Aliases for ZBTB44 Gene

Aliases for ZBTB44 Gene

  • Zinc Finger And BTB Domain Containing 44 2 3 5
  • Zinc Finger And BTB Domain-Containing Protein 44 3 4
  • BTB/POZ Domain-Containing Protein 15 3 4
  • BTB (POZ) Domain Containing 15 2 3
  • Zinc Finger Protein 851 3 4
  • BTBD15 3 4
  • ZNF851 3 4
  • HSPC063 3

External Ids for ZBTB44 Gene

Previous HGNC Symbols for ZBTB44 Gene

  • BTBD15

Previous GeneCards Identifiers for ZBTB44 Gene

  • GC11M129603
  • GC11M130096
  • GC11M126049

Summaries for ZBTB44 Gene

GeneCards Summary for ZBTB44 Gene

ZBTB44 (Zinc Finger And BTB Domain Containing 44) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF618.

UniProtKB/Swiss-Prot Summary for ZBTB44 Gene

Additional gene information for ZBTB44 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZBTB44 Gene

Genomics for ZBTB44 Gene

GeneHancer (GH) Regulatory Elements for ZBTB44 Gene

Promoters and enhancers for ZBTB44 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J130312 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 755.6 +0.3 328 4 POLR2A MYC HLF L3MBTL2 CEBPB MAX ZNF148 NKRF ZFX SP1 ZBTB44 ZBTB44-DT PRDM10 NFRKB
GH11J130301 Promoter/Enhancer 1 EPDnew Ensembl 757.8 +12.3 12316 5.6 HLF ZBTB33 IKZF1 IKZF2 PKNOX1 ZNF316 MAFK ELF1 MAFG FOXA1 ZBTB44 RF00012-009 DDX18P5
GH11J130915 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 10.5 -601.6 -601550 2.7 ZNF24 ZBTB40 CTCF POLR2A HCFC1 MYC ELF1 RAD21 L3MBTL2 MAX SNX19 piR-44546-001 NTM-AS1 ENSG00000237654 ZBTB44 PRDM10
GH11J129364 Enhancer 1.3 Ensembl ENCODE dbSUPER 10 +950.5 950456 1.1 CTCF RBPJ HCFC1 MIXL1 MYC CC2D1A MAX RAD21 TEAD4 ZNF652 NFRKB ARHGAP32 ZBTB44 BARX2 piR-45726-010
GH11J130191 Enhancer 0.9 ENCODE dbSUPER 6.3 +122.0 122002 2.4 MIXL1 ZNF652 ELF3 SP1 CEBPG PPARG CEBPA RXRA GATAD2A RXRB ZBTB44 lnc-ZBTB44-1 ST14
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZBTB44 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZBTB44 gene promoter:
  • aMEF-2
  • AREB6
  • FOXL1
  • HSF2
  • Lhx3a
  • LHX3b
  • LyF-1
  • MEF-2A
  • Spz1

Genomic Locations for ZBTB44 Gene

Genomic Locations for ZBTB44 Gene
88,241 bases
Minus strand
88,036 bases
Minus strand

Genomic View for ZBTB44 Gene

Genes around ZBTB44 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBTB44 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBTB44 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB44 Gene

Proteins for ZBTB44 Gene

  • Protein details for ZBTB44 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger and BTB domain-containing protein 44
    Protein Accession:
    Secondary Accessions:
    • Q6IPT8
    • Q86VJ7
    • Q86XX5

    Protein attributes for ZBTB44 Gene

    570 amino acids
    Molecular mass:
    63848 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZBTB44 Gene


neXtProt entry for ZBTB44 Gene

Post-translational modifications for ZBTB44 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZBTB44 Gene

Domains & Families for ZBTB44 Gene

Gene Families for ZBTB44 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZBTB44 Gene

Suggested Antigen Peptide Sequences for ZBTB44 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 851 (ZBT44_HUMAN)
genes like me logo Genes that share domains with ZBTB44: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ZBTB44 Gene

Function for ZBTB44 Gene

Molecular function for ZBTB44 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZBTB44 Gene

Gene Ontology (GO) - Molecular Function for ZBTB44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IEA,IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZBTB44: view
genes like me logo Genes that share phenotypes with ZBTB44: view

Animal Model Products

CRISPR Products

miRNA for ZBTB44 Gene

miRTarBase miRNAs that target ZBTB44

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZBTB44

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZBTB44 Gene

Localization for ZBTB44 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB44 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZBTB44 gene
Compartment Confidence
nucleus 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZBTB44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZBTB44: view

