Aliases for ZBTB5 Gene

Aliases for ZBTB5 Gene

  • Zinc Finger And BTB Domain Containing 5 2 3 5
  • Zinc Finger And BTB Domain-Containing Protein 5 3 4
  • KIAA0354 4

External Ids for ZBTB5 Gene

Previous GeneCards Identifiers for ZBTB5 Gene

  • GC09M037429
  • GC09M037430

Summaries for ZBTB5 Gene

GeneCards Summary for ZBTB5 Gene

ZBTB5 (Zinc Finger And BTB Domain Containing 5) is a Protein Coding gene. An important paralog of this gene is ZBTB7A.

UniProtKB/Swiss-Prot Summary for ZBTB5 Gene

Additional gene information for ZBTB5 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZBTB5 Gene

Genomics for ZBTB5 Gene

GeneHancer (GH) Regulatory Elements for ZBTB5 Gene

Promoters and enhancers for ZBTB5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZBTB5 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZBTB5

Top Transcription factor binding sites by QIAGEN in the ZBTB5 gene promoter:
  • aMEF-2
  • FOXJ2
  • FOXJ2 (long isoform)
  • FOXO1
  • FOXO1a
  • Ik-2
  • MEF-2
  • MEF-2A
  • POU6F1 (c2)

Genomic Locations for ZBTB5 Gene

Genomic Locations for ZBTB5 Gene
chr9:37,438,102-37,465,450
(GRCh38/hg38)
Size:
27,349 bases
Orientation:
Minus strand
chr9:37,438,099-37,465,407
(GRCh37/hg19)
Size:
27,309 bases
Orientation:
Minus strand

Genomic View for ZBTB5 Gene

Genes around ZBTB5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBTB5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBTB5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB5 Gene

Proteins for ZBTB5 Gene

  • Protein details for ZBTB5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15062-ZBTB5_HUMAN
    Recommended name:
    Zinc finger and BTB domain-containing protein 5
    Protein Accession:
    O15062

    Protein attributes for ZBTB5 Gene

    Size:
    677 amino acids
    Molecular mass:
    74278 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA20811.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZBTB5 Gene

Post-translational modifications for ZBTB5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZBTB5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZBTB5 Gene

Domains & Families for ZBTB5 Gene

Gene Families for ZBTB5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZBTB5 Gene

Blocks:
  • BTB/POZ domain
  • C2H2-type zinc finger signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZBTB5 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ77230, highly similar to Homo sapiens zinc finger and BTB domain containing 5 (ZBTB5), mRNA (Q5T942_HUMAN)
  • Zinc finger and BTB domain-containing protein 5 (ZBTB5_HUMAN)
genes like me logo Genes that share domains with ZBTB5: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ZBTB5 Gene

Function for ZBTB5 Gene

Molecular function for ZBTB5 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZBTB5 Gene

Gene Ontology (GO) - Molecular Function for ZBTB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 19491398
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific IDA,IBA 19491398
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with ZBTB5: view
genes like me logo Genes that share phenotypes with ZBTB5: view

Animal Models for ZBTB5 Gene

MGI Knock Outs for ZBTB5:
  • Zbtb5 Zbtb5<tm2b(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

miRNA for ZBTB5 Gene

miRTarBase miRNAs that target ZBTB5

Clone Products

  • Addgene plasmids for ZBTB5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZBTB5 Gene

Localization for ZBTB5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZBTB5 gene
Compartment Confidence
nucleus 5
cytosol 2
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nuclear bodies (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZBTB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IBA,IDA 19491398
genes like me logo Genes that share ontologies with ZBTB5: view

Pathways & Interactions for ZBTB5 Gene

PathCards logo

SuperPathways for ZBTB5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZBTB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 19491398
GO:0006974 cellular response to DNA damage stimulus IBA 21873635
genes like me logo Genes that share ontologies with ZBTB5: view

No data available for Pathways by source and SIGNOR curated interactions for ZBTB5 Gene

Drugs & Compounds for ZBTB5 Gene

No Compound Related Data Available

Transcripts for ZBTB5 Gene

mRNA/cDNA for ZBTB5 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for ZBTB5

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB5 Gene

No ASD Table

Relevant External Links for ZBTB5 Gene

GeneLoc Exon Structure for
ZBTB5

Expression for ZBTB5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZBTB5 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZBTB5

SOURCE GeneReport for Unigene cluster for ZBTB5 Gene:

Hs.161276

Evidence on tissue expression from TISSUES for ZBTB5 Gene

  • Nervous system(4.7)
  • Pancreas(4.1)
genes like me logo Genes that share expression patterns with ZBTB5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZBTB5 Gene

Orthologs for ZBTB5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZBTB5 31 30
  • 99.66 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZBTB5 31 30
  • 92.22 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ZBTB5 31 30
  • 89.69 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zbtb5 30
  • 89.35 (n)
mouse
(Mus musculus)
Mammalia Zbtb5 17 31 30
  • 88.81 (n)
oppossum
(Monodelphis domestica)
Mammalia ZBTB5 31
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZBTB5 31 30
  • 79.69 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZBTB5 31
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zbtb5 30
  • 71.78 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.4309 30
zebrafish
(Danio rerio)
Actinopterygii LOC797291 30
  • 57.96 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 30 (a)
OneToOne
Species where no ortholog for ZBTB5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB5 Gene

ENSEMBL:
Gene Tree for ZBTB5 (if available)
TreeFam:
Gene Tree for ZBTB5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZBTB5: view image

Paralogs for ZBTB5 Gene

Paralogs for ZBTB5 Gene

Pseudogenes.org Pseudogenes for ZBTB5 Gene

genes like me logo Genes that share paralogs with ZBTB5: view

Variants for ZBTB5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZBTB5 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
rs17502738 - p.Asp300Gly

Additional dbSNP identifiers (rs#s) for ZBTB5 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZBTB5 Gene

Variant ID Type Subtype PubMed ID
esv3544827 CNV deletion 23714750
esv3620407 CNV loss 21293372
nsv1125318 OTHER inversion 24896259

Variation tolerance for ZBTB5 Gene

Residual Variation Intolerance Score: 13.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.34; 70.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZBTB5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZBTB5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBTB5 Gene

Disorders for ZBTB5 Gene

Additional Disease Information for ZBTB5

No disorders were found for ZBTB5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZBTB5 Gene

Publications for ZBTB5 Gene

No publications were found for ZBTB5 Gene.

Products for ZBTB5 Gene

Sources for ZBTB5 Gene