1 (PubMed:25514493). Interacts with SP1; ZBTB7A prevents the binding to GC-rich motifs in promoters and represses the transcriptional activity of SP1 (PubMed:12004059). Interacts with the DNA-dependent protein kinase complex/DNA-PKc (PubMed:26446488). Interacts with KHDRBS1; negatively regulates KHDRBS1 splicing activity (PubMed:24514149).
    SequenceCaution:
    • Sequence=AAB58414.1; Type=Frameshift; Positions=8, 324; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ZBTB7A Gene

neXtProt entry for ZBTB7A Gene

Post-translational modifications for ZBTB7A Gene

  • Sumoylated. Undergoes sumoylation with SUMO1 that may regulate its transcriptional activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZBTB7A Gene

No data available for DME Specific Peptides for ZBTB7A Gene

Domains & Families for ZBTB7A Gene

Gene Families for ZBTB7A Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZBTB7A Gene

Suggested Antigen Peptide Sequences for ZBTB7A Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger and BTB domain containing 7A, isoform CRA_a (Q8TB76_HUMAN)
  • Zinc finger protein 857A (ZBT7A_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O95365

UniProtKB/Swiss-Prot:

ZBT7A_HUMAN :
  • The BTB domain mediates the interaction with the androgen receptor/AR and HDAC1 (PubMed:20812024, PubMed:25514493). Also mediates the interaction with SP1 (PubMed:12004059).
Domain:
  • The BTB domain mediates the interaction with the androgen receptor/AR and HDAC1 (PubMed:20812024, PubMed:25514493). Also mediates the interaction with SP1 (PubMed:12004059).
genes like me logo Genes that share domains with ZBTB7A: view

Function for ZBTB7A Gene

Molecular function for ZBTB7A Gene

UniProtKB/Swiss-Prot Function:
Transcription factor that represses the transcription of a wide range of genes involved in cell proliferation and differentiation (PubMed:14701838, PubMed:17595526, PubMed:20812024, PubMed:25514493, PubMed:26455326, PubMed:26816381). Directly and specifically binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3' and represses transcription both by regulating the organization of chromatin and through the direct recruitment of transcription factors to gene regulatory regions (PubMed:12004059, PubMed:17595526, PubMed:20812024, PubMed:25514493, PubMed:26816381). Negatively regulates SMAD4 transcriptional activity in the TGF-beta signaling pathway through these two mechanisms (PubMed:25514493). That is, recruits the chromatin regulator HDAC1 to the SMAD4-DNA complex and in parallel prevents the recruitment of the transcriptional activators CREBBP and EP300 (PubMed:25514493). Collaborates with transcription factors like RELA to modify the accessibility of gene transcription regulatory regions to secondary transcription factors (By similarity). Also directly interacts with transcription factors like SP1 to prevent their binding to DNA (PubMed:12004059). Functions as an androgen receptor/AR transcriptional corepressor by recruiting NCOR1 and NCOR2 to the androgen response elements/ARE on target genes (PubMed:20812024). Thereby, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Involved in the switch between fetal and adult globin expression during erythroid cells maturation (PubMed:26816381). Through its interaction with the NuRD complex regulates chromatin at the fetal globin genes to repress their transcription (PubMed:26816381). Specifically represses the transcription of the tumor suppressor ARF isoform from the CDKN2A gene (By similarity). Efficiently abrogates E2F1-dependent CDKN2A transactivation (By similarity). Regulates chondrogenesis through the transcriptional repression of specific genes via a mechanism that also requires histone deacetylation (By similarity). Regulates cell proliferation through the transcriptional regulation of genes involved in glycolysis (PubMed:26455326). Involved in adipogenesis through the regulation of genes involved in adipocyte differentiation (PubMed:14701838). Plays a key role in the differentiation of lymphoid progenitors into B and T lineages (By similarity). Promotes differentiation towards the B lineage by inhibiting the T-cell instructive Notch signaling pathway through the specific transcriptional repression of Notch downstream target genes (By similarity). Also regulates osteoclast differentiation (By similarity). May also play a role, independently of its transcriptional activity, in double-strand break repair via classical non-homologous end joining/cNHEJ (By similarity). Recruited to double-strand break sites on damage DNA, interacts with the DNA-dependent protein kinase complex and directly regulates its stability and activity in DNA repair (By similarity). May also modulate the splicing activity of KHDRBS1 toward BCL2L1 in a mechanism which is histone deacetylase-dependent and thereby negatively regulates the pro-apoptotic effect of KHDRBS1 (PubMed:24514149).