Pathways & Interactions for ZBTB44 Gene

PathCards logo

SuperPathways for ZBTB44 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZBTB44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZBTB44: view

No data available for Pathways by source and SIGNOR curated interactions for ZBTB44 Gene

Drugs & Compounds for ZBTB44 Gene

No Compound Related Data Available

Transcripts for ZBTB44 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZBTB44

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB44 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b
SP1: - - - - -
SP2: - - - - -
SP3: - - -
SP4: - - - - - - -
SP5: - - - - -
SP6: - - - - -
SP7: - -
SP9: -

Relevant External Links for ZBTB44 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZBTB44 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZBTB44 Gene

Protein differential expression in normal tissues from HIPED for ZBTB44 Gene

This gene is overexpressed in Plasma (45.3) and Peripheral blood mononuclear cells (21.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZBTB44 Gene

Protein tissue co-expression partners for ZBTB44 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZBTB44 Gene:


SOURCE GeneReport for Unigene cluster for ZBTB44 Gene:


Evidence on tissue expression from TISSUES for ZBTB44 Gene

  • Nervous system(4.6)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with ZBTB44: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZBTB44 Gene

Orthologs for ZBTB44 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB44 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZBTB44 33 32
  • 99.63 (n)
(Canis familiaris)
Mammalia ZBTB44 33 32
  • 94.22 (n)
(Bos Taurus)
Mammalia ZBTB44 33 32
  • 93.7 (n)
(Ornithorhynchus anatinus)
Mammalia ZBTB44 33
  • 93 (a)
(Mus musculus)
Mammalia Zbtb44 17 33 32
  • 91.83 (n)
(Rattus norvegicus)
Mammalia Zbtb44 32
  • 91.39 (n)
(Monodelphis domestica)
Mammalia -- 33
  • 91 (a)
-- 33
  • 69 (a)
(Gallus gallus)
Aves ZBTB44 33 32
  • 83.48 (n)
(Anolis carolinensis)
Reptilia ZBTB44 33
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia zbtb44 32
  • 77.9 (n)
Str.16848 32
African clawed frog
(Xenopus laevis)
Amphibia Xl.15152 32
(Danio rerio)
Actinopterygii zbtb44 33 32
  • 65.08 (n)
Species where no ortholog for ZBTB44 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB44 Gene

Gene Tree for ZBTB44 (if available)
Gene Tree for ZBTB44 (if available)
Evolutionary constrained regions (ECRs) for ZBTB44: view image

Paralogs for ZBTB44 Gene

Paralogs for ZBTB44 Gene Pseudogenes for ZBTB44 Gene

genes like me logo Genes that share paralogs with ZBTB44: view

Variants for ZBTB44 Gene

Sequence variations from dbSNP and Humsavar for ZBTB44 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000011780 -- 130,303,041(-) T/C/G intron_variant
rs1000015652 -- 130,266,536(-) A/G intron_variant
rs1000027205 -- 130,282,642(-) C/G intron_variant
rs1000083558 -- 130,248,752(-) A/G intron_variant
rs1000148684 -- 130,299,188(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZBTB44 Gene

Variant ID Type Subtype PubMed ID
dgv74e215 CNV deletion 23714750
esv2759871 CNV loss 17122850
esv33203 CNV loss 17666407
esv34550 CNV loss 17911159
esv3628078 CNV loss 21293372
esv3628079 CNV loss 21293372
nsv1070496 CNV deletion 25765185
nsv39016 CNV deletion 16902084
nsv468896 CNV loss 19166990
nsv556571 CNV loss 21841781
nsv818872 CNV loss 17921354
nsv832295 CNV gain 17160897
nsv975998 CNV duplication 23825009

Variation tolerance for ZBTB44 Gene

Residual Variation Intolerance Score: 29.8% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZBTB44 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBTB44 Gene

Disorders for ZBTB44 Gene

Additional Disease Information for ZBTB44

No disorders were found for ZBTB44 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZBTB44 Gene

Publications for ZBTB44 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 2 3 56
  3. E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins. (PMID: 29676528) Khanna R … Parnaik VK (The FEBS journal 2018) 3 56
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56
  5. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 56

Products for ZBTB44 Gene

Sources for ZBTB44 Gene