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Aliases for ZBTB43 Gene

Aliases for ZBTB43 Gene

  • Zinc Finger And BTB Domain Containing 43 2 3 5
  • Zinc Finger Protein 297B 2 3 4
  • Zinc Finger And BTB Domain-Containing Protein 22B 3 4
  • ZNF297B 3 4
  • ZBTB22B 3 4
  • ZNF-X 3 4
  • Zinc Finger And BTB Domain-Containing Protein 43 3
  • KIAA0414 4

External Ids for ZBTB43 Gene

Previous HGNC Symbols for ZBTB43 Gene

  • ZNF297B

Previous GeneCards Identifiers for ZBTB43 Gene

  • GC09P128607
  • GC09P129567
  • GC09P099180

Summaries for ZBTB43 Gene

GeneCards Summary for ZBTB43 Gene

ZBTB43 (Zinc Finger And BTB Domain Containing 43) is a Protein Coding gene. An important paralog of this gene is ZBTB22.

UniProtKB/Swiss-Prot for ZBTB43 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZBTB43 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB43 Gene

Genomics for ZBTB43 Gene

GeneHancer (GH) Regulatory Elements for ZBTB43 Gene

Promoters and enhancers for ZBTB43 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I126804 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 557.9 +1.6 1647 3 HDGF PKNOX1 SMAD1 ARID4B SIN3A YBX1 YY1 SLC30A9 POLR2B CBX5 ZBTB43 ZBTB34 RALGPS1
GH09I126803 Enhancer 0.6 ENCODE 550.8 -1.2 -1209 0.1 CHD1 CEBPB CEBPG ZNF217 GATA3 CEBPA HNF4A TCF7L2 ZBTB43 PIR57638
GH09I126802 Enhancer 0.5 ENCODE 550.8 -1.6 -1555 0.2 ZNF217 GATA3 FOXA2 CHD1 FOXA1 TCF7L2 ZBTB43 PIR57638
GH09I126819 Promoter 0.5 EPDnew 550.4 +15.2 15215 0.1 ZBTB43 ZBTB34
GH09I126763 Enhancer 0.7 FANTOM5 17.4 -40.5 -40485 0.2 MEIS2 PKNOX1 USF1 E4F1 ZNF335 NFYB PRDM10 FOS ATF7 ZNF362 ZBTB43 LMX1B LOC105376277 ENSG00000226078 MVB12B PIR57638
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZBTB43 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZBTB43 gene promoter:

Genomic Locations for ZBTB43 Gene

Genomic Locations for ZBTB43 Gene
chr9:126,804,072-126,838,210
(GRCh38/hg38)
Size:
34,139 bases
Orientation:
Plus strand
chr9:129,567,285-129,600,489
(GRCh37/hg19)

Genomic View for ZBTB43 Gene

Genes around ZBTB43 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBTB43 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBTB43 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB43 Gene

Proteins for ZBTB43 Gene

  • Protein details for ZBTB43 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43298-ZBT43_HUMAN
    Recommended name:
    Zinc finger and BTB domain-containing protein 43
    Protein Accession:
    O43298
    Secondary Accessions:
    • Q5JU96

    Protein attributes for ZBTB43 Gene

    Size:
    467 amino acids
    Molecular mass:
    52630 Da
    Quaternary structure:
    • Interacts with BDP1.
    SequenceCaution:
    • Sequence=BAA24844.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ZBTB43 Gene

neXtProt entry for ZBTB43 Gene

Post-translational modifications for ZBTB43 Gene

No Post-translational modifications

Other Protein References for ZBTB43 Gene

No data available for DME Specific Peptides for ZBTB43 Gene

Domains & Families for ZBTB43 Gene

Gene Families for ZBTB43 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for ZBTB43 Gene

Graphical View of Domain Structure for InterPro Entry

O43298

UniProtKB/Swiss-Prot:

ZBT43_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZBTB43: view

Function for ZBTB43 Gene

Molecular function for ZBTB43 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZBTB43 Gene

Gene Ontology (GO) - Molecular Function for ZBTB43 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 16189514
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZBTB43: view
genes like me logo Genes that share phenotypes with ZBTB43: view

Animal Model Products

CRISPR Products

miRNA for ZBTB43 Gene

miRTarBase miRNAs that target ZBTB43

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZBTB43 Gene

Localization for ZBTB43 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB43 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZBTB43 gene
Compartment Confidence
nucleus 5
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZBTB43 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZBTB43: view

