Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZBTB41 Gene

Aliases for ZBTB41 Gene

  • Zinc Finger And BTB Domain Containing 41 2 3 5
  • FRBZ1 3 4
  • Zinc Finger And BTB Domain-Containing Protein 41 3
  • FRBZ1 Protein (FRBZ1) 3
  • ZNF924 3

External Ids for ZBTB41 Gene

Previous GeneCards Identifiers for ZBTB41 Gene

  • GC01M193860
  • GC01M195389
  • GC01M197122
  • GC01M168280

Summaries for ZBTB41 Gene

GeneCards Summary for ZBTB41 Gene

ZBTB41 (Zinc Finger And BTB Domain Containing 41) is a Protein Coding gene.

UniProtKB/Swiss-Prot for ZBTB41 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZBTB41 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB41 Gene

Genomics for ZBTB41 Gene

GeneHancer (GH) Regulatory Elements for ZBTB41 Gene

Promoters and enhancers for ZBTB41 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I197198 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 555 +0.2 241 4.6 SMAD1 ARNT ZFP64 ARID4B NEUROD1 SIN3A DMAP1 ZNF2 IRF4 YY1 ZBTB41 GC01P197201 CRB1 CFHR3 ASPM
GH01I198154 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 23.8 -957.3 -957340 6.1 HDGF PKNOX1 CLOCK SMAD1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 NEK7 ZBTB41 DENND1B PTPRC C1orf53 GC01P198155 GC01M198198
GH01I197173 Enhancer 0.9 ENCODE 11.4 +26.3 26310 1.7 FOXA2 MLX ARID4B DMAP1 YY1 RXRA MXD4 PPARG KAT8 NFIL3 ASPM CRB1 ZBTB41 CFHR3 GC01P197135
GH01I197144 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 5 +54.4 54437 3.3 PKNOX1 CLOCK ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B ZNF213 FOS ASPM CFHR3 ZBTB41 SEPT14P12 GC01P197135
GH01I197178 Enhancer 0.7 ENCODE 11.4 +21.4 21418 0.9 CTCF MEIS2 PKNOX1 NFATC3 BACH1 BATF RAD21 ZNF316 NCOR1 FOXK2 ASPM CRB1 ZBTB41 CFHR3 GC01P197135
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZBTB41 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZBTB41 gene promoter:

Genomic Locations for ZBTB41 Gene

Genomic Locations for ZBTB41 Gene
chr1:197,153,680-197,200,542
(GRCh38/hg38)
Size:
46,863 bases
Orientation:
Minus strand
chr1:197,122,810-197,169,672
(GRCh37/hg19)

Genomic View for ZBTB41 Gene

Genes around ZBTB41 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBTB41 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBTB41 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB41 Gene

Proteins for ZBTB41 Gene

  • Protein details for ZBTB41 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5SVQ8-ZBT41_HUMAN
    Recommended name:
    Zinc finger and BTB domain-containing protein 41
    Protein Accession:
    Q5SVQ8
    Secondary Accessions:
    • A2RUA8
    • Q6MZT8
    • Q6ZR25
    • Q7Z4T1
    • Q8IZ99

    Protein attributes for ZBTB41 Gene

    Size:
    909 amino acids
    Molecular mass:
    105192 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZBTB41 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZBTB41 Gene

Post-translational modifications for ZBTB41 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZBTB41 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZBTB41 Gene

Domains & Families for ZBTB41 Gene

Gene Families for ZBTB41 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZBTB41 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZBTB41: view

No data available for UniProtKB/Swiss-Prot for ZBTB41 Gene

Function for ZBTB41 Gene

Molecular function for ZBTB41 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZBTB41 Gene

Gene Ontology (GO) - Molecular Function for ZBTB41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZBTB41: view
genes like me logo Genes that share phenotypes with ZBTB41: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZBTB41 Gene

Localization for ZBTB41 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB41 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZBTB41 gene
Compartment Confidence
nucleus 5
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear membrane (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZBTB41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZBTB41: view

Pathways & Interactions for ZBTB41 Gene

SuperPathways for ZBTB41 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZBTB41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZBTB41: view

No data available for Pathways by source and SIGNOR curated interactions for ZBTB41 Gene

