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Aliases for ZBTB45 Gene

Aliases for ZBTB45 Gene

  • Zinc Finger And BTB Domain Containing 45 2 3 5
  • Zinc Finger Protein 499 2 3 4
  • ZNF499 3 4
  • Zinc Finger And BTB Domain-Containing Protein 45 3

External Ids for ZBTB45 Gene

Previous HGNC Symbols for ZBTB45 Gene

  • ZNF499

Previous GeneCards Identifiers for ZBTB45 Gene

  • GC19M063717
  • GC19M059024
  • GC19M055335

Summaries for ZBTB45 Gene

GeneCards Summary for ZBTB45 Gene

ZBTB45 (Zinc Finger And BTB Domain Containing 45) is a Protein Coding gene. An important paralog of this gene is ZBTB20.

UniProtKB/Swiss-Prot for ZBTB45 Gene

  • May be involved in transcriptional regulation (Probable). In the central nervous system, may play a role in glial cell differentiation (By similarity).

Additional gene information for ZBTB45 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB45 Gene

Genomics for ZBTB45 Gene

GeneHancer (GH) Regulatory Elements for ZBTB45 Gene

Promoters and enhancers for ZBTB45 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I058517 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 560 +19.2 19203 4.9 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZNF143 ZBTB45 PIR40518 ZNF324B TRIM28 ZNF446 ZNF134 ZNF417 ZSCAN22 ZNF549 ZNF274
GH19I058537 Promoter/Enhancer 1.5 FANTOM5 Ensembl ENCODE 550.8 +0.6 592 2.3 SOX13 USF1 RB1 BACH1 ETS1 POLR2A NR2F6 SOX5 ZNF687 SP5 ZBTB45 ZNF584 ZSCAN18 ENSG00000232098 ZNF8 ZNF544 TRIM28 ZNF329 ZNF497 ZNF324
GH19I058571 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 12.3 -35.3 -35308 4.8 CLOCK MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 MZF1 CENPBD1P1 TRIM28 ZSCAN18 ZNF446 LOC100128398 ZNF135 ZNF132 ZNF418 ENSG00000268201
GH19I058498 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 13.1 +39.7 39746 2.2 HDGF PKNOX1 CLOCK SMAD1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 LOC105372485 ZNF584 ZNF324B TRIM28 LOC105372483 ENSG00000268543 ZBTB45 ZNF132 ENSG00000268912 ZNF134
GH19I058181 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 9.7 +355.7 355675 2.5 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF274 ZNF134 ZNF606 ZNF17 ZNF417 ZNF549 ZNF550 ZNF773 LOC105372483 ZNF264
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZBTB45 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZBTB45 gene promoter:

Genomic Locations for ZBTB45 Gene

Genomic Locations for ZBTB45 Gene
25,382 bases
Minus strand

Genomic View for ZBTB45 Gene

Genes around ZBTB45 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBTB45 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBTB45 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB45 Gene

Proteins for ZBTB45 Gene

  • Protein details for ZBTB45 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger and BTB domain-containing protein 45
    Protein Accession:

    Protein attributes for ZBTB45 Gene

    511 amino acids
    Molecular mass:
    54008 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZBTB45 Gene

Post-translational modifications for ZBTB45 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZBTB45 Gene

Domains & Families for ZBTB45 Gene

Gene Families for ZBTB45 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZBTB45 Gene

Suggested Antigen Peptide Sequences for ZBTB45 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZBTB45: view

Function for ZBTB45 Gene

Molecular function for ZBTB45 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation (Probable). In the central nervous system, may play a role in glial cell differentiation (By similarity).

