Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZBTB6 Gene

Aliases for ZBTB6 Gene

  • Zinc Finger And BTB Domain Containing 6 2 3 5
  • Zinc Finger Protein 482 2 3 4
  • Zinc Finger Protein With Interaction Domain 3 4
  • ZNF482 3 4
  • ZID 3 4
  • Zinc Finger And BTB Domain-Containing Protein 6 3

External Ids for ZBTB6 Gene

Previous HGNC Symbols for ZBTB6 Gene

  • ZNF482

Previous GeneCards Identifiers for ZBTB6 Gene

  • GC09M124710
  • GC09M125670
  • GC09M095286

Summaries for ZBTB6 Gene

GeneCards Summary for ZBTB6 Gene

ZBTB6 (Zinc Finger And BTB Domain Containing 6) is a Protein Coding gene. Diseases associated with ZBTB6 include Myasthenic Syndrome, Congenital, 5. An important paralog of this gene is ZBTB26.

UniProtKB/Swiss-Prot for ZBTB6 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZBTB6 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB6 Gene

Genomics for ZBTB6 Gene

GeneHancer (GH) Regulatory Elements for ZBTB6 Gene

Promoters and enhancers for ZBTB6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I122911 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.3 270 2.3 PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 IRF4 YY1 SLC30A9 POLR2B ZBTB6 RABGAP1 RC3H2
GH09I122939 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 11.9 -28.2 -28164 3.1 HDGF PKNOX1 CLOCK FOXA2 ARNT ARID4B NEUROD1 SIN3A DMAP1 ZNF2 RABGAP1 ZBTB6 RC3H2 ENSG00000261094 RNY1P15
GH09I122401 Enhancer 1.2 Ensembl ENCODE 12.7 +510.1 510126 2.8 PKNOX1 ATF1 NEUROD1 ZBTB7B BRCA1 TCF12 GATA2 E2F8 ATF7 FOS ENSG00000229245 ENSG00000233616 ENSG00000261094 ZBTB6 ZBTB26 RC3H2 DAB2IP
GH09I123326 Enhancer 1.3 Ensembl ENCODE dbSUPER 10 -414.0 -414040 2.7 PKNOX1 CLOCK ATF1 NEUROD1 SIN3A YBX1 ZNF766 ZNF207 ATF7 NCOA1 ZBTB26 RC3H2 ZBTB6 STRBP LOC105376265 CRB2
GH09I122330 Enhancer 1.1 Ensembl ENCODE 10.8 +581.1 581065 2.8 HDAC1 HDGF TCF12 EGR1 CREM EGR2 SMARCA5 ZBTB2 NCOA1 ZNF592 GC09P122331 MRRF ZBTB26 ZBTB6 RC3H2 PTGS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZBTB6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZBTB6 gene promoter:

Genomic Locations for ZBTB6 Gene

Genomic Locations for ZBTB6 Gene
chr9:122,908,056-122,913,330
(GRCh38/hg38)
Size:
5,275 bases
Orientation:
Minus strand
chr9:125,670,335-125,675,609
(GRCh37/hg19)

Genomic View for ZBTB6 Gene

Genes around ZBTB6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBTB6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBTB6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB6 Gene

Proteins for ZBTB6 Gene

  • Protein details for ZBTB6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15916-ZBTB6_HUMAN
    Recommended name:
    Zinc finger and BTB domain-containing protein 6
    Protein Accession:
    Q15916
    Secondary Accessions:
    • A8K8N6

    Protein attributes for ZBTB6 Gene

    Size:
    424 amino acids
    Molecular mass:
    48236 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZBTB6 Gene

Post-translational modifications for ZBTB6 Gene

No Post-translational modifications

Other Protein References for ZBTB6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZBTB6 Gene

Domains & Families for ZBTB6 Gene

Gene Families for ZBTB6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for ZBTB6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZBTB6: view

No data available for UniProtKB/Swiss-Prot for ZBTB6 Gene

Function for ZBTB6 Gene

Molecular function for ZBTB6 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZBTB6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding TAS,IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZBTB6: view
genes like me logo Genes that share phenotypes with ZBTB6: view

