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Aliases for ZBTB5 Gene

Aliases for ZBTB5 Gene

  • Zinc Finger And BTB Domain Containing 5 2 3 5
  • KIAA0354 4

External Ids for ZBTB5 Gene

Previous GeneCards Identifiers for ZBTB5 Gene

  • GC09M037429
  • GC09M037430

Summaries for ZBTB5 Gene

GeneCards Summary for ZBTB5 Gene

ZBTB5 (Zinc Finger And BTB Domain Containing 5) is a Protein Coding gene. An important paralog of this gene is ZBTB3.

UniProtKB/Swiss-Prot for ZBTB5 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZBTB5 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB5 Gene

Genomics for ZBTB5 Gene

GeneHancer (GH) Regulatory Elements for ZBTB5 Gene

Promoters and enhancers for ZBTB5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I037463 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 574.7 -0.9 -855 5.8 HDGF PKNOX1 CLOCK FOXA2 SMAD1 ARNT ARID4B SIN3A DMAP1 YY1 ZBTB5 DCAF10 EXOSC3 ZCCHC7 RPL21P83 RNF38 TRMT10B GRHPR TMX2P1 POLR1E
GH09I037799 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 30.7 -335.7 -335719 2.9 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF416 EXOSC3 DCAF10 TRMT10B ZBTB5 ZCCHC7 POLR1E SLC25A51 TMX2P1 RPL21P83 ENSG00000255872
GH09I037485 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 16.4 -21.4 -21391 3.5 HDGF FOXA2 PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 YY1 POLR2B POLR1E RPL21P83 ZCCHC7 EXOSC3 ZBTB5 FBXO10 ENSG00000234160 DCAF10 ENSG00000256966 TOMM5
GH09I037119 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 12.8 +344.5 344529 2.7 HDGF PKNOX1 SMAD1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZBTB7B ZCCHC7 LOC105376034 EXOSC3 DCAF10 TRMT10B ZBTB5 HMGB3P24 GC09P037160
GH09I037412 Enhancer 1 ENCODE dbSUPER 23.2 +54.0 53991 0.2 HDGF RB1 ARID4B IRF4 RAD21 ZNF48 ZNF143 BCLAF1 IKZF2 RUNX3 ZBTB5 EXOSC3 DCAF10 ZCCHC7 GRHPR LINC01627 LOC105376035
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZBTB5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZBTB5 gene promoter:

Genomic Locations for ZBTB5 Gene

Genomic Locations for ZBTB5 Gene
chr9:37,438,102-37,465,410
(GRCh38/hg38)
Size:
27,309 bases
Orientation:
Minus strand
chr9:37,438,099-37,465,407
(GRCh37/hg19)

Genomic View for ZBTB5 Gene

Genes around ZBTB5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBTB5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBTB5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB5 Gene

Proteins for ZBTB5 Gene

  • Protein details for ZBTB5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15062-ZBTB5_HUMAN
    Recommended name:
    Zinc finger and BTB domain-containing protein 5
    Protein Accession:
    O15062

    Protein attributes for ZBTB5 Gene

    Size:
    677 amino acids
    Molecular mass:
    74278 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA20811.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZBTB5 Gene

Post-translational modifications for ZBTB5 Gene

No Post-translational modifications

Other Protein References for ZBTB5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZBTB5 Gene

Domains & Families for ZBTB5 Gene

Gene Families for ZBTB5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZBTB5: view

No data available for UniProtKB/Swiss-Prot for ZBTB5 Gene

Function for ZBTB5 Gene

Molecular function for ZBTB5 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZBTB5 Gene

Gene Ontology (GO) - Molecular Function for ZBTB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 19491398
GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA 19491398
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with ZBTB5: view
genes like me logo Genes that share phenotypes with ZBTB5: view

Animal Model Products

miRNA for ZBTB5 Gene

miRTarBase miRNAs that target ZBTB5

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZBTB5 Gene

Localization for ZBTB5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZBTB5 gene
Compartment Confidence
nucleus 5
cytosol 2
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nuclear bodies (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZBTB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 19491398
genes like me logo Genes that share ontologies with ZBTB5: view

Pathways & Interactions for ZBTB5 Gene

SuperPathways for ZBTB5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZBTB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 19491398
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZBTB5: view

No data available for Pathways by source and SIGNOR curated interactions for ZBTB5 Gene

Drugs & Compounds for ZBTB5 Gene

No Compound Related Data Available

Transcripts for ZBTB5 Gene

mRNA/cDNA for ZBTB5 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(183) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZBTB5 Gene

Zinc finger and BTB domain containing 5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB5 Gene

No ASD Table

Relevant External Links for ZBTB5 Gene

GeneLoc Exon Structure for
ZBTB5
ECgene alternative splicing isoforms for
ZBTB5

Expression for ZBTB5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZBTB5 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZBTB5 Gene:

ZBTB5

SOURCE GeneReport for Unigene cluster for ZBTB5 Gene:

Hs.161276

Evidence on tissue expression from TISSUES for ZBTB5 Gene

  • Nervous system(4.7)
  • Pancreas(4.1)
genes like me logo Genes that share expression patterns with ZBTB5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZBTB5 Gene

Orthologs for ZBTB5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZBTB5 33 34
  • 99.66 (n)
dog
(Canis familiaris)
Mammalia ZBTB5 33 34
  • 92.22 (n)
cow
(Bos Taurus)
Mammalia ZBTB5 33 34
  • 89.69 (n)
rat
(Rattus norvegicus)
Mammalia Zbtb5 33
  • 89.35 (n)
mouse
(Mus musculus)
Mammalia Zbtb5 33 16 34
  • 88.81 (n)
oppossum
(Monodelphis domestica)
Mammalia ZBTB5 34
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZBTB5 33 34
  • 79.69 (n)
lizard
(Anolis carolinensis)
Reptilia ZBTB5 34
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zbtb5 33
  • 71.78 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.4309 33
zebrafish
(Danio rerio)
Actinopterygii LOC797291 33
  • 57.96 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 30 (a)
OneToOne
Species where no ortholog for ZBTB5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB5 Gene

ENSEMBL:
Gene Tree for ZBTB5 (if available)
TreeFam:
Gene Tree for ZBTB5 (if available)

Paralogs for ZBTB5 Gene

Pseudogenes.org Pseudogenes for ZBTB5 Gene

genes like me logo Genes that share paralogs with ZBTB5: view

Variants for ZBTB5 Gene

Sequence variations from dbSNP and Humsavar for ZBTB5 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000117495 -- 37,465,104(-) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000183440 -- 37,439,548(-) T/C 3_prime_UTR_variant
rs1000253941 -- 37,447,482(-) G/A/T intron_variant
rs1000295192 -- 37,454,352(-) T/C intron_variant
rs1000370890 -- 37,447,013(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZBTB5 Gene

Variant ID Type Subtype PubMed ID
nsv1125318 OTHER inversion 24896259
esv3620407 CNV loss 21293372
esv3544827 CNV deletion 23714750

Variation tolerance for ZBTB5 Gene

Residual Variation Intolerance Score: 13.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.34; 70.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZBTB5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZBTB5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBTB5 Gene

Disorders for ZBTB5 Gene

Additional Disease Information for ZBTB5

No disorders were found for ZBTB5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZBTB5 Gene

Publications for ZBTB5 Gene

  1. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1997) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58
  5. Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2. (PMID: 25476789) Galligan JT … Howley PM (Journal of proteome research 2015) 3 58

Products for ZBTB5 Gene

Sources for ZBTB5 Gene

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