Pathways & Interactions for ZBTB43 Gene

SuperPathways for ZBTB43 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZBTB43 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZBTB43: view

No data available for Pathways by source and SIGNOR curated interactions for ZBTB43 Gene

Drugs & Compounds for ZBTB43 Gene

No Compound Related Data Available

Transcripts for ZBTB43 Gene

Unigene Clusters for ZBTB43 Gene

Zinc finger and BTB domain containing 43:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB43 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d
SP1: - - -
SP2: -
SP3: -
SP4:
SP5: - -

Relevant External Links for ZBTB43 Gene

GeneLoc Exon Structure for
ZBTB43
ECgene alternative splicing isoforms for
ZBTB43

Expression for ZBTB43 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZBTB43 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZBTB43 Gene

This gene is overexpressed in Muscle - Skeletal (x6.1).

Protein differential expression in normal tissues from HIPED for ZBTB43 Gene

This gene is overexpressed in Testis (51.6) and Pancreas (13.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZBTB43 Gene



Protein tissue co-expression partners for ZBTB43 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZBTB43 Gene:

ZBTB43

SOURCE GeneReport for Unigene cluster for ZBTB43 Gene:

Hs.355581

Evidence on tissue expression from TISSUES for ZBTB43 Gene

  • Muscle(4.3)
  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with ZBTB43: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZBTB43 Gene

Orthologs for ZBTB43 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB43 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZBTB43 33 34
  • 99.79 (n)
dog
(Canis familiaris)
Mammalia ZBTB43 33 34
  • 93.93 (n)
cow
(Bos Taurus)
Mammalia ZBTB43 33
  • 92.7 (n)
ZNF297B 34
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZBTB43 34
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zbtb43 33
  • 89.01 (n)
mouse
(Mus musculus)
Mammalia Zbtb43 33 16 34
  • 88.51 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ZBTB43 34
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZBTB43 33 34
  • 79.02 (n)
lizard
(Anolis carolinensis)
Reptilia ZBTB43 34
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zbtb43 33
  • 71.05 (n)
zebrafish
(Danio rerio)
Actinopterygii zbtb43 33 34
  • 59.34 (n)
Species where no ortholog for ZBTB43 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB43 Gene

ENSEMBL:
Gene Tree for ZBTB43 (if available)
TreeFam:
Gene Tree for ZBTB43 (if available)

Paralogs for ZBTB43 Gene

(7) SIMAP similar genes for ZBTB43 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZBTB43: view

Variants for ZBTB43 Gene

Sequence variations from dbSNP and Humsavar for ZBTB43 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000017432 -- 126,824,595(+) C/T intron_variant
rs1000236593 -- 126,810,183(+) TTTGTTTATTTGTTT/TTTGTTT genic_upstream_transcript_variant, intron_variant
rs1000284693 -- 126,815,848(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000287706 -- 126,818,396(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000324115 -- 126,813,245(+) G/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZBTB43 Gene

Variant ID Type Subtype PubMed ID
nsv831724 CNV gain 17160897
esv3621766 CNV gain 21293372
esv3576707 CNV gain 25503493
esv3355530 CNV insertion 20981092
esv3335630 CNV insertion 20981092
esv3323931 CNV duplication 20981092
esv3306066 CNV mobile element insertion 20981092
esv3302511 CNV tandem duplication 20981092
esv1064562 CNV insertion 17803354
dgv4140n106 CNV tandem duplication 24896259

Variation tolerance for ZBTB43 Gene

Residual Variation Intolerance Score: 28.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.84; 17.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZBTB43 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZBTB43

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBTB43 Gene

Disorders for ZBTB43 Gene

Additional Disease Information for ZBTB43

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ZBTB43 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZBTB43 Gene

Publications for ZBTB43 Gene

  1. Detecting rare variants for complex traits using family and unrelated data. (PMID: 19847924) Zhu X … Elston RC (Genetic epidemiology 2010) 3 44 58
  2. The zinc finger protein ZNF297B interacts with BDP1, a subunit of TFIIIB. (PMID: 16542149) Schoenen F … Wirth B (Biological chemistry 2006) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9455477) Ishikawa K … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1997) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for ZBTB43 Gene

Sources for ZBTB43 Gene

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