Animal Model Products

CRISPR Products

Transcription Factor Targets for ZBTB6 Gene

Selected GeneGlobe predicted Target genes for ZBTB6

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models and HOMER Transcription for ZBTB6 Gene

Localization for ZBTB6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB6 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZBTB6 gene
Compartment Confidence
nucleus 5
mitochondrion 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Mitochondria (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZBTB6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,TAS --
GO:0005739 mitochondrion IDA --
genes like me logo Genes that share ontologies with ZBTB6: view

Pathways & Interactions for ZBTB6 Gene

SuperPathways for ZBTB6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZBTB6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZBTB6: view

No data available for Pathways by source and SIGNOR curated interactions for ZBTB6 Gene

Drugs & Compounds for ZBTB6 Gene

No Compound Related Data Available

Transcripts for ZBTB6 Gene

mRNA/cDNA for ZBTB6 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(43) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZBTB6 Gene

Zinc finger and BTB domain containing 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB6 Gene

No ASD Table

Relevant External Links for ZBTB6 Gene

GeneLoc Exon Structure for
ZBTB6
ECgene alternative splicing isoforms for
ZBTB6

Expression for ZBTB6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZBTB6 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZBTB6 Gene:

ZBTB6

SOURCE GeneReport for Unigene cluster for ZBTB6 Gene:

Hs.654596

mRNA Expression by UniProt/SwissProt for ZBTB6 Gene:

Q15916-ZBTB6_HUMAN
Tissue specificity: Widely expressed with highest levels in brain.
genes like me logo Genes that share expression patterns with ZBTB6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZBTB6 Gene

Orthologs for ZBTB6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZBTB6 33 34
  • 99.92 (n)
cow
(Bos Taurus)
Mammalia ZBTB6 33 34
  • 92.37 (n)
dog
(Canis familiaris)
Mammalia ZBTB6 33 34
  • 91.73 (n)
mouse
(Mus musculus)
Mammalia Zbtb6 33 16 34
  • 89.91 (n)
rat
(Rattus norvegicus)
Mammalia Zbtb6 33
  • 89.13 (n)
oppossum
(Monodelphis domestica)
Mammalia ZBTB6 34
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZBTB6 33 34
  • 72.82 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 33 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia zbtb6 33
  • 68.61 (n)
Str.19003 33
Species where no ortholog for ZBTB6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZBTB6 Gene

ENSEMBL:
Gene Tree for ZBTB6 (if available)
TreeFam:
Gene Tree for ZBTB6 (if available)

Paralogs for ZBTB6 Gene

(3) SIMAP similar genes for ZBTB6 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZBTB6: view

Variants for ZBTB6 Gene

Sequence variations from dbSNP and Humsavar for ZBTB6 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000074128 -- 122,908,471(-) A/C/G 3_prime_UTR_variant
rs1000862254 -- 122,914,532(-) TAAT/T upstream_transcript_variant
rs1002385562 -- 122,910,118(-) G/A 3_prime_UTR_variant
rs1002414909 -- 122,909,853(-) A/G 3_prime_UTR_variant
rs1002810229 -- 122,909,670(-) A/G 3_prime_UTR_variant

Variation tolerance for ZBTB6 Gene

Residual Variation Intolerance Score: 56.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.15; 23.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZBTB6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZBTB6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZBTB6 Gene

Disorders for ZBTB6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZBTB6 Gene - From: DISEASES

Disorder Aliases PubMed IDs
myasthenic syndrome, congenital, 5
  • cms5
- elite association - COSMIC cancer census association via MalaCards
Search ZBTB6 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ZBTB6

genes like me logo Genes that share disorders with ZBTB6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZBTB6 Gene

Publications for ZBTB6 Gene

  1. The POZ domain: a conserved protein-protein interaction motif. (PMID: 7958847) Bardwell VJ … Treisman R (Genes & development 1994) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  5. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H … Mohammed S (Journal of proteome research 2013) 4 58

Products for ZBTB6 Gene

Sources for ZBTB6 Gene

Content
Loading form....