Drugs & Compounds for ZBTB41 Gene

No Compound Related Data Available

Transcripts for ZBTB41 Gene

mRNA/cDNA for ZBTB41 Gene

Unigene Clusters for ZBTB41 Gene

Zinc finger and BTB domain containing 41:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB41 Gene

No ASD Table

Relevant External Links for ZBTB41 Gene

GeneLoc Exon Structure for
ZBTB41
ECgene alternative splicing isoforms for
ZBTB41

Expression for ZBTB41 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZBTB41 Gene

Protein differential expression in normal tissues from HIPED for ZBTB41 Gene

This gene is overexpressed in Testis (35.3) and Spleen (33.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZBTB41 Gene



Protein tissue co-expression partners for ZBTB41 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZBTB41 Gene:

ZBTB41

SOURCE GeneReport for Unigene cluster for ZBTB41 Gene:

Hs.529439

Evidence on tissue expression from TISSUES for ZBTB41 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with ZBTB41: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZBTB41 Gene

Orthologs for ZBTB41 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZBTB41 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZBTB41 33 34
  • 99.74 (n)
dog
(Canis familiaris)
Mammalia ZBTB41 33 34
  • 93.58 (n)
cow
(Bos Taurus)
Mammalia ZBTB41 33 34
  • 91.72 (n)
oppossum
(Monodelphis domestica)
Mammalia ZBTB41 34
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zbtb41 33
  • 88.9 (n)
mouse
(Mus musculus)
Mammalia Zbtb41 33 16 34
  • 88.68 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ZBTB41 34
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZBTB41 33 34
  • 78.75 (n)
lizard
(Anolis carolinensis)
Reptilia ZBTB41 34
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zbtb41 33
  • 67.7 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC573743 33
  • 63.92 (n)
ZBTB41 34
  • 61 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG7101 34
  • 28 (a)
OneToMany
CG12942 34
  • 10 (a)
OneToMany
CG30020 34
  • 8 (a)
OneToMany
Species where no ortholog for ZBTB41 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB41 Gene

ENSEMBL:
Gene Tree for ZBTB41 (if available)
TreeFam:
Gene Tree for ZBTB41 (if available)

Paralogs for ZBTB41 Gene

(387) SIMAP similar genes for ZBTB41 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZBTB41: view

No data available for Paralogs for ZBTB41 Gene

Variants for ZBTB41 Gene

Sequence variations from dbSNP and Humsavar for ZBTB41 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000014055 -- 197,183,434(-) C/G intron_variant
rs1000146916 -- 197,153,219(-) T/C downstream_transcript_variant
rs1000150979 -- 197,183,650(-) C/A/G intron_variant
rs1000289961 -- 197,154,041(-) C/T 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant
rs1000299612 -- 197,168,924(-) G/A genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZBTB41 Gene

Variant ID Type Subtype PubMed ID
esv2445525 CNV deletion 19546169
esv2758990 CNV gain+loss 17122850
esv3588492 CNV loss 21293372
esv3588493 CNV loss 21293372
nsv1068409 CNV deletion 25765185
nsv1145390 CNV deletion 24896259
nsv528460 CNV gain 19592680
nsv548871 CNV loss 21841781

Variation tolerance for ZBTB41 Gene

Residual Variation Intolerance Score: 11.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.10; 69.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZBTB41 Gene

Human Gene Mutation Database (HGMD)
ZBTB41
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZBTB41

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBTB41 Gene

Disorders for ZBTB41 Gene

Additional Disease Information for ZBTB41

No disorders were found for ZBTB41 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZBTB41 Gene

Publications for ZBTB41 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58
  4. Lupus nephritis susceptibility loci in women with systemic lupus erythematosus. (PMID: 24925725) Chung SA … International Consortium for Systemic Lupus Erythematosus Genetics (Journal of the American Society of Nephrology : JASN 2014) 3 58
  5. Ischemic stroke is associated with the ABO locus: the EuroCLOT study. (PMID: 23381943) Williams FM … International Stroke Genetics Consortium (Annals of neurology 2013) 3 58

Products for ZBTB41 Gene

Sources for ZBTB41 Gene

Content
Loading form....