Phenotypes From GWAS Catalog for ZBTB45 Gene

Gene Ontology (GO) - Molecular Function for ZBTB45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZBTB45: view
genes like me logo Genes that share phenotypes with ZBTB45: view

Animal Models for ZBTB45 Gene

MGI Knock Outs for ZBTB45:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZBTB45 Gene

Localization for ZBTB45 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB45 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZBTB45 gene
Compartment Confidence
nucleus 5
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZBTB45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZBTB45: view

Pathways & Interactions for ZBTB45 Gene

SuperPathways for ZBTB45 Gene

No Data Available

Interacting Proteins for ZBTB45 Gene

Gene Ontology (GO) - Biological Process for ZBTB45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007399 nervous system development IEA --
genes like me logo Genes that share ontologies with ZBTB45: view

No data available for Pathways by source and SIGNOR curated interactions for ZBTB45 Gene

Drugs & Compounds for ZBTB45 Gene

No Compound Related Data Available

Transcripts for ZBTB45 Gene

Unigene Clusters for ZBTB45 Gene

Zinc finger and BTB domain containing 45:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB45 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4
SP1: - - -
SP2: -
SP3: - -

Relevant External Links for ZBTB45 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZBTB45 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZBTB45 Gene

Protein differential expression in normal tissues from HIPED for ZBTB45 Gene

This gene is overexpressed in Kidney (62.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZBTB45 Gene

Protein tissue co-expression partners for ZBTB45 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZBTB45 Gene:


SOURCE GeneReport for Unigene cluster for ZBTB45 Gene:


Evidence on tissue expression from TISSUES for ZBTB45 Gene

  • Stomach(3.1)
  • Nervous system(2.7)
genes like me logo Genes that share expression patterns with ZBTB45: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZBTB45 Gene

Orthologs for ZBTB45 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB45 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZBTB45 34 33
  • 99.59 (n)
(Canis familiaris)
Mammalia ZBTB45 33 34
  • 81.96 (n)
(Bos Taurus)
Mammalia ZBTB45 33
  • 81.72 (n)
(Mus musculus)
Mammalia Zbtb45 33 16 34
  • 80.5 (n)
(Rattus norvegicus)
Mammalia Zbtb45 33
  • 79.91 (n)
(Anolis carolinensis)
Reptilia ZBTB45 34
  • 39 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485837 33
  • 57.45 (n)
Str.14835 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.19474 33
Species where no ortholog for ZBTB45 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZBTB45 Gene

Gene Tree for ZBTB45 (if available)
Gene Tree for ZBTB45 (if available)

Paralogs for ZBTB45 Gene Pseudogenes for ZBTB45 Gene

genes like me logo Genes that share paralogs with ZBTB45: view

Variants for ZBTB45 Gene

Sequence variations from dbSNP and Humsavar for ZBTB45 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000009784 -- 58,527,218(-) C/G genic_upstream_transcript_variant, intron_variant
rs1000064811 -- 58,526,962(-) G/C genic_upstream_transcript_variant, intron_variant
rs1000091034 -- 58,513,695(-) C/G 3_prime_UTR_variant
rs1000121357 -- 58,531,596(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000130008 -- 58,521,018(-) C/G/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZBTB45 Gene

Variant ID Type Subtype PubMed ID
dgv3687n100 CNV gain 25217958
dgv3688n100 CNV gain 25217958
nsv1057077 CNV gain 25217958
nsv1160670 CNV deletion 26073780
nsv515731 CNV gain+loss 19592680
nsv828657 CNV gain 20364138
nsv952156 CNV deletion 24416366

Variation tolerance for ZBTB45 Gene

Residual Variation Intolerance Score: 22.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.40; 27.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZBTB45 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBTB45 Gene

Disorders for ZBTB45 Gene

Additional Disease Information for ZBTB45

No disorders were found for ZBTB45 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZBTB45 Gene

Publications for ZBTB45 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Recruitment of the Mammalian Histone-modifying EMSY Complex to Target Genes Is Regulated by ZNF131. (PMID: 26841866) Varier RA … Vermeulen M (The Journal of biological chemistry 2016) 3 58
  4. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U … Wanker EE (Cell 2005) 3 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for ZBTB45 Gene

Sources for ZBTB45 Gene

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