Phenotypes From GWAS Catalog for ZBTB7A Gene

Gene Ontology (GO) - Molecular Function for ZBTB7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA 21873635
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific NAS 19274049
GO:0001222 transcription corepressor binding IPI 20812024
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific IEA --
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with ZBTB7A: view
genes like me logo Genes that share phenotypes with ZBTB7A: view

Animal Models for ZBTB7A Gene

MGI Knock Outs for ZBTB7A:

Animal Model Products

CRISPR Products

miRNA for ZBTB7A Gene

miRTarBase miRNAs that target ZBTB7A

Clone Products

  • Applied Biological Materials (abm): Clones for ZBTB7A - Now 50% OFF >
  • * ZBTB7A as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * ZBTB7A tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZBTB7A Gene

Localization for ZBTB7A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB7A Gene

Nucleus. Note=Recruited to double-strand break sites of damaged DNA. {ECO:0000250 UniProtKB:O88939}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZBTB7A gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZBTB7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IBA 15917220
GO:0005737 cytoplasm IDA 15917220
GO:0016581 colocalizes_with NuRD complex IDA 26816381
GO:0035861 colocalizes_with site of double-strand break ISS --
GO:0070418 colocalizes_with DNA-dependent protein kinase complex ISS --
genes like me logo Genes that share ontologies with ZBTB7A: view

Pathways & Interactions for ZBTB7A Gene

PathCards logo

SuperPathways for ZBTB7A Gene

No Data Available

SIGNOR curated interactions for ZBTB7A Gene

Inactivates:

Gene Ontology (GO) - Biological Process for ZBTB7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0000381 regulation of alternative mRNA splicing, via spliceosome IDA 24514149
GO:0006110 regulation of glycolytic process IMP 26455326
GO:0006325 chromatin organization ISS --
GO:0006338 chromatin remodeling IMP 26816381
genes like me logo Genes that share ontologies with ZBTB7A: view

No data available for Pathways by source for ZBTB7A Gene

Drugs & Compounds for ZBTB7A Gene

(1) Drugs for ZBTB7A Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with ZBTB7A: view

Transcripts for ZBTB7A Gene

mRNA/cDNA for ZBTB7A Gene

(2) REFSEQ mRNAs :
(13) Additional mRNA sequences :
(339) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for ZBTB7A Gene

Zinc finger and BTB domain containing 7A:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for ZBTB7A - Now 50% OFF >
  • * ZBTB7A as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * ZBTB7A tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB7A Gene

No ASD Table

Relevant External Links for ZBTB7A Gene

GeneLoc Exon Structure for
ZBTB7A
ECgene alternative splicing isoforms for
ZBTB7A

Expression for ZBTB7A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZBTB7A Gene

Protein differential expression in normal tissues from HIPED for ZBTB7A Gene

This gene is overexpressed in Pancreas (14.7), Adrenal (13.0), and Peripheral blood mononuclear cells (12.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZBTB7A Gene



Protein tissue co-expression partners for ZBTB7A Gene

NURSA nuclear receptor signaling pathways regulating expression of ZBTB7A Gene:

ZBTB7A

SOURCE GeneReport for Unigene cluster for ZBTB7A Gene:

Hs.591384

mRNA Expression by UniProt/SwissProt for ZBTB7A Gene:

O95365-ZBT7A_HUMAN
Tissue specificity: Widely expressed (PubMed:9927193). In normal thymus, expressed in medullary epithelial cells and Hassle's corpuscles (at protein level) (PubMed:15662416). In tonsil, expressed in squamous epithelium and germinal center lymphocytes (at protein level) (PubMed:15662416). Up-regulated in a subset of lymphomas, as well as in a subset of breast, lung, colon, prostate and bladder carcinomas (at protein level) (PubMed:15662416). Expressed in adipose tissues (PubMed:14701838).

Evidence on tissue expression from TISSUES for ZBTB7A Gene

  • Nervous system(4.5)
  • Liver(4.4)
  • Lung(4.4)
  • Pancreas(4.2)
genes like me logo Genes that share expression patterns with ZBTB7A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZBTB7A Gene

Orthologs for ZBTB7A Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB7A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZBTB7A 35 34
  • 99.83 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZBTB7A 35 34
  • 92.84 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ZBTB7A 35 34
  • 89.48 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Zbtb7a 17 35 34
  • 85.2 (n)
rat
(Rattus norvegicus)
Mammalia Zbtb7a 34
  • 84.49 (n)
oppossum
(Monodelphis domestica)
Mammalia ZBTB7A 35
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZBTB7A 35
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZBTB7A 35 34
  • 75.26 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZBTB7A 35
  • 65 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii zbtb7a 35 34
  • 62.53 (n)
OneToOne
Species where no ortholog for ZBTB7A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB7A Gene

ENSEMBL:
Gene Tree for ZBTB7A (if available)
TreeFam:
Gene Tree for ZBTB7A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZBTB7A: view image

Paralogs for ZBTB7A Gene

Paralogs for ZBTB7A Gene

(6) SIMAP similar genes for ZBTB7A Gene using alignment to 3 proteins:

  • ZBT7A_HUMAN
  • L8E8Q6_HUMAN
  • Q8TB76_HUMAN
genes like me logo Genes that share paralogs with ZBTB7A: view

Variants for ZBTB7A Gene

Sequence variations from dbSNP and Humsavar for ZBTB7A Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000102457 -- 4,058,684(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000194530 -- 4,044,031(-) C/T 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000233927 -- 4,054,955(-) T/C coding_sequence_variant, missense_variant
rs1000352683 -- 4,048,300(-) C/T intron_variant
rs1000381452 -- 4,063,255(-) C/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZBTB7A Gene

Variant ID Type Subtype PubMed ID
dgv6231n54 CNV gain+loss 21841781
esv2670713 CNV deletion 23128226
esv2671159 CNV deletion 23128226
esv26783 CNV loss 19812545
esv2717979 CNV deletion 23290073
esv2717990 CNV deletion 23290073
nsv1071500 CNV deletion 25765185
nsv1121966 CNV deletion 24896259
nsv1126508 CNV deletion 24896259
nsv1133440 CNV deletion 24896259
nsv1136269 CNV deletion 24896259
nsv470115 CNV loss 18288195
nsv578435 CNV loss 21841781
nsv578436 CNV loss 21841781
nsv578441 CNV gain+loss 21841781
nsv828402 CNV gain 20364138
nsv828403 CNV loss 20364138
nsv953949 CNV deletion 24416366

Variation tolerance for ZBTB7A Gene

Residual Variation Intolerance Score: 14.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.17; 39.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZBTB7A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZBTB7A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBTB7A Gene

Disorders for ZBTB7A Gene

Additional Disease Information for ZBTB7A

No disorders were found for ZBTB7A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZBTB7A Gene

Publications for ZBTB7A Gene

  1. FBI-1, a factor that binds to the HIV-1 inducer of short transcripts (IST), is a POZ domain protein. (PMID: 9973611) Morrison DJ … Hernandez N (Nucleic acids research 1999) 2 3 4 23 58
  2. Crystal structure of the BTB domain from the LRF/ZBTB7 transcriptional regulator. (PMID: 17189472) Stogios PJ … Privé GG (Protein science : a publication of the Protein Society 2007) 3 4 23 58
  3. Novel BTB/POZ domain zinc-finger protein, LRF, is a potential target of the LAZ-3/BCL-6 oncogene. (PMID: 9927193) Davies JM … Zelent A (Oncogene 1999) 2 3 4 58
  4. Zbtb7a is a transducer for the control of promoter accessibility by NF-kappa B and multiple other transcription factors. (PMID: 29813070) Ramos Pittol JM … van Essen D (PLoS biology 2018) 3 4 58
  5. Transcription factors LRF and BCL11A independently repress expression of fetal hemoglobin. (PMID: 26816381) Masuda T … Maeda T (Science (New York, N.Y.) 2016) 3 4 58

Products for ZBTB7A Gene

Sources for ZBTB7A Gene

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